iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Tru-118091

Ensembl Protein ID

ENSTRUP00000029017.1

UniProt Accession

H2TWF8; H2TWF8_TAKRU

Protein Name

Uncharacterized protein

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTRUG00000011492.1	ENSTRUT00000029133.1	ENSTRUP00000029017.1
ENSTRUG00000011492.1	ENSTRUT00000029134.1	ENSTRUP00000029018.1
ENSTRUG00000011492.1	ENSTRUT00000029135.1	ENSTRUP00000029019.1
ENSTRUG00000011492.1	ENSTRUT00000029136.1	ENSTRUP00000029020.1
ENSTRUG00000011492.1	ENSTRUT00000029137.1	ENSTRUP00000029021.1
ENSTRUG00000011492.1	ENSTRUT00000029138.1	ENSTRUP00000029022.1
ENSTRUG00000011492.1	ENSTRUT00000029139.1	ENSTRUP00000029023.1
ENSTRUG00000011492.1	ENSTRUT00000029140.1	ENSTRUP00000029024.1
ENSTRUG00000011492.1	ENSTRUT00000029141.1	ENSTRUP00000029025.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	5.30e-26	90.8	1340	1374
UBD/Beta-Prp	1.60e-42	146.9	1445	1648

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclafsdtllvsGsdDgtikvWDlrtgvl 35
           gH+  v c++ +d+ll +Gs D t+kvW+l tg  
   Q: 1340 GHSKAVLCVDSTDDLLFTGSKDRTCKVWNLVTGQE 1374
           89999***99766*****************99976 PP

UBD/Beta-Prp

   S: 11   svitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgk....ilvtgseDrtikvwdls.....tgkcvh 88
           ++i+ ++  p++++l ++   ++++vwd+++     +l gh ++v +++ +++g     + +tgs+D+ ik++d+      +  ++h
   Q: 1445 NQINQIALNPNGTVLYAAA-GNSVRVWDLRRFASTGKLMGHLGPVMCLTVDQSGTssqdLVITGSKDHYIKLFDVTegslgSIGPTH 1530
           4455566666666555553.6666666666666666666666666666666665555556666666666666666622222223333 PP
   S: 89   tlk.ghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrt 174
            ++  h d + sl +  +gd + sGs+d+ i+ wdl+ +  l+++ + h+++v+ + v p + +l sG+  ++++lW   t   l +
   Q: 1531 NFEpPHYDGIESLVV--QGDMFFSGSRDNGIKKWDLDRKDLLQQVPNAHRDWVCALGVVPGSPVLLSGCRAGVLKLWHTDTLGPLGE 1615
           333333344444333..3466666666666666666666666666666666666666666666666666666666666666666666 PP
   S: 175  ltgghtdsvyslsfdsngkelvsgsldgtvklwdlq 210
           l+g h+++++s+s +s   +l ++s+d+tvk+w  +
   Q: 1616 LRG-HESPITSISTNS--SHLFTASDDRTVKIWRAR 1648
           666.666666666555..566666666666666654 PP

Organism

Takifugu rubripes

Protein Sequence
(Fasta)

LLGAPDTSEA AALVFLRIRP QLAREKIEGC HICTYVMPGE PQVILGKDKA FTYDYMFDMD 60
SQQDAIYTTC TEKLIDGCFE GYNATIFAYG QTGSGKTYTM GTGFDVNIAD DELGIVPRAV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTGCTCGGAG CGCCTGACAC TTCAGAAGCT GCTGCTTTAG GGAGTGATTG ACAGGAGGAT 60
TAAGAGTAAA GGCAGGGGAG AGGATCAGAA ACAATTAGGT GAAACCTACC GGACCAGTTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0505--Motor protein
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR019821--Kinesin_motor_CS
IPR001752--Kinesin_motor_dom
IPR027417--P-loop_NTPase
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00411--KINESIN_MOTOR_1
PS50067--KINESIN_MOTOR_2
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00225--Kinesin
PF00400--WD40

PRINTS

PR00380--KINESINHEAVY

SMART

SM00129--KISc
SM00320--WD40

Gene Ontology

GO:0005871--C:kinesin complex
GO:0005524--F:ATP binding
GO:0016887--F:ATPase activity
GO:0003777--F:microtubule motor activity
GO:0007018--P:microtubule-based movement

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001391	Ailuropoda melanoleuca	64.51	0.00e+00	1298.00
IUUC-Apl-003353	Anas platyrhynchos	66.02	0.00e+00	2038.00
IUUC-Aca-004467	Anolis carolinensis	67.83	0.00e+00	2147.00
IUUC-Ame-011430	Astyanax mexicanus	75.53	0.00e+00	1487.00
IUUC-Bta-013485	Bos taurus	67.15	0.00e+00	1511.00
IUUC-Cel-018402	Caenorhabditis elegans	53.15	5.00e-148	519.00
IUUC-Cpo-022297	Cavia porcellus	68.65	0.00e+00	1507.00
IUUC-Cho-024531	Choloepus hoffmanni	75.91	1.00e-176	614.00
IUUC-Cin-025160	Ciona intestinalis	47.52	2.00e-87	316.00
IUUC-Dre-028532	Danio rerio	73.27	0.00e+00	2305.00
IUUC-Eca-033518	Equus caballus	67.58	0.00e+00	1540.00
IUUC-Gmo-039407	Gadus morhua	79.45	0.00e+00	858.00
IUUC-Gga-040687	Gallus gallus	67.38	0.00e+00	2058.00
IUUC-Gac-041626	Gasterosteus aculeatus	80.70	0.00e+00	2579.00
IUUC-Loc-052689	Lepisosteus oculatus	74.48	0.00e+00	2392.00
IUUC-Laf-054018	Loxodonta africana	64.37	0.00e+00	1965.00
IUUC-Meu-056080	Macropus eugenii	57.64	0.00e+00	1129.00
IUUC-Mga-059283	Meleagris gallopavo	65.85	0.00e+00	1998.00
IUUC-Mmr-060773	Microcebus murinus	62.93	0.00e+00	1219.00
IUUC-Mmu-063997	Mus musculus	64.78	0.00e+00	1261.00
IUUC-Mlu-067599	Myotis lucifugus	67.28	0.00e+00	1543.00
IUUC-Ont-071938	Oreochromis niloticus	84.66	0.00e+00	2648.00
IUUC-Oan-073055	Ornithorhynchus anatinus	65.39	0.00e+00	1946.00
IUUC-Ola-086604	Oryzias latipes	81.98	0.00e+00	2562.00
IUUC-Oar-089629	Ovis aries	66.29	0.00e+00	1516.00
IUUC-Psi-093757	Pelodiscus sinensis	63.10	0.00e+00	1177.00
IUUC-Rno-105354	Rattus norvegicus	65.01	0.00e+00	1253.00
IUUC-Sha-106938	Sarcophilus harrisii	62.23	0.00e+00	1246.00
IUUC-Tgu-117076	Taeniopygia guttata	61.82	0.00e+00	1175.00
IUUC-Tni-120813	Tetraodon nigroviridis	85.08	0.00e+00	2697.00
IUUC-Tbe-127494	Tupaia belangeri	55.11	4.00e-149	523.00
IUUC-Ttr-128393	Tursiops truncatus	64.32	0.00e+00	1269.00
IUUC-Vpa-130675	Vicugna pacos	78.72	6.00e-171	595.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence