iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Psi-093390

Ensembl Protein ID

ENSPSIP00000006279.1

UniProt Accession

K7FE19; K7FE19_PELSI

Genbank Protein ID

ENSPSIP00000006279

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AGCU01041605

Gene Name

HECTD1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPSIG00000005810.1	ENSPSIT00000006316.1	ENSPSIP00000006279.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.20e-121	406.3	2065	2523

Active Site

Position(s)	Description	Evidence
2492	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysen..dketlqpnpdsglknp..................... 65
           ++d+k++levef+gEeg++l G+t+ef+al+++e+q+++lg +l +++  d+e++q++   glk+p                     
   Q: 2065 HADRKSVLEVEFLGEEGTGL-GPTLEFYALVAAEFQRTELGTWLSDDDfpDDESRQVDIGGGLKPPgyyvqrscglftapfpqdsde 2150
           6899****************.******************************************988********************* PP
   S: 66   ..ehlklFeflGrllgkalqdgrlldlplsksfykll.................................................. 100
             + +klF+flG++l+k++qd+rl+dlp+sk+f+kl+                                                  
   Q: 2151 leRITKLFHFLGIFLAKCIQDNRLVDLPISKPFFKLMcmgdiksnmskliyesrgdrdlhctesqseasteeghdslsvgsfeedsk 2237
           *************************************99999999999999999999999999999999999999988888888887 PP
   S: 101  ...............lgkklsledleevdpelykslkeikena.......es...........................dieelgld 138
                          ++  l++ed+e v+p+++++lk ik++a       ++                           +ie+lgl+
   Q: 2238 sefildppkpkppawFNGILTWEDFELVNPHRARFLKDIKDLAvkrrqilSNkglsedekntklqelmlknpsgsgpplSIEDLGLN 2324
           7777777777766666668***********************97666665005666667788899999999999************* PP
   S: 139  ltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeid 225
           ++f++s++++g t+++ Lkp+Ge+++Vt++N+eeYv+l++++++++gi++q++afr+Gfn+v+p+e+ls+F++ee+++++cG+   +
   Q: 2325 FQFCPSSRVYGFTAVD-LKPNGEDEMVTMDNAEEYVELMFDFCMQTGIQKQMDAFRDGFNRVFPMEKLSSFSHEEVQMILCGN---Q 2407
           *************999.******************************************************************...6 PP
   S: 226  vedlkket..ky...kggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnTCfn 306
           ++++++e+  +y   k gyt+dsp++ +F++vl+++ss+erkafLqF+Tg+s+lP+gG+a+l+prl+v+rk da+d+++Ps+nTC++
   Q: 2408 SPSWAAEDiiNYtepKLGYTRDSPGFLRFVRVLCGMSSDERKAFLQFTTGCSTLPPGGLANLHPRLTVVRKvDATDASYPSVNTCVH 2494
           666666665555555************************************************************************ PP
   S: 307  yLkLPeYsskeilkekLlyAieetkgFels 336
           yLkLPeYss+ei++e+Ll+A++e kgF+l+
   Q: 2495 YLKLPEYSSEEIMRERLLAATME-KGFHLN 2523
           ***********************.****86 PP

Organism

Pelodiscus sinensis

Protein Sequence
(Fasta)

MADVDPDTLL EWLQMGQGDE RDMQLIALEQ LCMLLLMSDN VDRCFETCPP RTFLPALCKI 60
FLDESAPDNV LEVTARAITY YLDVSAECTR RIVGVDGAIK ALCNRLVVVE LNNRTSRDLA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTGAAGACTG CAAAAATCCG AGTCTGACTG GAAGGAAAGT TTAATTGTAC ACAGGCTATC 60
CTGCCTTGAA CACTTTCACG GGTTTTTGGT CCTTATTAAT TTAAGTGAAG ACCGCTTTTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0040--ANK repeat
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR008979--Galactose-bd-like
IPR000569--HECT_dom
IPR010606--Mib_Herc2
IPR012919--SUN_dom

PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50237--HECT
PS51416--MIB_HERC2

Pfam

PF12796--Ank_2
PF00632--HECT
PF06701--MIB_HERC2
PF07738--Sad1_UNC

SMART

SM00248--ANK
SM00119--HECTc

Gene Ontology

GO:0046872--F:metal ion binding
GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001987	Ailuropoda melanoleuca	94.26	0.00e+00	2731.00
IUUC-Apl-003493	Anas platyrhynchos	95.71	0.00e+00	2779.00
IUUC-Aca-004521	Anolis carolinensis	95.56	0.00e+00	4401.00
IUUC-Ame-011258	Astyanax mexicanus	94.49	0.00e+00	2413.00
IUUC-Bta-012835	Bos taurus	94.20	0.00e+00	2740.00
IUUC-Cel-018153	Caenorhabditis elegans	52.23	4.00e-173	603.00
IUUC-Cja-019174	Callithrix jacchus	92.61	0.00e+00	2652.00
IUUC-Cfa-021115	Canis familiaris	93.90	0.00e+00	2684.00
IUUC-Cpo-022382	Cavia porcellus	87.99	0.00e+00	2488.00
IUUC-Csa-023230	Chlorocebus sabaeus	94.26	0.00e+00	2733.00
IUUC-Cho-024711	Choloepus hoffmanni	93.25	0.00e+00	1606.00
IUUC-Cin-025342	Ciona intestinalis	52.92	0.00e+00	1391.00
IUUC-Csv-026031	Ciona savignyi	51.64	0.00e+00	1368.00
IUUC-Dre-027435	Danio rerio	87.93	0.00e+00	2519.00
IUUC-Dno-029954	Dasypus novemcinctus	94.56	0.00e+00	2717.00
IUUC-Dor-030734	Dipodomys ordii	93.13	0.00e+00	1421.00
IUUC-Dme-031739	Drosophila melanogaster	59.31	0.00e+00	1592.00
IUUC-Ete-033192	Echinops telfairi	89.52	0.00e+00	1174.00
IUUC-Eca-033434	Equus caballus	93.21	0.00e+00	2692.00
IUUC-Eeu-035031	Erinaceus europaeus	81.78	0.00e+00	1066.00
IUUC-Fca-035998	Felis catus	97.17	0.00e+00	2761.00
IUUC-Fal-037468	Ficedula albicollis	95.32	0.00e+00	4384.00
IUUC-Gmo-038495	Gadus morhua	90.71	0.00e+00	1367.00
IUUC-Gga-040736	Gallus gallus	96.19	0.00e+00	4388.00
IUUC-Gac-041777	Gasterosteus aculeatus	88.74	0.00e+00	2316.00
IUUC-Ggo-044677	Gorilla gorilla	90.03	0.00e+00	2548.00
IUUC-Hsa-045879	Homo sapiens	94.26	0.00e+00	2733.00
IUUC-Itr-048664	Ictidomys tridecemlineatus	94.44	0.00e+00	2738.00
IUUC-Lch-050444	Latimeria chalumnae	91.76	0.00e+00	2578.00
IUUC-Loc-051986	Lepisosteus oculatus	92.75	0.00e+00	2650.00
IUUC-Laf-054230	Loxodonta africana	93.50	0.00e+00	2668.00
IUUC-Mcc-054787	Macaca mulatta	94.26	0.00e+00	2733.00
IUUC-Meu-056502	Macropus eugenii	88.77	0.00e+00	1313.00
IUUC-Mga-059409	Meleagris gallopavo	98.34	0.00e+00	1944.00
IUUC-Mmr-061667	Microcebus murinus	93.29	0.00e+00	2695.00
IUUC-Mdo-061960	Monodelphis domestica	94.57	0.00e+00	2724.00
IUUC-Mmu-063941	Mus musculus	93.03	0.00e+00	2670.00
IUUC-Mpu-065939	Mustela putorius furo	94.26	0.00e+00	2732.00
IUUC-Mlu-068112	Myotis lucifugus	94.20	0.00e+00	2729.00
IUUC-Nle-069001	Nomascus leucogenys	94.26	0.00e+00	2734.00
IUUC-Opr-071222	Ochotona princeps	92.88	0.00e+00	2078.00
IUUC-Ont-072101	Oreochromis niloticus	83.69	0.00e+00	2518.00
IUUC-Oan-072814	Ornithorhynchus anatinus	94.62	0.00e+00	2725.00
IUUC-Ocu-074011	Oryctolagus cuniculus	94.32	0.00e+00	2734.00
IUUC-Ola-086412	Oryzias latipes	92.52	0.00e+00	2326.00
IUUC-Oar-089668	Ovis aries	94.20	0.00e+00	2734.00
IUUC-Ptr-090517	Pan troglodytes	93.49	0.00e+00	2683.00
IUUC-Pan-091849	Papio anubis	90.97	0.00e+00	2597.00
IUUC-Pma-094628	Petromyzon marinus	83.72	0.00e+00	1602.00
IUUC-Pfo-097075	Poecilia formosa	92.58	0.00e+00	2367.00
IUUC-Pab-098176	Pongo abelii	94.26	0.00e+00	2733.00
IUUC-Pca-101123	Procavia capensis	90.23	0.00e+00	1548.00
IUUC-Pva-103008	Pteropus vampyrus	98.63	0.00e+00	1584.00
IUUC-Rno-105885	Rattus norvegicus	93.66	0.00e+00	2719.00
IUUC-Sha-107048	Sarcophilus harrisii	93.88	0.00e+00	2707.00
IUUC-Sar-113071	Sorex araneus	92.92	0.00e+00	1272.00
IUUC-Ssc-115963	Sus scrofa	93.66	0.00e+00	2712.00
IUUC-Tgu-117167	Taeniopygia guttata	97.09	0.00e+00	1679.00
IUUC-Tru-118626	Takifugu rubripes	88.85	0.00e+00	2356.00
IUUC-Tsy-119504	Tarsius syrichta	90.57	0.00e+00	2148.00
IUUC-Tni-119877	Tetraodon nigroviridis	92.22	0.00e+00	2318.00
IUUC-Tbe-127602	Tupaia belangeri	88.71	0.00e+00	1023.00
IUUC-Ttr-128394	Tursiops truncatus	96.04	0.00e+00	1665.00
IUUC-Vpa-130280	Vicugna pacos	93.60	0.00e+00	2704.00
IUUC-Xtr-131787	Xenopus tropicalis	85.29	0.00e+00	3995.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence