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Tag Content
iUUCD ID IUUC-Mcc-055789
Ensembl Protein ID ENSMMUP00000011578.2
UniProt Accession F7EWU7; F7EWU7_MACMU
Genbank Protein ID AFH34589.1; AFI38732.1
Protein Name Hepatocyte growth factor-regulated tyrosine kinase substrate
Genbank Nucleotide ID JSUE03017635; JV048661
Gene Name HGS
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMMUG00000008833.3 ENSMMUT00000012345.3 ENSMMUP00000011578.2
ENSMMUG00000008833.3 ENSMMUT00000054189.1 ENSMMUP00000052426.1
ENSMMUG00000008833.3 ENSMMUT00000073770.1 ENSMMUP00000055453.1
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/Alpha-Helix/VHS 5.20e-51 173.2 15 143
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/Alpha-Helix/VHS
   S: 1    atselvtsedwelileicdliqetkegakdalralrkrinnknphvalraLtlLdscvsnCgkkfhvevaskdlleelrellknenepk 89
           ats+l+ ++dwe+il+icdli++ +++ak+a+++++k++n+knphval+aL++++s+v+nCg+++h+eva+k+++eel++llk+++e++
   Q: 15   ATSQLLLETDWESILQICDLIRQGDTQAKYAVNSIKKKVNDKNPHVALYALEVMESVVKNCGQTVHDEVANKQTMEELKDLLKRQVEVN 103
           799************************************************************************************** PP
   S: 90   vieKlkalivsWadelknepalslivaliktlkeeGlefp 129
           v++K+++li++Wa++++nep++++++++++ +k eG++fp
   Q: 104  VRNKILYLIQAWAHAFRNEPKYKVVQDTYQIMKVEGHVFP 143
           ***************************************8 PP
   
Organism Macaca mulatta
Protein Sequence
(Fasta)
MGRGSGTFER LLDKATSQLL LETDWESILQ ICDLIRQGDT QAKYAVNSIK KKVNDKNPHV 60
ALYALEVMES VVKNCGQTVH DEVANKQTME ELKDLLKRQV EVNVRNKILY LIQAWAHAFR 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mcc-055789|UBD,VHS|Macaca mulatta
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGCGGAAGTC GGGGGGCGCG CCAGCTGGGA TCAGGGGAGC GCCCGCGGCG ACGGGTCTGT 60
GCTGGAGGTC GCCATGGGGC GAGGTAGCGG CACCTTCGAG CGTCTTCTAG GTAACGCATC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mcc-055789|UBD,VHS|Macaca mulatta
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0418--Kinase
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR008942--ENTH_VHS
IPR024641--HRS_helical
IPR017073--Ubi-bd_Hrs_VPS27
IPR003903--UIM_dom
IPR002014--VHS_dom
IPR000306--Znf_FYVE
IPR017455--Znf_FYVE-rel
IPR011011--Znf_FYVE_PHD
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50330--UIM
PS50179--VHS
PS50178--ZF_FYVE
Pfam

PF01363--FYVE
PF12210--Hrs_helical
PF00790--VHS
SMART

SM00064--FYVE
SM00288--VHS
Gene Ontology

GO:0005829--C:cytosol
GO:0005769--C:early endosome
GO:0070062--C:extracellular exosome
GO:0005764--C:lysosome
GO:0016301--F:kinase activity
GO:0046872--F:metal ion binding
GO:0010324--P:membrane invagination
GO:0046426--P:negative regulation of JAK-STAT cascade
GO:1903543--P:positive regulation of exosomal secretion
GO:0010628--P:positive regulation of gene expression
GO:0072657--P:protein localization to membrane
GO:0006622--P:protein targeting to lysosome
GO:0043405--P:regulation of MAP kinase activity
KEGG mcc:714385
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001518 Ailuropoda melanoleuca 87.64 0.00e+00 1007.00
IUUC-Apl-003662 Anas platyrhynchos 81.79 0.00e+00 957.00
IUUC-Aca-004940 Anolis carolinensis 82.78 0.00e+00 1135.00
IUUC-Ago-007931 Ashbya gossypii 30.43 7.00e-27 115.00
IUUC-Acl-008274 Aspergillus clavatus 31.41 3.00e-40 160.00
IUUC-Afl-008521 Aspergillus flavus 33.98 5.00e-41 162.00
IUUC-Afu-008774 Aspergillus fumigatus 33.33 6.00e-41 162.00
IUUC-Ani-009445 Aspergillus nidulans 32.96 1.00e-41 164.00
IUUC-Ang-009863 Aspergillus niger 33.57 8.00e-43 168.00
IUUC-Ate-010444 Aspergillus terreus 35.53 6.00e-43 168.00
IUUC-Ame-011111 Astyanax mexicanus 77.73 0.00e+00 947.00
IUUC-Bgr-012087 Blumeria graminis 33.57 5.00e-43 169.00
IUUC-Bta-012506 Bos taurus 92.44 0.00e+00 1177.00
IUUC-Bci-013782 Botrytis cinerea 34.57 1.00e-41 164.00
IUUC-Cel-018493 Caenorhabditis elegans 52.61 2.00e-68 253.00
IUUC-Cja-019998 Callithrix jacchus 95.12 0.00e+00 1169.00
IUUC-Cfa-020615 Canis familiaris 89.40 0.00e+00 1093.00
IUUC-Cpo-022019 Cavia porcellus 92.96 0.00e+00 1244.00
IUUC-Csa-023596 Chlorocebus sabaeus 99.49 0.00e+00 1173.00
IUUC-Cin-025488 Ciona intestinalis 45.91 7.00e-127 447.00
IUUC-Csv-025802 Ciona savignyi 49.72 8.00e-113 400.00
IUUC-Cgl-026560 Colletotrichum gloeosporioides 35.42 2.00e-40 160.00
IUUC-Cne-026847 Cryptococcus neoformans 31.89 3.00e-38 153.00
IUUC-Dre-028353 Danio rerio 77.53 0.00e+00 924.00
IUUC-Dno-029005 Dasypus novemcinctus 86.87 0.00e+00 1140.00
IUUC-Dor-030280 Dipodomys ordii 92.02 0.00e+00 1179.00
IUUC-Dse-031238 Dothistroma septosporum 38.71 9.00e-43 168.00
IUUC-Dme-031952 Drosophila melanogaster 48.24 4.00e-79 289.00
IUUC-Ete-032235 Echinops telfairi 96.36 2.00e-132 466.00
IUUC-Eca-033873 Equus caballus 93.62 0.00e+00 1179.00
IUUC-Eeu-034652 Erinaceus europaeus 95.53 1.00e-104 374.00
IUUC-Fca-036563 Felis catus 90.77 0.00e+00 1137.00
IUUC-Fal-036649 Ficedula albicollis 82.82 0.00e+00 1028.00
IUUC-Fox-037962 Fusarium oxysporum 32.86 1.00e-39 158.00
IUUC-Fso-038396 Fusarium solani 33.57 3.00e-40 160.00
IUUC-Gmo-039510 Gadus morhua 74.05 0.00e+00 951.00
IUUC-Ggr-039938 Gaeumannomyces graminis 31.91 9.00e-38 152.00
IUUC-Gga-040201 Gallus gallus 82.07 0.00e+00 1095.00
IUUC-Gac-041459 Gasterosteus aculeatus 74.65 0.00e+00 954.00
IUUC-Ggo-044573 Gorilla gorilla 98.97 0.00e+00 1271.00
IUUC-Hsa-046009 Homo sapiens 98.84 0.00e+00 1315.00
IUUC-Itr-049065 Ictidomys tridecemlineatus 94.47 0.00e+00 1252.00
IUUC-Kpa-049327 Komagataella pastoris 30.13 5.00e-33 136.00
IUUC-Lch-049944 Latimeria chalumnae 73.71 1.00e-155 542.00
IUUC-Loc-051850 Lepisosteus oculatus 79.32 0.00e+00 1010.00
IUUC-Lma-053252 Leptosphaeria maculans 35.65 4.00e-41 163.00
IUUC-Laf-053346 Loxodonta africana 83.85 0.00e+00 1043.00
IUUC-Meu-056329 Macropus eugenii 72.47 8.00e-158 550.00
IUUC-Mor-057205 Magnaporthe oryzae 33.56 1.00e-38 155.00
IUUC-Mpo-057295 Magnaporthe poae 31.56 3.00e-39 157.00
IUUC-Mla-058849 Melampsora laricipopulina 33.03 6.00e-32 132.00
IUUC-Mga-059361 Meleagris gallopavo 81.43 0.00e+00 1024.00
IUUC-Mvi-060561 Microbotryum violaceum 38.14 1.00e-39 158.00
IUUC-Mmr-061122 Microcebus murinus 95.53 0.00e+00 1043.00
IUUC-Mdo-062171 Monodelphis domestica 89.19 0.00e+00 1185.00
IUUC-Mmu-063952 Mus musculus 93.05 0.00e+00 1273.00
IUUC-Mpu-065852 Mustela putorius furo 91.04 0.00e+00 1102.00
IUUC-Mlu-066996 Myotis lucifugus 84.18 2.00e-147 515.00
IUUC-Nfi-068539 Neosartorya fischeri 33.33 3.00e-41 163.00
IUUC-Ncr-068726 Neurospora crassa 39.19 5.00e-40 159.00
IUUC-Nle-070148 Nomascus leucogenys 92.66 0.00e+00 1135.00
IUUC-Opr-070833 Ochotona princeps 72.20 0.00e+00 793.00
IUUC-Ont-071261 Oreochromis niloticus 77.33 0.00e+00 962.00
IUUC-Oan-073684 Ornithorhynchus anatinus 70.59 2.00e-154 538.00
IUUC-Ola-087570 Oryzias latipes 74.54 0.00e+00 975.00
IUUC-Oga-089087 Otolemur garnettii 89.20 0.00e+00 1097.00
IUUC-Oar-089534 Ovis aries 92.04 0.00e+00 1175.00
IUUC-Ptr-091654 Pan troglodytes 93.56 0.00e+00 1161.00
IUUC-Pan-092652 Papio anubis 99.87 0.00e+00 1249.00
IUUC-Pno-095125 Phaeosphaeria nodorum 38.53 2.00e-42 167.00
IUUC-Pfo-096757 Poecilia formosa 76.11 0.00e+00 938.00
IUUC-Pab-097788 Pongo abelii 99.36 0.00e+00 880.00
IUUC-Pca-100145 Procavia capensis 79.15 0.00e+00 910.00
IUUC-Pva-102965 Pteropus vampyrus 86.39 0.00e+00 1106.00
IUUC-Pgr-103609 Puccinia graminis 34.69 2.00e-33 137.00
IUUC-Ptt-103865 Puccinia triticina 35.71 3.00e-34 140.00
IUUC-Pte-104095 Pyrenophora teres 35.24 7.00e-42 165.00
IUUC-Pyt-104668 Pyrenophora triticirepentis 35.87 2.00e-41 164.00
IUUC-Rno-105125 Rattus norvegicus 93.39 0.00e+00 1203.00
IUUC-Sce-106192 Saccharomyces cerevisiae 28.00 7.00e-27 115.00
IUUC-Sha-107066 Sarcophilus harrisii 90.04 0.00e+00 1152.00
IUUC-Sja-107931 Schizosaccharomyces japonicus 33.42 1.00e-41 164.00
IUUC-Spo-108220 Schizosaccharomyces pombe 36.41 1.00e-36 147.00
IUUC-Stu-112464 Solanum tuberosum 45.90 3.00e-13 70.90
IUUC-Sar-113393 Sorex araneus 91.58 3.00e-106 379.00
IUUC-Sre-114986 Sporisorium reilianum 38.12 1.00e-42 168.00
IUUC-Tgu-117505 Taeniopygia guttata 81.18 0.00e+00 1043.00
IUUC-Tru-118494 Takifugu rubripes 77.19 0.00e+00 991.00
IUUC-Tsy-119626 Tarsius syrichta 100.00 3.00e-54 206.00
IUUC-Tni-120174 Tetraodon nigroviridis 73.24 0.00e+00 996.00
IUUC-Tre-122191 Trichoderma reesei 33.82 1.00e-40 161.00
IUUC-Tvi-122318 Trichoderma virens 33.33 1.00e-41 165.00
IUUC-Tme-126914 Tuber melanosporum 34.40 5.00e-44 172.00
IUUC-Ttr-129095 Tursiops truncatus 92.71 0.00e+00 1221.00
IUUC-Uma-129475 Ustilago maydis 36.61 2.00e-39 157.00
IUUC-Vda-129908 Verticillium dahliae 32.87 1.00e-35 144.00
IUUC-Xtr-131900 Xenopus tropicalis 76.26 0.00e+00 1028.00
IUUC-Xma-133124 Xiphophorus maculatus 75.81 0.00e+00 977.00
IUUC-Yli-134682 Yarrowia lipolytica 35.27 9.00e-33 135.00
Created Date 25-Jun-2017

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