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Tag Content
UUCD2 ID IUUC-Mcc-055849
UUCD1 version UUC-MaM-01143
Ensembl Protein ID ENSMMUP00000016018.3
UniProt Accession F6VMX6; F6VMX6_MACMU
Genbank Protein ID ENSMMUP00000016018
Protein Name Uncharacterized protein
Genbank Nucleotide ID JSUE03026196
Gene Name CYLD
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMMUG00000012209.3 ENSMMUT00000078247.1 ENSMMUP00000057215.1
ENSMMUG00000012209.3 ENSMMUT00000017104.3 ENSMMUP00000016018.3
ENSMMUG00000012209.3 ENSMMUT00000075665.1 ENSMMUP00000058688.1
ENSMMUG00000012209.3 ENSMMUT00000017099.3 ENSMMUP00000016013.3
Status Unreviewed
Classification
Family E-Value Score Start End
DUB/USP 1.10e-24 88.3 593 949
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   DUB/USP
   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw.kskkkavsprellkalkkeaeefsgyeq 89
           G++ + N+CY++S+L cL++++++ + +l + kek + e ++e+++ l +++ + ++     + +k ++ r++l+++++++    ++e+
   Q: 593  GIQGHYNSCYLDSTLFCLFAFSSVLDTVLLRPKEKNDVEYYSETQELLRTEIVNPLRIYGyVCATKIMKLRKILEKVEAASGF--TSEE 679
           999***************************99999999999999999999****999887899**************988875..899* PP
   S: 90   qDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksq.ik...clecdnvs.sreepfldls 173
           +D +Efl++l++++ +       k ++  ++ +++   ++  ek++k +  +i++l+++++ ++ +k    ++c  ++  r+ + ++l 
   Q: 680  KDPEEFLNILFHHILRVE--PLLKIRSAGQKVQDCYFYQIFMEKNEKVGVPTIQQLLEWSFINSnLKfaeAPSCLIIQmPRFGKDFKLF 766
           ****************99..88999999999999**************************9854144444799****99********** PP
   S: 174  lpvpgkeetkkeslqdcLesftkeeelegenk.yycekckkkqeaekklklkklPe....vLilhLkRfsfseeqksrekinkkvefpl 257
            ++  + e    +++d+Le+  ++++++g  + y+c++c+++ + +   k+k++++      +lh kR   +       +  + v++p+
   Q: 767  KKIFPSLEL---NITDLLEDTPRQCRICGGLAmYECRECYDDPDISAG-KIKQFCKtcntQVHLHPKRL--N-------HKYNPVSLPK 842
           ****99998...***************987655********9984433.55555553334688999999..2.......3356788886 PP
   S: 258  eL...dlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgk..WllfdD.............skVtevke.eevleetg 327
            L   d ++ c+        ++k eL+av++ +      HYva+vk  k++  Wl fd               +Vt+++e  e l+++ 
   Q: 843  DLpdwDWRHGCIP-------CQKMELFAVLCIET----SHYVAFVKYGKDDsaWLFFDSmadrdggqngfniPQVTPCPEvGEYLKMSL 920
           6511144444555.......9**********999....9********777788*****9999*******99999999976678888776 PP
   S: 328  ...................staYvlfYkr 337
                              ++aY+++Y++
   Q: 921  edlhsldsrriqgcarrllCDAYMCMYQS 949
           899999999999999************85 PP
   
Organism Macaca mulatta
Protein Sequence
(Fasta)
MSSGLWSQEK VTSPYWEERI FYLLLQECSV TDKQTQKLLK VPKGSIGQYI QDRSVGHSRI 60
PSAKGKKNQI GLKILEQPHA VLFVDEKDVA EINEKFTELL LAITNCEERF SLFKNRNRLS 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mcc-055849|DUB,USP|Macaca mulatta
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CGGAGGAGAG AGGACTTGGG GCGGGAGTCG CGCGGGACAC TGTCCCCCTC CTCGCCCCCC 60
ACCCCATTTA CAGATGGGGA GACTGAGGCA CAGGCCGCTG GCGGGCCCCG ACGGCCACCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mcc-055849|DUB,USP|Macaca mulatta
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
Interpro

IPR000938--CAP-Gly_domain
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
PROSITE

PS00845--CAP_GLY_1
PS50245--CAP_GLY_2
PS00972--USP_1
PS50235--USP_3
Pfam

PF01302--CAP_GLY
PF00443--UCH
SMART

SM01052--CAP_GLY
Gene Ontology

GO:0005813--C:centrosome
GO:0036064--C:ciliary basal body
GO:0097542--C:ciliary tip
GO:0005881--C:cytoplasmic microtubule
GO:0005829--C:cytosol
GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0030496--C:midbody
GO:0005819--C:spindle
GO:1990380--F:Lys48-specific deubiquitinase activity
GO:0061578--F:Lys63-specific deubiquitinase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0043369--P:CD4-positive or CD8-positive, alpha-beta T cell lineage commitment
GO:0048872--P:homeostasis of number of cells
GO:0045087--P:innate immune response
GO:0070266--P:necroptotic process
GO:0090090--P:negative regulation of canonical Wnt signaling pathway
GO:0042347--P:negative regulation of NF-kappaB import into nucleus
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0045581--P:negative regulation of T cell differentiation
GO:1903829--P:positive regulation of cellular protein localization
GO:2001238--P:positive regulation of extrinsic apoptotic signaling pathway
GO:0045582--P:positive regulation of T cell differentiation
GO:0050862--P:positive regulation of T cell receptor signaling pathway
GO:1990108--P:protein linear deubiquitination
GO:0045577--P:regulation of B cell differentiation
GO:1902017--P:regulation of cilium assembly
GO:2001242--P:regulation of intrinsic apoptotic signaling pathway
GO:0070507--P:regulation of microtubule cytoskeleton organization
GO:0007346--P:regulation of mitotic cell cycle
GO:0043393--P:regulation of protein binding
GO:0010803--P:regulation of tumor necrosis factor-mediated signaling pathway
GO:1901026--P:ripoptosome assembly involved in necroptotic process
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG mcc:695652
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001298 Ailuropoda melanoleuca 96.86 0.00e+00 1921.00
IUUC-Apl-003356 Anas platyrhynchos 87.67 0.00e+00 1697.00
IUUC-Aca-004402 Anolis carolinensis 81.10 0.00e+00 1523.00
IUUC-Ame-011581 Astyanax mexicanus 68.22 0.00e+00 1225.00
IUUC-Bta-012359 Bos taurus 96.65 0.00e+00 1901.00
IUUC-Cel-018528 Caenorhabditis elegans 34.97 7.00e-56 213.00
IUUC-Cja-018797 Callithrix jacchus 98.74 0.00e+00 1960.00
IUUC-Cfa-020264 Canis familiaris 96.76 0.00e+00 1910.00
IUUC-Cpo-022057 Cavia porcellus 96.23 0.00e+00 1910.00
IUUC-Csa-023093 Chlorocebus sabaeus 99.48 0.00e+00 1961.00
IUUC-Cho-024486 Choloepus hoffmanni 82.85 5.00e-180 625.00
IUUC-Cin-025179 Ciona intestinalis 43.69 5.00e-116 411.00
IUUC-Dre-028233 Danio rerio 67.25 0.00e+00 1258.00
IUUC-Dno-029496 Dasypus novemcinctus 95.92 0.00e+00 1897.00
IUUC-Dor-030919 Dipodomys ordii 90.59 0.00e+00 1768.00
IUUC-Dme-032159 Drosophila melanogaster 45.68 8.00e-125 441.00
IUUC-Ete-032734 Echinops telfairi 90.06 0.00e+00 1772.00
IUUC-Eca-033350 Equus caballus 96.86 0.00e+00 1916.00
IUUC-Eeu-034566 Erinaceus europaeus 98.92 4.00e-115 409.00
IUUC-Fca-035632 Felis catus 95.44 0.00e+00 1326.00
IUUC-Fal-037313 Ficedula albicollis 82.65 0.00e+00 1580.00
IUUC-Gmo-039239 Gadus morhua 67.36 0.00e+00 1209.00
IUUC-Gga-040668 Gallus gallus 87.77 0.00e+00 1696.00
IUUC-Gac-042630 Gasterosteus aculeatus 67.63 0.00e+00 1199.00
IUUC-Ggo-044462 Gorilla gorilla 99.37 0.00e+00 1967.00
IUUC-Hsa-045846 Homo sapiens 99.48 0.00e+00 1968.00
IUUC-Itr-048894 Ictidomys tridecemlineatus 93.55 0.00e+00 835.00
IUUC-Lch-050303 Latimeria chalumnae 70.85 0.00e+00 1315.00
IUUC-Loc-052190 Lepisosteus oculatus 69.81 0.00e+00 1280.00
IUUC-Laf-054480 Loxodonta africana 92.73 0.00e+00 762.00
IUUC-Meu-056755 Macropus eugenii 82.77 0.00e+00 881.00
IUUC-Mga-059561 Meleagris gallopavo 87.29 0.00e+00 1684.00
IUUC-Mmr-060942 Microcebus murinus 97.59 0.00e+00 1915.00
IUUC-Mdo-062618 Monodelphis domestica 92.89 0.00e+00 1857.00
IUUC-Mmu-063843 Mus musculus 94.67 0.00e+00 1823.00
IUUC-Mpu-066919 Mustela putorius furo 96.65 0.00e+00 1910.00
IUUC-Mlu-066983 Myotis lucifugus 90.27 0.00e+00 1765.00
IUUC-Nle-069893 Nomascus leucogenys 99.48 0.00e+00 1968.00
IUUC-Opr-071181 Ochotona princeps 87.60 0.00e+00 1597.00
IUUC-Ont-071697 Oreochromis niloticus 68.78 0.00e+00 1189.00
IUUC-Oan-073658 Ornithorhynchus anatinus 90.38 0.00e+00 1784.00
IUUC-Ocu-074954 Oryctolagus cuniculus 96.76 0.00e+00 1914.00
IUUC-Ola-086523 Oryzias latipes 66.22 0.00e+00 1182.00
IUUC-Oga-089003 Otolemur garnettii 97.49 0.00e+00 1928.00
IUUC-Oar-090376 Ovis aries 96.67 0.00e+00 1914.00
IUUC-Ptr-090520 Pan troglodytes 97.59 0.00e+00 1917.00
IUUC-Pan-092281 Papio anubis 99.48 0.00e+00 1961.00
IUUC-Psi-093047 Pelodiscus sinensis 89.08 0.00e+00 1623.00
IUUC-Pma-094575 Petromyzon marinus 55.50 7.00e-67 246.00
IUUC-Pfo-096358 Poecilia formosa 66.33 0.00e+00 1136.00
IUUC-Pab-097740 Pongo abelii 98.85 0.00e+00 1957.00
IUUC-Pca-100461 Procavia capensis 86.26 0.00e+00 1535.00
IUUC-Pva-102134 Pteropus vampyrus 85.88 0.00e+00 1679.00
IUUC-Rno-105807 Rattus norvegicus 92.68 0.00e+00 1778.00
IUUC-Sha-107236 Sarcophilus harrisii 93.18 0.00e+00 1789.00
IUUC-Sar-113366 Sorex araneus 98.67 0.00e+00 940.00
IUUC-Tgu-117201 Taeniopygia guttata 84.67 0.00e+00 1622.00
IUUC-Tru-117953 Takifugu rubripes 67.95 0.00e+00 1187.00
IUUC-Tsy-119610 Tarsius syrichta 95.19 0.00e+00 1878.00
IUUC-Tni-120743 Tetraodon nigroviridis 40.60 7.00e-166 577.00
IUUC-Tbe-128155 Tupaia belangeri 78.21 0.00e+00 752.00
IUUC-Ttr-128942 Tursiops truncatus 91.74 0.00e+00 1798.00
IUUC-Vpa-130281 Vicugna pacos 86.19 0.00e+00 1660.00
IUUC-Xtr-132627 Xenopus tropicalis 76.32 0.00e+00 1402.00
Created Date 25-Jun-2017

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