iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Cpo-022367

Ensembl Protein ID

ENSCPOP00000011885.2

UniProt Accession

H0VN71; H0VN71_CAVPO

Genbank Protein ID

ENSCPOP00000011885

Protein Name

Tyrosine-protein kinase

Genbank Nucleotide ID

AAKN02017690

Gene Name

ABL2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCPOG00000013202.3	ENSCPOT00000013329.2	ENSCPOP00000011885.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.70e-12	47.1	38	95

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
            +++ +lyd+ a+ d++L+++kG++++v+  ++q+++W +     ++ +G +P+n+++ ++
   Q: 38   PNLFVALYDFVASGDNTLSITKGEKLRVL-GYNQNGEWSEV--RSKNGQGWVPSNYITPVN 95
           67899************************.*********98..788899*********997 PP

Organism

Cavia porcellus

Protein Sequence
(Fasta)

LSEALHRPYG CDAESQALTE AIRWSSKENL LGATESDPNL FVALYDFVAS GDNTLSITKG 60
EKLRVLGYNQ NGEWSEVRSK NGQGWVPSNY ITPVNSLEKH SWYHGPVSRS AAEYLLSSLI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTTTCAGAAG CTTTGCACCG CCCCTACGGT TGTGATGCTG AATCCCAGGC GCTGACTGAA 60
GCCATCAGGT GGAGCTCCAA GGAGAACTTA CTTGGAGCCA CTGAGAGTGA CCCTAATCTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR015015--F-actin_binding
IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF08919--F_actin_bind
PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00109--TYRKINASE

SMART

SM00808--FABD
SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0005623--C:cell
GO:0005524--F:ATP binding
GO:0000287--F:magnesium ion binding
GO:0030145--F:manganese ion binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0071300--P:cellular response to retinoic acid
GO:0007204--P:positive regulation of cytosolic calcium ion concentration
GO:0010976--P:positive regulation of neuron projection development
GO:0051353--P:positive regulation of oxidoreductase activity
GO:0010863--P:positive regulation of phospholipase C activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002263	Ailuropoda melanoleuca	94.75	0.00e+00	1524.00
IUUC-Apl-003389	Anas platyrhynchos	82.09	0.00e+00	1634.00
IUUC-Ame-010629	Astyanax mexicanus	58.15	0.00e+00	1036.00
IUUC-Bta-013370	Bos taurus	94.02	0.00e+00	1499.00
IUUC-Cja-018894	Callithrix jacchus	89.17	0.00e+00	1805.00
IUUC-Cfa-020398	Canis familiaris	96.92	0.00e+00	1218.00
IUUC-Csa-023386	Chlorocebus sabaeus	95.13	0.00e+00	1529.00
IUUC-Cho-024714	Choloepus hoffmanni	94.87	0.00e+00	1408.00
IUUC-Dre-027741	Danio rerio	66.87	0.00e+00	1347.00
IUUC-Dno-029246	Dasypus novemcinctus	93.89	0.00e+00	1475.00
IUUC-Dor-030416	Dipodomys ordii	87.56	0.00e+00	1352.00
IUUC-Ete-032899	Echinops telfairi	63.37	7.00e-138	485.00
IUUC-Eca-033387	Equus caballus	95.12	0.00e+00	1520.00
IUUC-Eeu-035058	Erinaceus europaeus	80.00	0.00e+00	1654.00
IUUC-Fca-036578	Felis catus	87.49	0.00e+00	1702.00
IUUC-Fal-037491	Ficedula albicollis	83.85	0.00e+00	1743.00
IUUC-Gmo-038509	Gadus morhua	77.68	0.00e+00	1132.00
IUUC-Gga-040638	Gallus gallus	83.11	0.00e+00	1697.00
IUUC-Gac-042550	Gasterosteus aculeatus	78.33	0.00e+00	1189.00
IUUC-Ggo-044487	Gorilla gorilla	94.87	0.00e+00	1522.00
IUUC-Hsa-046636	Homo sapiens	94.87	0.00e+00	1522.00
IUUC-Itr-048685	Ictidomys tridecemlineatus	94.65	0.00e+00	1529.00
IUUC-Lch-049530	Latimeria chalumnae	75.04	0.00e+00	1516.00
IUUC-Loc-051933	Lepisosteus oculatus	70.34	0.00e+00	1403.00
IUUC-Laf-053802	Loxodonta africana	94.51	0.00e+00	1560.00
IUUC-Mcc-054836	Macaca mulatta	95.00	0.00e+00	1526.00
IUUC-Mga-059277	Meleagris gallopavo	83.76	0.00e+00	1711.00
IUUC-Mmr-061206	Microcebus murinus	94.51	0.00e+00	1442.00
IUUC-Mdo-062281	Monodelphis domestica	78.36	0.00e+00	1482.00
IUUC-Mmu-063847	Mus musculus	92.42	0.00e+00	1429.00
IUUC-Mpu-066309	Mustela putorius furo	96.75	0.00e+00	1218.00
IUUC-Mlu-068070	Myotis lucifugus	93.90	0.00e+00	1503.00
IUUC-Nle-070062	Nomascus leucogenys	96.91	0.00e+00	1222.00
IUUC-Opr-070534	Ochotona princeps	90.64	0.00e+00	994.00
IUUC-Ont-072440	Oreochromis niloticus	76.40	0.00e+00	1163.00
IUUC-Oan-073526	Ornithorhynchus anatinus	90.05	0.00e+00	1445.00
IUUC-Ocu-074051	Oryctolagus cuniculus	93.41	0.00e+00	1466.00
IUUC-Opu-083538	Oryza punctata	34.39	4.00e-23	103.00
IUUC-Oga-088767	Otolemur garnettii	87.00	0.00e+00	1326.00
IUUC-Oar-089800	Ovis aries	93.90	0.00e+00	1501.00
IUUC-Ptr-090857	Pan troglodytes	97.24	0.00e+00	1222.00
IUUC-Pan-092279	Papio anubis	95.27	0.00e+00	1526.00
IUUC-Psi-093573	Pelodiscus sinensis	83.14	0.00e+00	1682.00
IUUC-Pfo-096543	Poecilia formosa	76.61	0.00e+00	1152.00
IUUC-Pab-097949	Pongo abelii	94.51	0.00e+00	1479.00
IUUC-Pca-100370	Procavia capensis	93.18	0.00e+00	1039.00
IUUC-Pva-103220	Pteropus vampyrus	86.19	0.00e+00	1279.00
IUUC-Rno-105924	Rattus norvegicus	94.42	0.00e+00	1451.00
IUUC-Sha-107114	Sarcophilus harrisii	89.53	0.00e+00	1361.00
IUUC-Sit-110219	Setaria italica	29.79	5.00e-20	93.20
IUUC-Ssc-115968	Sus scrofa	95.32	0.00e+00	1521.00
IUUC-Tgu-117301	Taeniopygia guttata	83.67	0.00e+00	1669.00
IUUC-Tru-118410	Takifugu rubripes	77.68	0.00e+00	1173.00
IUUC-Tni-119991	Tetraodon nigroviridis	76.74	0.00e+00	1199.00
IUUC-Tbe-127362	Tupaia belangeri	94.24	0.00e+00	1459.00
IUUC-Ttr-129291	Tursiops truncatus	94.89	0.00e+00	1536.00
IUUC-Vpa-130800	Vicugna pacos	94.67	0.00e+00	1522.00
IUUC-Xtr-132965	Xenopus tropicalis	71.58	0.00e+00	1356.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence