iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Aca-004978

Ensembl Protein ID

ENSACAP00000008312.2

UniProt Accession

H9GDX7; H9GDX7_ANOCA

Protein Name

Tyrosine-protein kinase

Gene Name

BTK

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSACAG00000008298.3	ENSACAT00000008491.3	ENSACAP00000008312.2
ENSACAG00000008298.3	ENSACAT00000029905.1	ENSACAP00000022488.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.30e-14	53.8	218	273

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           kv +lydy++ n+ +L+l+kG+  lv+  ee +e W++++ + +gk+G +P+n+v++++
   Q: 218  KVVALYDYTPMNEQDLQLQKGEEYLVL--EESNESWWRAQ-DQAGKQGYIPSNYVTEAR 273
           899***********************9..9999******7.**************9986 PP

Organism

Anolis carolinensis

Protein Sequence
(Fasta)

MSNVLLESIF LKRSQQKKKT SPLNFKKRFF LLTESKLSYY EYDFERGRRG SKKGSVDVEK 60
VTCVETVTPE SNPPPERRIP EKKGDDLNEP EQISIIERFP YPFQVVYDEG PLYVFSPTEE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGCCGAAGAG CCAGCGTTGT CCATAGACAC CTCCAAGGTC ATGTGGCCAT AGGCATGACT 60
GCATGGAGCT CTGTTACCTT CCCGTTGGAG CAGTATCTAT TGATCTACTC ACATTTGCAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom
IPR001562--Znf_Btk_motif

PROSITE

PS50003--PH_DOMAIN
PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3
PS51113--ZF_BTK

Pfam

PF00779--BTK
PF00169--PH
PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00107--BTK
SM00233--PH
SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0031410--C:cytoplasmic vesicle
GO:0005829--C:cytosol
GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0045121--C:membrane raft
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0005547--F:phosphatidylinositol-3,4,5-trisphosphate binding
GO:0005102--F:receptor binding
GO:0002344--P:B cell affinity maturation
GO:0030154--P:cell differentiation
GO:0048469--P:cell maturation
GO:0098761--P:cellular response to interleukin-7
GO:0007249--P:I-kappaB kinase/NF-kappaB signaling
GO:0045087--P:innate immune response
GO:0030889--P:negative regulation of B cell proliferation
GO:0001818--P:negative regulation of cytokine production
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0042127--P:regulation of cell proliferation
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001365	Ailuropoda melanoleuca	77.95	0.00e+00	1047.00
IUUC-Apl-003907	Anas platyrhynchos	78.32	0.00e+00	1038.00
IUUC-Ame-010694	Astyanax mexicanus	55.28	5.00e-145	507.00
IUUC-Bta-012467	Bos taurus	77.95	0.00e+00	1046.00
IUUC-Cja-018841	Callithrix jacchus	77.19	0.00e+00	1035.00
IUUC-Cfa-020983	Canis familiaris	78.10	0.00e+00	1026.00
IUUC-Cpo-021307	Cavia porcellus	77.79	0.00e+00	1046.00
IUUC-Csa-023508	Chlorocebus sabaeus	75.35	0.00e+00	756.00
IUUC-Dre-028544	Danio rerio	55.58	2.00e-138	484.00
IUUC-Dno-029828	Dasypus novemcinctus	76.55	0.00e+00	1021.00
IUUC-Dor-030102	Dipodomys ordii	69.59	0.00e+00	838.00
IUUC-Ete-032981	Echinops telfairi	70.69	0.00e+00	926.00
IUUC-Eca-033594	Equus caballus	77.79	0.00e+00	1046.00
IUUC-Eeu-035281	Erinaceus europaeus	75.69	0.00e+00	837.00
IUUC-Fca-035495	Felis catus	77.95	0.00e+00	1024.00
IUUC-Fal-036719	Ficedula albicollis	78.76	0.00e+00	1082.00
IUUC-Gga-041193	Gallus gallus	78.33	0.00e+00	1051.00
IUUC-Gac-042383	Gasterosteus aculeatus	46.76	1.00e-121	429.00
IUUC-Hsa-045931	Homo sapiens	77.49	0.00e+00	1023.00
IUUC-Itr-048061	Ictidomys tridecemlineatus	77.79	0.00e+00	1046.00
IUUC-Lch-049868	Latimeria chalumnae	72.29	0.00e+00	921.00
IUUC-Loc-052730	Lepisosteus oculatus	56.04	9.00e-153	533.00
IUUC-Laf-053516	Loxodonta africana	77.41	0.00e+00	1059.00
IUUC-Mcc-054795	Macaca mulatta	77.49	0.00e+00	1024.00
IUUC-Meu-056157	Macropus eugenii	68.58	0.00e+00	889.00
IUUC-Mga-059529	Meleagris gallopavo	77.09	0.00e+00	887.00
IUUC-Mmr-060824	Microcebus murinus	74.06	0.00e+00	952.00
IUUC-Mdo-063036	Monodelphis domestica	78.00	0.00e+00	1031.00
IUUC-Mmu-064047	Mus musculus	77.79	0.00e+00	1045.00
IUUC-Mpu-066810	Mustela putorius furo	78.40	0.00e+00	1049.00
IUUC-Mlu-067671	Myotis lucifugus	77.59	0.00e+00	1039.00
IUUC-Nle-069108	Nomascus leucogenys	77.49	0.00e+00	1025.00
IUUC-Opr-070505	Ochotona princeps	62.05	6.00e-156	543.00
IUUC-Ont-072585	Oreochromis niloticus	57.60	3.00e-154	538.00
IUUC-Oan-073495	Ornithorhynchus anatinus	77.12	0.00e+00	1060.00
IUUC-Ocu-074416	Oryctolagus cuniculus	77.34	0.00e+00	1040.00
IUUC-Ola-086938	Oryzias latipes	56.19	2.00e-145	508.00
IUUC-Oga-088995	Otolemur garnettii	77.26	0.00e+00	1026.00
IUUC-Oar-089632	Ovis aries	76.89	0.00e+00	1029.00
IUUC-Ptr-090941	Pan troglodytes	77.49	0.00e+00	1024.00
IUUC-Pan-091900	Papio anubis	74.92	0.00e+00	981.00
IUUC-Psi-093048	Pelodiscus sinensis	79.00	0.00e+00	1034.00
IUUC-Pfo-096955	Poecilia formosa	57.11	4.00e-155	540.00
IUUC-Pab-097587	Pongo abelii	77.64	0.00e+00	1025.00
IUUC-Pca-100374	Procavia capensis	67.55	2.00e-114	406.00
IUUC-Pva-102583	Pteropus vampyrus	77.64	0.00e+00	1019.00
IUUC-Rno-104868	Rattus norvegicus	73.80	0.00e+00	977.00
IUUC-Sha-106744	Sarcophilus harrisii	77.19	0.00e+00	1057.00
IUUC-Sar-113041	Sorex araneus	77.74	0.00e+00	911.00
IUUC-Ssc-115294	Sus scrofa	77.79	0.00e+00	1046.00
IUUC-Tgu-116458	Taeniopygia guttata	50.61	0.00e+00	669.00
IUUC-Tsy-118945	Tarsius syrichta	79.05	0.00e+00	710.00
IUUC-Tae-122934	Triticum aestivum	25.42	5.00e-20	92.40
IUUC-Ttr-128769	Tursiops truncatus	70.95	0.00e+00	933.00
IUUC-Vpa-130517	Vicugna pacos	74.24	3.00e-167	581.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence