iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Aly-005466

UUCD1 version

UUC-ArL-01198

Ensembl Protein ID

fgenesh2_kg.1__465__AT1G05180.1

UniProt Accession

D7KEC1; D7KEC1_ARALL

Genbank Protein ID

EFH68531.1

Protein Name

NEDD8-activating enzyme E1 regulatory subunit

Genbank Nucleotide ID

GL348713

Gene Name

ARALYDRAFT_470511

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
fgenesh2_kg.1__465__AT1G05180.1	fgenesh2_kg.1__465__AT1G05180.1	fgenesh2_kg.1__465__AT1G05180.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	5.80e-128	428.3	24	531

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGvgsitvvDmdtvevsnlnrqFLfraedvgksKAevaa 78
           YDRQ+r+wGe++q++l++a+++l+++g++G+E lKnLvl+Gvg it+vD++tv++ +l+++F+++a++vg+sKA++++
   Q: 24   YDRQLRIWGEVGQAALEEASICLLNCGPTGSEALKNLVLGGVGCITIVDGSTVQIGDLGNNFMVDAKSVGQSKAKSVC 101
           ****************************************************************************** PP
   S: 79   ealkelnpdvnveaheesiteleeeiv.FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikg 155
           ++l+eln++vn+ + ee++++l ++++ Ff++f++V++++  ++++ k++r+c++a+v+l+ ++++Gl G+vr+++k+
   Q: 102  AFLQELNDSVNARFIEENPDTLITTNPsFFSQFTLVIATQLVEDSMVKLDRICREANVKLVLVRSYGLAGFVRISVKE 179
           ****************************************************************************** PP
   S: 156  ltecyscsd...dppqktiPfctlketpn..........aaehtiewavlfnklleeeageeevlekldseekeegkd 220
           +++++s++d   d++++++P+++lk++++          aa+++i+++v++ k++ee+a +++++ ++++eek+e+kd
   Q: 180  HPIIDSKPDhflDDLRLNNPWPELKSFVEtidlnvseppAAHKHIPYVVILVKMAEEWALSHSGNLPSTREEKKEFKD 257
           ***************************666677777777*************************************** PP
   S: 221  kvkselksedeenfeeaieiavkafakttins.ikqllksfecdivtkskspfwv....................... 274
           +vks++ s+de+n++eaie+a+k fa++ i+s +++l+++ +c++ ++++s+fwv                       
   Q: 258  LVKSKMISTDEDNYKEAIEAAFKVFAPRGISSeVQKLIND-SCAEANSNSSAFWVmvaalkefvlnegdgeaplegsi 334
           ********************************9*****99.************************************* PP
   S: 275  ....................................................sfcsnaealq...........vpekv 289
                                                               sfc+na++l+           ++++v
   Q: 335  pdmtsstehyinlqkiylakaeadflameervknilkkigrdpnsiskptikSFCKNARKLKlcryrmvedefSNPSV 412
           **************************************************************9999999999999*** PP
   S: 290  ekdeevvkasap.....lylllralerfekkkgrkpgelsfekdddsavdlvtaaanlraeslgiep.kldddlikei 361
           ++ +++++++++     +y+llra++rf++++++ pg+++  +d+d + +l+t+a++l  ++lg+++ +l+ddli e+
   Q: 413  TEIQKYLADEDYsgamgFYILLRAADRFAANYNKFPGQFDGGMDED-ISRLKTTALSLL-TDLGCNGaVLPDDLINEM 488
           **********************************************.**********99.****************** PP
   S: 362  agniipaiattnavvgGlaaqEviKvvsgkfeplknfflfdae 404
           +++++++i++++a+vgG+a+qEviK+v+++f+p+  +++f+++
   Q: 489  CRFGASEIHVVSAFVGGIASQEVIKLVTKQFVPMLGTYIFNGI 531
           **********************************999999986 PP

Organism

Arabidopsis lyrata

Functional Description
(View)

Regulatory subunit of the dimeric E1 enzyme. E1 activates RUB1/NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a RUB1-ECR1 thioester and free AMP. E1 finally transfers RUB1 to the catalytic cysteine of RCE1.

Protein Sequence
(Fasta)

MQPIKRSRKH VEEEPTMAEP KIKYDRQLRI WGEVGQAALE EASICLLNCG PTGSEALKNL 60
VLGGVGCITI VDGSTVQIGD LGNNFMVDAK SVGQSKAKSV CAFLQELNDS VNARFIEENP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCAGTTCACC GGAGGCAAAA ATCATCTCTC GCTCTCAGCT GCGAAGATGC AACCAATCAA 60
AAGATCCAGA AAACATGTTG AAGAAGAGCC AACAATGGCT GAACCTAAAA TCAAGTACGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR030667--APP-BP1
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd

Pfam

PF00899--ThiF

Gene Ontology

GO:0019781--F:NEDD8 activating enzyme activity
GO:0045116--P:protein neddylation

KEGG

aly:ARALYDRAFT_470511

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000764	Aegilops tauschii	64.52	0.00e+00	728.00
IUUC-Atr-002644	Amborella trichopoda	70.61	0.00e+00	762.00
IUUC-Ath-006692	Arabidopsis thaliana	95.56	0.00e+00	1072.00
IUUC-Ani-009443	Aspergillus nidulans	31.19	1.00e-65	243.00
IUUC-Bgr-012111	Blumeria graminis	32.65	7.00e-60	224.00
IUUC-Bci-013892	Botrytis cinerea	30.86	5.00e-59	221.00
IUUC-Bdi-014592	Brachypodium distachyon	65.33	0.00e+00	735.00
IUUC-Bol-016399	Brassica oleracea	90.65	0.00e+00	989.00
IUUC-Bra-018084	Brassica rapa	84.92	0.00e+00	909.00
IUUC-Cpo-022248	Cavia porcellus	34.92	8.00e-67	247.00
IUUC-Cgl-026428	Colletotrichum gloeosporioides	30.50	6.00e-58	217.00
IUUC-Dse-031536	Dothistroma septosporum	31.16	2.00e-68	253.00
IUUC-Dme-031683	Drosophila melanogaster	36.98	3.00e-101	361.00
IUUC-Fox-038037	Fusarium oxysporum	31.16	1.00e-65	243.00
IUUC-Fso-038387	Fusarium solani	32.12	6.00e-66	244.00
IUUC-Gmo-038562	Gadus morhua	40.04	4.00e-121	427.00
IUUC-Gac-042558	Gasterosteus aculeatus	40.64	1.00e-122	432.00
IUUC-Gma-043610	Glycine max	77.67	0.00e+00	851.00
IUUC-Hvu-047790	Hordeum vulgare	63.59	5.00e-152	530.00
IUUC-Lpe-051535	Leersia perrieri	64.24	0.00e+00	661.00
IUUC-Lma-053112	Leptosphaeria maculans	33.81	3.00e-78	285.00
IUUC-Mor-057230	Magnaporthe oryzae	31.10	1.00e-64	239.00
IUUC-Mpo-057514	Magnaporthe poae	32.48	7.00e-63	234.00
IUUC-Mtr-058551	Medicago truncatula	73.52	0.00e+00	805.00
IUUC-Mla-059183	Melampsora laricipopulina	34.93	3.00e-86	312.00
IUUC-Mac-064521	Musa acuminata	68.46	0.00e+00	768.00
IUUC-Ncr-068910	Neurospora crassa	31.20	5.00e-65	241.00
IUUC-Oan-073389	Ornithorhynchus anatinus	37.30	5.00e-89	320.00
IUUC-Oba-075437	Oryza barthii	67.82	0.00e+00	720.00
IUUC-Obr-076684	Oryza brachyantha	66.73	0.00e+00	672.00
IUUC-Ogl-077170	Oryza glaberrima	67.82	0.00e+00	720.00
IUUC-Ogu-078844	Oryza glumaepatula	66.20	0.00e+00	665.00
IUUC-Oin-079105	Oryza indica	67.62	0.00e+00	716.00
IUUC-Olo-080943	Oryza longistaminata	61.76	0.00e+00	645.00
IUUC-Oni-082891	Oryza nivara	64.37	0.00e+00	692.00
IUUC-Opu-083457	Oryza punctata	67.62	0.00e+00	717.00
IUUC-Oru-084960	Oryza rufipogon	61.72	0.00e+00	647.00
IUUC-Osa-085358	Oryza sativa	67.43	0.00e+00	712.00
IUUC-Ola-086420	Oryzias latipes	39.26	2.00e-78	285.00
IUUC-Pno-095084	Phaeosphaeria nodorum	31.57	7.00e-65	242.00
IUUC-Ppa-095798	Physcomitrella patens	55.53	8.00e-180	622.00
IUUC-Pop-099722	Populus trichocarpa	77.67	0.00e+00	875.00
IUUC-Ppe-101280	Prunus persica	78.05	0.00e+00	872.00
IUUC-Pva-102333	Pteropus vampyrus	37.85	5.00e-115	407.00
IUUC-Pgr-103401	Puccinia graminis	30.16	2.00e-74	273.00
IUUC-Ptt-103889	Puccinia triticina	28.42	2.00e-62	232.00
IUUC-Pte-104355	Pyrenophora teres	33.09	8.00e-75	273.00
IUUC-Pyt-104545	Pyrenophora triticirepentis	33.57	7.00e-75	274.00
IUUC-Sja-107926	Schizosaccharomyces japonicus	32.17	7.00e-76	277.00
IUUC-Ssl-108387	Sclerotinia sclerotiorum	33.21	7.00e-62	231.00
IUUC-Sit-110157	Setaria italica	67.56	0.00e+00	776.00
IUUC-Sly-111105	Solanum lycopersicum	73.42	0.00e+00	840.00
IUUC-Stu-112469	Solanum tuberosum	74.72	0.00e+00	855.00
IUUC-Sbi-113813	Sorghum bicolor	67.05	0.00e+00	763.00
IUUC-Sre-115058	Sporisorium reilianum	33.69	2.00e-64	239.00
IUUC-Tni-120231	Tetraodon nigroviridis	37.57	1.00e-107	383.00
IUUC-Tca-121491	Theobroma cacao	79.77	0.00e+00	854.00
IUUC-Tre-122103	Trichoderma reesei	32.77	2.00e-67	249.00
IUUC-Tvi-122672	Trichoderma virens	31.89	3.00e-65	242.00
IUUC-Tae-125316	Triticum aestivum	65.33	0.00e+00	734.00
IUUC-Tur-126487	Triticum urartu	63.90	0.00e+00	707.00
IUUC-Uma-129645	Ustilago maydis	30.20	3.00e-70	259.00
IUUC-Vda-129989	Verticillium dahliae	27.81	2.00e-48	186.00
IUUC-Vvi-131059	Vitis vinifera	79.58	0.00e+00	875.00
IUUC-Yli-134505	Yarrowia lipolytica	33.89	4.00e-88	317.00
IUUC-Zma-135895	Zea mays	66.09	0.00e+00	748.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence