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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Ath-007496
UUCD1 version UUC-ArT-01664
Ensembl Protein ID AT1G71230.1
UniProt Accession Q9FVU9; O82523; CSN5B_ARATH
Genbank Protein ID AAC36343.1; AAL58104.1; AAG51882.1; AEE35176.1; AAL06468.1; AAM70525.1
Protein Name COP9 signalosome complex subunit 5b; Jun activation domain-binding homolog 2
Genbank Nucleotide ID AF087412; AF395061; AC016162; CP002684; AF411778; AY124816
Gene Name CSN5A; CSN5B; AJH2; At1g71230; F3I17.12
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
AT1G71230 AT1G71230.1 AT1G71230.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
Protein-protein Interaction
iRefIndexPINAHINTMentha
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
DUB/JAMM 1.60e-07 32.0 142 155
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   DUB/JAMM
   S: 1    HSHPgftcwlSsVD 14
           HSHPg++cwlS++D
   Q: 142  HSHPGYGCWLSGID 155
           *************9 PP
   
Organism Arabidopsis thaliana
Functional Description
(View)

Functional Description


     Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes such as photomorphogenesis and auxin and jasmonate responses. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex (By similarity). The CSN complex is involved in repression of photomorphogenesis in darkness by regulating the activity of COP1-containing Ubl ligase complexes. The complex is also required for degradation of PSIAA6 by regulating the activity of the Ubl ligase SCF-TIR complex. Not involved in CSN's deneddylation/derubylation activity (PubMed:15486099, PubMed:17307927). Essential for the structural integrity of the CSN holocomplex (PubMed:17307927).
 Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes such as photomorphogenesis and auxin and jasmonate responses. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex (By similarity). The CSN complex is involved in repression of photomorphogenesis in darkness by regulating the activity of COP1-containing Ubl ligase complexes. The complex is also required for degradation of PSIAA6 by regulating the activity of the Ubl ligase SCF-TIR complex. Not involved in CSN's deneddylation/derubylation activity (PubMed:15486099, PubMed:17307927). Essential for the structural integrity of the CSN holocomplex (PubMed:17307927).
Protein Sequence
(Fasta)
MEGSSSTIAR KTWELENSIL TVDSPDSTSD NIFYYDDTSQ TRFQQEKPWE NDPHYFKRVK 60
ISALALLKMV VHARSGGTIE IMGLMQGKTD GDTIIVMDAF ALPVEGTETR VNAQDDAYEY 120
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Protein Fasta Sequence


>IUUC-Ath-007496|DUB,JAMM|Arabidopsis thaliana
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Nucleotide Sequence
(Fasta)
ATTTTCACCA CTTTTCTCTT CTTATATATA AGTCAATCCC CGAAGTAACA TTTTTGACAC 60
AGTTTTCAAT TCTTCAGCAG ACAGATCGAT CACACTCCAT CGATTCCGTA TGAAACCCTA 120
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Nucleotide Fasta Sequence


>IUUC-Ath-007496|DUB,JAMM|Arabidopsis thaliana
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Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0217--Developmental protein
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0482--Metalloprotease
KW-0539--Nucleus
KW-0607--Phytochrome signaling pathway
KW-0645--Protease
KW-1185--Reference proteome
KW-0736--Signalosome
KW-0862--Zinc
Interpro

IPR000555--JAMM/MPN+_dom
Pfam

PF01398--JAB
SMART

SM00232--JAB_MPN
Gene Ontology

GO:0008180--C:COP9 signalosome
GO:0005737--C:cytoplasm
GO:0046872--F:metal ion binding
GO:0008237--F:metallopeptidase activity
GO:0010387--P:COP9 signalosome assembly
GO:0007275--P:multicellular organism development
GO:0010100--P:negative regulation of photomorphogenesis
GO:0010971--P:positive regulation of G2/M transition of mitotic cell cycle
GO:0045732--P:positive regulation of protein catabolic process
GO:0000338--P:protein deneddylation
GO:0009585--P:red, far-red light phototransduction
GO:2000082--P:regulation of L-ascorbic acid biosynthetic process
GO:0009733--P:response to auxin
KEGG ath:AT1G71230
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001429 Ailuropoda melanoleuca 67.47 5.00e-116 409.00
IUUC-Atr-003048 Amborella trichopoda 79.89 2.00e-164 571.00
IUUC-Apl-003610 Anas platyrhynchos 72.41 3.00e-110 390.00
IUUC-Aca-004662 Anolis carolinensis 72.63 3.00e-108 384.00
IUUC-Aly-005914 Arabidopsis lyrata 94.96 0.00e+00 683.00
IUUC-Acl-008155 Aspergillus clavatus 55.12 2.00e-99 355.00
IUUC-Afu-008820 Aspergillus fumigatus 54.19 1.00e-98 352.00
IUUC-Ani-009303 Aspergillus nidulans 53.92 3.00e-99 354.00
IUUC-Ang-009617 Aspergillus niger 50.27 3.00e-94 337.00
IUUC-Aor-009888 Aspergillus oryzae 54.46 2.00e-98 351.00
IUUC-Ate-010575 Aspergillus terreus 55.42 7.00e-102 362.00
IUUC-Ame-010617 Astyanax mexicanus 68.80 1.00e-122 432.00
IUUC-Bgr-012019 Blumeria graminis 57.74 9.00e-104 369.00
IUUC-Bta-013211 Bos taurus 66.86 2.00e-118 417.00
IUUC-Cja-019703 Callithrix jacchus 66.86 2.00e-118 417.00
IUUC-Cfa-020181 Canis familiaris 66.86 2.00e-118 417.00
IUUC-Cpo-021499 Cavia porcellus 66.86 2.00e-118 417.00
IUUC-Csa-024200 Chlorocebus sabaeus 66.86 2.00e-118 417.00
IUUC-Cne-026988 Cryptococcus neoformans 50.14 8.00e-85 306.00
IUUC-Dre-028134 Danio rerio 67.65 2.00e-119 421.00
IUUC-Dno-029658 Dasypus novemcinctus 66.86 2.00e-118 417.00
IUUC-Dor-031074 Dipodomys ordii 66.86 2.00e-118 417.00
IUUC-Dme-032199 Drosophila melanogaster 65.47 2.00e-117 414.00
IUUC-Eca-034095 Equus caballus 66.86 2.00e-118 417.00
IUUC-Eeu-034934 Erinaceus europaeus 71.43 1.00e-96 345.00
IUUC-Fca-035569 Felis catus 66.86 2.00e-118 417.00
IUUC-Fal-037553 Ficedula albicollis 72.98 1.00e-108 384.00
IUUC-Gmo-039438 Gadus morhua 66.86 8.00e-115 405.00
IUUC-Gga-040344 Gallus gallus 68.09 3.00e-116 410.00
IUUC-Gac-042256 Gasterosteus aculeatus 67.54 4.00e-116 410.00
IUUC-Gma-043226 Glycine max 79.67 4.00e-166 576.00
IUUC-Hsa-046659 Homo sapiens 66.86 2.00e-118 417.00
IUUC-Itr-048834 Ictidomys tridecemlineatus 67.16 3.00e-118 417.00
IUUC-Lch-049562 Latimeria chalumnae 67.25 4.00e-118 417.00
IUUC-Loc-051798 Lepisosteus oculatus 67.96 3.00e-115 407.00
IUUC-Lma-052979 Leptosphaeria maculans 54.09 8.00e-98 349.00
IUUC-Laf-053391 Loxodonta africana 70.54 8.00e-87 311.00
IUUC-Mcc-055667 Macaca mulatta 66.86 2.00e-118 417.00
IUUC-Meu-056067 Macropus eugenii 47.31 7.00e-52 196.00
IUUC-Mpo-057347 Magnaporthe poae 53.51 8.00e-100 356.00
IUUC-Mga-059473 Meleagris gallopavo 72.98 1.00e-108 384.00
IUUC-Mvi-060540 Microbotryum violaceum 54.62 3.00e-109 387.00
IUUC-Mmr-061138 Microcebus murinus 78.92 2.00e-76 277.00
IUUC-Mdo-062893 Monodelphis domestica 66.57 6.00e-118 416.00
IUUC-Mmu-063637 Mus musculus 67.16 3.00e-118 417.00
IUUC-Mac-064683 Musa acuminata 78.67 6.00e-159 552.00
IUUC-Mlu-067872 Myotis lucifugus 65.98 3.00e-115 407.00
IUUC-Nfi-068443 Neosartorya fischeri 53.61 6.00e-97 346.00
IUUC-Nle-068972 Nomascus leucogenys 66.86 2.00e-118 417.00
IUUC-Ont-072538 Oreochromis niloticus 67.65 1.00e-116 412.00
IUUC-Oan-073143 Ornithorhynchus anatinus 66.28 8.00e-118 416.00
IUUC-Ocu-074197 Oryctolagus cuniculus 66.86 2.00e-118 417.00
IUUC-Ola-086850 Oryzias latipes 67.93 5.00e-117 413.00
IUUC-Olu-087607 Ostreococcus lucimarinus 54.13 5.00e-93 333.00
IUUC-Oga-088640 Otolemur garnettii 67.47 5.00e-116 410.00
IUUC-Oar-090299 Ovis aries 67.47 3.00e-116 410.00
IUUC-Ptr-091499 Pan troglodytes 66.86 2.00e-118 417.00
IUUC-Pan-091751 Papio anubis 72.22 7.00e-108 383.00
IUUC-Psi-092978 Pelodiscus sinensis 66.87 5.00e-115 406.00
IUUC-Pma-094634 Petromyzon marinus 67.07 3.00e-116 410.00
IUUC-Pno-095094 Phaeosphaeria nodorum 52.45 1.00e-98 352.00
IUUC-Ppa-095440 Physcomitrella patens 78.42 2.00e-162 564.00
IUUC-Pfo-097332 Poecilia formosa 67.64 8.00e-117 412.00
IUUC-Pab-097998 Pongo abelii 66.86 2.00e-118 417.00
IUUC-Pca-100521 Procavia capensis 66.95 5.00e-32 130.00
IUUC-Ppe-101309 Prunus persica 81.54 8.00e-171 592.00
IUUC-Pva-102953 Pteropus vampyrus 66.86 2.00e-118 417.00
IUUC-Pte-104273 Pyrenophora teres 54.12 2.00e-99 355.00
IUUC-Pyt-104627 Pyrenophora triticirepentis 52.41 8.00e-98 349.00
IUUC-Rno-105666 Rattus norvegicus 67.16 9.00e-118 416.00
IUUC-Sha-106602 Sarcophilus harrisii 66.57 6.00e-118 416.00
IUUC-Spo-108318 Schizosaccharomyces pombe 47.33 1.00e-67 248.00
IUUC-Sit-110526 Setaria italica 78.59 3.00e-149 520.00
IUUC-Sar-113459 Sorex araneus 67.16 2.00e-118 417.00
IUUC-Sbi-114873 Sorghum bicolor 79.53 1.00e-155 541.00
IUUC-Sre-114919 Sporisorium reilianum 63.54 9.00e-99 353.00
IUUC-Ssc-116102 Sus scrofa 66.86 2.00e-118 417.00
IUUC-Tgu-116937 Taeniopygia guttata 73.46 3.00e-97 347.00
IUUC-Tru-118615 Takifugu rubripes 67.35 4.00e-116 410.00
IUUC-Tsy-119173 Tarsius syrichta 67.08 4.00e-109 386.00
IUUC-Tni-120246 Tetraodon nigroviridis 67.35 4.00e-116 410.00
IUUC-Tca-121859 Theobroma cacao 84.33 8.00e-171 592.00
IUUC-Tbe-128108 Tupaia belangeri 66.28 6.00e-115 406.00
IUUC-Ttr-128644 Tursiops truncatus 66.86 2.00e-118 417.00
IUUC-Vpa-130110 Vicugna pacos 66.86 2.00e-118 417.00
IUUC-Xtr-132739 Xenopus tropicalis 67.16 7.00e-119 419.00
IUUC-Xma-133919 Xiphophorus maculatus 67.64 1.00e-116 412.00
IUUC-Yli-134677 Yarrowia lipolytica 49.28 1.00e-87 315.00
IUUC-Zma-135578 Zea mays 78.37 9.00e-159 551.00
Created Date 25-Jun-2017

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