iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
RAID2
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	1.60e-06	28.8	617	688
UBD/ZnF/UBZ	1.50e-09	38.2	228	253

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 1    aDvilvvg.geeffahkivLaasSsvFyalf....lmeleesksklmveikdvqpevfrallkFlYtgklde 67
           +Dv+++++ ge+  ahk vL a+++ +         +  e+++ + +v ++dv+ e+  a+l++lYt   d 
   Q: 617  SDVQFQLDsGEVLYAHKFVLYARCPLLIQCVntegFSAVEDGDLTQRVLLSDVSSEAAHAFLNYLYTADTDV 688
           69****************************964333446788999**********************99886 PP

UBD/ZnF/UBZ

   S: 2    lvCPvCqkm...vdqtdfeeHlDeCl 24
           ++C++Cqk    +++t++e+H+++Cl
   Q: 228  FFCQICQKNlsaMNVTRREQHVNRCL 253
           89***********************8 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MDESDDDFKE LCASFFQRVK KNATKEASGE RTRRKASGHT QERGKRKEAS QAVARSKALQ 60
GPSEKKPRLG SQTSRTKKQR APKSQEGDPA LPVNGKGGVL APTPDQPVLC ERPQSTQTEN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TATGTCGTTT AGCAGATATT GGTGGAGCAT CTACCGGAGA GGACAGTCTT ATGACTGGAT 60
TGTCAGGAGA GATGTGGGGA CTCGTAGAAA TGTACACATC TAGCACCGTA CAATTCAGGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR000210--BTB/POZ_dom
IPR011333--SKP1/BTB/POZ
IPR018574--Structure-sp_endonuc_su_Slx4

PROSITE

PS50097--BTB

Pfam

PF00651--BTB
PF09494--Slx4

SMART

SM00225--BTB

Gene Ontology

GO:0030054--C:cell junction
GO:0005829--C:cytosol
GO:0070522--C:ERCC4-ERCC1 complex
GO:0048476--C:Holliday junction resolvase complex
GO:0000790--C:nuclear chromatin
GO:0000784--C:nuclear chromosome, telomeric region
GO:0005654--C:nucleoplasm
GO:0033557--C:Slx1-Slx4 complex
GO:0048257--F:3'-flap endonuclease activity
GO:0017108--F:5'-flap endonuclease activity
GO:0008821--F:crossover junction endodeoxyribonuclease activity
GO:0008047--F:enzyme activator activity
GO:0010792--P:DNA double-strand break processing involved in repair via single-strand annealing
GO:0006260--P:DNA replication
GO:0000724--P:double-strand break repair via homologous recombination
GO:0036297--P:interstrand cross-link repair
GO:0000706--P:meiotic DNA double-strand break processing
GO:1904357--P:negative regulation of telomere maintenance via telomere lengthening
GO:0006289--P:nucleotide-excision repair
GO:1904431--P:positive regulation of t-circle formation
GO:0000712--P:resolution of meiotic recombination intermediates
GO:0072429--P:response to intra-S DNA damage checkpoint signaling
GO:0090656--P:t-circle formation
GO:0061820--P:telomeric D-loop disassembly

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001225	Ailuropoda melanoleuca	62.58	0.00e+00	843.00
IUUC-Apl-003261	Anas platyrhynchos	46.88	4.00e-155	543.00
IUUC-Aca-004455	Anolis carolinensis	57.97	2.00e-18	83.20
IUUC-Ame-010993	Astyanax mexicanus	28.09	4.00e-13	67.80
IUUC-Bta-013472	Bos taurus	51.09	0.00e+00	880.00
IUUC-Cja-019406	Callithrix jacchus	57.84	0.00e+00	1380.00
IUUC-Cfa-020129	Canis familiaris	54.43	0.00e+00	1272.00
IUUC-Cpo-021944	Cavia porcellus	55.96	0.00e+00	1316.00
IUUC-Csa-023941	Chlorocebus sabaeus	53.78	2.00e-160	559.00
IUUC-Cho-024847	Choloepus hoffmanni	59.52	2.00e-139	491.00
IUUC-Cin-025405	Ciona intestinalis	36.54	7.00e-06	45.10
IUUC-Csv-025916	Ciona savignyi	33.90	1.00e-07	50.10
IUUC-Dre-027764	Danio rerio	32.10	2.00e-74	275.00
IUUC-Dno-030083	Dasypus novemcinctus	55.57	0.00e+00	768.00
IUUC-Dor-031129	Dipodomys ordii	55.36	0.00e+00	710.00
IUUC-Ete-032536	Echinops telfairi	41.83	6.00e-92	333.00
IUUC-Eca-033407	Equus caballus	56.98	0.00e+00	1171.00
IUUC-Eeu-034473	Erinaceus europaeus	51.94	2.00e-28	122.00
IUUC-Fca-035730	Felis catus	53.21	0.00e+00	1225.00
IUUC-Fal-036850	Ficedula albicollis	44.03	9.00e-139	488.00
IUUC-Gmo-038677	Gadus morhua	46.01	2.00e-33	137.00
IUUC-Gga-041088	Gallus gallus	42.89	6.00e-137	482.00
IUUC-Gac-041824	Gasterosteus aculeatus	42.05	2.00e-14	72.00
IUUC-Ggo-045642	Gorilla gorilla	55.44	0.00e+00	1292.00
IUUC-Hsa-047035	Homo sapiens	57.02	0.00e+00	1398.00
IUUC-Itr-049010	Ictidomys tridecemlineatus	62.15	0.00e+00	1556.00
IUUC-Lch-050364	Latimeria chalumnae	37.65	3.00e-78	287.00
IUUC-Loc-052423	Lepisosteus oculatus	41.14	5.00e-42	167.00
IUUC-Laf-053910	Loxodonta africana	52.74	0.00e+00	1202.00
IUUC-Mcc-055883	Macaca mulatta	57.75	0.00e+00	1399.00
IUUC-Meu-056224	Macropus eugenii	50.78	1.00e-88	321.00
IUUC-Mga-059880	Meleagris gallopavo	46.46	8.00e-145	508.00
IUUC-Mvi-060510	Microbotryum violaceum	31.34	2.00e-04	41.60
IUUC-Mmr-061715	Microcebus murinus	61.21	0.00e+00	1595.00
IUUC-Mdo-062426	Monodelphis domestica	39.23	0.00e+00	660.00
IUUC-Mmu-063947	Mus musculus	77.85	0.00e+00	2204.00
IUUC-Mpu-066184	Mustela putorius furo	60.65	0.00e+00	896.00
IUUC-Mlu-067533	Myotis lucifugus	56.65	0.00e+00	1261.00
IUUC-Nle-069204	Nomascus leucogenys	57.63	0.00e+00	1404.00
IUUC-Opr-070377	Ochotona princeps	60.19	0.00e+00	824.00
IUUC-Ont-072551	Oreochromis niloticus	31.57	3.00e-69	257.00
IUUC-Oan-073350	Ornithorhynchus anatinus	47.88	5.00e-101	361.00
IUUC-Ocu-074915	Oryctolagus cuniculus	53.01	0.00e+00	951.00
IUUC-Ola-087360	Oryzias latipes	37.64	3.00e-30	125.00
IUUC-Oga-089106	Otolemur garnettii	53.45	0.00e+00	1123.00
IUUC-Oar-089289	Ovis aries	53.38	0.00e+00	830.00
IUUC-Ptr-091469	Pan troglodytes	57.63	0.00e+00	1409.00
IUUC-Pan-091841	Papio anubis	56.01	0.00e+00	1052.00
IUUC-Psi-093842	Pelodiscus sinensis	47.05	5.00e-131	463.00
IUUC-Pma-094732	Petromyzon marinus	53.52	3.00e-08	51.60
IUUC-Pfo-097299	Poecilia formosa	44.10	2.00e-30	128.00
IUUC-Pab-098271	Pongo abelii	57.55	0.00e+00	1400.00
IUUC-Pca-100721	Procavia capensis	48.00	0.00e+00	777.00
IUUC-Pva-102276	Pteropus vampyrus	58.58	0.00e+00	1421.00
IUUC-Sha-106722	Sarcophilus harrisii	42.48	0.00e+00	983.00
IUUC-Sar-113673	Sorex araneus	44.82	8.00e-75	276.00
IUUC-Ssc-115383	Sus scrofa	61.94	0.00e+00	699.00
IUUC-Tgu-117243	Taeniopygia guttata	50.00	2.00e-93	335.00
IUUC-Tru-118092	Takifugu rubripes	41.11	9.00e-32	130.00
IUUC-Tsy-119362	Tarsius syrichta	62.43	2.00e-154	541.00
IUUC-Tni-120380	Tetraodon nigroviridis	76.79	8.00e-20	90.50
IUUC-Tbe-127404	Tupaia belangeri	44.41	9.00e-169	588.00
IUUC-Ttr-128317	Tursiops truncatus	56.24	0.00e+00	1264.00
IUUC-Uma-129640	Ustilago maydis	33.33	3.00e-05	42.40
IUUC-Xtr-132533	Xenopus tropicalis	38.43	2.00e-88	321.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence