iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Sce-106327

Ensembl Protein ID

YFR021W

UniProt Accession

P43601; D6VTQ1; ATG18_YEAST

Genbank Protein ID

BAA09260.1; DAA12461.1

Protein Name

Autophagy-related protein 18; Cytoplasm to vacuole targeting protein 18; Needed for premeiotic replication protein 1; Swollen vacuole phenotype protein 1

Genbank Nucleotide ID

D50617; BK006940

Gene Name

ATG18; AUT10; CVT18; NMR1; SVP1; YFR021W

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
YFR021W	YFR021W	YFR021W

Annotation

mRNA Expression
GEO	FFGED
DNA & RNA Element
TRANSFAC
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Post-translational Modifications (PTMs)
dbPAF	dbPTM	UniProt	BioGRID
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	3.10e-06	25.9	244	281

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdDgt.ikvWDlrtgvll 36
           H++++ ++a   d tl++++sd gt i+v+D+ tg+++
   Q: 244  HKGEIAAMAIsFDgTLMATASDKGTiIRVFDIETGDKI 281
           88888887777466*******************99876 PP

Organism

Saccharomyces cerevisiae

Functional Description
(View)

The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). May negatively regulate FAB1 activity by sequestering or masking VAC7 from FAB1. Necessary for proper vacuole morphology. Plays an important role in osmotically-induced vacuole fragmentation. Required for cytoplasm to vacuole transport (Cvt) vesicle formation, pexophagy and starvation-induced autophagy. Involved in correct ATG9 trafficking to the pre-autophagosomal structure. Might also be involved in premeiotic DNA replication. With ATG2, protects ATG8 from ATG4-mediated cleavage.

Protein Sequence
(Fasta)

MSDSSPTINF INFNQTGTCI SLGTSKGFKI FNCEPFGKFY SEDSGGYAIV EMLFSTSLLA 60
LVGIGDQPAL SPRRLRIINT KKHSIICEVT FPTSILSVKM NKSRLVVLLQ EQIYIYDINT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTCTGATT CATCACCTAC TATCAACTTT ATTAATTTCA ATCAAACCGG AACGTGTATT 60
TCCCTTGGAA CGTCGAAAGG TTTCAAAATA TTCAATTGTG AGCCCTTCGG AAAATTTTAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0072--Autophagy
KW-0181--Complete proteome
KW-0967--Endosome
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0926--Vacuole
KW-0853--WD repeat

Interpro

IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

PROSITE

PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0005829--C:cytosol
GO:0005768--C:endosome
GO:0010008--C:endosome membrane
GO:0000329--C:fungal-type vacuole membrane
GO:0070772--C:PAS complex
GO:0000407--C:pre-autophagosomal structure
GO:0034045--C:pre-autophagosomal structure membrane
GO:0005774--C:vacuolar membrane
GO:0080025--F:phosphatidylinositol-3,5-bisphosphate binding
GO:0043130--F:ubiquitin binding
GO:0032258--P:CVT pathway
GO:0045324--P:late endosome to vacuole transport
GO:0044805--P:late nucleophagy
GO:0016236--P:macroautophagy
GO:0030242--P:pexophagy
GO:0034727--P:piecemeal microautophagy of nucleus
GO:0006624--P:vacuolar protein processing

KEGG

sce:YFR021W

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000966	Aegilops tauschii	32.35	7.00e-31	125.00
IUUC-Aml-001504	Ailuropoda melanoleuca	29.58	8.00e-29	119.00
IUUC-Atr-002710	Amborella trichopoda	30.94	3.00e-33	134.00
IUUC-Apl-003741	Anas platyrhynchos	29.80	4.00e-31	126.00
IUUC-Aca-004629	Anolis carolinensis	30.23	2.00e-31	127.00
IUUC-Aly-006440	Arabidopsis lyrata	30.56	4.00e-28	117.00
IUUC-Ath-006629	Arabidopsis thaliana	29.93	1.00e-27	115.00
IUUC-Ago-007948	Ashbya gossypii	57.71	5.00e-173	598.00
IUUC-Acl-008148	Aspergillus clavatus	36.82	5.00e-76	275.00
IUUC-Afl-008562	Aspergillus flavus	36.51	2.00e-74	270.00
IUUC-Afu-008936	Aspergillus fumigatus	37.00	7.00e-75	272.00
IUUC-Ani-009254	Aspergillus nidulans	37.90	8.00e-80	288.00
IUUC-Ang-009798	Aspergillus niger	38.18	2.00e-77	280.00
IUUC-Aor-010066	Aspergillus oryzae	36.51	2.00e-74	270.00
IUUC-Ate-010266	Aspergillus terreus	38.82	3.00e-82	296.00
IUUC-Ame-011233	Astyanax mexicanus	29.26	2.00e-33	134.00
IUUC-Bta-012842	Bos taurus	28.30	1.00e-31	127.00
IUUC-Bci-013627	Botrytis cinerea	33.74	1.00e-69	254.00
IUUC-Bdi-014739	Brachypodium distachyon	31.02	3.00e-30	124.00
IUUC-Bol-015944	Brassica oleracea	30.91	2.00e-26	111.00
IUUC-Bra-017319	Brassica rapa	29.52	5.00e-27	113.00
IUUC-Cel-018503	Caenorhabditis elegans	27.15	7.00e-21	92.80
IUUC-Cja-018855	Callithrix jacchus	29.59	6.00e-29	119.00
IUUC-Cfa-020539	Canis familiaris	29.59	2.00e-28	117.00
IUUC-Cpo-021981	Cavia porcellus	29.58	3.00e-29	120.00
IUUC-Cre-022613	Chlamydomonas reinhardtii	30.03	6.00e-37	146.00
IUUC-Csa-023140	Chlorocebus sabaeus	29.58	3.00e-29	120.00
IUUC-Cho-024328	Choloepus hoffmanni	27.57	3.00e-24	103.00
IUUC-Cin-025343	Ciona intestinalis	36.05	6.00e-26	109.00
IUUC-Csv-025920	Ciona savignyi	26.35	3.00e-40	157.00
IUUC-Cgl-026425	Colletotrichum gloeosporioides	37.19	8.00e-28	115.00
IUUC-Cne-026947	Cryptococcus neoformans	56.25	8.00e-46	175.00
IUUC-Dre-027490	Danio rerio	40.24	2.00e-29	121.00
IUUC-Dno-029987	Dasypus novemcinctus	29.26	5.00e-32	129.00
IUUC-Dor-030393	Dipodomys ordii	27.54	6.00e-27	113.00
IUUC-Dse-031215	Dothistroma septosporum	28.54	4.00e-56	210.00
IUUC-Dme-031881	Drosophila melanogaster	27.24	3.00e-26	110.00
IUUC-Ete-032362	Echinops telfairi	27.01	3.00e-24	103.00
IUUC-Eca-033323	Equus caballus	29.47	1.00e-30	124.00
IUUC-Eeu-034479	Erinaceus europaeus	44.05	1.00e-18	84.70
IUUC-Fca-035675	Felis catus	28.57	1.00e-30	124.00
IUUC-Fal-037218	Ficedula albicollis	29.58	5.00e-31	126.00
IUUC-Fox-037797	Fusarium oxysporum	52.70	2.00e-46	177.00
IUUC-Fso-038174	Fusarium solani	52.03	2.00e-45	174.00
IUUC-Gmo-039706	Gadus morhua	27.34	5.00e-24	103.00
IUUC-Ggr-040113	Gaeumannomyces graminis	33.71	1.00e-72	265.00
IUUC-Gga-040977	Gallus gallus	29.58	2.00e-30	124.00
IUUC-Gac-041360	Gasterosteus aculeatus	40.24	3.00e-29	120.00
IUUC-Gma-043876	Glycine max	46.31	5.00e-36	142.00
IUUC-Ggo-045610	Gorilla gorilla	28.10	2.00e-30	124.00
IUUC-Hsa-046532	Homo sapiens	29.58	3.00e-29	120.00
IUUC-Hvu-047851	Hordeum vulgare	32.35	7.00e-31	125.00
IUUC-Itr-048277	Ictidomys tridecemlineatus	29.58	4.00e-29	119.00
IUUC-Kpa-049378	Komagataella pastoris	51.95	2.00e-96	344.00
IUUC-Lch-049800	Latimeria chalumnae	30.55	1.00e-32	131.00
IUUC-Lpe-051205	Leersia perrieri	39.86	4.00e-30	123.00
IUUC-Loc-052379	Lepisosteus oculatus	29.80	7.00e-31	125.00
IUUC-Lma-052948	Leptosphaeria maculans	34.85	3.00e-70	256.00
IUUC-Laf-054084	Loxodonta africana	29.14	2.00e-30	124.00
IUUC-Mcc-055304	Macaca mulatta	29.59	7.00e-29	119.00
IUUC-Meu-056020	Macropus eugenii	27.33	1.00e-22	97.80
IUUC-Mor-057125	Magnaporthe oryzae	36.43	7.00e-76	275.00
IUUC-Mpo-057416	Magnaporthe poae	39.77	3.00e-16	77.40
IUUC-Mtr-058536	Medicago truncatula	30.18	9.00e-31	125.00
IUUC-Mla-058885	Melampsora laricipopulina	34.15	5.00e-13	65.90
IUUC-Mga-060051	Meleagris gallopavo	29.26	9.00e-32	128.00
IUUC-Mvi-060219	Microbotryum violaceum	62.86	1.00e-47	181.00
IUUC-Mmr-061076	Microcebus murinus	27.91	6.00e-29	119.00
IUUC-Mdo-062465	Monodelphis domestica	29.90	2.00e-31	127.00
IUUC-Mmu-063289	Mus musculus	29.58	3.00e-29	120.00
IUUC-Mac-064838	Musa acuminata	29.06	6.00e-31	126.00
IUUC-Mpu-066052	Mustela putorius furo	29.14	6.00e-30	122.00
IUUC-Mlu-067972	Myotis lucifugus	29.90	1.00e-29	121.00
IUUC-Nfi-068424	Neosartorya fischeri	37.12	8.00e-76	275.00
IUUC-Ncr-068833	Neurospora crassa	34.94	4.00e-75	273.00
IUUC-Nle-069047	Nomascus leucogenys	29.58	3.00e-29	120.00
IUUC-Opr-070933	Ochotona princeps	43.62	1.00e-17	82.40
IUUC-Ont-071875	Oreochromis niloticus	28.30	7.00e-34	135.00
IUUC-Oan-073084	Ornithorhynchus anatinus	27.37	2.00e-24	104.00
IUUC-Ocu-074689	Oryctolagus cuniculus	38.41	1.00e-27	115.00
IUUC-Oba-075601	Oryza barthii	41.38	9.00e-24	102.00
IUUC-Obr-076476	Oryza brachyantha	39.86	1.00e-30	125.00
IUUC-Ogl-077630	Oryza glaberrima	39.86	3.00e-30	124.00
IUUC-Ogu-078089	Oryza glumaepatula	41.38	8.00e-24	102.00
IUUC-Oin-079071	Oryza indica	41.38	8.00e-24	102.00
IUUC-Olo-080657	Oryza longistaminata	31.70	2.00e-29	122.00
IUUC-Ome-081702	Oryza meridionalis	39.86	5.00e-30	123.00
IUUC-Oni-083063	Oryza nivara	41.38	8.00e-24	102.00
IUUC-Opu-083460	Oryza punctata	31.70	3.00e-29	121.00
IUUC-Oru-084845	Oryza rufipogon	41.38	7.00e-24	102.00
IUUC-Osa-086113	Oryza sativa	41.38	8.00e-24	102.00
IUUC-Ola-086628	Oryzias latipes	27.97	6.00e-33	132.00
IUUC-Olu-087808	Ostreococcus lucimarinus	33.56	1.00e-24	105.00
IUUC-Oga-088642	Otolemur garnettii	29.58	3.00e-29	120.00
