iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Tru-118723

UUCD1 version

UUC-TaR-00682

Ensembl Protein ID

ENSTRUP00000032205.1

UniProt Accession

H2U5I9; H2U5I9_TAKRU

Protein Name

Uncharacterized protein

Gene Name

LOC101076414

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTRUG00000012728.1	ENSTRUT00000032329.1	ENSTRUP00000032205.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.90e-82	278.6	4473	4807
E3 adaptor/Cullin RING/DCX/DWD	4.20e-09	37.6	3390	3425

Active Site

Position(s)	Description	Evidence
4776	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 6    kkrle.vefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknp.....ehlklFeflGrllgkalqdgr 86
            +r++ v++vgE + d+gGv+ ++++++++elq+  + l+ +++n+ + +  n d++l np     +h+  F+flG+l+++a+++++
   Q: 4473 PSRAWkVKLVGEGADDAGGVFDDTITEMCQELQSGAVDLLIHTPNGFADVGSNTDRFLLNPaafseDHMIQFRFLGILMAVAIRTRK 4559
           556666********************************************************************************* PP
   S: 87   lldlplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeee..LkpgGenipVtneNke 171
           +ldl+l++ ++k+l++ +l   d+eevd  +y++l+ i+++++s i+e ++++++  ++  + +++ +    +pgG+ni  t +N+ 
   Q: 4560 PLDLHLAPWVWKQLCSIPLGGADIEEVDLLTYRTLQGILHLENSGITEDNFHVMIPLDSFMVHSADGRLvpVVPGGQNIALTFANRT 4646
           ********************************************************99999888887766689************** PP
   S: 172  eYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefss 258
           +Yv++ ++yrl+e +++qv+a+reG++++ip  llsl+t+++le+l+cG +e++ve+lkk  +y++ +te+++ i wFw+ l+ef++
   Q: 4647 DYVERGLDYRLHE-MDSQVAAVREGMSTIIPVPLLSLLTPQQLEQLVCGLPEVSVEMLKKLVRYRD-VTESHQLIVWFWQSLQEFTN 4731
           *************.**************************************************88.******************** PP
   S: 259  eerkafLqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           eer  fL+Fv+g+srlP  + a++  ++f+i k d+  + lP+++TCf++L+LP+Y+s+ il e+L+y i+++ ++++
   Q: 4732 EERVLFLRFVSGRSRLP-SNPADIT-QKFQIIKvDRPINGLPTAQTCFFLLRLPPYTSQAILSERLRYSIHNCPSIDM 4807
           *****************.6899999.556666637777**********************************988776 PP

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgv 34
           gH ++v+++ + sd  ll+++s D+++++W++++++
   Q: 3390 GHYNKVSSCFWnSDqSLLATCSQDKVVQIWSITQNT 3425
           78889999978*9999***************99876 PP

Organism

Takifugu rubripes

Protein Sequence
(Fasta)

MVPCQTHVLL KWQEHFNSSW AVEDTTETAR RRWAAALYDR LLQNKEVVTL AQPIQELVGP 60
RLPDFECESS ASAEKEDYLA SLLNSQRWLA HRMLTQTSFT LSLHHRLVVF QRIYYAIHSK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGTTCCCT GTCAGACCCA TGTGTTACTG AAGTGGCAGG AGCACTTCAA TAGTTCCTGG 60
GCGGTGGAAG ACACCACAGA GACAGCCAGG AGGCGTTGGG CCGCTGCACT GTATGACAGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat

Interpro

IPR001870--B30.2/SPRY
IPR013320--ConA-like_dom
IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens
IPR003877--SPRY_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

PROSITE

PS50188--B302_SPRY
PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00632--HECT
PF00415--RCC1
PF00622--SPRY
PF00400--WD40

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc
SM00449--SPRY
SM00320--WD40

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ame-011268	Astyanax mexicanus	71.20	0.00e+00	2630.00
IUUC-Gac-042444	Gasterosteus aculeatus	78.14	0.00e+00	7188.00
IUUC-Loc-052805	Lepisosteus oculatus	63.76	0.00e+00	5563.00
IUUC-Ola-086308	Oryzias latipes	73.70	0.00e+00	6522.00
IUUC-Pfo-096464	Poecilia formosa	75.82	0.00e+00	6847.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence