• HOME
  • BROWSE
  • SEARCH
  • LINK
  • DOWNLOAD
  • USER GUIDE
  • Protein
  • Gene
  • Annotation
  • Details
  • Classification
  • Domain Profile
  • Function
  • Protein Sequence
  • Nucleotide Sequence
  • Keyword
  • GO
  • Orthology
  • TOP

Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046971
UUCD1 version UUC-HoS-00449
Ensembl Protein ID ENSP00000423995.1
UniProt Accession Q9UM13; D3DNZ7; Q2V500; Q9UG51; Q9Y5R0; APC10_HUMAN
Genbank Protein ID AAD30527.1; BAA86953.1; CAB45705.1; ABB96248.1; EAX05050.1; EAX05051.1; AAH05217.1
Protein Name Anaphase-promoting complex subunit 10; Cyclosome subunit 10
Genbank Nucleotide ID AF132794; AB012109; AL080090; DQ304649; CH471056; CH471056; BC005217
Gene Name ANAPC10; APC10
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000164162.12 ENST00000507656.5 ENSP00000423995.1
ENSG00000164162.12 ENST00000512680.5 ENSP00000425459.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBaseCircNet
miRTarBasemicroRNATRANSFACmiRWalk
TargetScanRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexMentha
Protein 3D Structure
PDBMMDB
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDUniProtPHOSIDABioGRID
mUbiSiDa
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/APC_C/APC_C APC_C 21107322; 16763193
Reviewed
Classification
Family Identity E-value Score Source Orthology
E3 adaptor/Cullin RING/APC_C/APC_C 36.23 2.00e-23 103.00 IUUC-Sce-106448
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
 Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
Protein Sequence
(Fasta)
MTTPNKTPPG ADPKQLERTG TVREIGSQAV WSLSSCKPGF GVDQLRDDNL ETYWQSDGSQ 60
PHLVNIQFRR KTTVKTLCIY ADYKSDESYT PSKISVRVGN NFHNLQEIRQ LELVEPSGWI 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046971|E3,APC_C|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ACGCGCTGCT GCTGTCTCCG CCACCTAAGG CCTAACCAAA GGCTCTCGGA GAACGTCCCT 60
ACATTCTTTC CAACCTGGCA GATGGCAGCT AACGGCCAAA CCTCTCCGGG CTATTCACGT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046971|E3,APC_C|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0498--Mitosis
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
Interpro

IPR016901--APC10
IPR004939--APC_su10/DOC_dom
IPR008979--Galactose-bd-like
PROSITE

PS51284--DOC
Pfam

PF03256--ANAPC10
SMART

SM01337--APC10
Gene Ontology

GO:0005680--C:anaphase-promoting complex
GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0031145--P:anaphase-promoting complex-dependent catabolic process
GO:0051301--P:cell division
GO:0007067--P:mitotic nuclear division
GO:0051436--P:negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051437--P:positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0070979--P:protein K11-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0030071--P:regulation of mitotic metaphase/anaphase transition
GO:0051439--P:regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
KEGG hsa:10393
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000560 Aegilops tauschii 55.24 2.00e-28 118.00
IUUC-Aml-001522 Ailuropoda melanoleuca 100.00 2.00e-110 390.00
IUUC-Atr-002797 Amborella trichopoda 57.83 1.00e-53 202.00
IUUC-Apl-004185 Anas platyrhynchos 98.38 5.00e-109 386.00
IUUC-Aca-004900 Anolis carolinensis 97.30 5.00e-107 379.00
IUUC-Aly-005760 Arabidopsis lyrata 55.42 2.00e-49 188.00
IUUC-Ath-007516 Arabidopsis thaliana 55.42 3.00e-49 187.00
IUUC-Ago-007889 Ashbya gossypii 33.15 1.00e-24 107.00
IUUC-Acl-008130 Aspergillus clavatus 41.75 2.00e-20 93.60
IUUC-Afl-008640 Aspergillus flavus 42.72 6.00e-20 92.00
IUUC-Afu-009101 Aspergillus fumigatus 41.75 5.00e-20 92.40
IUUC-Ani-009484 Aspergillus nidulans 42.72 3.00e-20 93.20
IUUC-Ang-009847 Aspergillus niger 40.78 6.00e-19 89.00
IUUC-Aor-010077 Aspergillus oryzae 42.72 6.00e-20 92.00
IUUC-Ate-010544 Aspergillus terreus 41.75 4.00e-20 92.80
IUUC-Ame-011330 Astyanax mexicanus 91.16 2.00e-80 291.00
IUUC-Bgr-011978 Blumeria graminis 42.24 9.00e-37 146.00
IUUC-Bta-013351 Bos taurus 100.00 2.00e-110 390.00
IUUC-Bci-013611 Botrytis cinerea 44.87 2.00e-36 146.00
IUUC-Bdi-014443 Brachypodium distachyon 53.76 3.00e-50 191.00
IUUC-Bol-015534 Brassica oleracea 56.29 5.00e-54 203.00
IUUC-Bra-017298 Brassica rapa 56.89 3.00e-54 204.00
IUUC-Cel-018170 Caenorhabditis elegans 48.55 4.00e-40 157.00
IUUC-Cja-019877 Callithrix jacchus 100.00 2.00e-110 390.00
IUUC-Cfa-020698 Canis familiaris 100.00 2.00e-110 390.00
IUUC-Cpo-022007 Cavia porcellus 99.46 1.00e-109 388.00
IUUC-Cre-023013 Chlamydomonas reinhardtii 51.52 2.00e-48 184.00
IUUC-Csa-023980 Chlorocebus sabaeus 100.00 2.00e-110 390.00
IUUC-Cho-024703 Choloepus hoffmanni 100.00 1.00e-84 304.00
IUUC-Cin-025346 Ciona intestinalis 52.46 3.00e-57 214.00
IUUC-Csv-026225 Ciona savignyi 53.41 6.00e-53 199.00
IUUC-Cgl-026544 Colletotrichum gloeosporioides 42.66 4.00e-32 131.00
IUUC-Cne-027042 Cryptococcus neoformans 40.82 5.00e-34 137.00
IUUC-Cme-027223 Cyanidioschyzon merolae 49.09 2.00e-28 120.00
IUUC-Dre-027804 Danio rerio 90.81 2.00e-101 360.00
IUUC-Dno-029995 Dasypus novemcinctus 100.00 2.00e-110 390.00
IUUC-Dor-030429 Dipodomys ordii 99.46 2.00e-109 387.00
IUUC-Dse-031499 Dothistroma septosporum 37.50 4.00e-32 131.00
IUUC-Dme-031675 Drosophila melanogaster 57.69 2.00e-62 231.00
IUUC-Ete-032499 Echinops telfairi 99.37 7.00e-94 335.00
IUUC-Eca-034281 Equus caballus 100.00 2.00e-110 390.00
IUUC-Eeu-034913 Erinaceus europaeus 99.19 2.00e-71 260.00
IUUC-Fca-036364 Felis catus 100.00 2.00e-110 390.00
IUUC-Fal-037041 Ficedula albicollis 98.38 5.00e-109 386.00
IUUC-Fox-037777 Fusarium oxysporum 39.61 1.00e-32 134.00
IUUC-Fso-038311 Fusarium solani 41.18 6.00e-33 135.00
IUUC-Gmo-039318 Gadus morhua 87.93 2.00e-59 219.00
IUUC-Ggr-039935 Gaeumannomyces graminis 41.10 2.00e-29 123.00
IUUC-Gga-041006 Gallus gallus 97.84 6.00e-109 385.00
IUUC-Gac-042367 Gasterosteus aculeatus 89.78 2.00e-100 357.00
IUUC-Gma-043650 Glycine max 56.71 2.00e-53 201.00
IUUC-Ggo-045044 Gorilla gorilla 100.00 2.00e-110 390.00
IUUC-Hvu-047485 Hordeum vulgare 57.69 5.00e-11 58.90
IUUC-Itr-048324 Ictidomys tridecemlineatus 100.00 9.00e-63 231.00
IUUC-Kpa-049293 Komagataella pastoris 42.28 3.00e-31 128.00
IUUC-Lch-049462 Latimeria chalumnae 91.84 7.00e-81 292.00
IUUC-Lpe-050846 Leersia perrieri 55.42 5.00e-48 184.00
IUUC-Loc-052857 Lepisosteus oculatus 91.89 2.00e-102 364.00
IUUC-Lma-052974 Leptosphaeria maculans 43.43 7.00e-18 85.10
IUUC-Laf-053536 Loxodonta africana 100.00 2.00e-110 390.00
IUUC-Mcc-054806 Macaca mulatta 100.00 2.00e-110 390.00
IUUC-Meu-056282 Macropus eugenii 96.05 8.00e-41 159.00
IUUC-Mor-057080 Magnaporthe oryzae 41.96 1.00e-29 124.00
IUUC-Mpo-057503 Magnaporthe poae 40.49 6.00e-29 121.00
IUUC-Mtr-057837 Medicago truncatula 56.29 3.00e-53 201.00
IUUC-Mla-059010 Melampsora laricipopulina 49.28 2.00e-32 131.00
IUUC-Mga-059728 Meleagris gallopavo 98.38 5.00e-109 386.00
IUUC-Mvi-060224 Microbotryum violaceum 40.83 3.00e-39 154.00
IUUC-Mdo-062602 Monodelphis domestica 98.38 4.00e-109 386.00
IUUC-Mmu-063528 Mus musculus 99.46 6.00e-110 389.00
IUUC-Mac-065629 Musa acuminata 60.40 1.00e-49 189.00
IUUC-Mpu-066046 Mustela putorius furo 100.00 2.00e-110 390.00
IUUC-Mlu-068107 Myotis lucifugus 100.00 2.00e-110 390.00
IUUC-Nfi-068426 Neosartorya fischeri 41.75 7.00e-20 92.00
IUUC-Ncr-068810 Neurospora crassa 41.96 6.00e-30 125.00
IUUC-Nle-069550 Nomascus leucogenys 100.00 2.00e-110 390.00
IUUC-Opr-071205 Ochotona princeps 100.00 3.00e-92 330.00
IUUC-Ont-071625 Oreochromis niloticus 90.81 2.00e-101 361.00
IUUC-Oan-073396 Ornithorhynchus anatinus 97.84 1.00e-108 385.00
IUUC-Ocu-074136 Oryctolagus cuniculus 99.46 4.00e-110 389.00
IUUC-Oba-075504 Oryza barthii 55.42 4.00e-48 184.00
IUUC-Obr-076300 Oryza brachyantha 56.02 4.00e-50 190.00
IUUC-Ogl-077163 Oryza glaberrima 55.42 4.00e-48 184.00
IUUC-Ogu-078459 Oryza glumaepatula 55.42 4.00e-48 184.00
IUUC-Oin-079095 Oryza indica 48.94 4.00e-44 171.00
IUUC-Olo-080226 Oryza longistaminata 48.65 4.00e-43 171.00
IUUC-Ome-081690 Oryza meridionalis 55.42 4.00e-48 184.00
IUUC-Oni-082984 Oryza nivara 55.42 4.00e-48 184.00
IUUC-Opu-083753 Oryza punctata 56.02 1.00e-52 199.00
IUUC-Oru-084459 Oryza rufipogon 55.42 4.00e-48 184.00
IUUC-Osa-085969 Oryza sativa 55.42 4.00e-48 184.00
IUUC-Ola-087291 Oryzias latipes 89.25 1.00e-99 355.00
IUUC-Olu-087704 Ostreococcus lucimarinus 51.92 2.00e-44 172.00
IUUC-Oga-088086 Otolemur garnettii 100.00 2.00e-110 390.00
IUUC-Oar-089191 Ovis aries 100.00 2.00e-110 390.00
IUUC-Ptr-091583 Pan troglodytes 100.00 2.00e-110 390.00
IUUC-Pan-092440 Papio anubis 100.00 2.00e-110 390.00
IUUC-Psi-093158 Pelodiscus sinensis 98.38 4.00e-109 386.00
IUUC-Pma-094382 Petromyzon marinus 69.74 3.00e-31 125.00
IUUC-Pno-094776 Phaeosphaeria nodorum 42.86 6.00e-21 95.10
IUUC-Ppa-095243 Physcomitrella patens 54.20 9.00e-39 153.00
IUUC-Pfo-096853 Poecilia formosa 89.78 2.00e-100 357.00
IUUC-Pab-098464 Pongo abelii 87.03 2.00e-91 327.00
IUUC-Pop-099055 Populus trichocarpa 56.47 9.00e-52 196.00
IUUC-Pca-100402 Procavia capensis 99.32 3.00e-85 306.00
IUUC-Ppe-101826 Prunus persica 54.22 1.00e-48 185.00
IUUC-Pva-102272 Pteropus vampyrus 100.00 2.00e-110 390.00
IUUC-Pgr-103519 Puccinia graminis 40.51 1.00e-34 139.00
IUUC-Ptt-103904 Puccinia triticina 32.76 2.00e-14 72.00
IUUC-Pte-104017 Pyrenophora teres 44.44 7.00e-22 98.60
IUUC-Pyt-104453 Pyrenophora triticirepentis 43.43 2.00e-21 96.30
IUUC-Rno-105561 Rattus norvegicus 99.46 6.00e-110 389.00
IUUC-Sce-106448 Saccharomyces cerevisiae 36.23 1.00e-23 103.00
IUUC-Sha-106901 Sarcophilus harrisii 98.38 4.00e-109 386.00
IUUC-Sja-107924 Schizosaccharomyces japonicus 43.56 4.00e-39 153.00
IUUC-Spo-108082 Schizosaccharomyces pombe 44.90 4.00e-37 147.00
IUUC-Ssl-108422 Sclerotinia sclerotiorum 46.15 2.00e-36 146.00
IUUC-Smo-109182 Selaginella moellendorffii 60.34 4.00e-57 213.00
IUUC-Sit-110292 Setaria italica 58.39 1.00e-48 186.00
IUUC-Sly-111772 Solanum lycopersicum 53.45 4.00e-46 177.00
IUUC-Stu-112789 Solanum tuberosum 54.02 3.00e-46 177.00
IUUC-Sar-113731 Sorex araneus 69.73 4.00e-68 250.00
IUUC-Sbi-114468 Sorghum bicolor 53.76 7.00e-53 199.00
IUUC-Sre-115201 Sporisorium reilianum 39.88 4.00e-33 135.00
IUUC-Ssc-115318 Sus scrofa 100.00 2.00e-110 390.00
IUUC-Tgu-116782 Taeniopygia guttata 97.84 6.00e-109 385.00
IUUC-Tru-117918 Takifugu rubripes 90.32 1.00e-100 358.00
IUUC-Tni-120731 Tetraodon nigroviridis 90.32 1.00e-100 358.00
IUUC-Tca-121546 Theobroma cacao 55.42 3.00e-49 187.00
IUUC-Tre-122092 Trichoderma reesei 42.96 4.00e-32 130.00
IUUC-Tvi-122416 Trichoderma virens 42.66 4.00e-32 132.00
IUUC-Tae-123195 Triticum aestivum 55.49 1.00e-51 195.00
IUUC-Tur-126519 Triticum urartu 54.34 8.00e-50 189.00
IUUC-Tme-127131 Tuber melanosporum 47.55 9.00e-41 159.00
IUUC-Tbe-128098 Tupaia belangeri 100.00 9.00e-63 231.00
IUUC-Ttr-128765 Tursiops truncatus 88.65 4.00e-95 340.00
IUUC-Uma-129533 Ustilago maydis 37.79 1.00e-31 130.00
IUUC-Vda-129741 Verticillium dahliae 41.96 9.00e-33 134.00
IUUC-Vpa-130667 Vicugna pacos 100.00 2.00e-110 391.00
IUUC-Vvi-131400 Vitis vinifera 55.42 7.00e-54 203.00
IUUC-Xtr-132526 Xenopus tropicalis 94.59 3.00e-105 373.00
IUUC-Xma-133326 Xiphophorus maculatus 89.78 3.00e-100 357.00
IUUC-Yli-134645 Yarrowia lipolytica 42.95 1.00e-34 139.00
IUUC-Zma-134968 Zea mays 54.34 4.00e-50 190.00
Created Date 25-Jun-2017

https://dev.news.makassarkota.go.id/public/pgsoft-demo/ https://jdih.sumbawabaratkab.go.id/lato/pg-soft-demo/ https://dev.news.makassarkota.go.id/public/slot-gacor/ http://pbb.tanahbumbukab.go.id/-/slot-gacor/ slot gacor https://siakad.unipra.ac.id/sass/slot-gacor-x500/ http://kpm.dinus.ac.id/assets/images/berita/slot/
Copyright © 2004-2017.The CUCKOO Workgroup. All Rights Reserved