iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mdo-062281

Ensembl Protein ID

ENSMODP00000007549.4

UniProt Accession

F7FED8; F7FED8_MONDO

Protein Name

Tyrosine-protein kinase

Gene Name

ABL2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000006090.4	ENSMODT00000007700.4	ENSMODP00000007549.4

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	2.10e-12	47.0	88	145

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
            +++ +lyd+ a+ d++L+++kG++++v+  ++q+++W +     ++ +G +P+n+++ ++
   Q: 88   PNLFVALYDFVASGDNTLSITKGEKLRVL-GYNQNGEWSEV--RSKNGQGWVPSNYITPVN 145
           67899************************.*********98..788899*********997 PP

Organism

Monodelphis domestica

Protein Sequence
(Fasta)

MGQQVGRVGE APGLQQPQPR GSRGSSAARP AGRRRDPAGR TEEAGFNIFT QHEALHRPYG 60
CDVESQALNE AIRWSSKENL LGATESDPNL FVALYDFVAS GDNTLSITKG EKLRVLGYNQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCACACTCGG CTTTGCACAC AATGGGTACT CAGTAAATTC GGCGGTGTTG GGTGGGGATC 60
GAAGAGGATC GGGTGGGAGA TGCCGGTAGG GCCAGGATAA CTTCGGAAAG GGATGGACGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR015015--F-actin_binding
IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF08919--F_actin_bind
PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00109--TYRKINASE

SMART

SM00808--FABD
SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0005524--F:ATP binding
GO:0000287--F:magnesium ion binding
GO:0030145--F:manganese ion binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0005102--F:receptor binding
GO:0030154--P:cell differentiation
GO:0071300--P:cellular response to retinoic acid
GO:0045087--P:innate immune response
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0007204--P:positive regulation of cytosolic calcium ion concentration
GO:0010976--P:positive regulation of neuron projection development
GO:0051353--P:positive regulation of oxidoreductase activity
GO:0010863--P:positive regulation of phospholipase C activity
GO:0042127--P:regulation of cell proliferation
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002263	Ailuropoda melanoleuca	97.07	0.00e+00	1187.00
IUUC-Apl-003389	Anas platyrhynchos	80.60	0.00e+00	1540.00
IUUC-Bta-013370	Bos taurus	93.74	0.00e+00	1242.00
IUUC-Cja-018894	Callithrix jacchus	92.69	0.00e+00	1184.00
IUUC-Cfa-020398	Canis familiaris	91.35	0.00e+00	1714.00
IUUC-Cpo-022367	Cavia porcellus	78.89	0.00e+00	1435.00
IUUC-Csa-023386	Chlorocebus sabaeus	96.74	0.00e+00	1185.00
IUUC-Cho-024714	Choloepus hoffmanni	96.91	0.00e+00	1155.00
IUUC-Dre-027741	Danio rerio	83.00	0.00e+00	1055.00
IUUC-Dno-029246	Dasypus novemcinctus	96.85	0.00e+00	1239.00
IUUC-Dor-030416	Dipodomys ordii	84.43	0.00e+00	1060.00
IUUC-Ete-032899	Echinops telfairi	90.62	3.00e-146	513.00
IUUC-Eca-033387	Equus caballus	97.56	0.00e+00	1190.00
IUUC-Eeu-035058	Erinaceus europaeus	84.43	0.00e+00	1088.00
IUUC-Fca-036578	Felis catus	93.78	0.00e+00	1144.00
IUUC-Fal-037491	Ficedula albicollis	97.72	0.00e+00	1190.00
IUUC-Gmo-038509	Gadus morhua	87.27	0.00e+00	1040.00
IUUC-Gga-040638	Gallus gallus	96.62	0.00e+00	1195.00
IUUC-Gac-042550	Gasterosteus aculeatus	87.13	0.00e+00	1045.00
IUUC-Ggo-044487	Gorilla gorilla	93.60	0.00e+00	1226.00
IUUC-Hsa-046636	Homo sapiens	93.60	0.00e+00	1227.00
IUUC-Itr-048685	Ictidomys tridecemlineatus	97.56	0.00e+00	1190.00
IUUC-Lch-049530	Latimeria chalumnae	87.63	0.00e+00	1177.00
IUUC-Loc-051933	Lepisosteus oculatus	84.53	0.00e+00	1113.00
IUUC-Laf-053802	Loxodonta africana	92.60	0.00e+00	1292.00
IUUC-Mcc-054836	Macaca mulatta	93.45	0.00e+00	1226.00
IUUC-Mga-059277	Meleagris gallopavo	97.72	0.00e+00	1191.00
IUUC-Mmr-061206	Microcebus murinus	93.16	0.00e+00	1254.00
IUUC-Mmu-063847	Mus musculus	92.44	0.00e+00	1206.00
IUUC-Mpu-066309	Mustela putorius furo	89.06	0.00e+00	1739.00
IUUC-Mlu-068070	Myotis lucifugus	96.91	0.00e+00	1183.00
IUUC-Nle-070062	Nomascus leucogenys	89.62	0.00e+00	1759.00
IUUC-Ont-072440	Oreochromis niloticus	80.66	0.00e+00	1065.00
IUUC-Oan-073526	Ornithorhynchus anatinus	96.92	0.00e+00	1184.00
IUUC-Ocu-074051	Oryctolagus cuniculus	93.51	0.00e+00	1173.00
IUUC-Oga-088767	Otolemur garnettii	86.55	0.00e+00	1025.00
IUUC-Oar-089800	Ovis aries	97.39	0.00e+00	1192.00
IUUC-Ptr-090857	Pan troglodytes	89.71	0.00e+00	1766.00
IUUC-Pan-092279	Papio anubis	96.40	0.00e+00	1239.00
IUUC-Psi-093573	Pelodiscus sinensis	97.56	0.00e+00	1187.00
IUUC-Pfo-096543	Poecilia formosa	78.79	0.00e+00	1039.00
IUUC-Pab-097949	Pongo abelii	96.70	0.00e+00	1241.00
IUUC-Pca-100370	Procavia capensis	88.86	0.00e+00	707.00
IUUC-Pva-103220	Pteropus vampyrus	82.36	0.00e+00	1070.00
IUUC-Rno-105924	Rattus norvegicus	93.43	0.00e+00	1220.00
IUUC-Sha-107114	Sarcophilus harrisii	97.56	0.00e+00	1167.00
IUUC-Ssc-115968	Sus scrofa	94.03	0.00e+00	1242.00
IUUC-Tgu-117301	Taeniopygia guttata	97.88	0.00e+00	1192.00
IUUC-Tru-118410	Takifugu rubripes	78.58	0.00e+00	1078.00
IUUC-Tni-119991	Tetraodon nigroviridis	77.57	0.00e+00	1070.00
IUUC-Tbe-127362	Tupaia belangeri	93.74	0.00e+00	1216.00
IUUC-Ttr-129291	Tursiops truncatus	97.56	0.00e+00	1189.00
IUUC-Vpa-130800	Vicugna pacos	96.74	0.00e+00	1178.00
IUUC-Xtr-132965	Xenopus tropicalis	85.41	0.00e+00	1129.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence