iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ont-071328

Ensembl Protein ID

ENSONIP00000006312.1

UniProt Accession

I3JBS2; I3JBS2_ORENI

Genbank Protein ID

ENSONIP00000006312

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AERX01006959

Gene Name

LOC100697587

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSONIG00000005018.1	ENSONIT00000006317.1	ENSONIP00000006312.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	4.90e-74	250.1	691	1007

Active Site

Position(s)	Description	Evidence
975	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 8    rlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlplsk 94
           +l v fv++   +++  +r+f+  +++el  p+ ++f y+e+++  ++p + +     e+  +F ++G+l+g+al++++++ l++++
   Q: 691  ELLVLFVEDRK-ETNVNKRDFFLHVFDELMAPESKMFIYNESQTVAWFPPKPKV----EEKTYF-LFGVLCGLALYNHNIIHLRFPQ 771
           55566666553.333678*******************************99997....456666.66******************** PP
   S: 95   sfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyr 181
           +++k+ll++k +l+d++e+dp l++s   ++e    d+ ++ ld tf+vs       +++eL p+     Vt +N++eYv + v+y 
   Q: 772  ALFKKLLRVKPTLDDMKEFDPVLAESWRIMLEDYTPDVVQT-LDTTFTVSW----AGETVELDPNEPGKLVTGSNRKEYVAAFVNYV 853
           **************************998888878888887.*****9776....667888************************** PP
   S: 182  lkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +++++++ +++f++Gf +v+++++++ F++eel+ ++ G+e++d+e +kk+t y+g+y++++p iq Fwev+e++++ee+k+fL F+
   Q: 854  FNKSVERVFDEFKRGFFKVCNMDVVDFFQPEELQAVMVGQENYDWEVFKKNTVYEGEYHDEHPNIQVFWEVFESLTAEEKKKFLLFL 940
           *************************************************************************************** PP
   S: 269  TgssrlPlgGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYssk...eilkekLlyAieetkgF 333
           Tgs+r+P+ G++++k r+ v+++ as+++lP+s TC ++L LP Y  +    +++ +Ll Ai++++gF
   Q: 941  TGSDRVPFLGMESIKMRVAVLPD-ASERHLPESLTCHFLLLLPIYRRYpveRTMRTRLLKAINHNRGF 1007
           ***************77666666.*******************8776422289**************9 PP

Organism

Oreochromis niloticus

Protein Sequence
(Fasta)

MQLFCWGDSS SGQFGPQAAP SPVSWTVPGV ITKICCGDRH TLFLNADGNV LSCGHNSQGQ 60
LGRQKKKNGK IIAQVEALGS VVAMACGQDH CLAVSASGHV FSWGAGEDGQ LGLLPTPSSS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTGAGCTAAA TTGCAGCACA GAGCCCATAA CGTCCTCATT TGAGACCAGG TGGAGACATG 60
CAGCTGTTCT GTTGGGGAGA CAGCTCCAGC GGACAGTTCG GGCCACAGGC GGCCCCCAGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens

PROSITE

PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3

Pfam

PF00632--HECT
PF00415--RCC1

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ame-011023	Astyanax mexicanus	45.75	0.00e+00	862.00
IUUC-Cho-025101	Choloepus hoffmanni	35.21	5.00e-81	296.00
IUUC-Eca-034098	Equus caballus	38.33	9.00e-172	597.00
IUUC-Gmo-038792	Gadus morhua	53.73	0.00e+00	961.00
IUUC-Gac-041342	Gasterosteus aculeatus	69.28	0.00e+00	1358.00
IUUC-Loc-052736	Lepisosteus oculatus	49.18	0.00e+00	926.00
IUUC-Mcc-055014	Macaca mulatta	35.85	1.00e-175	610.00
IUUC-Mlu-067407	Myotis lucifugus	36.97	8.00e-172	597.00
IUUC-Pfo-096202	Poecilia formosa	72.85	0.00e+00	1422.00
IUUC-Pva-102382	Pteropus vampyrus	35.71	9.00e-171	594.00
IUUC-Tru-117816	Takifugu rubripes	60.84	0.00e+00	1182.00
IUUC-Tni-120770	Tetraodon nigroviridis	53.51	0.00e+00	969.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence