iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Pfo-096737

Ensembl Protein ID

ENSPFOP00000007454.2

UniProt Accession

A0A087XNV1; A0A087XNV1_POEFO

Genbank Protein ID

ENSPFOP00000007454

Protein Name

Coatomer subunit beta'

Genbank Nucleotide ID

AYCK01006408

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPFOG00000007284.2	ENSPFOT00000023200.1	ENSPFOP00000021482.1
ENSPFOG00000007284.2	ENSPFOT00000007466.2	ENSPFOP00000007454.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.30e-29	101.5	183	224
UBD/Beta-Prp	2.10e-63	214.9	14	295

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf...sd.tllvsGsdDgtikvWDlrtgvllks 38
           gH+ +v+c+++    d ++l+sG+dD+ +k+WD+   +++++
   Q: 183  GHEKGVNCIDYyngGDkPYLISGADDHLVKIWDYQNKTCVQT 224
           8*********9999778****************999988875 PP

UBD/Beta-Prp

   S: 9    hksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsv 97
           +++++++ + +p +++++ + ++gt+ vw+ +t+  ++s++ ++ +v+  kf  ++ +++tg++D+ i+v++++t + v  +++h d++
   Q: 14   RSERVKSADLHPTEPWMVLSLYTGTVVVWNHETQAIVKSFELCDLPVRVAKFVARKHWIITGADDMQIRVFNYNTLDRVFMFEAHCDYI 102
           5678899999******************************************************************************* PP
   S: 98   lslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdg.nllvsGslDrtvrlWdlktgkllrtltgghtdsvys 185
           ++++++p++ ++++ s+d  i++wd++ ++   ++++gh + v+ vv++p++ n ++s+slDrt+++W+l +++   tl+g h++ v++
   Q: 103  RCVAVHPTQPFVLTSSDDMLIKLWDWDRKWTCCQVFEGHAHYVMQVVFNPKDnNQFASASLDRTIKVWQLGSKSPNFTLEG-HEKGVNC 190
           **************************99987777**********************************************9.******* PP
   S: 186  lsfdsng..kelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhnssvisvav 272
           +++   g  ++l+sg++d  vk+wd+q+++cv+tl+ h +nv++v f+p+   +++gs+Dg++r+W + +  l +tl++  ++v+++++
   Q: 191  IDYYNGGdkPYLISGADDHLVKIWDYQNKTCVQTLESHVQNVTCVCFHPELPVILTGSEDGTVRVWHSNTYRLENTLNYGLERVWCICG 279
           **8887778******************************************************************************** PP
   S: 273  lsfgdnvlvlgsedskv 289
            + g n+++lg +++++
   Q: 280  -QSGSNNIALGYDEGSI 295
           .7777777777665554 PP

Organism

Poecilia formosa

Functional Description
(View)

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

Protein Sequence
(Fasta)

MPLRLDIQRR LTARSERVKS ADLHPTEPWM VLSLYTGTVV VWNHETQAIV KSFELCDLPV 60
RVAKFVARKH WIITGADDMQ IRVFNYNTLD RVFMFEAHCD YIRCVAVHPT QPFVLTSSDD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGAAGTTGTT TAGATATTGT CTTCAGCATG ATAATCAAAC TTTTCTCCGT TTAACTGGAG 60
GGACCTGAAG CAGCACAGCA GCAGGATGGT AGGTGGGTTC TCCCTGGACT GTAACTGAGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0931--ER-Golgi transport
KW-0333--Golgi apparatus
KW-0472--Membrane
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0853--WD repeat

Interpro

IPR006692--Coatomer_WD-assoc_reg
IPR016453--COPB2
IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

PROSITE

PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF04053--Coatomer_WDAD
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0030663--C:COPI-coated vesicle membrane
GO:0000139--C:Golgi membrane
GO:0030117--C:membrane coat
GO:0005198--F:structural molecule activity
GO:0006886--P:intracellular protein transport
GO:0016192--P:vesicle-mediated transport

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Gac-041816	Gasterosteus aculeatus	83.04	0.00e+00	1509.00
IUUC-Ont-072111	Oreochromis niloticus	81.62	0.00e+00	1589.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence