iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Spo-108353

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Probable ubiquitin carboxyl-terminal hydrolase 3; Deubiquitinating enzyme 3; Ubiquitin thioesterase 3; Ubiquitin-specific-processing protease 3

Genbank Nucleotide ID

CU329671

Gene Name

ubp3; SPBP8B7.21

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
SPBP8B7.21	SPBP8B7.21.1	SPBP8B7.21.1:pep

Annotation

mRNA Expression
GEO
Protein-protein Interaction
iRefIndex	HINT	Mentha
Protein Expression/Proteomics

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	4.70e-64	214.7	134	511

Active Site

Position(s)	Description	Evidence
142	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}
453	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkk......avsprellkalkkeaeefs... 85
           G+ N gN C+mNS+LQ+L+ + ++ +ll++  ++ ++ +   e++++l++sl+ l + + ++++k      ++ p+ +++a k  +++f+   
   Q: 134  GFINTGNICFMNSILQALMYCVPFYNLLKQ-INRMVPYN--FERTTPLIESLTMLSRDFREYSEKfdlqgdSILPEVVYSATK-GNPRFEmlq 222
           9*****************************.77777766..568888999999888888744444444444899988777766.677777666 PP
   S: 86   gyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde.................................aeekkkkknkslisdl 145
           + eq+Da+Efl+ +ld+l+ee+ +e+++   +   ++++ +sd+                                    +  + ++s+is++
   Q: 223  TGEQEDAEEFLNLFLDELHEEFVRERRHYLLKN--DERNPKSDIkisngiksgldsfddqssveasgwtevgknkkpVIARSATVERSPISQI 313
           **********************66444443333..33334444468999999999***********999988877665556667777****** PP
   S: 146  FqgqlksqikclecdnvssreepfldlslpvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfs 238
           F+gql+s++++++ +  s+  epf+ l+l+++ ++     s+ d+Le++t++e l +   ++++k  ++++a+k++ +++lP+vLilhLkRf 
   Q: 314  FGGQLRSTLRVPSAR-DSVLLEPFQPLQLDIQAEDIH---SVIDALEHMTAPEILPE---WHSSK--GNVTATKQMYIESLPPVLILHLKRFF 397
           ***********9865.67799**************88...***************96...87776..6699*********************6 PP
   S: 239  fseeqksrekinkkvefpleLdlspfctspeekqkekkkYeLiavvvHsG.slssGHYvayvknekgk.WllfdDskVtevkeeevleetg.. 327
           + e+ +  +k+ k + +p +L++ + + sp+   + + +Y+L avv+H+G s+s+GHY+++v++ +++ W+++dD++++ v+ ++v++++   
   Q: 398  Y-EASGGTQKNYKPIAYPARLSIPQNVFSPSVRGSIHPEYDLNAVVYHHGtSASGGHYTVDVQQLDKSgWFRIDDTHIHRVPIHDVENSELsa 489
           6.5567788****************99999999999****************************66666*******************777** PP
   S: 328  ...........staYvlfYkrr 338
                      + aY+lfY+rr
   Q: 490  dpslsklghgdRVAYLLFYTRR 511
           *******************985 PP

Organism

Schizosaccharomyces pombe

Protein Sequence
(Fasta)

MRDLTSATDS ASLESDSSRN QFIINSLLPW YSCSEHEFPH RKARKRRSPK NLDWSVSVQM 60
PLVTSKTKES EKSPKSWSAI AKKHVQGDSP VKKSHSVPVP SDRSEKKSFN SSLGELIETY 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTTGAACTGA GGAACGAGGT ACAGTTCCTA GCTGTATCGA TGATCGATAC TAATAGCTTC 60
CTATAAACAT TGTCAGTTAA AAATATACTG CATCCCGCTA TATTGTAGAT CGCAAGAGAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0016579--P:protein deubiquitination
GO:0060628--P:regulation of ER to Golgi vesicle-mediated transport
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

spo:SPBP8B7.21

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000082	Aegilops tauschii	30.60	2.00e-42	165.00
IUUC-Aml-001584	Ailuropoda melanoleuca	36.29	9.00e-64	236.00
IUUC-Atr-002927	Amborella trichopoda	31.19	2.00e-45	175.00
IUUC-Apl-003988	Anas platyrhynchos	37.10	2.00e-54	205.00
IUUC-Aca-004461	Anolis carolinensis	39.60	2.00e-44	171.00
IUUC-Aly-006038	Arabidopsis lyrata	31.42	3.00e-40	157.00
IUUC-Ath-007328	Arabidopsis thaliana	32.17	1.00e-39	155.00
IUUC-Ago-007717	Ashbya gossypii	32.59	1.00e-51	196.00
IUUC-Acl-008188	Aspergillus clavatus	41.77	9.00e-87	313.00
IUUC-Afl-008456	Aspergillus flavus	45.72	4.00e-68	249.00
IUUC-Afu-009067	Aspergillus fumigatus	42.01	8.00e-87	313.00
IUUC-Ani-009483	Aspergillus nidulans	40.22	4.00e-88	317.00
IUUC-Ang-009639	Aspergillus niger	41.52	1.00e-84	305.00
IUUC-Aor-010040	Aspergillus oryzae	40.98	6.00e-84	303.00
IUUC-Ate-010310	Aspergillus terreus	42.01	1.00e-86	312.00
IUUC-Ame-011012	Astyanax mexicanus	34.16	3.00e-42	164.00
IUUC-Bgr-012311	Blumeria graminis	38.69	7.00e-72	263.00
IUUC-Bta-013299	Bos taurus	36.30	1.00e-61	229.00
IUUC-Bci-013783	Botrytis cinerea	44.07	2.00e-84	305.00
IUUC-Bdi-015039	Brachypodium distachyon	31.39	4.00e-45	174.00
IUUC-Bol-015910	Brassica oleracea	31.83	4.00e-46	177.00
IUUC-Bra-017000	Brassica rapa	31.26	3.00e-46	177.00
IUUC-Cja-018715	Callithrix jacchus	36.64	6.00e-65	240.00
IUUC-Cfa-020194	Canis familiaris	36.07	5.00e-63	234.00
IUUC-Cpo-022272	Cavia porcellus	37.05	7.00e-60	223.00
IUUC-Cre-022713	Chlamydomonas reinhardtii	34.03	1.00e-32	132.00
IUUC-Csa-023310	Chlorocebus sabaeus	36.21	6.00e-64	237.00
IUUC-Cin-025616	Ciona intestinalis	34.79	2.00e-54	205.00
IUUC-Csv-026043	Ciona savignyi	34.68	4.00e-55	206.00
IUUC-Cgl-026421	Colletotrichum gloeosporioides	40.53	4.00e-68	250.00
IUUC-Cne-026962	Cryptococcus neoformans	41.06	1.00e-71	262.00
IUUC-Cme-027113	Cyanidioschyzon merolae	29.25	1.00e-28	119.00
IUUC-Dre-028072	Danio rerio	36.78	1.00e-58	219.00
IUUC-Dno-029489	Dasypus novemcinctus	36.58	2.00e-64	238.00
IUUC-Dor-031068	Dipodomys ordii	40.25	7.00e-21	94.00
IUUC-Dse-031553	Dothistroma septosporum	41.22	2.00e-84	305.00
IUUC-Dme-031759	Drosophila melanogaster	32.02	2.00e-41	163.00
IUUC-Ete-032549	Echinops telfairi	33.80	1.00e-29	123.00
IUUC-Eca-033380	Equus caballus	35.56	2.00e-64	238.00
IUUC-Eeu-034818	Erinaceus europaeus	36.20	3.00e-62	231.00
IUUC-Fca-035535	Felis catus	34.49	3.00e-50	191.00
IUUC-Fal-036627	Ficedula albicollis	35.98	5.00e-59	220.00
IUUC-Fox-037904	Fusarium oxysporum	43.18	5.00e-79	287.00
IUUC-Fso-038170	Fusarium solani	39.33	3.00e-68	251.00
IUUC-Gmo-039499	Gadus morhua	36.01	1.00e-50	192.00
IUUC-Ggr-040042	Gaeumannomyces graminis	46.31	5.00e-87	313.00
IUUC-Gga-040571	Gallus gallus	35.37	1.00e-55	209.00
IUUC-Gac-041345	Gasterosteus aculeatus	35.93	8.00e-53	200.00
IUUC-Gma-044407	Glycine max	31.80	1.00e-47	182.00
IUUC-Ggo-044652	Gorilla gorilla	35.78	3.00e-63	234.00
IUUC-Hsa-045864	Homo sapiens	35.78	3.00e-63	234.00
IUUC-Hvu-047071	Hordeum vulgare	31.68	7.00e-49	186.00
IUUC-Itr-048216	Ictidomys tridecemlineatus	35.11	5.00e-64	236.00
IUUC-Kpa-049132	Komagataella pastoris	32.69	1.00e-63	235.00
IUUC-Lch-050040	Latimeria chalumnae	37.50	2.00e-56	212.00
IUUC-Loc-052449	Lepisosteus oculatus	36.36	2.00e-57	215.00
IUUC-Lma-053248	Leptosphaeria maculans	42.82	1.00e-80	292.00
IUUC-Laf-054121	Loxodonta africana	35.38	4.00e-62	231.00
IUUC-Mcc-055514	Macaca mulatta	36.21	8.00e-64	236.00
IUUC-Meu-056873	Macropus eugenii	33.60	2.00e-20	92.00
IUUC-Mor-057243	Magnaporthe oryzae	42.86	1.00e-84	306.00
IUUC-Mpo-057439	Magnaporthe poae	46.22	6.00e-85	306.00
IUUC-Mtr-058457	Medicago truncatula	31.95	7.00e-46	176.00
IUUC-Mla-058929	Melampsora laricipopulina	37.29	6.00e-72	263.00
IUUC-Mga-060157	Meleagris gallopavo	35.29	4.00e-54	204.00
IUUC-Mvi-060442	Microbotryum violaceum	35.58	5.00e-67	247.00
IUUC-Mmr-061062	Microcebus murinus	36.64	6.00e-65	240.00
IUUC-Mdo-062798	Monodelphis domestica	36.21	7.00e-59	220.00
IUUC-Mmu-064050	Mus musculus	34.94	4.00e-64	237.00
IUUC-Mac-065619	Musa acuminata	30.07	6.00e-43	166.00
IUUC-Mpu-066554	Mustela putorius furo	37.32	5.00e-63	234.00
IUUC-Mlu-068003	Myotis lucifugus	36.99	4.00e-64	237.00
IUUC-Nfi-068612	Neosartorya fischeri	39.11	1.00e-83	302.00
IUUC-Ncr-068878	Neurospora crassa	43.07	3.00e-74	271.00
IUUC-Nle-069661	Nomascus leucogenys	36.21	5.00e-64	237.00
IUUC-Opr-070944	Ochotona princeps	31.80	3.00e-27	114.00
IUUC-Ont-071266	Oreochromis niloticus	35.31	3.00e-53	201.00
IUUC-Oan-073442	Ornithorhynchus anatinus	36.33	1.00e-65	242.00
IUUC-Ocu-073788	Oryctolagus cuniculus	37.80	7.00e-59	220.00
IUUC-Oba-075085	Oryza barthii	35.19	4.00e-34	135.00
IUUC-Obr-076663	Oryza brachyantha	32.10	8.00e-42	163.00
IUUC-Ogl-076937	Oryza glaberrima	31.20	4.00e-47	180.00
IUUC-Ogu-078909	Oryza glumaepatula	31.79	6.00e-47	180.00
IUUC-Oin-079617	Oryza indica	32.27	9.00e-48	183.00
IUUC-Olo-081043	Oryza longistaminata	28.29	4.00e-26	110.00
IUUC-Ome-081646	Oryza meridionalis	26.96	1.00e-23	102.00
IUUC-Oni-082914	Oryza nivara	31.79	6.00e-47	180.00
IUUC-Oru-084878	Oryza rufipogon	31.79	6.00e-47	180.00
IUUC-Osa-085822	Oryza sativa	31.93	3.00e-49	187.00
IUUC-Ola-086931	Oryzias latipes	35.21	5.00e-53	200.00
IUUC-Oga-088443	Otolemur garnettii	36.64	3.00e-64	238.00
IUUC-Oar-089325	Ovis aries	36.76	1.00e-61	229.00
IUUC-Ptr-091584	Pan troglodytes	34.27	6.00e-56	210.00
IUUC-Pan-092551	Papio anubis	34.48	8.00e-57	213.00
IUUC-Psi-093366	Pelodiscus sinensis	30.10	6.00e-21	93.60
IUUC-Pno-095136	Phaeosphaeria nodorum	41.19	2.00e-72	265.00
IUUC-Ppa-095574	Physcomitrella patens	32.14	3.00e-48	184.00
IUUC-Pfo-097462	Poecilia formosa	35.14	6.00e-55	207.00
IUUC-Pab-098547	Pongo abelii	36.90	1.00e-63	236.00
IUUC-Pop-099529	Populus trichocarpa	32.68	1.00e-46	179.00
IUUC-Pca-101066	Procavia capensis	40.48	2.00e-50	192.00
IUUC-Ppe-102110	Prunus persica	31.25	4.00e-43	166.00
IUUC-Pva-103015	Pteropus vampyrus	35.74	5.00e-64	237.00
IUUC-Ptt-103998	Puccinia triticina	38.58	2.00e-69	254.00
IUUC-Pte-104417	Pyrenophora teres	41.90	1.00e-76	279.00
IUUC-Pyt-104820	Pyrenophora triticirepentis	42.46	7.00e-77	280.00
IUUC-Rno-105533	Rattus norvegicus	34.39	2.00e-66	244.00
IUUC-Sce-106160	Saccharomyces cerevisiae	31.12	3.00e-51	194.00
IUUC-Sha-106590	Sarcophilus harrisii	36.36	7.00e-59	220.00
IUUC-Sja-107669	Schizosaccharomyces japonicus	45.76	1.00e-118	417.00
IUUC-Ssl-108599	Sclerotinia sclerotiorum	43.67	7.00e-85	306.00
IUUC-Smo-109645	Selaginella moellendorffii	31.06	3.00e-28	116.00
IUUC-Sit-110781	Setaria italica	30.69	9.00e-44	169.00
IUUC-Sly-111797	Solanum lycopersicum	30.75	7.00e-41	159.00
IUUC-Stu-112188	Solanum tuberosum	30.71	9.00e-45	172.00
IUUC-Sbi-114862	Sorghum bicolor	29.75	2.00e-36	145.00
IUUC-Sre-115162	Sporisorium reilianum	43.29	1.00e-93	335.00
IUUC-Ssc-115505	Sus scrofa	41.22	4.00e-52	196.00
IUUC-Tgu-116535	Taeniopygia guttata	35.73	4.00e-59	220.00
IUUC-Tru-117542	Takifugu rubripes	36.12	2.00e-57	215.00
IUUC-Tni-120200	Tetraodon nigroviridis	35.34	1.00e-58	219.00
IUUC-Tca-121548	Theobroma cacao	30.99	7.00e-35	140.00
IUUC-Tre-122124	Trichoderma reesei	43.14	2.00e-86	311.00
IUUC-Tvi-122457	Trichoderma virens	39.35	1.00e-70	259.00
IUUC-Tae-125352	Triticum aestivum	32.34	8.00e-49	186.00
IUUC-Tme-127180	Tuber melanosporum	42.72	2.00e-90	325.00
IUUC-Tbe-127530	Tupaia belangeri	31.71	3.00e-40	158.00
IUUC-Ttr-128549	Tursiops truncatus	33.26	3.00e-51	194.00
IUUC-Uma-129381	Ustilago maydis	40.60	3.00e-91	327.00
IUUC-Vda-129889	Verticillium dahliae	40.54	9.00e-76	276.00
IUUC-Vpa-130100	Vicugna pacos	35.01	1.00e-51	196.00
IUUC-Vvi-131366	Vitis vinifera	33.33	2.00e-50	191.00
IUUC-Xtr-132048	Xenopus tropicalis	33.21	2.00e-59	222.00
IUUC-Xma-133593	Xiphophorus maculatus	35.14	2.00e-54	205.00
IUUC-Yli-134338	Yarrowia lipolytica	32.25	7.00e-42	163.00
IUUC-Zma-135255	Zea mays	32.02	2.00e-44	172.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence