iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Dre-027860

Ensembl Protein ID

ENSDARP00000128402.1

UniProt Accession

E7FF93; E7FF93_DANRE

Genbank Protein ID

ENSDARP00000128402

Protein Name

Fizzy/cell division cycle 20-related 1b

Genbank Nucleotide ID

CU467854

Gene Name

fzr1b

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000022810.8	ENSDART00000153916.1	ENSDARP00000128402.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	4.90e-27	93.7	303	338
E3 adaptor/Cullin RING/APC_C/CDC20	1.10e-143	479.0	168	470

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgv 34
           gH  +v++l++ +d  +l+sG++D+++ vW+ ++  
   Q: 303  GHRQEVCGLKWsPDhQHLASGGNDNKLLVWNSSSLL 338
           8***********999***************976655 PP

E3 adaptor/Cullin RING/APC_C/CDC20

   S: 1    pekvldapelrddfylnLldWssknvlavaLgssvylwsaktgdvskladl.eekdlvtsvswieegtllavGtkkgeveiyDveekkk 88
           p+kvldapel+ddfylnL+dWs+ n l+v+Lg++vylwsa+t++v++l+dl  ++d+vtsv w e+g+l+avGt+kg v+i+D++  +k
   Q: 168  PFKVLDAPELQDDFYLNLVDWSAGNLLSVGLGACVYLWSACTSQVTRLCDLsVDGDSVTSVCWNERGSLVAVGTHKGFVQIWDAAGGRK 256
           689************************************************999*********************************** PP
   S: 89   vrtltghsarvgaLsWnaevlssGsrdgeilhrdvrvkelklstlqahaqevCGlkwnedaklLasGGnDnsvsvwdasssePlkkfke 177
           + +l+ghsarvgaL+Wn e+lssGsrd+ il+rdvr++    ++lq+h+qevCGlkw+ d+++LasGGnDn++ vw++ss  P++++++
   Q: 257  LTSLEGHSARVGALAWNGEQLSSGSRDRVILQRDVRTPPPVERRLQGHRQEVCGLKWSPDHQHLASGGNDNKLLVWNSSSLLPVQQYSD 345
           ***************************************************************************************** PP
   S: 178  hkaavkaiawsPwqkslLasGGGtaDrcikfwntltgalleeidtgsqvcsllwskkskelvsthGfaenkitlwkypslskvaelkgh 266
           h aavkaiawsP+q++lLasGGGtaDrc++fwntltg+ l++ dtgsqvc+l+wsk+++elvsthG+++n+i +wkypsl++va+l+gh
   Q: 346  HLAAVKAIAWSPHQHGLLASGGGTADRCLRFWNTLTGQALQSTDTGSQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGH 434
           ***************************************************************************************** PP
   S: 267  eaRvlslalspdgeaivtaagDetlrfwklfdkkka 302
           ++Rvl+la+spdgeaivt+agDetlrfw++f+k++ 
   Q: 435  SYRVLYLAVSPDGEAIVTGAGDETLRFWNVFSKTRC 470
           ********************************9875 PP

Organism

Danio rerio

Protein Sequence
(Fasta)

MDQDYERRLL RQINHQNVPE GHPTKQSNYA ACSPVSVKSG DRFIPTRAGS NWSINFHYAN 60
ENCWSPNQNQ RAKDASTDTG KDAVAYAALL RNELLGAGIE TVPDPHTDDR RHTILTQDTH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACTGCGCCTC TTCTGGTAGA GTGCGGAATT ACACTCCCTC ACAGCTGATT TGCTCGCCAT 60
CTTGACATGA ACATAAACAT TGATGCCCCC TGCTCAATGA TCGCCCTATT ATCCATAAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR024977--Apc4_WD40_dom
IPR033010--Cdc20/Fizzy
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12894--ANAPC4_WD40
PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0097027--F:ubiquitin-protein transferase activator activity
GO:1904668--P:positive regulation of ubiquitin protein ligase activity

KEGG

dre:100148604

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ame-011773	Astyanax mexicanus	96.10	0.00e+00	956.00
IUUC-Fox-037814	Fusarium oxysporum	64.49	2.00e-123	435.00
IUUC-Gmo-039431	Gadus morhua	86.45	0.00e+00	868.00
IUUC-Gac-041566	Gasterosteus aculeatus	91.17	0.00e+00	884.00
IUUC-Loc-052240	Lepisosteus oculatus	86.65	0.00e+00	870.00
IUUC-Ont-071725	Oreochromis niloticus	93.02	0.00e+00	940.00
IUUC-Ola-086983	Oryzias latipes	92.07	0.00e+00	929.00
IUUC-Pfo-096991	Poecilia formosa	91.58	0.00e+00	883.00
IUUC-Tru-118528	Takifugu rubripes	90.67	0.00e+00	880.00
IUUC-Tni-120312	Tetraodon nigroviridis	90.98	0.00e+00	875.00
IUUC-Tae-123028	Triticum aestivum	52.76	2.00e-125	442.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence