iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000098349.1	ENSDART00000169682.1	ENSDARP00000138997.1
ENSDARG00000098349.1	ENSDART00000165238.1	ENSDARP00000131327.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/Other	77.14	0.00e+00	1367.00	IUUC-Hsa-046925

Active Site

Position(s)	Description	Evidence
771	N/A	{ECO:0000256\|PIRSR:PIRSR037911-1}

Organism

Danio rerio

Functional Description
(View)

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.

Protein Sequence
(Fasta)

MTSHSRPDGL PSKEQPLELL KPSGVNHIPP VDVSVALPLQ VPPSAIPMDL RVDHQFALAP 60
TDPAQREHQL QQELLALKQK QQIQRQLLIE EFQRQHEQLS RQHEAQLQEH VKHQQDLLAL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TAAACTTATC GAGTGAAGAA GAAACAACAA ACCTAAAGAG CTGGATTACA ACCAAAAGGA 60
GTGCTATGAG TTTCTGAGAT TGCTCTTCTT TCCACTCCTG ACTCATCTTC CCATTGGGCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc

Interpro

IPR033660--HDAC4
IPR000286--His_deacetylse
IPR023801--His_deacetylse_dom
IPR024643--Hist_deacetylase_Gln_rich_N
IPR017320--Histone_deAcase_II_euk

Pfam

PF12203--HDAC4_Gln
PF00850--Hist_deacetyl

PRINTS

PR01270--HDASUPER

Gene Ontology

GO:0000118--C:histone deacetylase complex
GO:0046872--F:metal ion binding
GO:0032041--F:NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0048701--P:embryonic cranial skeleton morphogenesis
GO:0001755--P:neural crest cell migration
GO:0090299--P:regulation of neural crest formation
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002279	Ailuropoda melanoleuca	76.28	0.00e+00	1411.00
IUUC-Apl-003250	Anas platyrhynchos	75.79	0.00e+00	1370.00
IUUC-Aca-004668	Anolis carolinensis	73.12	0.00e+00	1400.00
IUUC-Ang-009522	Aspergillus niger	29.02	2.00e-35	144.00
IUUC-Bta-013215	Bos taurus	77.22	0.00e+00	1415.00
IUUC-Cja-019816	Callithrix jacchus	77.94	0.00e+00	1448.00
IUUC-Cfa-020861	Canis familiaris	76.35	0.00e+00	1393.00
IUUC-Cpo-021562	Cavia porcellus	77.03	0.00e+00	1439.00
IUUC-Cre-022561	Chlamydomonas reinhardtii	52.02	4.00e-55	207.00
IUUC-Csa-023612	Chlorocebus sabaeus	77.40	0.00e+00	1420.00
IUUC-Csv-026359	Ciona savignyi	54.18	9.00e-94	336.00
IUUC-Dno-029951	Dasypus novemcinctus	76.63	0.00e+00	1315.00
IUUC-Dor-030362	Dipodomys ordii	67.35	0.00e+00	1164.00
IUUC-Dme-031766	Drosophila melanogaster	57.85	8.00e-157	548.00
IUUC-Fca-036187	Felis catus	77.91	0.00e+00	1399.00
IUUC-Gmo-038473	Gadus morhua	82.19	0.00e+00	791.00
IUUC-Gga-040501	Gallus gallus	77.50	0.00e+00	1426.00
IUUC-Gac-042335	Gasterosteus aculeatus	77.08	0.00e+00	1404.00
IUUC-Ggo-045380	Gorilla gorilla	77.03	0.00e+00	1409.00
IUUC-Hsa-046925	Homo sapiens	77.50	0.00e+00	1436.00
IUUC-Itr-048036	Ictidomys tridecemlineatus	78.96	0.00e+00	1382.00
IUUC-Lch-050325	Latimeria chalumnae	76.23	0.00e+00	1359.00
IUUC-Loc-052231	Lepisosteus oculatus	85.12	0.00e+00	1553.00
IUUC-Laf-054490	Loxodonta africana	73.97	0.00e+00	1362.00
IUUC-Mcc-055265	Macaca mulatta	77.06	0.00e+00	1418.00
IUUC-Meu-056676	Macropus eugenii	77.55	0.00e+00	660.00
IUUC-Mmr-061633	Microcebus murinus	72.41	0.00e+00	1244.00
IUUC-Mmu-063089	Mus musculus	78.32	0.00e+00	1413.00
IUUC-Mpu-065887	Mustela putorius furo	77.22	0.00e+00	1424.00
IUUC-Mlu-067470	Myotis lucifugus	78.56	0.00e+00	1421.00
IUUC-Nle-069099	Nomascus leucogenys	71.32	0.00e+00	860.00
IUUC-Ont-071613	Oreochromis niloticus	73.57	0.00e+00	1397.00
IUUC-Oan-073275	Ornithorhynchus anatinus	79.50	0.00e+00	1421.00
IUUC-Ola-087031	Oryzias latipes	72.95	0.00e+00	1321.00
IUUC-Oga-088201	Otolemur garnettii	71.64	0.00e+00	1233.00
IUUC-Oar-089997	Ovis aries	72.17	0.00e+00	1162.00
IUUC-Ptr-091116	Pan troglodytes	77.78	0.00e+00	1450.00
IUUC-Pan-092132	Papio anubis	79.88	0.00e+00	956.00
IUUC-Psi-093734	Pelodiscus sinensis	77.70	0.00e+00	1346.00
IUUC-Pma-094347	Petromyzon marinus	68.80	0.00e+00	701.00
IUUC-Pfo-096293	Poecilia formosa	72.52	0.00e+00	1367.00
IUUC-Pab-098491	Pongo abelii	74.51	0.00e+00	1347.00
IUUC-Pca-101004	Procavia capensis	65.79	0.00e+00	685.00
IUUC-Pva-102961	Pteropus vampyrus	57.31	0.00e+00	681.00
IUUC-Rno-105005	Rattus norvegicus	78.22	0.00e+00	1383.00
IUUC-Sha-107646	Sarcophilus harrisii	60.09	0.00e+00	846.00
IUUC-Ssc-115428	Sus scrofa	77.44	0.00e+00	1370.00
IUUC-Tgu-116776	Taeniopygia guttata	77.89	0.00e+00	1430.00
IUUC-Tru-118180	Takifugu rubripes	73.38	0.00e+00	1385.00
IUUC-Tsy-119468	Tarsius syrichta	71.46	6.00e-167	582.00
IUUC-Tni-120196	Tetraodon nigroviridis	73.62	0.00e+00	1365.00
IUUC-Ttr-128360	Tursiops truncatus	74.47	0.00e+00	829.00
IUUC-Xtr-132956	Xenopus tropicalis	73.99	0.00e+00	1291.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence