iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Bta-136414

Ensembl Protein ID

ENSBTAP00000016444.4

UniProt Accession

Q2KI23; MINY2_BOVIN

Genbank Protein ID

BC112797

Protein Name

Ubiquitin carboxyl-terminal hydrolase MINDY-2;Deubiquitinating enzyme MINDY-2;Protein FAM63B

Genbank Nucleotide ID

AAI12798.1

Gene Name

MINDY2;FAM63B

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000012391.4	ENSBTAT00000016444.4	ENSBTAP00000016444.4

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/MINDY	5.20e-66	220.5	274	396

Active Site

Position(s)	Description	Evidence
267	Nucleophile	{ECO:0000250\|UniProtKB:Q8N5J2}
449	Proton acceptor	{ECO:0000250\|UniProtKB:Q8N5J2}

Domain Profile

DUB/MINDY

   S: 1    nilllswkvklvpkkevitleelievlgdilldvkdkekseiselnyeqnvddalsllpklaeGldvnvrftGvrsfeytkecsvfdll 89
           n+lll+wkvkl+p++e+it+e+l+e+lgd++ld k+ke+sei++lnyeqn++da+++l+kl++Gldvnv+ftGvr+feyt+ec+vfdll
   Q: 274  NVLLLAWKVKLPPMMEIITAEQLMEYLGDYMLDTKPKEISEIQRLNYEQNMSDAMAVLHKLQTGLDVNVKFTGVRVFEYTPECIVFDLL 362
           9**************************************************************************************** PP
   S: 90   didlyhGWlvdsqideavkavgklsyeqlveril 123
           di+lyhGWlvd+qid++vkavg++sy+qlve+i+
   Q: 363  DIPLYHGWLVDPQIDDIVKAVGNCSYNQLVEKII 396
           *********************************8 PP

Organism

Bos taurus

Functional Description
(View)

Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins. Can also bind to polyubiquitin chains of different linkage types, including 'Lys-6', 'Lys-11', 'Lys-29', 'Lys-33' and 'Lys-63'. May play a regulatory role at the level of protein turnover.

Protein Sequence
(Fasta)

MESGPESLQP LEHGVAAGPA PGTGSPQEGQ QETRLAAGDG PGVWAAESSG GKGQGAAAGG 60
RSLSDSASPA GSPQVLVPCS SLPRLDLKES DLESPAAQKE PVRGQHKVTA SPETAEAGAD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGTGCCGCTG TCATGGCGTC TGAGGCGCTG TCTGAGGAGA TCCCGCCGTG GTCTCTTTAG 60
AGCGAGGGGC GGGCGGCTGG GTATGGAGAG CGGCCCCGAG AGCCTGCAAC CGCTAGAACA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR007518--MINDY
IPR033979--MINDY_domain

Pfam

PF04424--MINDY_DUB

Gene Ontology

GO:0005654--C:nucleoplasm
GO:0016807--F:cysteine-type carboxypeptidase activity
GO:0071795--F:K11-linked polyubiquitin binding
GO:0036435--F:K48-linked polyubiquitin binding
GO:0071796--F:K6-linked polyubiquitin binding
GO:0070530--F:K63-linked polyubiquitin binding
GO:1990380--F:Lys48-specific deubiquitinase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity

KEGG

bta:524749

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-136382	Ailuropoda melanoleuca	91.70	0.00e+00	652.00
IUUC-Apl-136387	Anas platyrhynchos	96.42	3.00e-152	530.00
IUUC-Aca-136392	Anolis carolinensis	92.68	8.00e-172	596.00
IUUC-Ang-136404	Aspergillus niger	30.75	7.00e-27	116.00
IUUC-Ate-136406	Aspergillus terreus	29.08	9.00e-22	99.00
IUUC-Cja-136427	Callithrix jacchus	97.88	0.00e+00	636.00
IUUC-Cfa-136430	Canis familiaris	99.09	0.00e+00	640.00
IUUC-Cpo-136434	Cavia porcellus	84.22	3.00e-179	621.00
IUUC-Csa-136441	Chlorocebus sabaeus	91.20	0.00e+00	901.00
IUUC-Cho-136445	Choloepus hoffmanni	77.40	2.00e-74	272.00
IUUC-Cin-136446	Ciona intestinalis	35.63	9.00e-05	38.50
IUUC-Csv-136449	Ciona savignyi	56.08	7.00e-79	286.00
IUUC-Cgl-136450	Colletotrichum gloeosporioides	27.59	1.00e-22	102.00
IUUC-Dre-136454	Danio rerio	82.22	9.00e-177	613.00
IUUC-Dno-136459	Dasypus novemcinctus	87.79	0.00e+00	730.00
IUUC-Dor-136463	Dipodomys ordii	74.55	2.00e-105	376.00
IUUC-Ete-136469	Echinops telfairi	90.58	3.00e-159	555.00
IUUC-Eca-136473	Equus caballus	92.86	0.00e+00	639.00
IUUC-Fca-136479	Felis catus	94.33	0.00e+00	651.00
IUUC-Fal-136483	Ficedula albicollis	96.75	1.00e-151	529.00
IUUC-Gmo-136489	Gadus morhua	80.25	4.00e-176	610.00
IUUC-Ggr-136490	Gaeumannomyces graminis	26.23	2.00e-23	104.00
IUUC-Gga-136493	Gallus gallus	86.82	0.00e+00	630.00
IUUC-Gac-136497	Gasterosteus aculeatus	78.23	1.00e-176	612.00
IUUC-Ggo-136505	Gorilla gorilla	87.31	0.00e+00	788.00
IUUC-Hsa-136507	Homo sapiens	91.38	0.00e+00	887.00
IUUC-Lch-136517	Latimeria chalumnae	85.48	2.00e-177	615.00
IUUC-Lpe-136520	Leersia perrieri	33.86	3.00e-30	127.00
IUUC-Loc-136524	Lepisosteus oculatus	83.59	0.00e+00	639.00
IUUC-Lma-136525	Leptosphaeria maculans	33.45	3.00e-30	126.00
IUUC-Laf-136528	Loxodonta africana	97.76	6.00e-171	593.00
IUUC-Mcc-136532	Macaca mulatta	87.59	4.00e-179	620.00
IUUC-Mpo-136538	Magnaporthe poae	27.11	1.00e-21	98.60
IUUC-Mga-136545	Meleagris gallopavo	95.74	7.00e-177	612.00
IUUC-Mmr-136549	Microcebus murinus	91.02	0.00e+00	805.00
IUUC-Mdo-136553	Monodelphis domestica	86.58	0.00e+00	670.00
IUUC-Mmu-136558	Mus musculus	77.78	0.00e+00	666.00
IUUC-Mpu-136563	Mustela putorius furo	85.51	4.00e-156	545.00
IUUC-Mlu-136568	Myotis lucifugus	81.82	0.00e+00	673.00
IUUC-Nle-136575	Nomascus leucogenys	91.38	0.00e+00	857.00
IUUC-Oan-136584	Ornithorhynchus anatinus	91.56	2.00e-108	384.00
IUUC-Ocu-136588	Oryctolagus cuniculus	86.77	0.00e+00	773.00
IUUC-Ola-136611	Oryzias latipes	80.25	3.00e-171	594.00
IUUC-Olu-136613	Ostreococcus lucimarinus	46.39	4.00e-19	89.40
IUUC-Oga-136616	Otolemur garnettii	88.87	0.00e+00	718.00
IUUC-Oar-136622	Ovis aries	92.32	0.00e+00	821.00
IUUC-Ptr-136626	Pan troglodytes	91.56	0.00e+00	879.00
IUUC-Pan-136629	Papio anubis	91.02	0.00e+00	894.00
IUUC-Psi-136633	Pelodiscus sinensis	87.31	0.00e+00	630.00
IUUC-Pma-136636	Petromyzon marinus	56.90	4.00e-136	478.00
IUUC-Pno-136637	Phaeosphaeria nodorum	31.96	3.00e-28	120.00
IUUC-Pfo-136644	Poecilia formosa	82.03	3.00e-177	614.00
IUUC-Pab-136647	Pongo abelii	91.56	0.00e+00	874.00
IUUC-Pca-136655	Procavia capensis	96.76	4.00e-155	540.00
IUUC-Pva-136659	Pteropus vampyrus	83.66	0.00e+00	680.00
IUUC-Pte-136663	Pyrenophora teres	30.60	3.00e-27	117.00
IUUC-Pyt-136664	Pyrenophora triticirepentis	30.28	8.00e-27	115.00
IUUC-Rno-136667	Rattus norvegicus	72.94	0.00e+00	670.00
IUUC-Sce-136670	Saccharomyces cerevisiae	33.46	5.00e-28	118.00
IUUC-Sha-136674	Sarcophilus harrisii	95.42	2.00e-144	504.00
IUUC-Tgu-136696	Taeniopygia guttata	82.40	0.00e+00	644.00
IUUC-Tru-136700	Takifugu rubripes	77.58	5.00e-174	603.00
IUUC-Tsy-136704	Tarsius syrichta	90.48	0.00e+00	774.00
IUUC-Tni-136709	Tetraodon nigroviridis	82.05	5.00e-171	593.00
IUUC-Tre-136712	Trichoderma reesei	31.12	6.00e-25	108.00
IUUC-Tbe-136721	Tupaia belangeri	89.97	1.00e-156	545.00
IUUC-Ttr-136724	Tursiops truncatus	93.19	0.00e+00	851.00
IUUC-Vpa-136731	Vicugna pacos	93.78	0.00e+00	644.00
IUUC-Xtr-136736	Xenopus tropicalis	80.41	2.00e-172	598.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence