iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oar-089214

Ensembl Protein ID

ENSOARP00000022267.1

UniProt Accession

W5QHR7; W5QHR7_SHEEP

Genbank Protein ID

ENSOARP00000022267

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AMGL01009579

Gene Name

TBL1XR1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOARG00000020719.1	ENSOART00000022572.1	ENSOARP00000022267.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	8.40e-54	177.3	348	386
UBD/Beta-Prp	1.30e-65	221.7	312	514

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllk 37
           gHt++v+++++ ++ +ll+s+sdD t+k+W+++++++++
   Q: 348  GHTNEVNAIKWdPTgNLLASCSDDMTLKIWSMKQDNCVH 386
           8***********778*********************987 PP

UBD/Beta-Prp

   S: 13   itcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlsls 101
             +v++ ++++ +a+ s+d +i v ++ +   +++++gh++ev+a+k++p+g++l+++s+D+t+k+w++++  cvh l++h++++++++
   Q: 312  ALDVDW-QSNNTFASCSTDMCIHVCKLGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIK 399
           444555.6667777777777777777777777777777777777777777777777777777777777777777777777777777777 PP
   S: 102  fsp........sg.dklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtd 181
           +sp        +    l+s+s d+t+r+wd++ g c++ tl++h++ v +v+++pdg++l+sGs D++v +W+ +tg l++  +g  t+
   Q: 400  WSPtgpgtsnpNAnLMLASASFDSTVRLWDVDRGICIH-TLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWNTQTGALVHSYRG--TG 485
           77755554444222467777777777777777777777.7777777777777777777777777777777777777777777776..77 PP
   S: 182  svyslsfdsngkelvsgsldgtvklwdlq 210
            +  + ++  g  + + + dg+v + dl+
   Q: 486  GIFEVCWNAAGDKVGASASDGSVCVLDLR 514
           77777777777777777777777766665 PP

Organism

Ovis aries

Protein Sequence
(Fasta)

KMSISSDEVN FLVYRYLQES GFSHSAFTFG IESHISQSNI NGALVPPAAL ISIIQKGLQY 60
VEAEVSINED GTLFDGRPIE SLSLIDAVMP DVVQTRQQAY RDKLAQQQAA AAAAAAAATN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCGGGGGGGG GGGGGGGGGG GGGGGGGGGG GGGGGGGGGG GGGGGGCCGC GGTGGTCTGG 60
GGGGCGCCAG GCCGCGGTGG TGGTGGGGGG GATGGGCGCA AGTGGAACAT GCATTTTTCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR006594--LisH
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50896--LISH
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08513--LisH
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00667--LisH
SM00320--WD40

Gene Ontology

GO:0000118--C:histone deacetylase complex
GO:0005876--C:spindle microtubule
GO:0017053--C:transcriptional repressor complex
GO:0003714--F:transcription corepressor activity
GO:0044212--F:transcription regulatory region DNA binding
GO:0060070--P:canonical Wnt signaling pathway
GO:0060613--P:fat pad development
GO:0016042--P:lipid catabolic process
GO:0035264--P:multicellular organism growth
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0030814--P:regulation of cAMP metabolic process
GO:0090207--P:regulation of triglyceride metabolic process
GO:0002021--P:response to dietary excess
GO:0050872--P:white fat cell differentiation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000916	Aegilops tauschii	60.00	3.00e-54	203.00
IUUC-Aml-001717	Ailuropoda melanoleuca	99.03	0.00e+00	959.00
IUUC-Atr-002514	Amborella trichopoda	65.11	2.00e-144	506.00
IUUC-Apl-003708	Anas platyrhynchos	99.19	0.00e+00	926.00
IUUC-Aca-004611	Anolis carolinensis	99.03	0.00e+00	964.00
IUUC-Ath-007137	Arabidopsis thaliana	59.23	1.00e-120	427.00
IUUC-Ame-011601	Astyanax mexicanus	92.41	0.00e+00	905.00
IUUC-Bta-012418	Bos taurus	99.81	0.00e+00	997.00
IUUC-Bol-016277	Brassica oleracea	56.99	2.00e-126	446.00
IUUC-Bra-016944	Brassica rapa	60.28	5.00e-126	444.00
IUUC-Cja-018832	Callithrix jacchus	99.61	0.00e+00	966.00
IUUC-Cfa-020029	Canis familiaris	99.22	0.00e+00	960.00
IUUC-Cpo-022080	Cavia porcellus	94.19	0.00e+00	928.00
IUUC-Csa-024075	Chlorocebus sabaeus	99.42	0.00e+00	960.00
IUUC-Cho-024872	Choloepus hoffmanni	99.57	1.00e-112	400.00
IUUC-Dre-028075	Danio rerio	96.11	0.00e+00	931.00
IUUC-Dno-029196	Dasypus novemcinctus	99.81	0.00e+00	977.00
IUUC-Dor-030732	Dipodomys ordii	99.18	0.00e+00	734.00
IUUC-Eeu-034952	Erinaceus europaeus	89.41	0.00e+00	832.00
IUUC-Fca-035734	Felis catus	99.42	0.00e+00	971.00
IUUC-Fal-037185	Ficedula albicollis	99.22	0.00e+00	966.00
IUUC-Gmo-038870	Gadus morhua	90.27	0.00e+00	930.00
IUUC-Gga-041161	Gallus gallus	99.42	0.00e+00	969.00
IUUC-Gac-041844	Gasterosteus aculeatus	92.04	0.00e+00	954.00
IUUC-Gma-044208	Glycine max	48.78	9.00e-152	530.00
IUUC-Ggo-044882	Gorilla gorilla	99.42	0.00e+00	960.00
IUUC-Hsa-046488	Homo sapiens	99.42	0.00e+00	960.00
IUUC-Itr-047958	Ictidomys tridecemlineatus	99.73	0.00e+00	741.00
IUUC-Lch-050672	Latimeria chalumnae	96.50	0.00e+00	975.00
IUUC-Lpe-051084	Leersia perrieri	62.36	8.00e-136	477.00
IUUC-Loc-052030	Lepisosteus oculatus	96.14	0.00e+00	962.00
IUUC-Laf-054280	Loxodonta africana	99.42	0.00e+00	996.00
IUUC-Mcc-055203	Macaca mulatta	99.42	0.00e+00	962.00
IUUC-Meu-056563	Macropus eugenii	97.90	3.00e-135	474.00
IUUC-Mtr-058624	Medicago truncatula	60.16	3.00e-128	452.00
IUUC-Mga-059660	Meleagris gallopavo	99.42	0.00e+00	969.00
IUUC-Mvi-060557	Microbotryum violaceum	36.77	9.00e-71	261.00
IUUC-Mmr-060925	Microcebus murinus	98.00	0.00e+00	924.00
IUUC-Mdo-062078	Monodelphis domestica	98.83	0.00e+00	962.00
IUUC-Mmu-063603	Mus musculus	99.22	0.00e+00	970.00
IUUC-Mac-065508	Musa acuminata	61.42	1.00e-92	333.00
IUUC-Mpu-066741	Mustela putorius furo	99.22	0.00e+00	960.00
IUUC-Mlu-068152	Myotis lucifugus	99.61	0.00e+00	966.00
IUUC-Nle-069229	Nomascus leucogenys	99.42	0.00e+00	960.00
IUUC-Opr-070277	Ochotona princeps	88.76	0.00e+00	823.00
IUUC-Ont-072623	Oreochromis niloticus	92.23	0.00e+00	954.00
IUUC-Ocu-074280	Oryctolagus cuniculus	97.71	0.00e+00	964.00
IUUC-Oba-075618	Oryza barthii	48.47	5.00e-144	504.00
IUUC-Obr-076718	Oryza brachyantha	62.64	2.00e-136	479.00
IUUC-Ogl-077302	Oryza glaberrima	50.63	3.00e-156	545.00
IUUC-Ogu-078718	Oryza glumaepatula	50.63	3.00e-156	545.00
IUUC-Oin-079515	Oryza indica	44.12	2.00e-94	340.00
IUUC-Olo-080427	Oryza longistaminata	63.04	2.00e-131	462.00
IUUC-Ome-081696	Oryza meridionalis	49.55	5.00e-151	527.00
IUUC-Oni-082137	Oryza nivara	50.63	3.00e-156	545.00
IUUC-Opu-083505	Oryza punctata	48.47	8.00e-143	500.00
IUUC-Oru-085276	Oryza rufipogon	50.45	9.00e-156	543.00
IUUC-Osa-085791	Oryza sativa	50.63	3.00e-156	545.00
IUUC-Ola-087365	Oryzias latipes	95.74	0.00e+00	957.00
IUUC-Oga-088357	Otolemur garnettii	95.14	0.00e+00	907.00
IUUC-Ptr-091532	Pan troglodytes	99.42	0.00e+00	960.00
IUUC-Pan-091927	Papio anubis	99.42	0.00e+00	960.00
IUUC-Psi-093941	Pelodiscus sinensis	92.41	0.00e+00	942.00
IUUC-Pma-094105	Petromyzon marinus	63.28	9.00e-101	359.00
IUUC-Ppa-095868	Physcomitrella patens	66.57	2.00e-140	492.00
IUUC-Pfo-096158	Poecilia formosa	92.23	0.00e+00	954.00
IUUC-Pab-098705	Pongo abelii	99.42	0.00e+00	960.00
IUUC-Pca-100256	Procavia capensis	98.82	0.00e+00	951.00
IUUC-Pva-102616	Pteropus vampyrus	99.21	0.00e+00	952.00
IUUC-Rno-105411	Rattus norvegicus	99.42	0.00e+00	972.00
IUUC-Sce-106132	Saccharomyces cerevisiae	24.96	4.00e-43	169.00
IUUC-Sha-106636	Sarcophilus harrisii	98.26	0.00e+00	957.00
IUUC-Smo-109301	Selaginella moellendorffii	63.76	2.00e-143	502.00
IUUC-Sit-110710	Setaria italica	63.43	6.00e-142	497.00
IUUC-Sar-112971	Sorex araneus	90.59	0.00e+00	868.00
IUUC-Sbi-114420	Sorghum bicolor	62.91	7.00e-142	497.00
IUUC-Sre-115175	Sporisorium reilianum	37.17	5.00e-58	219.00
IUUC-Ssc-115695	Sus scrofa	97.86	0.00e+00	952.00
IUUC-Tgu-117009	Taeniopygia guttata	99.41	0.00e+00	953.00
IUUC-Tru-118581	Takifugu rubripes	94.95	0.00e+00	956.00
IUUC-Tsy-119424	Tarsius syrichta	82.25	0.00e+00	740.00
IUUC-Tni-119986	Tetraodon nigroviridis	95.34	0.00e+00	957.00
IUUC-Tca-121739	Theobroma cacao	56.59	2.00e-124	439.00
IUUC-Tae-125368	Triticum aestivum	61.35	3.00e-135	475.00
IUUC-Tur-126856	Triticum urartu	41.88	1.00e-74	273.00
IUUC-Tme-127126	Tuber melanosporum	38.71	2.00e-58	219.00
IUUC-Tbe-127665	Tupaia belangeri	83.43	0.00e+00	829.00
IUUC-Vpa-130768	Vicugna pacos	99.02	0.00e+00	946.00
IUUC-Xtr-132842	Xenopus tropicalis	92.38	0.00e+00	913.00
IUUC-Xma-134020	Xiphophorus maculatus	92.25	0.00e+00	957.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence