iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Laf-054230

UUCD1 version

UUC-LoA-00192

Ensembl Protein ID

ENSLAFP00000004605.4

UniProt Accession

G3SWB8; G3SWB8_LOXAF

Protein Name

Uncharacterized protein

Gene Name

HECTD1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000005491.4	ENSLAFT00000005491.4	ENSLAFP00000004605.4

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	4.20e-121	404.8	2156	2617

Active Site

Position(s)	Description	Evidence
2586	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysen..dketlqpnpdsglknp..................... 65
           ++d+k++levef+gEeg++l G+t+ef+al+++e+q++dlg++l+++n  d+e+++++   g+k+p                     
   Q: 2156 HADRKSVLEVEFLGEEGTGL-GPTLEFYALVAAEFQRTDLGAWLCDDNfpDDESRHVDLGGGVKPPgyyvqrscglftapfpqdsde 2241
           6899****************.******************************************999********************* PP
   S: 66   ..ehlklFeflGrllgkalqdgrlldlplsksfykll.................................................. 100
             + +klF+flG++l+k++qd+rl+dlp+sk+f+kl+                                                  
   Q: 2242 leRITKLFHFLGIFLAKCIQDNRLVDLPISKPFFKLMcmgdiksnmskliyesrgdrdlhctesqseasteeghdslsvgsfeedsk 2328
           *************************************99999999999999999999999999999999999999988888888887 PP
   S: 101  ...............lgkklsledleevdpelykslkeikenaes..................................dieelgld 138
                          ++  l++ed+e v+p+++++lkeik++a +                                  +ie+lgl+
   Q: 2329 sefildppkpkppawFNGILNWEDFELVNPHRARFLKEIKDLAIKrrqilsnkdlsedekntklqelvlknpsgsgpplSIEDLGLN 2415
           7777777777766666668***********************9334455555666777788899999999999************** PP
   S: 139  ltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegikeqveafr...eGfneviplellslFteeelellicGee 222
           ++f++s++i+g t+++ Lkp+Ge++++t++N+eeYv+l++++++++gi++q+eafr   +Gfn+v+p+e+ls+F++ee+++++cG+ 
   Q: 2416 FQFCPSSRIYGFTAVD-LKPSGEDEMITMDNAEEYVDLMFDFCMHTGIQKQMEAFRgnvDGFNKVFPMEKLSSFSHEEVQMILCGN- 2500
           *************999.**************************************97778**************************. PP
   S: 223  eidvedlkket..ky...kggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnT 303
             +++++++e+  +y   k gyt+dsp++ +F++vl+++ss+erkafLqF+Tg+s+lP+gG+a+l+prl+v+rk da+d+++Ps+nT
   Q: 2501 --QSPSWAAEDiiNYtepKLGYTRDSPGFLRFVRVLCGMSSDERKAFLQFTTGCSTLPPGGLANLHPRLTVVRKvDATDASYPSVNT 2585
           ..6666666665555555********************************************************************* PP
   S: 304  CfnyLkLPeYsskeilkekLlyAieetkgFels 336
           C++yLkLPeYss+ei++e+Ll+A++e kgF+l+
   Q: 2586 CVHYLKLPEYSSEEIMRERLLAATME-KGFHLN 2617
           **************************.****86 PP

Organism

Loxodonta africana

Protein Sequence
(Fasta)

MADVDPDTLL EWLQMGQGDE RDMQLIALEQ LCMLLLMSDN VDRCFETCPP RTFLPALCKI 60
FLDESAPDNV LEVTARAITY YLDVSAECTR RIVGVDGAIK ALCNRLVVVE LNNRTSRDLA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCAGATG TGGATCCGGA TACATTGCTG GAATGGCTAC AGATGGGACA GGGAGATGAA 60
AGGGACATGC AACTAATAGC CCTTGAACAG CTATGCATGC TGCTTTTGAT GTCTGACAAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0040--ANK repeat
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR008979--Galactose-bd-like
IPR000569--HECT_dom
IPR010606--Mib_Herc2
IPR012919--SUN_dom

PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50237--HECT
PS51416--MIB_HERC2

Pfam

PF12796--Ank_2
PF00632--HECT
PF06701--MIB_HERC2
PF07738--Sad1_UNC

SMART

SM00248--ANK
SM00119--HECTc

Gene Ontology

GO:0046872--F:metal ion binding
GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001987	Ailuropoda melanoleuca	98.82	0.00e+00	4646.00
IUUC-Apl-003493	Anas platyrhynchos	95.31	0.00e+00	4498.00
IUUC-Aca-004521	Anolis carolinensis	96.12	0.00e+00	2792.00
IUUC-Ame-011258	Astyanax mexicanus	91.20	0.00e+00	2378.00
IUUC-Bta-012835	Bos taurus	98.85	0.00e+00	4652.00
IUUC-Cel-018153	Caenorhabditis elegans	52.54	4.00e-168	586.00
IUUC-Cja-019174	Callithrix jacchus	98.02	0.00e+00	4575.00
IUUC-Cfa-021115	Canis familiaris	98.66	0.00e+00	4594.00
IUUC-Cpo-022382	Cavia porcellus	94.90	0.00e+00	4407.00
IUUC-Csa-023230	Chlorocebus sabaeus	99.01	0.00e+00	4648.00
IUUC-Cho-024711	Choloepus hoffmanni	95.82	0.00e+00	1641.00
IUUC-Cin-025342	Ciona intestinalis	53.18	0.00e+00	1372.00
IUUC-Csv-026031	Ciona savignyi	51.65	0.00e+00	1399.00
IUUC-Dre-027435	Danio rerio	86.79	0.00e+00	4106.00
IUUC-Dno-029954	Dasypus novemcinctus	98.89	0.00e+00	4618.00
IUUC-Dor-030734	Dipodomys ordii	97.64	0.00e+00	1495.00
IUUC-Dme-031739	Drosophila melanogaster	59.97	0.00e+00	1622.00
IUUC-Ete-033192	Echinops telfairi	98.44	0.00e+00	702.00
IUUC-Eca-033434	Equus caballus	98.51	0.00e+00	4619.00
IUUC-Eeu-035031	Erinaceus europaeus	83.38	3.00e-169	588.00
IUUC-Fca-035998	Felis catus	97.21	0.00e+00	4529.00
IUUC-Fal-037468	Ficedula albicollis	95.21	0.00e+00	2794.00
IUUC-Gmo-038495	Gadus morhua	90.84	0.00e+00	1367.00
IUUC-Gga-040736	Gallus gallus	97.20	0.00e+00	2810.00
IUUC-Gac-041777	Gasterosteus aculeatus	91.53	0.00e+00	2407.00
IUUC-Ggo-044677	Gorilla gorilla	94.78	0.00e+00	4368.00
IUUC-Hsa-045879	Homo sapiens	99.01	0.00e+00	4648.00
IUUC-Itr-048664	Ictidomys tridecemlineatus	98.82	0.00e+00	4644.00
IUUC-Lch-050444	Latimeria chalumnae	91.69	0.00e+00	4183.00
IUUC-Loc-051986	Lepisosteus oculatus	87.98	0.00e+00	4144.00
IUUC-Mcc-054787	Macaca mulatta	99.01	0.00e+00	4648.00
IUUC-Meu-056502	Macropus eugenii	88.67	0.00e+00	1325.00
IUUC-Mga-059409	Meleagris gallopavo	90.80	0.00e+00	2065.00
IUUC-Mmr-061667	Microcebus murinus	98.55	0.00e+00	4614.00
IUUC-Mdo-061960	Monodelphis domestica	97.14	0.00e+00	4570.00
IUUC-Mmu-063941	Mus musculus	98.17	0.00e+00	4616.00
IUUC-Mpu-065939	Mustela putorius furo	98.82	0.00e+00	4641.00
IUUC-Mlu-068112	Myotis lucifugus	98.51	0.00e+00	4598.00
IUUC-Nle-069001	Nomascus leucogenys	98.93	0.00e+00	4644.00
IUUC-Opr-071222	Ochotona princeps	94.07	0.00e+00	2095.00
IUUC-Ont-072101	Oreochromis niloticus	81.17	0.00e+00	3906.00
IUUC-Oan-072814	Ornithorhynchus anatinus	97.25	0.00e+00	4565.00
IUUC-Ocu-074011	Oryctolagus cuniculus	98.82	0.00e+00	4638.00
IUUC-Ola-086412	Oryzias latipes	91.24	0.00e+00	2396.00
IUUC-Oar-089668	Ovis aries	98.93	0.00e+00	4647.00
IUUC-Ptr-090517	Pan troglodytes	98.78	0.00e+00	4606.00
IUUC-Pan-091849	Papio anubis	96.29	0.00e+00	4476.00
IUUC-Psi-093390	Pelodiscus sinensis	93.50	0.00e+00	2709.00
IUUC-Pma-094628	Petromyzon marinus	83.42	0.00e+00	1586.00
IUUC-Pfo-097075	Poecilia formosa	92.08	0.00e+00	2442.00
IUUC-Pab-098176	Pongo abelii	99.01	0.00e+00	4648.00
IUUC-Pca-101123	Procavia capensis	94.05	0.00e+00	2487.00
IUUC-Pva-103008	Pteropus vampyrus	94.26	0.00e+00	1905.00
IUUC-Rno-105885	Rattus norvegicus	98.20	0.00e+00	4615.00
IUUC-Sha-107048	Sarcophilus harrisii	95.85	0.00e+00	4507.00
IUUC-Sar-113071	Sorex araneus	93.85	0.00e+00	1271.00
IUUC-Ssc-115963	Sus scrofa	98.51	0.00e+00	4622.00
IUUC-Tgu-117167	Taeniopygia guttata	93.49	0.00e+00	2612.00
IUUC-Tru-118626	Takifugu rubripes	92.60	0.00e+00	2474.00
IUUC-Tsy-119504	Tarsius syrichta	96.36	0.00e+00	2295.00
IUUC-Tni-119877	Tetraodon nigroviridis	91.84	0.00e+00	2419.00
IUUC-Tbe-127602	Tupaia belangeri	96.68	0.00e+00	988.00
IUUC-Ttr-128394	Tursiops truncatus	97.42	0.00e+00	3123.00
IUUC-Vpa-130280	Vicugna pacos	98.06	0.00e+00	4416.00
IUUC-Xtr-131787	Xenopus tropicalis	86.45	0.00e+00	2585.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence