iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Sha-107419

Ensembl Protein ID

ENSSHAP00000011913.1

UniProt Accession

G3W908; G3W908_SARHA

Genbank Protein ID

ENSSHAP00000011913

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AEFK01079018

Gene Name

TLE1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSHAG00000010221.1	ENSSHAT00000012011.1	ENSSHAP00000011913.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	3.30e-22	77.8	625	663

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllk 37
           gHtd+ +c++  +d t l++G+ D+t++ WDlr+g++l+
   Q: 625  GHTDGASCIDIsNDgTKLWTGGLDNTVRSWDLREGRQLQ 663
           8***********999*********************998 PP

Organism

Sarcophilus harrisii

Protein Sequence
(Fasta)

MFPQSRHPVR SAGAPGPWAY AGGPTFYTLW EFRDKFHHNL RSINAHLSSL KLECEKLASE 60
KTEMQRHYVM YYEMSYGLNI EMHKQTEIAK RLNTICAQVI PFLSQEHQQQ VAQAVERAKQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTTCCCGC AAAGCCGGCA CCCGGTAAGG AGCGCCGGGG CCCCGGGGCC CTGGGCGTAT 60
GCTGGAGGGT TTGTGTTGGG GGGAAGTATA ACAACGTTTT GCGTTGGGGG AGGCGCTGTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR005617--Groucho/TLE_N
IPR009146--Groucho_enhance
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF03920--TLE_N
PF00400--WD40

PRINTS

PR01850--GROUCHOFAMLY

SMART

SM00320--WD40

Gene Ontology

GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0001106--F:RNA polymerase II transcription corepressor activity
GO:2000811--P:negative regulation of anoikis
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0010628--P:positive regulation of gene expression

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001746	Ailuropoda melanoleuca	90.31	0.00e+00	1190.00
IUUC-Apl-003594	Anas platyrhynchos	95.50	0.00e+00	1256.00
IUUC-Aca-005053	Anolis carolinensis	90.14	0.00e+00	1226.00
IUUC-Bta-013380	Bos taurus	85.68	0.00e+00	1088.00
IUUC-Cja-019135	Callithrix jacchus	93.73	0.00e+00	1236.00
IUUC-Cfa-020611	Canis familiaris	97.63	0.00e+00	1182.00
IUUC-Cpo-022495	Cavia porcellus	92.96	0.00e+00	1228.00
IUUC-Csa-024056	Chlorocebus sabaeus	93.60	0.00e+00	1253.00
IUUC-Cho-024590	Choloepus hoffmanni	78.69	0.00e+00	1070.00
IUUC-Dno-029011	Dasypus novemcinctus	93.85	0.00e+00	1239.00
IUUC-Dor-030533	Dipodomys ordii	82.88	0.00e+00	1040.00
IUUC-Ete-032533	Echinops telfairi	81.56	0.00e+00	1120.00
IUUC-Eca-033351	Equus caballus	93.98	0.00e+00	1238.00
IUUC-Eeu-034666	Erinaceus europaeus	99.13	0.00e+00	1074.00
IUUC-Fca-036429	Felis catus	86.62	0.00e+00	1202.00
IUUC-Fal-036696	Ficedula albicollis	98.33	0.00e+00	1261.00
IUUC-Gmo-038805	Gadus morhua	76.86	0.00e+00	1107.00
IUUC-Gga-041113	Gallus gallus	93.85	0.00e+00	1298.00
IUUC-Gac-041999	Gasterosteus aculeatus	76.50	0.00e+00	1111.00
IUUC-Ggo-045164	Gorilla gorilla	93.73	0.00e+00	1254.00
IUUC-Hsa-047011	Homo sapiens	93.73	0.00e+00	1254.00
IUUC-Itr-048040	Ictidomys tridecemlineatus	91.09	0.00e+00	1194.00
IUUC-Lch-050437	Latimeria chalumnae	94.23	0.00e+00	1122.00
IUUC-Loc-052819	Lepisosteus oculatus	86.62	0.00e+00	1165.00
IUUC-Laf-053862	Loxodonta africana	90.77	0.00e+00	1201.00
IUUC-Mcc-055735	Macaca mulatta	89.82	0.00e+00	1238.00
IUUC-Meu-056209	Macropus eugenii	79.46	0.00e+00	1155.00
IUUC-Mmr-061207	Microcebus murinus	90.64	0.00e+00	1187.00
IUUC-Mdo-062493	Monodelphis domestica	95.26	0.00e+00	1302.00
IUUC-Mmu-063795	Mus musculus	88.65	0.00e+00	1194.00
IUUC-Mpu-065819	Mustela putorius furo	93.48	0.00e+00	1263.00
IUUC-Mlu-067047	Myotis lucifugus	98.79	0.00e+00	1073.00
IUUC-Nle-069684	Nomascus leucogenys	93.47	0.00e+00	1246.00
IUUC-Opr-071172	Ochotona princeps	92.83	0.00e+00	1220.00
IUUC-Ont-072102	Oreochromis niloticus	77.05	0.00e+00	1123.00
IUUC-Oan-072842	Ornithorhynchus anatinus	81.22	0.00e+00	1145.00
IUUC-Ocu-074592	Oryctolagus cuniculus	90.01	0.00e+00	1239.00
IUUC-Ola-087267	Oryzias latipes	75.50	0.00e+00	1044.00
IUUC-Oga-088629	Otolemur garnettii	90.77	0.00e+00	1193.00
IUUC-Oar-089551	Ovis aries	93.91	0.00e+00	1219.00
IUUC-Ptr-091207	Pan troglodytes	93.34	0.00e+00	1248.00
IUUC-Pan-091822	Papio anubis	89.82	0.00e+00	1238.00
IUUC-Psi-093594	Pelodiscus sinensis	92.52	0.00e+00	1229.00
IUUC-Pma-094452	Petromyzon marinus	75.69	0.00e+00	1064.00
IUUC-Pfo-096239	Poecilia formosa	76.91	0.00e+00	1114.00
IUUC-Pab-097687	Pongo abelii	94.64	0.00e+00	1243.00
IUUC-Pca-100675	Procavia capensis	98.43	0.00e+00	1054.00
IUUC-Pva-102355	Pteropus vampyrus	91.98	0.00e+00	1147.00
IUUC-Rno-106027	Rattus norvegicus	91.70	0.00e+00	1244.00
IUUC-Sar-113585	Sorex araneus	86.51	0.00e+00	713.00
IUUC-Ssc-116151	Sus scrofa	93.73	0.00e+00	1235.00
IUUC-Tgu-117387	Taeniopygia guttata	93.60	0.00e+00	1271.00
IUUC-Tru-118051	Takifugu rubripes	74.72	0.00e+00	1063.00
IUUC-Tsy-119342	Tarsius syrichta	90.37	0.00e+00	1013.00
IUUC-Tbe-127881	Tupaia belangeri	90.91	0.00e+00	1221.00
IUUC-Ttr-129285	Tursiops truncatus	81.19	0.00e+00	1169.00
IUUC-Vpa-130577	Vicugna pacos	68.37	9.00e-146	510.00
IUUC-Xtr-131792	Xenopus tropicalis	85.64	0.00e+00	1174.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence