iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000182247.9	ENST00000425792.5	ENSP00000401053.1
ENSG00000182247.9	ENST00000452894.5	ENSP00000392800.1
ENSG00000182247.9	ENST00000335798.8	ENSP00000338340.4
ENSG00000182247.9	ENST00000628311.1	ENSP00000486775.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
miRWalk	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWASdb	OMIM
Drug and target
TTD
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	UniProt	BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E2/UBC	E2_UBC	20704751; 18597043

Classification

Family	E-value	Score	Start	End
E2/UBC	8.60e-50	169.8	59	194

Active Site

Position(s)	Description	Evidence
139	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00388, ECO:0000255\|PROSITE-ProRule:PRU10133}

Domain Profile

E2/UBC

   S: 1    RlkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilkeeekW 92
           R++kel+e++ dpp+++sa+p+ + +++ew+ +ilGp++++YeggvF l+i+f++dYPfkPPkv+f t+i+h+n++++G +Cl+ilk  ++W
   Q: 59   RIQKELAEITLDPPPNCSAGPKGD-NIYEWRSTILGPPGSVYEGGVFFLDITFSPDYPFKPPKVTFRTRIYHCNINSQGVICLDILK--DNW 147
           9***********************.9************************************************************9..*** PP
   S: 93   spalsvesvllsiqsllaepnpesplneeaaellkknreeykkkvre 139
           spal++++vllsi+sll+++np++pl  ++a+++ +nr+e+++++r+
   Q: 148  SPALTISKVLLSICSLLTDCNPADPLVGSIATQYMTNRAEHDRMARQ 194
           ******************************************99985 PP

Organism

Homo sapiens

Functional Description
(View)

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. Catalyzes the ISGylation of influenza A virus NS1 protein.

Protein Sequence
(Fasta)

MSTEAQRVDD SPSTSGGSSD GDQRESVQQE PEREQVQPKK KEGKISSKTA AKLSTSAKRI 60
QKELAEITLD PPPNCSAGPK GDNIYEWRST ILGPPGSVYE GGVFFLDITF SPDYPFKPPK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAGGAGGGAG GCGCGCGGCG CCGCATGGCC GACGTGGGGC TCGCGCTCTC GCGGTCTCTC 60
CCGGGCGGGC GCGCAGGCAC GCGCACTCGC GGGTGCGCGC GCGGACGGCC GGGCGGCGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005524--F:ATP binding
GO:0042296--F:ISG15 transferase activity
GO:0061631--F:ubiquitin conjugating enzyme activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0006974--P:cellular response to DNA damage stimulus
GO:0032020--P:ISG15-protein conjugation
GO:1900087--P:positive regulation of G1/S transition of mitotic cell cycle
GO:0070979--P:protein K11-linked ubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0070534--P:protein K63-linked ubiquitination

KEGG

hsa:7325

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aca-005044	Anolis carolinensis	98.01	1.00e-97	348.00
IUUC-Ame-011419	Astyanax mexicanus	95.80	2.00e-82	298.00
IUUC-Cre-022791	Chlamydomonas reinhardtii	80.13	1.00e-71	261.00
IUUC-Cho-024986	Choloepus hoffmanni	89.55	9.00e-87	312.00
IUUC-Dno-029130	Dasypus novemcinctus	100.00	1.00e-74	271.00
IUUC-Dme-032042	Drosophila melanogaster	87.65	2.00e-84	305.00
IUUC-Fca-035425	Felis catus	99.50	3.00e-85	307.00
IUUC-Fal-037043	Ficedula albicollis	98.51	2.00e-85	308.00
IUUC-Gmo-039645	Gadus morhua	91.13	8.00e-92	329.00
IUUC-Gga-040236	Gallus gallus	100.00	4.00e-85	306.00
IUUC-Gac-041661	Gasterosteus aculeatus	91.54	3.00e-91	327.00
IUUC-Loc-052673	Lepisosteus oculatus	94.53	2.00e-94	337.00
IUUC-Mcc-055072	Macaca mulatta	100.00	6.00e-86	309.00
IUUC-Mmr-060629	Microcebus murinus	100.00	6.00e-86	309.00
IUUC-Mmu-063733	Mus musculus	99.50	2.00e-99	354.00
IUUC-Mlu-067897	Myotis lucifugus	99.50	6.00e-86	309.00
IUUC-Nle-069421	Nomascus leucogenys	100.00	6.00e-86	309.00
IUUC-Ont-071325	Oreochromis niloticus	92.04	4.00e-92	330.00
IUUC-Oan-073704	Ornithorhynchus anatinus	100.00	1.00e-74	270.00
IUUC-Pab-098017	Pongo abelii	100.00	6.00e-86	309.00
IUUC-Pva-102561	Pteropus vampyrus	99.50	6.00e-86	309.00
IUUC-Tru-118527	Takifugu rubripes	95.77	1.00e-81	295.00
IUUC-Ttr-128358	Tursiops truncatus	100.00	6.00e-86	309.00
IUUC-Vpa-130232	Vicugna pacos	98.58	5.00e-81	293.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence