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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-064422
UUCD1 version UUC-MuM-00724
Ensembl Protein ID ENSMUSP00000062344.7
UniProt Accession Q8CCE9; Q05BH7; Q3UNJ9; Q62065; Q6IR08; Q6PGI1; Q9QY56; E4F1_MOUSE
Genbank Protein ID AAF22563.1; BAC28222.1; BAE25748.1; AAH46459.1; AAH57011.1; AAH71228.1; CAA54188.1
Protein Name Transcription factor E4F1; E4F transcription factor 1; Putative E3 ubiquitin-protein ligase E4F1; RING-type E3 ubiquitin transferase E4F1; Transcription factor E4F; Transcription factor phi AP3; p120E4F
Genbank Nucleotide ID AF126967; AK033285; AK144176; BC046459; BC057011; BC071228; X76858
Gene Name E4f1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000024137.8 ENSMUST00000056032.7 ENSMUSP00000062344.7
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
miRTarBasemicroRNATRANSFACRepTar
miRNAMapRAID2
Protein-protein Interaction
IIDiRefIndexMentha
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTM
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 activity/Other 87.73 0.00e+00 1177.00 IUUC-Hsa-046947
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Mus musculus
Functional Description
(View)

Functional Description


     May function as a transcriptional repressor. May also function as a ubiquitin ligase mediating ubiquitination of chromatin-associated TP53. Functions in cell survival and proliferation through control of the cell cycle. Functions in the p53 and pRB tumor suppressor pathways and regulates the cyclin CCNA2 transcription.
 May function as a transcriptional repressor. May also function as a ubiquitin ligase mediating ubiquitination of chromatin-associated TP53. Functions in cell survival and proliferation through control of the cell cycle. Functions in the p53 and pRB tumor suppressor pathways and regulates the cyclin CCNA2 transcription.
Protein Sequence
(Fasta)
MEGAMAVRVT AAHTAEARAE AGREAGEGGV AAAAALSSGG FLGLPAPFSE EDEDDVHRCG 60
RCQVEFTALE DFVQHKIQKT CHRAPQEALP TTPAATALLD QEVVPTAAEG GPDEPITVAH 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-064422|E3,E3 activity/Other|Mus musculus
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Nucleotide Sequence
(Fasta)
ATCTTCCTGT GGCGCGTTGC GACATGGAGG GCGCGATGGC AGTGCGGGTG ACGGCCGCTC 60
ATACGGCAGA AGCCCGGGCC GAAGCCGGGC GTGAAGCGGG CGAGGGCGGG GTTGCGGCGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-064422|E3,E3 activity/Other|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0238--DNA-binding
KW-0341--Growth regulation
KW-0479--Metal-binding
KW-0498--Mitosis
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR004039--Rubredoxin-type_fold
IPR013087--Znf_C2H2_type
PROSITE

PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2
SMART

SM00355--ZnF_C2H2
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005819--C:spindle
GO:0035497--F:cAMP response element binding
GO:0003677--F:DNA binding
GO:0046872--F:metal ion binding
GO:0000977--F:RNA polymerase II regulatory region sequence-specific DNA binding
GO:0016740--F:transferase activity
GO:0051301--P:cell division
GO:0006260--P:DNA replication
GO:0007067--P:mitotic nuclear division
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0016567--P:protein ubiquitination
GO:0010564--P:regulation of cell cycle process
GO:0040008--P:regulation of growth
GO:0009794--P:regulation of mitotic cell cycle, embryonic
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
KEGG mmu:13560
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001466 Ailuropoda melanoleuca 84.51 0.00e+00 1075.00
IUUC-Apl-004190 Anas platyrhynchos 65.95 0.00e+00 919.00
IUUC-Aca-005100 Anolis carolinensis 59.92 0.00e+00 815.00
IUUC-Ame-010704 Astyanax mexicanus 56.75 2.00e-117 416.00
IUUC-Bta-013540 Bos taurus 87.23 0.00e+00 1165.00
IUUC-Cja-018918 Callithrix jacchus 86.24 0.00e+00 1165.00
IUUC-Cfa-020601 Canis familiaris 88.04 0.00e+00 644.00
IUUC-Cpo-021573 Cavia porcellus 89.37 0.00e+00 1252.00
IUUC-Csa-023729 Chlorocebus sabaeus 87.53 0.00e+00 1126.00
IUUC-Dre-028803 Danio rerio 44.52 4.00e-151 528.00
IUUC-Dno-030072 Dasypus novemcinctus 86.47 6.00e-174 604.00
IUUC-Dor-030640 Dipodomys ordii 84.57 0.00e+00 1068.00
IUUC-Eca-034223 Equus caballus 89.65 0.00e+00 1135.00
IUUC-Fca-036268 Felis catus 83.29 0.00e+00 1069.00
IUUC-Fal-037359 Ficedula albicollis 64.25 0.00e+00 791.00
IUUC-Gmo-039016 Gadus morhua 41.53 5.00e-118 418.00
IUUC-Gga-040305 Gallus gallus 65.38 0.00e+00 902.00
IUUC-Gac-042016 Gasterosteus aculeatus 45.31 1.00e-161 563.00
IUUC-Ggo-044459 Gorilla gorilla 87.52 0.00e+00 1097.00
IUUC-Hsa-046947 Homo sapiens 86.90 0.00e+00 1079.00
IUUC-Itr-048641 Ictidomys tridecemlineatus 90.64 0.00e+00 1149.00
IUUC-Lch-049557 Latimeria chalumnae 44.13 5.00e-156 545.00
IUUC-Loc-052894 Lepisosteus oculatus 50.13 0.00e+00 634.00
IUUC-Laf-053791 Loxodonta africana 82.52 0.00e+00 1110.00
IUUC-Mcc-054901 Macaca mulatta 87.15 0.00e+00 1113.00
IUUC-Meu-056299 Macropus eugenii 70.39 0.00e+00 944.00
IUUC-Mga-059323 Meleagris gallopavo 65.23 0.00e+00 924.00
IUUC-Mmr-061422 Microcebus murinus 89.54 0.00e+00 1152.00
IUUC-Mdo-061906 Monodelphis domestica 69.59 0.00e+00 949.00
IUUC-Mpu-066440 Mustela putorius furo 87.14 0.00e+00 1079.00
IUUC-Mlu-067352 Myotis lucifugus 87.25 0.00e+00 1132.00
IUUC-Nle-069201 Nomascus leucogenys 90.96 8.00e-179 620.00
IUUC-Opr-071166 Ochotona princeps 84.72 0.00e+00 1070.00
IUUC-Ont-071370 Oreochromis niloticus 45.96 2.00e-153 535.00
IUUC-Oan-072749 Ornithorhynchus anatinus 56.71 0.00e+00 672.00
IUUC-Ocu-074254 Oryctolagus cuniculus 87.57 0.00e+00 1145.00
IUUC-Ola-086897 Oryzias latipes 46.14 8.00e-164 570.00
IUUC-Oga-089179 Otolemur garnettii 88.21 0.00e+00 963.00
IUUC-Oar-090290 Ovis aries 74.73 0.00e+00 1061.00
IUUC-Ptr-091531 Pan troglodytes 85.01 0.00e+00 1025.00
IUUC-Pan-091839 Papio anubis 87.15 0.00e+00 1113.00
IUUC-Psi-093276 Pelodiscus sinensis 66.67 0.00e+00 746.00
IUUC-Pfo-096039 Poecilia formosa 49.30 3.00e-156 545.00
IUUC-Pca-100262 Procavia capensis 80.19 0.00e+00 1011.00
IUUC-Pva-102678 Pteropus vampyrus 84.95 0.00e+00 1097.00
IUUC-Rno-106036 Rattus norvegicus 96.50 0.00e+00 1276.00
IUUC-Sha-107571 Sarcophilus harrisii 70.08 0.00e+00 935.00
IUUC-Ssc-115849 Sus scrofa 88.44 0.00e+00 1099.00
IUUC-Tgu-117296 Taeniopygia guttata 65.35 0.00e+00 843.00
IUUC-Tru-118085 Takifugu rubripes 44.76 2.00e-156 546.00
IUUC-Tni-119719 Tetraodon nigroviridis 46.48 9.00e-168 583.00
IUUC-Ttr-129067 Tursiops truncatus 89.01 0.00e+00 1125.00
IUUC-Xtr-132116 Xenopus tropicalis 49.43 6.00e-174 604.00
Created Date 25-Jun-2017

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