iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Cpo-021529

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAKN02012891

Gene Name

USP19

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCPOG00000009975.3	ENSCPOT00000010065.2	ENSCPOP00000008953.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	3.90e-114	381.3	530	1244

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsg 86
           tGl NlgNtC+mNSv+Q+Lsn++elr+++++ +++ ++n +np ++ g+l+  ++ l+++lwk++++a++p++l+++++++a++f+g
   Q: 530  TGLVNLGNTCFMNSVIQSLSNTRELRDFFHDrSFEAEINYNNPLGTGGRLAIGFAVLLRALWKGTHHAFQPSKLKAIVASKASQFTG 616
           7*****************************999****************************************************** PP
   S: 87   yeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde.....aeekkkkknkslisdlFqgqlksqikclecdnvssreep 168
           y+q+DaqEf+aflld+l+e+l++ +nkp++e+ ++d   ++de     a++++k++n+s+i+dlFqgq+ks+++c+ c++vs +++p
   Q: 617  YAQHDAQEFMAFLLDGLHEDLNRIQNKPYTETVDSD--GRPDEvvaaeAWQRHKMRNDSFIVDLFQGQYKSKLVCPVCAKVSITFDP 701
           ********************************9999..6666677888*************************************** PP
   S: 169  fldlslpvpgkeetkke...................................................................... 185
           fl+l++p+p+k++  +                                                                       
   Q: 702  FLYLPVPLPQKQKVLPIfyfarephckpikflvsvskenssasevldslsqsvhvkpenlrlaeviknrfhrvflpsqsldtvspsd 788
           ************87666********************************************************************** PP
   S: 186  ....................................................................................... 185
                                                                                                  
   Q: 789  tllcfellspelakervvvlevqqrpqvpsipiskcaacqrkqqsedeklkrctrcyrvgycnqlcqkshwpdhkglcrpenigypf 875
           *************************************************************************************** PP
   S: 186  ....................................................................................... 185
                                                                                                  
   Q: 876  lvsvpasrltyarltqllegyarysvsvfqppfqpgrmalesqspgcttllstssleagdserepsqspelqlvaegdtgvprlwaa 962
           *************************************************************************************** PP
   S: 186  ....................................................................................... 185
                                                                                                  
   Q: 963  pdrgpvtstsgissemltsgptessslpvgervsrpeaavhgyqhpseainahtpqffiykidasnreqrledkgetplelgedcsl 1049
           *************************************************************************************** PP
   S: 186  .......................................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilh 233
                                                  +l++cL+ ft++e l  e+++yc++ck ++ea+k+l l++lP+vLi++
   Q: 1050 alvwrnnerlqefvlvaskelecaedpgsageaaraghfTLDQCLNLFTRPEVLAPEEAWYCPQCKLHREASKQLLLWRLPNVLIVQ 1136
           *************************************************************************************** PP
   S: 234  LkRfsfseeqksrekinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgk........WllfdD 311
           LkRfsf++  +++ kin+ vefp + Ldls+fc+ ++e+q    +Y+L+av++H+G++ +GHY+a+++  +++        W lfdD
   Q: 1137 LKRFSFRSFIWRD-KINDLVEFPVRnLDLSKFCIGQKEEQ--LPSYDLYAVINHYGGMIGGHYTACARLPNDRssqrsdvgWRLFDD 1220
           *********8886.**********9**********99888..9**************************544445566777****** PP
   S: 312  skVtevkeeevleetgstaYvlfYkrr 338
           s+Vt+v+e++v++   + aYvlfY+rr
   Q: 1221 STVTTVDESQVVT---RYAYVLFYRRR 1244
           *************...********996 PP

Organism

Cavia porcellus

Protein Sequence
(Fasta)

MSGGASATGS RRGTPGLEEA TSKKKQKDRA NQESKDGDPR RGSLSTPREE QIKEELLLDW 60
RQSADEVIIK LRVGTGPLRL EEVDAAFTDT DCVVRFPGGQ QWGGVFYAEI ESSCTKVQAR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTCTGGAG GGGCCAGTGC CACGGGCTCA AGGAGAGGGA CCCCAGGACT GGAGGAGGCT 60
ACTAGTAAGA AGAAGCAGAA GGACCGAGCA AACCAGGAAA GCAAGGATGG AGATCCTAGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR007052--CS_dom
IPR008978--HSP20-like_chaperone
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR002893--Znf_MYND

PROSITE

PS51203--CS
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS01360--ZF_MYND_1
PS50865--ZF_MYND_2

Pfam

PF04969--CS
PF00443--UCH
PF01753--zf-MYND

Gene Ontology

GO:0005829--C:cytosol
GO:0005789--C:endoplasmic reticulum membrane
GO:0016021--C:integral component of membrane
GO:1990380--F:Lys48-specific deubiquitinase activity
GO:0046872--F:metal ion binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:1901799--P:negative regulation of proteasomal protein catabolic process
GO:0048642--P:negative regulation of skeletal muscle tissue development
GO:0050821--P:protein stabilization
GO:1900037--P:regulation of cellular response to hypoxia
GO:1904292--P:regulation of ERAD pathway
GO:0030433--P:ubiquitin-dependent ERAD pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001999	Ailuropoda melanoleuca	87.38	0.00e+00	2201.00
IUUC-Apl-003368	Anas platyrhynchos	65.77	0.00e+00	1670.00
IUUC-Aca-004267	Anolis carolinensis	66.84	0.00e+00	1660.00
IUUC-Ame-010970	Astyanax mexicanus	69.77	0.00e+00	1318.00
IUUC-Bta-012905	Bos taurus	87.39	0.00e+00	2192.00
IUUC-Cja-018789	Callithrix jacchus	86.20	0.00e+00	2288.00
IUUC-Cfa-021004	Canis familiaris	87.35	0.00e+00	2197.00
IUUC-Csa-024035	Chlorocebus sabaeus	89.51	0.00e+00	2258.00
IUUC-Cho-025036	Choloepus hoffmanni	82.26	0.00e+00	1212.00
IUUC-Cin-025451	Ciona intestinalis	43.54	4.00e-86	313.00
IUUC-Csv-025931	Ciona savignyi	36.34	6.00e-109	388.00
IUUC-Dre-028556	Danio rerio	69.62	0.00e+00	1311.00
IUUC-Dno-029240	Dasypus novemcinctus	87.22	0.00e+00	2100.00
IUUC-Dor-030495	Dipodomys ordii	93.39	0.00e+00	1219.00
IUUC-Ete-032741	Echinops telfairi	88.67	0.00e+00	1786.00
IUUC-Eca-033661	Equus caballus	91.11	0.00e+00	2343.00
IUUC-Eeu-034648	Erinaceus europaeus	84.43	0.00e+00	766.00
IUUC-Fca-035646	Felis catus	87.20	0.00e+00	2167.00
IUUC-Fal-037094	Ficedula albicollis	67.38	0.00e+00	1759.00
IUUC-Gmo-038869	Gadus morhua	71.08	0.00e+00	840.00
IUUC-Gga-041170	Gallus gallus	64.88	0.00e+00	1701.00
IUUC-Gac-041901	Gasterosteus aculeatus	66.88	0.00e+00	1309.00
IUUC-Ggo-044708	Gorilla gorilla	86.70	0.00e+00	2325.00
IUUC-Hsa-046791	Homo sapiens	91.47	0.00e+00	1992.00
IUUC-Itr-048892	Ictidomys tridecemlineatus	87.48	0.00e+00	2271.00
IUUC-Lch-050456	Latimeria chalumnae	51.38	0.00e+00	1180.00
IUUC-Loc-052861	Lepisosteus oculatus	58.69	0.00e+00	1130.00
IUUC-Laf-053788	Loxodonta africana	90.09	0.00e+00	2254.00
IUUC-Mcc-055693	Macaca mulatta	85.05	0.00e+00	2225.00
IUUC-Meu-055921	Macropus eugenii	77.19	0.00e+00	1494.00
IUUC-Mga-059879	Meleagris gallopavo	64.46	0.00e+00	1710.00
IUUC-Mmr-060802	Microcebus murinus	88.21	0.00e+00	2328.00
IUUC-Mdo-061856	Monodelphis domestica	78.67	0.00e+00	1586.00
IUUC-Mmu-063874	Mus musculus	89.44	0.00e+00	2299.00
IUUC-Mpu-066166	Mustela putorius furo	87.14	0.00e+00	2173.00
IUUC-Nle-070161	Nomascus leucogenys	86.77	0.00e+00	2350.00
IUUC-Opr-071015	Ochotona princeps	89.80	0.00e+00	1862.00
IUUC-Ont-072308	Oreochromis niloticus	70.02	0.00e+00	1353.00
IUUC-Oan-072723	Ornithorhynchus anatinus	66.00	0.00e+00	1612.00
IUUC-Ocu-073938	Oryctolagus cuniculus	86.62	0.00e+00	2175.00
IUUC-Ola-086375	Oryzias latipes	61.48	0.00e+00	1380.00
IUUC-Oga-088297	Otolemur garnettii	87.53	0.00e+00	2263.00
IUUC-Oar-089675	Ovis aries	91.84	0.00e+00	1607.00
IUUC-Ptr-091621	Pan troglodytes	91.21	0.00e+00	1988.00
IUUC-Pan-092118	Papio anubis	86.19	0.00e+00	2256.00
IUUC-Pma-094154	Petromyzon marinus	51.31	5.00e-113	401.00
IUUC-Pfo-097246	Poecilia formosa	58.79	0.00e+00	1404.00
IUUC-Pab-098551	Pongo abelii	90.59	0.00e+00	1969.00
IUUC-Pca-100158	Procavia capensis	85.60	0.00e+00	2194.00
IUUC-Pva-103160	Pteropus vampyrus	90.82	0.00e+00	2274.00
IUUC-Rno-105355	Rattus norvegicus	89.20	0.00e+00	2303.00
IUUC-Sha-107057	Sarcophilus harrisii	75.18	0.00e+00	1759.00
IUUC-Sar-113011	Sorex araneus	84.82	0.00e+00	1419.00
IUUC-Ssc-115761	Sus scrofa	86.62	0.00e+00	2212.00
IUUC-Tgu-116956	Taeniopygia guttata	61.23	0.00e+00	811.00
IUUC-Tru-118739	Takifugu rubripes	68.67	0.00e+00	1348.00
IUUC-Tsy-118827	Tarsius syrichta	84.77	0.00e+00	1239.00
IUUC-Tni-119921	Tetraodon nigroviridis	70.01	0.00e+00	1313.00
IUUC-Tbe-128017	Tupaia belangeri	88.55	0.00e+00	1902.00
IUUC-Ttr-128869	Tursiops truncatus	90.08	0.00e+00	2266.00
IUUC-Vpa-130427	Vicugna pacos	92.74	0.00e+00	892.00
IUUC-Xtr-132734	Xenopus tropicalis	62.09	0.00e+00	1546.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence