iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Csv-026339

UUCD1 version

UUC-CiS-00371

Ensembl Protein ID

ENSCSAVP00000007524.1

UniProt Accession

H2YQB6; H2YQB6_CIOSA

Protein Name

E3 ubiquitin-protein ligase

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCSAVG00000004498.1	ENSCSAVT00000007623.1	ENSCSAVP00000007524.1
ENSCSAVG00000004498.1	ENSCSAVT00000007624.1	ENSCSAVP00000007525.1
ENSCSAVG00000004498.1	ENSCSAVT00000007625.1	ENSCSAVP00000007526.1
ENSCSAVG00000004498.1	ENSCSAVT00000007626.1	ENSCSAVP00000007527.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.10e-122	408.7	420	753

Active Site

Position(s)	Description	Evidence
723	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlld 89
           ++dl+krl+v+fvgE+gld+gG++re+l+ ls+e+ np++glf+ys +d++tlq+npds + np+hl++F+f+Gr+lg+a+++g+++d
   Q: 420  PKDLRKRLMVKFVGEDGLDYGGLAREWLYILSHEMLNPYYGLFQYSREDNYTLQINPDSHI-NPDHLSYFHFVGRILGMAVYHGHYID 506
           689********************************************************98.89************************ PP
   S: 90   lplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklv 177
             ++  fyk+llgk++sl+d+eevdp lyks+k+i++n   di++  ld tf+++++++ge+ ++eLkp+G+n++Vt+eNk+eYvkl+
   Q: 507  GGFTMLFYKQLLGKPISLDDMEEVDPALYKSMKWILQN---DIHDV-LDHTFCADHDSFGERITHELKPNGANVEVTEENKREYVKLY 590
           ************************************99...9***8.***************************************** PP
   S: 178  veyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafL 265
           v++r+ +gi+ q+ ++++Gf+e+ip++ll+ F+e+elel+i G  +id+ d++k+tk k+ +++ds+ ++wFw+++e+f++e+r++ L
   Q: 591  VNWRFMRGIEAQFLSLSKGFYELIPQHLLRPFDERELELIIGGLGKIDLVDWRKHTKLKH-CSQDSNIVKWFWQAVESFDQEKRARVL 677
           **********************************************************99.*************************** PP
   S: 266  qFvTgssrlPlgGfaelk.......prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           qFvTgs r+Pl+Gf++l+       prlf+i+  d+++d+lP+++TCfn+++LP+Y+++e+l +kL++A+e+t gF 
   Q: 678  QFVTGS-RVPLQGFKALQgstgtqgPRLFTIQFiDSKTDSLPKAHTCFNRIDLPPYETYEKLLDKLTCAVENTCGFY 753
           *****7.6*************************99999*************************************96 PP

Organism

Ciona savignyi

Protein Sequence
(Fasta)

MSSSSSARRS GTMKLRLTVF CAKNICKRDF FRLPDPFAKI MVDGSGQCHA TGTCKATIDP 60
KWNQHYDLYV GKADSITISV WDNRKVRKKN GAGFLGCIRI MSNAINRLKD TGYQRLDLCK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAAGGACGCC ATCTCAAGCC CTGTGGTGGA TACGAAAGAG TTTTTAAGTA TTTTACATTT 60
TAAATGCCAA GTGGCACGTA ACTACTGTGT TAAAATTTGC TTTGTTTTTT TATAGCAGTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001305	Ailuropoda melanoleuca	64.95	0.00e+00	1009.00
IUUC-Apl-003513	Anas platyrhynchos	65.42	0.00e+00	1011.00
IUUC-Aca-005358	Anolis carolinensis	65.09	0.00e+00	1016.00
IUUC-Ame-011320	Astyanax mexicanus	62.10	0.00e+00	986.00
IUUC-Bta-013399	Bos taurus	64.98	0.00e+00	1003.00
IUUC-Cja-019355	Callithrix jacchus	64.99	0.00e+00	1008.00
IUUC-Cfa-020568	Canis familiaris	60.82	0.00e+00	932.00
IUUC-Cpo-022200	Cavia porcellus	64.99	0.00e+00	1008.00
IUUC-Csa-024145	Chlorocebus sabaeus	62.98	0.00e+00	944.00
IUUC-Cho-024804	Choloepus hoffmanni	74.68	1.00e-143	501.00
IUUC-Cin-025126	Ciona intestinalis	88.89	0.00e+00	1301.00
IUUC-Dre-027650	Danio rerio	63.32	0.00e+00	1013.00
IUUC-Dno-029534	Dasypus novemcinctus	65.48	0.00e+00	1014.00
IUUC-Dme-031740	Drosophila melanogaster	70.10	1.00e-168	585.00
IUUC-Ete-032715	Echinops telfairi	61.65	0.00e+00	937.00
IUUC-Eca-033580	Equus caballus	65.12	0.00e+00	1008.00
IUUC-Eeu-034945	Erinaceus europaeus	64.21	0.00e+00	927.00
IUUC-Fca-035905	Felis catus	63.14	0.00e+00	944.00
IUUC-Fal-037275	Ficedula albicollis	64.35	0.00e+00	1009.00
IUUC-Gmo-039486	Gadus morhua	64.23	0.00e+00	681.00
IUUC-Gga-040218	Gallus gallus	62.39	0.00e+00	949.00
IUUC-Gac-041295	Gasterosteus aculeatus	63.75	0.00e+00	1007.00
IUUC-Ggo-045408	Gorilla gorilla	57.09	0.00e+00	843.00
IUUC-Hsa-046726	Homo sapiens	65.13	0.00e+00	1014.00
IUUC-Itr-048317	Ictidomys tridecemlineatus	61.71	0.00e+00	929.00
IUUC-Lch-050026	Latimeria chalumnae	64.50	0.00e+00	1008.00
IUUC-Loc-051760	Lepisosteus oculatus	61.51	0.00e+00	978.00
IUUC-Laf-053753	Loxodonta africana	65.07	0.00e+00	1007.00
IUUC-Mcc-054815	Macaca mulatta	65.26	0.00e+00	1016.00
IUUC-Meu-056436	Macropus eugenii	48.81	0.00e+00	682.00
IUUC-Mga-059723	Meleagris gallopavo	63.49	0.00e+00	939.00
IUUC-Mvi-060395	Microbotryum violaceum	48.62	3.00e-144	503.00
IUUC-Mmr-060806	Microcebus murinus	64.85	0.00e+00	1006.00
IUUC-Mdo-062805	Monodelphis domestica	65.56	0.00e+00	1014.00
IUUC-Mmu-064034	Mus musculus	65.13	0.00e+00	1014.00
IUUC-Mpu-066762	Mustela putorius furo	65.29	0.00e+00	1006.00
IUUC-Mlu-066981	Myotis lucifugus	65.07	0.00e+00	1006.00
IUUC-Nle-069804	Nomascus leucogenys	65.13	0.00e+00	1014.00
IUUC-Opr-070591	Ochotona princeps	61.52	0.00e+00	934.00
IUUC-Ont-071239	Oreochromis niloticus	64.17	0.00e+00	1011.00
IUUC-Oan-072699	Ornithorhynchus anatinus	63.43	0.00e+00	1009.00
IUUC-Ocu-074913	Oryctolagus cuniculus	65.13	0.00e+00	1016.00
IUUC-Ola-087161	Oryzias latipes	61.42	0.00e+00	938.00
IUUC-Oga-089116	Otolemur garnettii	63.88	0.00e+00	979.00
IUUC-Oar-089366	Ovis aries	64.81	0.00e+00	1003.00
IUUC-Ptr-091382	Pan troglodytes	65.13	0.00e+00	1014.00
IUUC-Pan-092479	Papio anubis	61.30	0.00e+00	931.00
IUUC-Psi-093298	Pelodiscus sinensis	64.78	0.00e+00	999.00
IUUC-Pma-094354	Petromyzon marinus	60.53	0.00e+00	911.00
IUUC-Ppa-095250	Physcomitrella patens	45.25	7.00e-81	292.00
IUUC-Pfo-096071	Poecilia formosa	63.54	0.00e+00	1009.00
IUUC-Pab-098682	Pongo abelii	65.13	0.00e+00	1014.00
IUUC-Pca-100516	Procavia capensis	66.57	6.00e-138	483.00
IUUC-Pva-102754	Pteropus vampyrus	63.91	0.00e+00	971.00
IUUC-Ptt-103806	Puccinia triticina	46.62	4.00e-120	423.00
IUUC-Rno-105396	Rattus norvegicus	63.65	0.00e+00	957.00
IUUC-Sha-107216	Sarcophilus harrisii	61.22	0.00e+00	936.00
IUUC-Sja-107941	Schizosaccharomyces japonicus	39.35	8.00e-162	562.00
IUUC-Spo-108171	Schizosaccharomyces pombe	40.55	6.00e-161	559.00
IUUC-Sar-113122	Sorex araneus	56.32	0.00e+00	823.00
IUUC-Ssc-116413	Sus scrofa	62.63	0.00e+00	915.00
IUUC-Tgu-117112	Taeniopygia guttata	65.10	0.00e+00	1015.00
IUUC-Tru-118497	Takifugu rubripes	63.32	0.00e+00	989.00
IUUC-Tsy-119455	Tarsius syrichta	61.40	0.00e+00	876.00
IUUC-Tni-120829	Tetraodon nigroviridis	66.16	0.00e+00	725.00
IUUC-Tme-126897	Tuber melanosporum	38.27	4.00e-147	513.00
IUUC-Tbe-127371	Tupaia belangeri	57.53	0.00e+00	790.00
IUUC-Ttr-128423	Tursiops truncatus	60.93	0.00e+00	880.00
IUUC-Vpa-130591	Vicugna pacos	58.08	0.00e+00	862.00
IUUC-Xtr-132979	Xenopus tropicalis	53.83	0.00e+00	750.00
IUUC-Xma-134026	Xiphophorus maculatus	63.80	0.00e+00	1014.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence