iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ocu-074503

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAGW02012648

Gene Name

UBR5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOCUG00000008549.3	ENSOCUT00000008570.3	ENSOCUP00000007408.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	3.40e-80	270.0	2501	2824

Active Site

Position(s)	Description	Evidence
2794	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 16   EegldlgGvtreflallskelqnpd..lglf.lysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlplsksfykl 99
           +e+ + +G++r ++++ ++++ + d  ++lf +  +++ +t +p +++      +l++F+ +Gr+lg++l +++l++++l+++++k 
   Q: 2501 QENRKRHGSSRSVVDMDLDDTDDGDdnAPLFyQPGKRGFYTPRPGKNTE----ARLNCFRNIGRILGLCLLQNELCPITLNRHVIKV 2583
           5667888**************9999778888334444777777777775....89******************************** PP
   S: 100  llgkklsledleevdpelyks.lkeikena..esdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlk 183
           llg+k++++d++ +dp +y+s  + i++++  ++d   +++dl+f ++ ++ +   ++eL+p+G n+pVt +N +eYv++++e+r+ 
   Q: 2584 LLGRKVNWHDFAFFDPVMYESlRQLILASQssDADAVFSAMDLAFAIDLCKEEGGGQVELIPNGVNVPVTPQNVYEYVRKYAEHRML 2670
           *********************5556666655556888999*********************************************** PP
   S: 184  egikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspai....qwFwevleefsseerkafLq 266
              ++ ++a+r+G+ +v+p+++l+ +t+e+++ll++G+ e++v++l ++t+++++  e+ +++    +wFw+++e++s++er++++ 
   Q: 2671 VVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENAEKLlqfkRWFWSIVEKMSMTERQDLVY 2757
           ****************************************************9999999999989999******************* PP
   S: 267  FvTgssrlPl..gGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           F+T+s++lP+  +Gf++++  +++ir   +d++lP++nTC+++L +P Yssk+ilk+kLl+Ai++ k+F++
   Q: 2758 FWTSSPSLPAseEGFQPMP--SITIRP-PDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIKT-KNFGF 2824
           **********999******..799999.99**********************************9.99875 PP

Organism

Oryctolagus cuniculus

Protein Sequence
(Fasta)

MVFGGKENPK EAGENRRGPS SGRGREGSAM TSIHFVVHPL PGTEDQLNDR LREVSEKLNK 60
YNLNSHPPLN VLEQATIKQC VVGPNHAAFL LEDGRVCRIG FSVQPDRLEL GKPDNTDGSK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CATTTATTGA TCGAAGGCAA CACCGGCGAC AGAGGCTATG GTATTTGGAG GAAAAGAGAA 60
CCCGAAGGAG GCGGGCGAGA ACAGGAGGGG GCCGTCCTCG GGAAGAGGAC GAGAAGGAAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR024725--E3_UbLigase_EDD_UBA
IPR000569--HECT_dom
IPR002004--PABP_HYD
IPR009091--RCC1/BLIP-II
IPR003126--Znf_UBR

PROSITE

PS50237--HECT
PS51309--PABC
PS51157--ZF_UBR

Pfam

PF11547--E3_UbLigase_EDD
PF00632--HECT
PF00658--PABP

SMART

SM00119--HECTc
SM00517--PolyA
SM00396--ZnF_UBR1

Gene Ontology

GO:0005829--C:cytosol
GO:0016020--C:membrane
GO:0005654--C:nucleoplasm
GO:0048471--C:perinuclear region of cytoplasm
GO:0043234--C:protein complex
GO:0003723--F:RNA binding
GO:0034450--F:ubiquitin-ubiquitin ligase activity
GO:0008270--F:zinc ion binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:2000780--P:negative regulation of double-strand break repair
GO:1901315--P:negative regulation of histone H2A K63-linked ubiquitination
GO:0090263--P:positive regulation of canonical Wnt signaling pathway
GO:0035413--P:positive regulation of catenin import into nucleus
GO:0010628--P:positive regulation of gene expression
GO:0033160--P:positive regulation of protein import into nucleus, translocation
GO:0050847--P:progesterone receptor signaling pathway
GO:0000209--P:protein polyubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002217	Ailuropoda melanoleuca	96.78	0.00e+00	4490.00
IUUC-Apl-004165	Anas platyrhynchos	95.75	0.00e+00	4415.00
IUUC-Aca-004577	Anolis carolinensis	93.85	0.00e+00	3822.00
IUUC-Ame-010702	Astyanax mexicanus	84.12	0.00e+00	2456.00
IUUC-Bta-012313	Bos taurus	96.29	0.00e+00	4543.00
IUUC-Cel-018165	Caenorhabditis elegans	26.59	6.00e-87	317.00
IUUC-Cja-019858	Callithrix jacchus	96.16	0.00e+00	4512.00
IUUC-Cfa-020973	Canis familiaris	96.22	0.00e+00	4543.00
IUUC-Cpo-022108	Cavia porcellus	95.12	0.00e+00	1873.00
IUUC-Csa-023985	Chlorocebus sabaeus	97.21	0.00e+00	4580.00
IUUC-Cho-025034	Choloepus hoffmanni	85.90	0.00e+00	968.00
IUUC-Cin-025715	Ciona intestinalis	45.15	0.00e+00	796.00
IUUC-Csv-026088	Ciona savignyi	40.63	2.00e-142	499.00
IUUC-Dre-027730	Danio rerio	85.85	0.00e+00	3954.00
IUUC-Dno-029123	Dasypus novemcinctus	93.51	0.00e+00	4351.00
IUUC-Dor-030757	Dipodomys ordii	91.39	0.00e+00	2821.00
IUUC-Dme-032192	Drosophila melanogaster	52.79	3.00e-177	617.00
IUUC-Ete-032292	Echinops telfairi	95.03	0.00e+00	2159.00
IUUC-Eca-034347	Equus caballus	95.90	0.00e+00	4432.00
IUUC-Eeu-034873	Erinaceus europaeus	91.69	0.00e+00	4271.00
IUUC-Fca-036485	Felis catus	94.87	0.00e+00	4375.00
IUUC-Fal-037071	Ficedula albicollis	95.75	0.00e+00	4407.00
IUUC-Gmo-039589	Gadus morhua	87.16	0.00e+00	3907.00
IUUC-Gga-041195	Gallus gallus	93.50	0.00e+00	4339.00
IUUC-Gac-042538	Gasterosteus aculeatus	87.57	0.00e+00	3928.00
IUUC-Ggo-045351	Gorilla gorilla	96.05	0.00e+00	4575.00
IUUC-Hsa-045941	Homo sapiens	96.29	0.00e+00	4590.00
IUUC-Itr-048635	Ictidomys tridecemlineatus	96.15	0.00e+00	4501.00
IUUC-Lch-050480	Latimeria chalumnae	91.29	0.00e+00	4247.00
IUUC-Loc-052664	Lepisosteus oculatus	87.59	0.00e+00	4059.00
IUUC-Laf-053935	Loxodonta africana	95.74	0.00e+00	1540.00
IUUC-Mcc-054703	Macaca mulatta	97.28	0.00e+00	4586.00
IUUC-Meu-056431	Macropus eugenii	87.32	0.00e+00	799.00
IUUC-Mga-059289	Meleagris gallopavo	95.08	0.00e+00	3523.00
IUUC-Mmr-061737	Microcebus murinus	95.80	0.00e+00	4428.00
IUUC-Mdo-062499	Monodelphis domestica	94.79	0.00e+00	4398.00
IUUC-Mmu-063273	Mus musculus	95.50	0.00e+00	4465.00
IUUC-Mpu-066907	Mustela putorius furo	96.86	0.00e+00	4127.00
IUUC-Mlu-067942	Myotis lucifugus	97.09	0.00e+00	4510.00
IUUC-Nle-069527	Nomascus leucogenys	96.26	0.00e+00	4550.00
IUUC-Opr-070626	Ochotona princeps	94.79	0.00e+00	1285.00
IUUC-Ont-071951	Oreochromis niloticus	86.26	0.00e+00	3913.00
IUUC-Oan-072958	Ornithorhynchus anatinus	96.00	0.00e+00	4078.00
IUUC-Ola-086757	Oryzias latipes	87.23	0.00e+00	3999.00
IUUC-Oga-088781	Otolemur garnettii	96.15	0.00e+00	4530.00
IUUC-Oar-089274	Ovis aries	97.12	0.00e+00	4472.00
IUUC-Ptr-090669	Pan troglodytes	96.52	0.00e+00	3936.00
IUUC-Pan-092226	Papio anubis	96.22	0.00e+00	4553.00
IUUC-Psi-093502	Pelodiscus sinensis	94.97	0.00e+00	4403.00
IUUC-Pma-094454	Petromyzon marinus	83.00	0.00e+00	737.00
IUUC-Pfo-096173	Poecilia formosa	85.86	0.00e+00	3660.00
IUUC-Pab-098355	Pongo abelii	94.33	0.00e+00	3264.00
IUUC-Pca-100570	Procavia capensis	98.06	0.00e+00	1169.00
IUUC-Pva-102572	Pteropus vampyrus	93.95	0.00e+00	1349.00
IUUC-Rno-104916	Rattus norvegicus	94.95	0.00e+00	3936.00
IUUC-Sha-106653	Sarcophilus harrisii	95.26	0.00e+00	4455.00
IUUC-Sar-113517	Sorex araneus	84.96	0.00e+00	1211.00
IUUC-Ssc-115470	Sus scrofa	97.91	0.00e+00	2512.00
IUUC-Tgu-116932	Taeniopygia guttata	95.61	0.00e+00	4390.00
IUUC-Tru-117682	Takifugu rubripes	87.16	0.00e+00	2555.00
IUUC-Tsy-119417	Tarsius syrichta	93.14	0.00e+00	2454.00
IUUC-Tni-120442	Tetraodon nigroviridis	82.49	0.00e+00	3575.00
IUUC-Tbe-127456	Tupaia belangeri	83.98	0.00e+00	2048.00
IUUC-Ttr-128606	Tursiops truncatus	89.56	0.00e+00	1523.00
IUUC-Vpa-130112	Vicugna pacos	93.77	0.00e+00	3640.00
IUUC-Xtr-131929	Xenopus tropicalis	92.46	0.00e+00	4362.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence