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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063138
UUCD1 version UUC-MuM-00019
Ensembl Protein ID ENSMUSP00000095380.3
UniProt Accession Q3U410; B1AS70; Q3TZ30; KLH21_MOUSE
Genbank Protein ID BAE32625.1; BAE34380.1; CAM24575.1; EDL14916.1; AAI41159.1; AAI41160.1
Protein Name Kelch-like protein 21
Genbank Nucleotide ID AK154493; AK158141; AL611927; CH466594; BC141158; BC141159
Gene Name Klhl21
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000073700.3 ENSMUST00000097773.3 ENSMUSP00000095380.3
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarRAID2
Protein-protein Interaction
IIDHINTMentha
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB 4.40e-19 69.7 36 100
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box 6.70e-09 35.0 136 164
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB
   S: 2    Dvilvvg.geeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgkld 66
           Dv+l+ + g+ f+ah++vLaa+S++F+a+f ++l+es+  ++v +++v p+ ++ ll+F+Ytg++ 
   Q: 36   DVTLEAAgGRDFPAHRAVLAAASPYFRAMFAGQLRESR-AERVRLHGVPPDMLQLLLDFSYTGRVA 100
           9*****99******************************.************************986 PP
   

   E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box
   S: 2    eNclgilrfAdlydcpdLkdaaldfilkh 30
            Ncl++ +fA++++c+ L++aa++fil+h
   Q: 136  ANCLDMQDFAEAFSCSGLASAAQRFILRH 164
           6***************************9 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of AURKB. Ubiquitination of AURKB by BCR(KLHL21) E3 ubiquitin ligase complex may not lead to its degradation by the proteasome (By similarity).
 Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of AURKB. Ubiquitination of AURKB by BCR(KLHL21) E3 ubiquitin ligase complex may not lead to its degradation by the proteasome (By similarity).
Protein Sequence
(Fasta)
MERPAPLAVL PFSDPAHALS LLRGLSQLRA ERKFLDVTLE AAGGRDFPAH RAVLAAASPY 60
FRAMFAGQLR ESRAERVRLH GVPPDMLQLL LDFSYTGRVA VSGDNAEPLL RAADLLQFPA 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063138|E3,BTB_3-box|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGAACAGAAG GGTTAAATGG GCAAGGTTAG AGGCGCTCCG CCCCAACAGA CCCCGCCCAC 60
GGAGGCTGCG GCTGGTCTGC GTATTTATAG AGGCGGTGCC GGACGCGCTG GGGCGTCCCT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063138|E3,BTB_3-box|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0880--Kelch repeat
KW-0498--Mitosis
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
Interpro

IPR011705--BACK
IPR017096--BTB-kelch_protein
IPR000210--BTB/POZ_dom
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR011333--SKP1/BTB/POZ
PROSITE

PS50097--BTB
Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1
SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch
Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0005827--C:polar microtubule
GO:0004842--F:ubiquitin-protein transferase activity
GO:0051301--P:cell division
GO:0035853--P:chromosome passenger complex localization to spindle midzone
GO:0007067--P:mitotic nuclear division
GO:0016567--P:protein ubiquitination
GO:0032465--P:regulation of cytokinesis
KEGG mmu:242785
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001782 Ailuropoda melanoleuca 87.43 0.00e+00 925.00
IUUC-Apl-003189 Anas platyrhynchos 85.07 3.00e-142 497.00
IUUC-Ani-009467 Aspergillus nidulans 35.29 1.00e-07 50.80
IUUC-Ame-011774 Astyanax mexicanus 66.11 5.00e-137 480.00
IUUC-Bta-012367 Bos taurus 96.65 0.00e+00 1152.00
IUUC-Cja-019501 Callithrix jacchus 89.39 0.00e+00 1033.00
IUUC-Cfa-020550 Canis familiaris 96.48 0.00e+00 1151.00
IUUC-Cpo-022072 Cavia porcellus 95.64 0.00e+00 1120.00
IUUC-Csa-023364 Chlorocebus sabaeus 96.82 0.00e+00 1017.00
IUUC-Cin-025253 Ciona intestinalis 43.64 9.00e-147 513.00
IUUC-Csv-025871 Ciona savignyi 45.01 1.00e-152 533.00
IUUC-Dre-028694 Danio rerio 72.89 0.00e+00 861.00
IUUC-Dno-029082 Dasypus novemcinctus 92.98 0.00e+00 946.00
IUUC-Dor-030680 Dipodomys ordii 96.31 0.00e+00 1148.00
IUUC-Ete-032315 Echinops telfairi 94.47 0.00e+00 957.00
IUUC-Eca-033570 Equus caballus 94.60 0.00e+00 696.00
IUUC-Eeu-035067 Erinaceus europaeus 92.97 2.00e-145 509.00
IUUC-Fca-035663 Felis catus 89.79 3.00e-125 440.00
IUUC-Fal-037103 Ficedula albicollis 85.38 0.00e+00 897.00
IUUC-Gmo-039420 Gadus morhua 71.13 0.00e+00 842.00
IUUC-Ggr-039811 Gaeumannomyces graminis 38.36 4.00e-08 52.80
IUUC-Gga-040161 Gallus gallus 83.13 0.00e+00 864.00
IUUC-Gac-041755 Gasterosteus aculeatus 71.85 0.00e+00 868.00
IUUC-Ggo-044899 Gorilla gorilla 96.65 0.00e+00 1137.00
IUUC-Hsa-045834 Homo sapiens 96.65 0.00e+00 1132.00
IUUC-Itr-048413 Ictidomys tridecemlineatus 96.82 0.00e+00 1150.00
IUUC-Lch-050338 Latimeria chalumnae 70.08 0.00e+00 877.00
IUUC-Loc-051780 Lepisosteus oculatus 75.22 0.00e+00 885.00
IUUC-Laf-053725 Loxodonta africana 94.50 0.00e+00 794.00
IUUC-Mcc-055032 Macaca mulatta 98.80 0.00e+00 979.00
IUUC-Meu-056661 Macropus eugenii 94.57 0.00e+00 769.00
IUUC-Mpo-057626 Magnaporthe poae 31.67 4.00e-07 49.70
IUUC-Mga-059821 Meleagris gallopavo 84.58 9.00e-126 442.00
IUUC-Mdo-062095 Monodelphis domestica 95.26 0.00e+00 961.00
IUUC-Mpu-066386 Mustela putorius furo 95.03 0.00e+00 644.00
IUUC-Mlu-067807 Myotis lucifugus 94.38 0.00e+00 701.00
IUUC-Nle-069181 Nomascus leucogenys 95.81 0.00e+00 1131.00
IUUC-Opr-070658 Ochotona princeps 96.31 0.00e+00 1172.00
IUUC-Ont-072209 Oreochromis niloticus 72.36 0.00e+00 857.00
IUUC-Oan-072861 Ornithorhynchus anatinus 90.23 1.00e-118 418.00
IUUC-Ocu-074631 Oryctolagus cuniculus 87.21 0.00e+00 1001.00
IUUC-Ola-087553 Oryzias latipes 71.13 0.00e+00 845.00
IUUC-Oga-088782 Otolemur garnettii 97.15 0.00e+00 1160.00
IUUC-Oar-089634 Ovis aries 96.31 0.00e+00 1147.00
IUUC-Ptr-091259 Pan troglodytes 95.74 0.00e+00 842.00
IUUC-Pan-091734 Papio anubis 96.98 0.00e+00 1140.00
IUUC-Psi-092979 Pelodiscus sinensis 85.02 0.00e+00 924.00
IUUC-Pma-094459 Petromyzon marinus 53.47 3.00e-125 442.00
IUUC-Pfo-097446 Poecilia formosa 72.01 0.00e+00 855.00
IUUC-Pab-098765 Pongo abelii 96.82 0.00e+00 1150.00
IUUC-Pca-101018 Procavia capensis 99.42 5.00e-94 338.00
IUUC-Pva-102730 Pteropus vampyrus 92.96 0.00e+00 1097.00
IUUC-Rno-104972 Rattus norvegicus 98.83 0.00e+00 1179.00
IUUC-Ssc-115869 Sus scrofa 97.61 0.00e+00 975.00
IUUC-Tgu-116562 Taeniopygia guttata 85.25 0.00e+00 933.00
IUUC-Tru-118490 Takifugu rubripes 71.30 0.00e+00 847.00
IUUC-Tni-119898 Tetraodon nigroviridis 69.54 0.00e+00 815.00
IUUC-Ttr-128976 Tursiops truncatus 93.36 3.00e-145 508.00
IUUC-Xtr-132876 Xenopus tropicalis 74.39 0.00e+00 905.00
IUUC-Xma-133540 Xiphophorus maculatus 72.54 0.00e+00 859.00
Created Date 25-Jun-2017

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