IUUC-Oar-089538	Ovis aries	28.81	6.00e-30	122.00
IUUC-Ptr-091326	Pan troglodytes	29.58	3.00e-29	120.00
IUUC-Pan-091795	Papio anubis	29.58	3.00e-29	120.00
IUUC-Psi-093258	Pelodiscus sinensis	29.80	7.00e-31	125.00
IUUC-Pma-094403	Petromyzon marinus	24.46	4.00e-21	93.20
IUUC-Pno-095015	Phaeosphaeria nodorum	34.27	4.00e-65	239.00
IUUC-Ppa-095377	Physcomitrella patens	40.14	5.00e-25	106.00
IUUC-Pfo-096099	Poecilia formosa	27.97	2.00e-33	134.00
IUUC-Pab-098681	Pongo abelii	29.58	3.00e-29	120.00
IUUC-Pop-099760	Populus trichocarpa	29.60	7.00e-29	119.00
IUUC-Pca-100176	Procavia capensis	35.45	2.00e-17	80.90
IUUC-Ppe-101799	Prunus persica	32.36	2.00e-26	111.00
IUUC-Pva-103006	Pteropus vampyrus	29.80	5.00e-31	125.00
IUUC-Pgr-103496	Puccinia graminis	32.93	2.00e-11	62.00
IUUC-Ptt-103915	Puccinia triticina	20.00	7.00e-13	67.00
IUUC-Pte-104139	Pyrenophora teres	34.85	2.00e-69	254.00
IUUC-Pyt-104488	Pyrenophora triticirepentis	34.85	4.00e-69	253.00
IUUC-Rno-106112	Rattus norvegicus	29.58	3.00e-29	120.00
IUUC-Sha-107573	Sarcophilus harrisii	29.90	9.00e-31	125.00
IUUC-Sja-107913	Schizosaccharomyces japonicus	46.34	3.00e-39	153.00
IUUC-Spo-108068	Schizosaccharomyces pombe	54.55	1.00e-38	151.00
IUUC-Ssl-108418	Sclerotinia sclerotiorum	33.81	4.00e-77	279.00
IUUC-Smo-109157	Selaginella moellendorffii	31.83	1.00e-40	158.00
IUUC-Sit-110655	Setaria italica	28.36	2.00e-23	101.00
IUUC-Sly-111030	Solanum lycopersicum	28.73	1.00e-30	125.00
IUUC-Stu-112534	Solanum tuberosum	28.83	3.00e-27	114.00
IUUC-Sar-113276	Sorex araneus	44.05	2.00e-18	84.00
IUUC-Sbi-114020	Sorghum bicolor	31.32	2.00e-28	118.00
IUUC-Sre-115219	Sporisorium reilianum	56.85	2.00e-44	171.00
IUUC-Ssc-116163	Sus scrofa	28.62	2.00e-31	127.00
IUUC-Tgu-116488	Taeniopygia guttata	29.80	2.00e-31	127.00
IUUC-Tru-117889	Takifugu rubripes	36.87	5.00e-26	110.00
IUUC-Tsy-119533	Tarsius syrichta	35.45	2.00e-17	80.50
IUUC-Tni-119729	Tetraodon nigroviridis	27.12	5.00e-30	122.00
IUUC-Tca-121732	Theobroma cacao	40.56	3.00e-29	120.00
IUUC-Tre-121895	Trichoderma reesei	35.09	2.00e-75	274.00
IUUC-Tvi-122311	Trichoderma virens	34.70	3.00e-75	273.00
IUUC-Tae-125776	Triticum aestivum	32.35	7.00e-31	125.00
IUUC-Tur-126757	Triticum urartu	32.45	7.00e-30	122.00
IUUC-Ttr-128940	Tursiops truncatus	29.56	4.00e-26	109.00
IUUC-Uma-129438	Ustilago maydis	56.85	3.00e-44	171.00
IUUC-Vda-129782	Verticillium dahliae	30.94	9.00e-41	159.00
IUUC-Vvi-131053	Vitis vinifera	29.08	1.00e-27	115.00
IUUC-Xtr-131806	Xenopus tropicalis	29.90	1.00e-31	128.00
IUUC-Xma-134275	Xiphophorus maculatus	27.97	2.00e-33	134.00
IUUC-Yli-134337	Yarrowia lipolytica	38.00	5.00e-84	302.00
IUUC-Zma-135902	Zea mays	29.45	1.00e-23	102.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence