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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-046419
Ensembl Protein ID ENSP00000405965.2
UniProt Accession P61956; B2R4I2; P55855; Q32Q42; Q6IPZ6; Q96HK1; SUMO2_HUMAN
Genbank Protein ID AAD45399.1; CAA67897.1; BAG34779.1; EAW89249.1; AAH08450.1; AAH16775.1; AAH22340.1; AAH62713.1; AAH68465.1; AAH70159.1; AAH71645.1; AAH71646.1; AAI07854.1; ENSP00000400886
Protein Name Small ubiquitin-related modifier 2; HSMT3; SMT3 homolog 2; SUMO-3; Sentrin-2; Ubiquitin-like protein SMT3B
Genbank Nucleotide ID L76416; X99585; AK311837; AC022211; BC008450; BC016775; BC022340; BC062713; BC068465; BC070159; BC071645; BC071646; BC107853; BF978876
Gene Name SUMO2; SMT3B; SMT3H2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000188612.11 ENST00000420826.6 ENSP00000405965.2
ENSG00000188612.11 ENST00000314523.7 ENSP00000400886.2
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsiteCircNetmiRTarBase
microRNATRANSFACTargetScanRepTar
miRcodeRAID2
Protein-protein Interaction
IIDPINAHINTMentha
InWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDUniProtPHOSIDABioGRID
mUbiSiDa
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
ULD/UBL/SUMO SUMO 25748227; 25755297
Classification
Family E-value Score Start End
ULD/UBL/SUMO 1.00e-32 114.3 14 93
ULD/UDP/UBQ/UBQ_Other 5.30e-05 24.7 22 91
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   ULD/UBL/SUMO
   S: 5    fkapvslkvagqdGsevlfklklsaqlkklmeavYvkrinldensvrfvfngqkireqetpeelevededkiellcqksGG 85
           +  +++lkvagqdGs v+fk+k++++l+klm+a Y++r++l+++++rf+f+gq+i+e++tp++le+eded+i++++q++GG
   Q: 14   NNDHINLKVAGQDGSVVQFKIKRHTPLSKLMKA-YCERQGLSMRQIRFRFDGQPINETDTPAQLEMEDEDTIDVFQQQTGG 93
           789******************************.**********************************************9 PP
   

   ULD/UDP/UBQ/UBQ_Other
   S: 5    vksldgseltlkvnpsdtVaeLKekiekklgippeqqrLiykGkiLeddktLadyglkdgstihllekks 74
           v   dgs+ ++k++++++ ++L +   +++g+ ++q+r  ++G+++ + +t a++ + d++ti++ +++ 
   Q: 22   VAGQDGSVVQFKIKRHTPLSKLMKAYCERQGLSMRQIRFRFDGQPINETDTPAQLEMEDEDTIDVFQQQT 91
           5556999**********************************************************98875 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2, CBX4 or ZNF451 (PubMed:26524494). This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins (PubMed:18408734, PubMed:18538659, PubMed:21965678, PubMed:9556629). Plays a role in the regulation of sumoylation status of SETX (PubMed:24105744).
 Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2, CBX4 or ZNF451 (PubMed:26524494). This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins (PubMed:18408734, PubMed:18538659, PubMed:21965678, PubMed:9556629). Plays a role in the regulation of sumoylation status of SETX (PubMed:24105744).
Protein Sequence
(Fasta)
MADEKPKEGV KTENNDHINL KVAGQDGSVV QFKIKRHTPL SKLMKAYCER QGLSMRQIRF 60
RFDGQPINET DTPAQLEMED EDTIDVFQQQ TGGVY 95
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046419|ULD,SUMO;ULD,UBQ_Other|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGGAGCGCAC GACGTGCGCG CACCCTCTCC CCTCGTCCAC CGCTGCCGCC TCCTTCTTCT 60
GCCGCTCCTG GTGCTGCTTG TGTGCTCGTT TGGTGCGGAC CTGGTACCTC TTTTGTGAAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046419|ULD,SUMO;ULD,UBQ_Other|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-1017--Isopeptide bond
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
Interpro

IPR022617--Rad60/SUMO-like_dom
IPR033950--Sumo
IPR027218--SUMO_2/3
IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom
PROSITE

PS50053--UBIQUITIN_2
Pfam

PF11976--Rad60-SLD
SMART

SM00213--UBQ
Gene Ontology

GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0016605--C:PML body
GO:0031386--F:protein tag
GO:0003723--F:RNA binding
GO:0019789--F:SUMO transferase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0070911--P:global genome nucleotide-excision repair
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0016925--P:protein sumoylation
KEGG hsa:6613
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001918 Ailuropoda melanoleuca 100.00 2.00e-53 199.00
IUUC-Apl-003372 Anas platyrhynchos 98.88 3.00e-49 186.00
IUUC-Aca-005284 Anolis carolinensis 100.00 2.00e-53 199.00
IUUC-Aly-005765 Arabidopsis lyrata 52.17 2.00e-21 93.20
IUUC-Ath-007391 Arabidopsis thaliana 52.75 2.00e-21 93.20
IUUC-Acl-008286 Aspergillus clavatus 50.00 4.00e-17 79.30
IUUC-Afl-008650 Aspergillus flavus 47.31 7.00e-18 81.60
IUUC-Afu-008969 Aspergillus fumigatus 46.81 8.00e-18 81.30
IUUC-Ame-011427 Astyanax mexicanus 96.81 2.00e-51 192.00
IUUC-Bgr-012250 Blumeria graminis 46.51 4.00e-17 79.30
IUUC-Bta-013208 Bos taurus 95.79 5.00e-51 191.00
IUUC-Bol-015977 Brassica oleracea 52.17 2.00e-21 93.60
IUUC-Cfa-020546 Canis familiaris 100.00 2.00e-53 199.00
IUUC-Cpo-021498 Cavia porcellus 100.00 2.00e-53 199.00
IUUC-Csa-023133 Chlorocebus sabaeus 100.00 2.00e-53 199.00
IUUC-Cin-025314 Ciona intestinalis 76.04 3.00e-38 149.00
IUUC-Csv-026212 Ciona savignyi 76.04 9.00e-39 150.00
IUUC-Cme-027181 Cyanidioschyzon merolae 55.32 2.00e-23 100.00
IUUC-Dre-027994 Danio rerio 98.92 1.00e-51 193.00
IUUC-Dno-029390 Dasypus novemcinctus 100.00 6.00e-54 202.00
IUUC-Dse-031390 Dothistroma septosporum 49.00 5.00e-21 92.00
IUUC-Ete-032934 Echinops telfairi 81.05 3.00e-42 162.00
IUUC-Eca-033260 Equus caballus 100.00 2.00e-53 199.00
IUUC-Fca-036393 Felis catus 93.68 1.00e-49 187.00
IUUC-Fal-037226 Ficedula albicollis 98.89 8.00e-50 188.00
IUUC-Fox-037950 Fusarium oxysporum 52.50 1.00e-19 87.40
IUUC-Fso-038430 Fusarium solani 51.85 8.00e-20 88.20
IUUC-Gmo-038535 Gadus morhua 92.55 1.00e-49 186.00
IUUC-Ggr-040015 Gaeumannomyces graminis 54.43 1.00e-20 91.30
IUUC-Gga-040145 Gallus gallus 100.00 2.00e-53 199.00
IUUC-Gac-041723 Gasterosteus aculeatus 92.55 2.00e-49 186.00
IUUC-Gma-043216 Glycine max 53.85 2.00e-21 93.60
IUUC-Ggo-045467 Gorilla gorilla 100.00 2.00e-53 199.00
IUUC-Itr-048667 Ictidomys tridecemlineatus 95.70 7.00e-50 187.00
IUUC-Lch-050572 Latimeria chalumnae 89.69 4.00e-46 175.00
IUUC-Loc-052560 Lepisosteus oculatus 97.89 9.00e-53 197.00
IUUC-Laf-054343 Loxodonta africana 98.95 5.00e-53 198.00
IUUC-Mcc-054832 Macaca mulatta 100.00 4.00e-52 196.00
IUUC-Mtr-057985 Medicago truncatula 52.75 3.00e-21 92.80
IUUC-Mga-059768 Meleagris gallopavo 98.88 3.00e-49 186.00
IUUC-Mmr-061593 Microcebus murinus 100.00 4.00e-52 196.00
IUUC-Mdo-062678 Monodelphis domestica 98.95 3.00e-53 199.00
IUUC-Mmu-063990 Mus musculus 100.00 2.00e-53 199.00
IUUC-Mpu-065909 Mustela putorius furo 98.89 4.00e-50 188.00
IUUC-Mlu-067634 Myotis lucifugus 93.68 2.00e-49 186.00
IUUC-Ncr-068663 Neurospora crassa 51.28 7.00e-19 85.10
IUUC-Nle-069631 Nomascus leucogenys 96.84 1.00e-51 194.00
IUUC-Ont-071512 Oreochromis niloticus 96.77 3.00e-50 189.00
IUUC-Ocu-074239 Oryctolagus cuniculus 98.95 3.00e-53 198.00
IUUC-Ola-086710 Oryzias latipes 97.85 8.00e-51 191.00
IUUC-Oar-089624 Ovis aries 94.74 1.00e-50 190.00
IUUC-Ptr-091082 Pan troglodytes 100.00 2.00e-53 199.00
IUUC-Pan-091949 Papio anubis 100.00 3.00e-52 196.00
IUUC-Psi-094000 Pelodiscus sinensis 100.00 2.00e-53 199.00
IUUC-Pfo-097304 Poecilia formosa 97.85 2.00e-51 192.00
IUUC-Pab-098572 Pongo abelii 100.00 2.00e-53 199.00
IUUC-Ppe-101648 Prunus persica 51.61 1.00e-21 94.40
IUUC-Rno-105391 Rattus norvegicus 98.94 3.00e-52 195.00
IUUC-Sar-113337 Sorex araneus 84.04 5.00e-43 165.00
IUUC-Sbi-114801 Sorghum bicolor 53.85 2.00e-21 93.20
IUUC-Ssc-115915 Sus scrofa 100.00 2.00e-53 199.00
IUUC-Tgu-116815 Taeniopygia guttata 98.89 4.00e-50 188.00
IUUC-Tre-121926 Trichoderma reesei 49.45 2.00e-21 93.20
IUUC-Tvi-122514 Trichoderma virens 53.75 6.00e-20 88.60
IUUC-Tae-122900 Triticum aestivum 52.75 5.00e-22 95.50
IUUC-Tur-126333 Triticum urartu 40.68 3.00e-17 81.30
IUUC-Tbe-127363 Tupaia belangeri 92.55 7.00e-48 181.00
IUUC-Vda-129731 Verticillium dahliae 46.15 3.00e-19 86.30
IUUC-Vvi-131092 Vitis vinifera 53.26 1.00e-21 94.70
IUUC-Xtr-132691 Xenopus tropicalis 95.79 2.00e-51 193.00
IUUC-Xma-133892 Xiphophorus maculatus 97.85 8.00e-52 194.00
Created Date 25-Jun-2017

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