iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mpu-066786

Ensembl Protein ID

ENSMPUP00000005349.1

UniProt Accession

M3Y1Z8; M3Y1Z8_MUSPF

Genbank Protein ID

ENSMPUP00000005349

Protein Name

Tyrosine-protein kinase

Genbank Nucleotide ID

AEYP01062472

Gene Name

TEC

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMPUG00000005388.1	ENSMPUT00000005438.1	ENSMPUP00000005349.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.20e-10	41.2	180	235

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 2    skekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFve 60
           s+e v ++yd++a++  +L l++G    ++  e++d  W+k+ ++  g++G +P+n+v+
   Q: 180  SEEIVVAMYDFQATEAHDLRLERGQEYIIL--EKNDVHWWKA-RDKYGCEGYIPSNYVT 235
           57899********************99999..99********.5*************96 PP

Organism

Mustela putorius furo

Protein Sequence
(Fasta)

MNFNTILEEI LIKRSQQKKK TSPLNYKERL FVLTKSMLTY YEGRPEKKYR KGFIDVAKIK 60
CVEIVKNDEG VVPCQNKYPF QVVHDANTLY IFAPSAQSRD RWVKKLKEEI KNNNNIMIKY 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AATACTGGGA TCTTCAATGG CAGGAGACAG AGTGATCAGA AGACCGAGAT GAATTTTAAC 60
ACTATTCTAG AAGAGATTCT TATTAAAAGA TCACAACAGA AAAAGAAGAC ATCACCCTTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom
IPR001562--Znf_Btk_motif

PROSITE

PS50003--PH_DOMAIN
PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3
PS51113--ZF_BTK

Pfam

PF00779--BTK
PF00169--PH
PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00402--TECBTKDOMAIN
PR00109--TYRKINASE

SMART

SM00107--BTK
SM00233--PH
SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0005856--C:cytoskeleton
GO:0005886--C:plasma membrane
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0050853--P:B cell receptor signaling pathway
GO:0007229--P:integrin-mediated signaling pathway
GO:0035556--P:intracellular signal transduction
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0050731--P:positive regulation of peptidyl-tyrosine phosphorylation
GO:0010543--P:regulation of platelet activation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-003669	Anas platyrhynchos	77.31	0.00e+00	1019.00
IUUC-Ame-010694	Astyanax mexicanus	61.83	7.00e-164	570.00
IUUC-Dre-028544	Danio rerio	68.56	5.00e-167	580.00
IUUC-Fal-036771	Ficedula albicollis	80.48	0.00e+00	1051.00
IUUC-Gac-042383	Gasterosteus aculeatus	56.03	3.00e-139	488.00
IUUC-Lch-050516	Latimeria chalumnae	75.08	0.00e+00	964.00
IUUC-Loc-052730	Lepisosteus oculatus	66.22	0.00e+00	634.00
IUUC-Mga-060196	Meleagris gallopavo	77.65	0.00e+00	1009.00
IUUC-Mdo-062054	Monodelphis domestica	89.86	0.00e+00	1165.00
IUUC-Ont-072585	Oreochromis niloticus	68.17	4.00e-180	624.00
IUUC-Ola-086938	Oryzias latipes	66.89	9.00e-175	606.00
IUUC-Psi-093565	Pelodiscus sinensis	84.29	0.00e+00	1096.00
IUUC-Pfo-096955	Poecilia formosa	66.21	9.00e-180	623.00
IUUC-Tgu-116458	Taeniopygia guttata	82.06	0.00e+00	1075.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence