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Basic Information Integrated Annotations

Tag Content
iUUCD ID IUUC-Hsa-046692
Ensembl Protein ID ENSP00000407331.1
UniProt Accession P37198; B3KWU5; Q503A4; Q6GTM2; Q96C43; Q9NSL1; NUP62_HUMAN
Genbank Protein ID CAA41411.1; CAB82399.1; BAG54257.1; CAG46522.1; EAW52576.1; AAH03663.1; AAH14842.1; AAH50717.1; AAH95410.1; AAI01105.1; AAI01106.1; AAI01107.1; AAI01108.1
Protein Name Nuclear pore glycoprotein p62; 62 kDa nucleoporin; Nucleoporin Nup62
Genbank Nucleotide ID X58521; AL162061; AK125857; CR541721; AC011452; BC003663; BC014842; BC050717; BC095410; BC101104; BC101105; BC101106; BC101107
Gene Name NUP62
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000213024.11 ENST00000422090.2 ENSP00000407331.1
ENSG00000213024.11 ENST00000597723.5 ENSP00000469283.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
AREsiteCircNetmiRTarBasemicroRNA
TRANSFACTargetScanRepTarmiRcode
RAID2
Protein-protein Interaction
IIDPINAHINTMentha
InWeb_IM
Protein 3D Structure
PDB
Disease-associated Variation
ClinVarGWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDUniProtBioGRIDmUbiSiDa
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 activity/Other 27.81 9.00e-17 83.20 IUUC-Sce-106131
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Homo sapiens
Functional Description
(View)

Functional Description



     Component of the p62 complex, a complex at least composed of NUP62, NUP54, and NUP58. Interacts with NUTF2 (By similarity). Interacts with HIKESHI (PubMed:22541429). Interacts with OSBPL8 (PubMed:21698267). Interacts with CAPG (PubMed:18266911).
Component of the p62 complex, a complex at least composed of NUP62, NUP54, and NUP58. Interacts with NUTF2 (By similarity). Interacts with HIKESHI (PubMed:22541429). Interacts with OSBPL8 (PubMed:21698267). Interacts with CAPG (PubMed:18266911).
Protein Sequence
(Fasta)
MSGFNFGGTG APTGGFTFGT AKTATTTPAT GFSFSTSGTG GFNFGAPFQP ATSTPSTGLF 60
SLATQTPATQ TTGFTFGTAT LASGGTGFSL GIGASKLNLS NTAATPAMAN PSGFGLGSSN 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Hsa-046692|E3,E3 activity/Other|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TCAATGCGCA TGTGCGGCCA TTCAGGGTCC GCAGCTCTTT CACTACGGGG CACTGGTGGG 60
CTACTGCGCA GGAACAACCA AGCACGAAGA ATCGTTTAGA AAAAAAAAAA ACACACCCTC 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Hsa-046692|E3,E3 activity/Other|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0225--Disease mutation
KW-1015--Disulfide bond
KW-0325--Glycoprotein
KW-0945--Host-virus interaction
KW-0509--mRNA transport
KW-0906--Nuclear pore complex
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0677--Repeat
KW-0811--Translocation
KW-0813--Transport

Interpro

IPR026010--NSP1/NUP62
IPR007758--Nucleoporin_NSP1_C
IPR033072--NUP62_met

Pfam

PF05064--Nsp1_C

Gene Ontology

GO:0005642--C:annulate lamellae
GO:0005737--C:cytoplasm
GO:0090543--C:Flemming body
GO:0043231--C:intracellular membrane-bounded organelle
GO:0030529--C:intracellular ribonucleoprotein complex
GO:0005635--C:nuclear envelope
GO:0031965--C:nuclear membrane
GO:0005643--C:nuclear pore
GO:0044613--C:nuclear pore central transport channel
GO:0031074--C:nucleocytoplasmic shuttling complex
GO:0046930--C:pore complex
GO:0000922--C:spindle pole
GO:0003682--F:chromatin binding
GO:0005487--F:nucleocytoplasmic transporter activity
GO:0005543--F:phospholipid binding
GO:0030159--F:receptor signaling complex scaffold activity
GO:0042169--F:SH2 domain binding
GO:0017056--F:structural constituent of nuclear pore
GO:0046966--F:thyroid hormone receptor binding
GO:0043130--F:ubiquitin binding
GO:0007569--P:cell aging
GO:0008219--P:cell death
GO:0007166--P:cell surface receptor signaling pathway
GO:0031047--P:gene silencing by RNA
GO:0009755--P:hormone-mediated signaling pathway
GO:0075733--P:intracellular transport of virus
GO:0007067--P:mitotic nuclear division
GO:0007077--P:mitotic nuclear envelope disassembly
GO:0006406--P:mRNA export from nucleus
GO:0043066--P:negative regulation of apoptotic process
GO:0008285--P:negative regulation of cell proliferation
GO:0042059--P:negative regulation of epidermal growth factor receptor signaling pathway
GO:0043407--P:negative regulation of MAP kinase activity
GO:0043069--P:negative regulation of programmed cell death
GO:0046580--P:negative regulation of Ras protein signal transduction
GO:0045742--P:positive regulation of epidermal growth factor receptor signaling pathway
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0070208--P:protein heterotrimerization
GO:0006606--P:protein import into nucleus
GO:0016925--P:protein sumoylation
GO:1900034--P:regulation of cellular response to heat
GO:0010827--P:regulation of glucose transport
GO:0042306--P:regulation of protein import into nucleus
GO:0046578--P:regulation of Ras protein signal transduction
GO:0009966--P:regulation of signal transduction
GO:0071426--P:ribonucleoprotein complex export from nucleus
GO:0006405--P:RNA export from nucleus
GO:0007283--P:spermatogenesis
GO:0006351--P:transcription, DNA-templated
GO:0006409--P:tRNA export from nucleus
GO:0016032--P:viral process
GO:0019083--P:viral transcription

KEGG hsa:23636
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000103 Aegilops tauschii 27.38 6.00e-16 78.60
IUUC-Aml-002215 Ailuropoda melanoleuca 82.98 3.00e-128 452.00
IUUC-Atr-002951 Amborella trichopoda 28.09 3.00e-19 90.50
IUUC-Apl-003795 Anas platyrhynchos 71.47 5.00e-114 404.00
IUUC-Aca-004808 Anolis carolinensis 96.89 2.00e-111 396.00
IUUC-Aly-005471 Arabidopsis lyrata 25.84 2.00e-20 94.40
IUUC-Ath-007120 Arabidopsis thaliana 25.84 3.00e-19 90.50
IUUC-Ago-007770 Ashbya gossypii 27.06 4.00e-17 83.20
IUUC-Acl-008342 Aspergillus clavatus 35.36 9.00e-29 122.00
IUUC-Afl-008407 Aspergillus flavus 35.48 5.00e-28 119.00
IUUC-Ani-009240 Aspergillus nidulans 32.80 4.00e-28 119.00
IUUC-Ang-009754 Aspergillus niger 33.70 5.00e-29 122.00
IUUC-Aor-010138 Aspergillus oryzae 35.48 9.00e-29 122.00
IUUC-Ate-010408 Aspergillus terreus 35.48 1.00e-29 124.00
IUUC-Ame-011356 Astyanax mexicanus 74.14 2.00e-103 369.00
IUUC-Bgr-012171 Blumeria graminis 36.02 5.00e-33 135.00
IUUC-Bci-013631 Botrytis cinerea 36.81 3.00e-33 137.00
IUUC-Bdi-014451 Brachypodium distachyon 29.76 6.00e-16 77.40
IUUC-Bol-015251 Brassica oleracea 25.53 4.00e-19 90.50
IUUC-Bra-017238 Brassica rapa 25.53 7.00e-20 92.80
IUUC-Cja-019404 Callithrix jacchus 92.79 3.00e-153 535.00
IUUC-Cfa-020656 Canis familiaris 94.42 4.00e-113 402.00
IUUC-Cpo-021577 Cavia porcellus 76.94 4.00e-115 408.00
IUUC-Csa-023298 Chlorocebus sabaeus 95.40 1.00e-146 513.00
IUUC-Cin-025543 Ciona intestinalis 60.30 7.00e-55 208.00
IUUC-Csv-026171 Ciona savignyi 58.29 2.00e-52 199.00
IUUC-Cgl-026616 Colletotrichum gloeosporioides 36.93 4.00e-24 104.00
IUUC-Cne-026912 Cryptococcus neoformans 30.69 5.00e-26 113.00
IUUC-Dre-027936 Danio rerio 84.02 2.00e-94 340.00
IUUC-Dno-029425 Dasypus novemcinctus 88.46 7.00e-105 374.00
IUUC-Dor-030759 Dipodomys ordii 91.19 4.00e-84 305.00
IUUC-Dse-031327 Dothistroma septosporum 29.95 7.00e-22 99.40
IUUC-Eca-034163 Equus caballus 98.39 1.00e-101 362.00
IUUC-Fca-035933 Felis catus 83.47 5.00e-127 447.00
IUUC-Fal-036641 Ficedula albicollis 94.36 4.00e-110 392.00
IUUC-Fox-038065 Fusarium oxysporum 36.14 2.00e-29 124.00
IUUC-Fso-038180 Fusarium solani 35.91 1.00e-31 131.00
IUUC-Gmo-038896 Gadus morhua 85.05 2.00e-95 342.00
IUUC-Ggr-040080 Gaeumannomyces graminis 35.87 8.00e-31 128.00
IUUC-Gga-041135 Gallus gallus 84.55 2.00e-113 403.00
IUUC-Gac-041923 Gasterosteus aculeatus 85.64 1.00e-104 373.00
IUUC-Gma-043083 Glycine max 29.78 1.00e-22 102.00
IUUC-Ggo-044765 Gorilla gorilla 98.95 2.00e-154 538.00
IUUC-Itr-048010 Ictidomys tridecemlineatus 85.33 6.00e-143 501.00
IUUC-Kpa-049305 Komagataella pastoris 28.22 6.00e-18 86.30
IUUC-Lch-050204 Latimeria chalumnae 90.48 2.00e-87 316.00
IUUC-Lpe-050941 Leersia perrieri 36.62 6.00e-08 50.40
IUUC-Loc-051832 Lepisosteus oculatus 90.16 9.00e-101 361.00
IUUC-Laf-054586 Loxodonta africana 86.70 6.00e-114 404.00
IUUC-Mcc-054910 Macaca mulatta 96.09 2.00e-147 515.00
IUUC-Meu-056117 Macropus eugenii 93.71 8.00e-76 275.00
IUUC-Mor-057022 Magnaporthe oryzae 37.06 2.00e-31 130.00
IUUC-Mpo-057380 Magnaporthe poae 36.47 1.00e-29 124.00
IUUC-Mtr-057916 Medicago truncatula 30.95 4.00e-18 85.10
IUUC-Mga-059208 Meleagris gallopavo 86.27 3.00e-112 399.00
IUUC-Mvi-060361 Microbotryum violaceum 39.29 2.00e-12 68.20
IUUC-Mmr-061579 Microcebus murinus 95.71 4.00e-115 408.00
IUUC-Mdo-062211 Monodelphis domestica 55.53 3.00e-106 379.00
IUUC-Mmu-063320 Mus musculus 74.78 2.00e-121 429.00
IUUC-Mac-065316 Musa acuminata 29.78 6.00e-19 89.70
IUUC-Mpu-066778 Mustela putorius furo 81.84 3.00e-134 472.00
IUUC-Mlu-067961 Myotis lucifugus 85.41 8.00e-117 414.00
IUUC-Nfi-068470 Neosartorya fischeri 36.07 1.00e-28 121.00
IUUC-Ncr-068853 Neurospora crassa 36.11 2.00e-29 124.00
IUUC-Nle-069776 Nomascus leucogenys 71.70 4.00e-39 154.00
IUUC-Ont-071804 Oreochromis niloticus 86.67 2.00e-104 373.00
IUUC-Oan-073171 Ornithorhynchus anatinus 84.55 3.00e-113 402.00
IUUC-Ocu-074502 Oryctolagus cuniculus 60.43 1.00e-57 216.00
IUUC-Oba-075227 Oryza barthii 28.41 1.00e-10 59.70
IUUC-Obr-076100 Oryza brachyantha 28.65 2.00e-20 94.40
IUUC-Ogl-077722 Oryza glaberrima 30.51 5.00e-18 84.30
IUUC-Ogu-078656 Oryza glumaepatula 28.57 5.00e-17 81.30
IUUC-Oin-079356 Oryza indica 28.93 5.00e-15 74.70
IUUC-Olo-080776 Oryza longistaminata 30.99 2.00e-19 89.70
IUUC-Ome-081497 Oryza meridionalis 30.51 3.00e-18 85.50
IUUC-Oni-082204 Oryza nivara 30.51 7.00e-18 84.00
IUUC-Opu-083759 Oryza punctata 35.00 8.00e-11 59.70
IUUC-Ola-086898 Oryzias latipes 85.13 8.00e-103 367.00
IUUC-Oga-088255 Otolemur garnettii 85.98 2.00e-125 442.00
IUUC-Oar-089798 Ovis aries 84.73 8.00e-106 377.00
IUUC-Ptr-091608 Pan troglodytes 96.26 2.00e-151 529.00
IUUC-Pan-092757 Papio anubis 89.89 4.00e-143 501.00
IUUC-Psi-093357 Pelodiscus sinensis 96.41 2.00e-113 403.00
IUUC-Pma-094710 Petromyzon marinus 76.04 2.00e-82 299.00
IUUC-Pno-094791 Phaeosphaeria nodorum 30.69 2.00e-25 110.00
IUUC-Ppa-095481 Physcomitrella patens 27.84 5.00e-16 80.10
IUUC-Pfo-097470 Poecilia formosa 85.64 1.00e-102 367.00
IUUC-Pab-098408 Pongo abelii 96.85 2.00e-151 528.00
IUUC-Pop-100081 Populus trichocarpa 30.36 2.00e-18 85.90
IUUC-Pca-100349 Procavia capensis 87.45 2.00e-115 409.00
IUUC-Ppe-101825 Prunus persica 30.34 9.00e-23 102.00
IUUC-Pva-102608 Pteropus vampyrus 58.16 1.00e-71 263.00
IUUC-Pgr-103532 Puccinia graminis 32.13 3.00e-29 123.00
IUUC-Pte-104213 Pyrenophora teres 29.89 1.00e-26 115.00
IUUC-Pyt-104505 Pyrenophora triticirepentis 29.89 4.00e-25 109.00
IUUC-Rno-104985 Rattus norvegicus 86.70 1.00e-107 383.00
IUUC-Sce-106131 Saccharomyces cerevisiae 29.79 5.00e-23 103.00
IUUC-Sha-107579 Sarcophilus harrisii 88.72 2.00e-95 342.00
IUUC-Sja-107816 Schizosaccharomyces japonicus 30.51 2.00e-25 110.00
IUUC-Spo-108243 Schizosaccharomyces pombe 30.51 8.00e-26 112.00
IUUC-Sit-110530 Setaria italica 30.54 3.00e-21 97.40
IUUC-Sly-111305 Solanum lycopersicum 28.42 8.00e-21 95.90
IUUC-Sbi-114353 Sorghum bicolor 29.94 6.00e-17 82.40
IUUC-Sre-115119 Sporisorium reilianum 31.38 1.00e-25 111.00
IUUC-Ssc-116032 Sus scrofa 97.44 1.00e-105 377.00
IUUC-Tgu-117392 Taeniopygia guttata 94.36 8.00e-102 363.00
IUUC-Tru-118364 Takifugu rubripes 85.13 5.00e-103 368.00
IUUC-Tsy-119443 Tarsius syrichta 97.40 7.00e-104 371.00
IUUC-Tni-120115 Tetraodon nigroviridis 84.10 2.00e-102 366.00
IUUC-Tca-120955 Theobroma cacao 30.34 1.00e-22 102.00
IUUC-Tre-122173 Trichoderma reesei 36.90 2.00e-28 120.00
IUUC-Tvi-122527 Trichoderma virens 36.61 8.00e-27 113.00
IUUC-Tae-123047 Triticum aestivum 26.40 6.00e-19 89.70
IUUC-Tur-126776 Triticum urartu 38.46 4.00e-02 33.10
IUUC-Tme-127155 Tuber melanosporum 39.78 6.00e-33 135.00
IUUC-Tbe-127667 Tupaia belangeri 68.88 8.00e-77 280.00
IUUC-Ttr-128589 Tursiops truncatus 82.53 5.00e-139 488.00
IUUC-Vda-129888 Verticillium dahliae 35.54 6.00e-25 109.00
IUUC-Vpa-130367 Vicugna pacos 75.00 2.00e-83 302.00
IUUC-Vvi-131500 Vitis vinifera 30.90 3.00e-23 104.00
IUUC-Xtr-132497 Xenopus tropicalis 88.21 5.00e-105 375.00
IUUC-Xma-133341 Xiphophorus maculatus 86.15 1.00e-103 370.00
IUUC-Yli-134543 Yarrowia lipolytica 38.42 1.00e-33 138.00
IUUC-Zma-135505 Zea mays 28.81 1.00e-20 95.50
Created Date 25-Jun-2017

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