iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Ath-006677

UUCD1 version

UUC-ArT-01626

Ensembl Protein ID

AT5G50580.2

UniProt Accession

P0DI12; Q8LCB9; Q8LKN3; Q9LUF3; SA1B1_ARATH

Genbank Protein ID

AAN03850.1; BAB09143.1; AED95964.1; AED95965.1; AAM14034.1; AAM51305.1; BAE99099.1; AAM63741.1

Protein Name

SUMO-activating enzyme subunit 1B-1; SUMO-activating enzyme subunit 1-2; Ubiquitin-like 1-activating enzyme E1A

Genbank Nucleotide ID

AF510524; AB025619; CP002688; CP002688; AY091012; AY117230; AK227039; AY086686

Gene Name

SAE1B-1; SAE1-2; At5g50580; MBA10.22

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
AT5G50580	AT5G50580.2	AT5G50580.2
AT5G50580	AT5G50580.1	AT5G50580.1

Annotation

mRNA Expression
GEO
Protein-protein Interaction
PINA	HINT
Post-translational Modifications (PTMs)
UniProt
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E1	E1_ThiF	17644626; 20682785

Classification

Family	E-value	Score	Start	End
E1	3.90e-75	254.5	14	171

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGvgsitvvDmdtvevsnlnrqFLfraed...vgksKAevaaealkelnpdvnveahee 95
           YDRQir+wG+ aq++l++++vl++G++g+ +E++Kn+vlaGvgs+t++D++ v+++  n++FL+ ++    vgk+ Ae+++++lk++np+v+v++ + 
   Q: 14   YDRQIRVWGAGAQRRLSKSHVLVSGIKGTVAEFCKNIVLAGVGSVTLLDDRLVTTEVFNANFLILPDEnayVGKTVAEICCDSLKDFNPMVHVSIEKG 111
           ****************************************************************99542336************************** PP
   S: 96   siteleeeivFfkkfdvVvlaldnrearrkvnrlclna..rvpliesgtlGllGqvrviikgltecyscsddppqktiPfctlke 178
           ++++l+ +  Ff+kfdvVv+++ +r++++ vn+ c+n+  +v +++++++G +G++                       f++l++
   Q: 112  DLSTLGVD--FFEKFDVVVIGYSSRATKKAVNEKCRNLakDVAFYTVDCRGSCGEI-----------------------FVDLQN 171
           *****999..****************************99***************9.......................444444 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

The dimeric enzyme acts as an E1 ligase for SUMO1 and SUMO2. It mediates ATP-dependent activation of SUMO proteins and formation of a thioester with a conserved cysteine residue on SAE2. Functionally redundant with its paralog SAE1A.

Protein Sequence
(Fasta)

MDGDELTEQE TALYDRQIRV WGAGAQRRLS KSHVLVSGIK GTVAEFCKNI VLAGVGSVTL 60
LDDRLVTTEV FNANFLILPD ENAYVGKTVA EICCDSLKDF NPMVHVSIEK GDLSTLGVDF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACCATGTAAT TTGAATAAAT AAAAAGAAAG CAATTTTCCG GTTAACAAAA AATCTCAAAC 60
TCAGTGAGTG AGTCACCGAA AACCTCTTGT AGTAGATTCG TGACGGGTTT GATCATCTCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0436--Ligase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd
IPR000011--UBQ/SUMO-activ_enz_E1-like

Pfam

PF00899--ThiF

PRINTS

PR01849--UBIQUITINACT

Gene Ontology

GO:0005634--C:nucleus
GO:0019948--F:SUMO activating enzyme activity
GO:0016925--P:protein sumoylation

KEGG

ath:AT5G50580; ath:AT5G50680

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001477	Ailuropoda melanoleuca	33.23	2.00e-43	168.00
IUUC-Atr-002536	Amborella trichopoda	64.04	1.00e-124	438.00
IUUC-Aca-004868	Anolis carolinensis	32.82	7.00e-40	157.00
IUUC-Aly-005588	Arabidopsis lyrata	95.62	0.00e+00	628.00
IUUC-Ago-007891	Ashbya gossypii	35.75	2.00e-28	119.00
IUUC-Acl-008197	Aspergillus clavatus	26.14	3.00e-31	128.00
IUUC-Afl-008520	Aspergillus flavus	26.29	1.00e-32	133.00
IUUC-Afu-009107	Aspergillus fumigatus	24.85	3.00e-25	108.00
IUUC-Ani-009143	Aspergillus nidulans	26.48	2.00e-29	122.00
IUUC-Ang-009804	Aspergillus niger	25.94	1.00e-31	130.00
IUUC-Aor-010190	Aspergillus oryzae	26.29	1.00e-32	133.00
IUUC-Ate-010519	Aspergillus terreus	25.00	2.00e-15	75.90
IUUC-Ame-011043	Astyanax mexicanus	33.43	7.00e-39	153.00
IUUC-Bgr-012084	Blumeria graminis	25.15	4.00e-25	108.00
IUUC-Bta-012723	Bos taurus	32.83	7.00e-43	167.00
IUUC-Bci-013809	Botrytis cinerea	27.54	5.00e-28	117.00
IUUC-Cel-018434	Caenorhabditis elegans	28.49	4.00e-23	101.00
IUUC-Cja-019815	Callithrix jacchus	33.33	2.00e-45	175.00
IUUC-Cfa-020329	Canis familiaris	32.64	1.00e-42	166.00
IUUC-Cpo-022208	Cavia porcellus	32.17	4.00e-43	167.00
IUUC-Csa-023592	Chlorocebus sabaeus	31.10	3.00e-29	121.00
IUUC-Cin-025351	Ciona intestinalis	32.84	9.00e-45	173.00
IUUC-Cgl-026491	Colletotrichum gloeosporioides	27.19	1.00e-28	120.00
IUUC-Cne-026970	Cryptococcus neoformans	26.56	1.00e-21	96.30
IUUC-Dre-028263	Danio rerio	33.33	4.00e-40	157.00
IUUC-Dno-030055	Dasypus novemcinctus	31.75	5.00e-41	160.00
IUUC-Dor-030864	Dipodomys ordii	31.78	3.00e-37	148.00
IUUC-Dse-031565	Dothistroma septosporum	25.44	5.00e-25	108.00
IUUC-Dme-032011	Drosophila melanogaster	33.43	3.00e-30	124.00
IUUC-Ete-032982	Echinops telfairi	31.88	3.00e-42	165.00
IUUC-Eca-034164	Equus caballus	31.58	5.00e-36	144.00
IUUC-Fca-035564	Felis catus	33.53	7.00e-44	170.00
IUUC-Fso-038404	Fusarium solani	28.86	2.00e-30	126.00
IUUC-Ggr-040068	Gaeumannomyces graminis	29.71	2.00e-31	129.00
IUUC-Gga-041197	Gallus gallus	30.56	3.00e-25	108.00
IUUC-Gac-042609	Gasterosteus aculeatus	32.06	1.00e-36	146.00
IUUC-Gma-044135	Glycine max	71.70	3.00e-138	483.00
IUUC-Ggo-044600	Gorilla gorilla	33.23	2.00e-43	169.00
IUUC-Hsa-046731	Homo sapiens	33.23	2.00e-43	169.00
IUUC-Itr-049038	Ictidomys tridecemlineatus	32.74	1.00e-43	169.00
IUUC-Kpa-049371	Komagataella pastoris	24.27	1.00e-22	99.80
IUUC-Lch-050045	Latimeria chalumnae	33.84	8.00e-46	176.00
IUUC-Loc-051749	Lepisosteus oculatus	30.14	3.00e-32	131.00
IUUC-Lma-053150	Leptosphaeria maculans	29.01	2.00e-31	129.00
IUUC-Laf-053875	Loxodonta africana	33.23	2.00e-43	169.00
IUUC-Mcc-055163	Macaca mulatta	31.15	2.00e-34	138.00
IUUC-Mor-057029	Magnaporthe oryzae	28.49	7.00e-34	137.00
IUUC-Mla-059040	Melampsora laricipopulina	30.77	1.00e-25	109.00
IUUC-Mvi-060367	Microbotryum violaceum	34.53	4.00e-42	164.00
IUUC-Mmr-061294	Microcebus murinus	30.45	2.00e-32	132.00
IUUC-Mmu-063568	Mus musculus	33.33	2.00e-42	165.00
IUUC-Mpu-065826	Mustela putorius furo	32.94	7.00e-43	167.00
IUUC-Mlu-067751	Myotis lucifugus	30.96	2.00e-36	145.00
IUUC-Nfi-068597	Neosartorya fischeri	26.86	2.00e-34	139.00
IUUC-Ncr-068768	Neurospora crassa	26.29	1.00e-24	106.00
IUUC-Nle-069882	Nomascus leucogenys	38.04	3.00e-25	107.00
IUUC-Oan-073560	Ornithorhynchus anatinus	31.19	3.00e-34	137.00
IUUC-Ocu-074732	Oryctolagus cuniculus	30.18	1.00e-33	136.00
IUUC-Oga-089005	Otolemur garnettii	31.27	1.00e-38	153.00
IUUC-Oar-089611	Ovis aries	32.83	9.00e-43	166.00
IUUC-Ptr-091337	Pan troglodytes	33.23	2.00e-43	169.00
IUUC-Pan-092401	Papio anubis	32.64	3.00e-42	165.00
IUUC-Pma-094210	Petromyzon marinus	30.99	1.00e-42	166.00
IUUC-Pno-094975	Phaeosphaeria nodorum	28.81	2.00e-30	125.00
IUUC-Ppa-095925	Physcomitrella patens	54.57	1.00e-100	358.00
IUUC-Pfo-096890	Poecilia formosa	32.35	1.00e-34	139.00
IUUC-Pab-098173	Pongo abelii	33.23	2.00e-43	169.00
IUUC-Pva-102625	Pteropus vampyrus	32.14	3.00e-42	164.00
IUUC-Pyt-104818	Pyrenophora triticirepentis	28.65	1.00e-28	120.00
IUUC-Rno-106129	Rattus norvegicus	32.93	1.00e-44	172.00
IUUC-Sja-107996	Schizosaccharomyces japonicus	28.48	9.00e-30	123.00
IUUC-Spo-108321	Schizosaccharomyces pombe	26.79	2.00e-26	112.00
IUUC-Ssl-108608	Sclerotinia sclerotiorum	26.96	8.00e-28	117.00
IUUC-Smo-109539	Selaginella moellendorffii	49.21	3.00e-84	304.00
IUUC-Sly-111116	Solanum lycopersicum	69.38	5.00e-129	453.00
IUUC-Stu-112397	Solanum tuberosum	69.71	9.00e-130	455.00
IUUC-Sar-113506	Sorex araneus	28.07	6.00e-32	130.00
IUUC-Ssc-115891	Sus scrofa	32.94	3.00e-43	167.00
IUUC-Tru-118469	Takifugu rubripes	31.30	4.00e-35	141.00
IUUC-Tni-119803	Tetraodon nigroviridis	28.20	2.00e-27	115.00
IUUC-Tca-121747	Theobroma cacao	73.80	5.00e-141	493.00
IUUC-Tre-122060	Trichoderma reesei	30.75	2.00e-30	125.00
IUUC-Tvi-122324	Trichoderma virens	30.68	5.00e-32	130.00
IUUC-Tme-126939	Tuber melanosporum	30.56	1.00e-34	139.00
IUUC-Tbe-127982	Tupaia belangeri	31.45	3.00e-41	161.00
IUUC-Ttr-128758	Tursiops truncatus	32.94	5.00e-43	167.00
IUUC-Vda-129664	Verticillium dahliae	28.65	4.00e-30	125.00
IUUC-Vpa-130778	Vicugna pacos	32.03	1.00e-24	106.00
IUUC-Vvi-131399	Vitis vinifera	73.58	2.00e-144	503.00
IUUC-Xtr-131919	Xenopus tropicalis	31.18	8.00e-41	160.00
IUUC-Xma-133482	Xiphophorus maculatus	31.76	4.00e-34	137.00
IUUC-Yli-134596	Yarrowia lipolytica	28.37	2.00e-23	102.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence