iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Gac-041366

UUCD1 version

UUC-GaA-00035

Ensembl Protein ID

ENSGACP00000001165.1

UniProt Accession

G3N788; G3N788_GASAC

Protein Name

Uncharacterized protein

Gene Name

HECW1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGACG00000000895.1	ENSGACT00000001165.1	ENSGACP00000001165.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	4.40e-115	385.0	1239	1572

Active Site

Position(s)	Description	Evidence
1540	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEeg.ldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrll 88
           + ++++l+v+f+gEeg ld++G++ref++lls+el+np++glf+ys+nd++t+q++p s +  ++hl+++ fl ++lg+al ++ ll
   Q: 1239 ELQRNKLYVTFLGEEGwLDYSGPSREFFFLLSQELFNPYYGLFEYSANDTYTVQISPMSAFV-ENHLEWWAFLAKILGLALIHQYLL 1324
           567899*******99658*****************************************985.6*********************** PP
   S: 89   dlplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvk 175
           d++++++fyk ll+ + +l+dle +d+e+++sl+++k+n   di+++ ldltf+v+ee++g+++e+eLk+gG+ni+Vt++Nk++Y++
   Q: 1325 DAFFTRPFYKALLRLSTDLSDLEYLDEEFHQSLQWMKDN---DITDI-LDLTFTVNEEVFGQVTERELKSGGSNIQVTEKNKKDYIE 1407
           *************************************99...9***9.*************************************** PP
   S: 176  lvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerk 262
           +++++r+++g+ +q+ea+ +Gf+ev++ +l+s+F+++elel+i G+ eid+ d++++t+y+ggy++ + +++wFw ++e+f++e+r 
   Q: 1408 RMAKWRVERGVVQQTEALVRGFYEVVDSRLVSVFDARELELVIAGTVEIDLIDWRSNTEYRGGYHDGHIVMRWFWAAVERFNNEQRL 1494
           *************************************************************************************** PP
   S: 263  afLqFvTgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFels 336
           ++LqFvTg+s++P +Gfa+l+     r+f+i+k+++ ++lP+++TCfn+L+LP+Y+s++ l+ekLl+A+eet+ F+l+
   Q: 1495 RLLQFVTGTSSVPYEGFASLRgsngLRRFCIEKWGKVTSLPRAHTCFNRLDLPPYPSYTMLYEKLLVAVEETSTFGLE 1572
           *************************999***********************************************985 PP

Organism

Gasterosteus aculeatus

Protein Sequence
(Fasta)

VIMLMQLCSI KNLYQNRLLG LAAMASPTRG SRTRQRCKDA ARHSYGPDSY AVNGLTQEGF 60
MLGLPRSTSD TDLVSPDARS TLAISSSHYT IGQSEDMVVT WDIKEEVDAG DWIGMYLVDE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTCATTATGC TGATGCAGCT CTGTAGTATC AAGGTCAGTC CCCCCTCCCA CCCCGCTCAC 60
CACCACTCAG TCTGATGCCT GGTGCCAATA GTACGGTGGC CCTGAAGTGC AAAAACACAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR032348--HECW_N
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF16562--HECW_N
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001636	Ailuropoda melanoleuca	76.99	0.00e+00	1303.00
IUUC-Aca-005024	Anolis carolinensis	71.10	0.00e+00	1413.00
IUUC-Bta-012604	Bos taurus	76.84	0.00e+00	1337.00
IUUC-Cja-019880	Callithrix jacchus	72.30	0.00e+00	1248.00
IUUC-Cfa-021216	Canis familiaris	77.61	0.00e+00	1344.00
IUUC-Cpo-021466	Cavia porcellus	77.49	0.00e+00	1342.00
IUUC-Csa-023080	Chlorocebus sabaeus	66.09	0.00e+00	1903.00
IUUC-Cho-024740	Choloepus hoffmanni	82.42	0.00e+00	1017.00
IUUC-Dre-028750	Danio rerio	69.53	0.00e+00	1441.00
IUUC-Dno-030019	Dasypus novemcinctus	64.73	0.00e+00	1864.00
IUUC-Dor-031030	Dipodomys ordii	63.13	0.00e+00	952.00
IUUC-Ete-032352	Echinops telfairi	83.60	0.00e+00	1119.00
IUUC-Eca-033948	Equus caballus	77.32	0.00e+00	1342.00
IUUC-Eeu-034474	Erinaceus europaeus	63.58	0.00e+00	755.00
IUUC-Fca-036148	Felis catus	77.85	0.00e+00	1337.00
IUUC-Fal-036957	Ficedula albicollis	70.53	0.00e+00	1407.00
IUUC-Gmo-038714	Gadus morhua	68.88	0.00e+00	1112.00
IUUC-Gga-041194	Gallus gallus	70.69	0.00e+00	1412.00
IUUC-Ggo-045442	Gorilla gorilla	71.96	0.00e+00	1265.00
IUUC-Hsa-045730	Homo sapiens	65.20	0.00e+00	1891.00
IUUC-Itr-048439	Ictidomys tridecemlineatus	71.96	0.00e+00	1414.00
IUUC-Lch-050185	Latimeria chalumnae	63.81	0.00e+00	1190.00
IUUC-Loc-052744	Lepisosteus oculatus	65.82	0.00e+00	1969.00
IUUC-Laf-054368	Loxodonta africana	81.62	0.00e+00	1282.00
IUUC-Mcc-055487	Macaca mulatta	71.72	0.00e+00	1399.00
IUUC-Mga-059545	Meleagris gallopavo	70.64	0.00e+00	1415.00
IUUC-Mmr-061078	Microcebus murinus	75.36	0.00e+00	1285.00
IUUC-Mdo-062176	Monodelphis domestica	69.41	0.00e+00	1352.00
IUUC-Mmu-063513	Mus musculus	70.08	0.00e+00	1370.00
IUUC-Mpu-065786	Mustela putorius furo	77.65	0.00e+00	1339.00
IUUC-Mlu-067780	Myotis lucifugus	70.70	0.00e+00	1175.00
IUUC-Nle-069213	Nomascus leucogenys	71.63	0.00e+00	1405.00
IUUC-Opr-070208	Ochotona princeps	82.54	0.00e+00	1272.00
IUUC-Ont-072132	Oreochromis niloticus	79.01	0.00e+00	1674.00
IUUC-Oan-072807	Ornithorhynchus anatinus	76.93	0.00e+00	1335.00
IUUC-Ocu-074745	Oryctolagus cuniculus	77.70	0.00e+00	1340.00
IUUC-Ola-086981	Oryzias latipes	77.75	0.00e+00	2291.00
IUUC-Oga-087965	Otolemur garnettii	77.19	0.00e+00	1314.00
IUUC-Oar-089749	Ovis aries	76.59	0.00e+00	1329.00
IUUC-Ptr-091243	Pan troglodytes	77.63	0.00e+00	1345.00
IUUC-Pan-092201	Papio anubis	66.09	0.00e+00	1872.00
IUUC-Psi-093511	Pelodiscus sinensis	76.30	0.00e+00	1329.00
IUUC-Pfo-097001	Poecilia formosa	73.09	0.00e+00	1774.00
IUUC-Pab-098728	Pongo abelii	63.32	0.00e+00	1794.00
IUUC-Pca-100129	Procavia capensis	66.14	0.00e+00	987.00
IUUC-Pva-102250	Pteropus vampyrus	73.75	0.00e+00	1251.00
IUUC-Rno-105031	Rattus norvegicus	64.53	0.00e+00	1839.00
IUUC-Tgu-117515	Taeniopygia guttata	76.56	0.00e+00	1343.00
IUUC-Tru-117914	Takifugu rubripes	86.45	0.00e+00	1528.00
IUUC-Tsy-119379	Tarsius syrichta	71.08	0.00e+00	703.00
IUUC-Tni-120178	Tetraodon nigroviridis	84.88	0.00e+00	1525.00
IUUC-Tbe-127762	Tupaia belangeri	72.65	0.00e+00	1208.00
IUUC-Ttr-128806	Tursiops truncatus	77.21	0.00e+00	1332.00
IUUC-Vpa-130812	Vicugna pacos	66.67	6.00e-137	482.00
IUUC-Xtr-132903	Xenopus tropicalis	76.42	0.00e+00	1358.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence