iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Tca-121501

Ensembl Protein ID

EOY09648

UniProt Accession

A0A061EYD4; A0A061EYD4_THECC

Genbank Protein ID

EOY09648.1

Protein Name

Ubiquitin-specific protease 12

Genbank Nucleotide ID

CM001883

Gene Name

TCM_025045

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
TCM_025045	EOY09648	EOY09648

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	8.30e-71	239.9	196	519

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDaqEflaflld 101
           +GlkN+g+tCYmNS+LQ+L++ip +r+++ +     ++ ++++ p g++  +lq+lf +l ++++++v+++el+k++++    +++++q+D+qE+ ++l +
   Q: 196  VGLKNQGATCYMNSLLQTLYHIPYFRKAVYH-----MPTTENDMPIGSIPLALQSLFYKL-QYNDTSVATKELTKSFGWDT--YDSFMQHDVQELNRVLCE 288
           6******************************.....5555557899**************.88999************877..67**************** PP
   S: 102  qleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkkeslqdcLesftkeeeleg 202
           +le+++                          k +  + +i++lF+g+  + i c + d +s+r+e+f+dl+l+v+g +     ++  +++++++ e+leg
   Q: 289  KLEDKM--------------------------KGTVVEGTIQQLFEGHHMNYIECINVDYKSTRKESFYDLQLDVKGCR-----DVYASFDKYVEVERLEG 358
           ******..........................7899*******************************************.....9**************** PP
   S: 203  enkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdls....pfctspeekqkekkkYeLiavvvHsGslssGHYvayv 299
           +nky+ e+  ++q+a+k + +  +P+vL l+LkRf+++  ++   kin+++efpl+Ldl+    ++++ pe + ++++ Y L++v+vHsG++++GHY+a++
   Q: 359  DNKYHAEEH-GLQDAKKGVLFIDFPPVLQLQLKRFEYDFMRDTMVKINDRYEFPLQLDLDrengKYLS-PEADRSVRNLYTLHSVLVHSGGVHGGHYYAFI 457
           ******996.79***********************************************965544554.5666778************************* PP
   S: 300  kn.ekgkWllfdDskVtevkeeevleetg.......................staYvlfYkr 337
           +   +++W++fdD++Vt+ ++++ lee+                        s+aY+l+Y r
   Q: 458  RPtLSDQWYKFDDERVTKEDMKRALEEQYggeeelpqtnpgfnntpfkftkySNAYMLVYIR 519
           *945677*****************997779******************************87 PP

Organism

Theobroma cacao

Protein Sequence
(Fasta)

MTMMTTPPLD QEDEEMLVPH SDIVEGPQPM EVAQVEPAST VENQQVEDPP SMKFTWTIEN 60
FSRLNTKKHY SDIFVVGGYK WRILIFPKGN NVDHLSMYLD VADSSTLPYG WSRYAQFSLA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCATCAAACT GTCAATAATA CCCCTCCCGT TGAAGTAAAA CTCGAATGGC TTTTTTTTCT 60
GCACCAGTTC TTTGTCGACT CGCTTTGCAG TGCCCGCTTC TTCCCTTCCC CTTCCCTTCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome

Interpro

IPR002083--MATH/TRAF_dom
IPR001394--Peptidase_C19_UCH
IPR008974--TRAF-like
IPR024729--USP7_ICP0-binding_dom
IPR029346--USP_C
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS50144--MATH
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00917--MATH
PF00443--UCH
PF14533--USP7_C2
PF12436--USP7_ICP0_bdg

SMART

SM00061--MATH

Gene Ontology

GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aca-004518	Anolis carolinensis	35.00	4.00e-159	555.00
IUUC-Aly-006427	Arabidopsis lyrata	87.92	0.00e+00	1945.00
IUUC-Ath-006591	Arabidopsis thaliana	87.22	0.00e+00	1904.00
IUUC-Ame-010903	Astyanax mexicanus	35.73	4.00e-167	581.00
IUUC-Bol-015621	Brassica oleracea	87.38	0.00e+00	1929.00
IUUC-Bra-017080	Brassica rapa	86.94	0.00e+00	1932.00
IUUC-Cpo-022320	Cavia porcellus	36.46	5.00e-164	571.00
IUUC-Csa-024050	Chlorocebus sabaeus	36.20	4.00e-164	571.00
IUUC-Cho-024434	Choloepus hoffmanni	31.37	2.00e-88	319.00
IUUC-Cin-025689	Ciona intestinalis	34.75	4.00e-160	558.00
IUUC-Cne-026968	Cryptococcus neoformans	39.35	0.00e+00	705.00
IUUC-Dre-028510	Danio rerio	35.73	2.00e-167	582.00
IUUC-Fal-036964	Ficedula albicollis	36.64	1.00e-169	589.00
IUUC-Gmo-038644	Gadus morhua	35.45	4.00e-169	588.00
IUUC-Ggr-040029	Gaeumannomyces graminis	35.64	4.00e-167	581.00
IUUC-Gga-040944	Gallus gallus	36.64	3.00e-169	588.00
IUUC-Gac-041740	Gasterosteus aculeatus	36.18	2.00e-169	588.00
IUUC-Hsa-046278	Homo sapiens	35.49	3.00e-164	572.00
IUUC-Itr-047904	Ictidomys tridecemlineatus	37.32	5.00e-152	531.00
IUUC-Kpa-049121	Komagataella pastoris	31.50	5.00e-133	468.00
IUUC-Lch-049847	Latimeria chalumnae	36.09	2.00e-168	585.00
IUUC-Loc-052234	Lepisosteus oculatus	39.54	1.00e-134	473.00
IUUC-Laf-053566	Loxodonta africana	36.30	6.00e-164	571.00
IUUC-Mcc-055549	Macaca mulatta	36.36	7.00e-164	570.00
IUUC-Meu-056887	Macropus eugenii	28.95	2.00e-67	250.00
IUUC-Mpo-057536	Magnaporthe poae	35.26	2.00e-167	582.00
IUUC-Mdo-062079	Monodelphis domestica	36.52	3.00e-147	515.00
IUUC-Mmu-063678	Mus musculus	36.39	2.00e-163	569.00
IUUC-Mac-064796	Musa acuminata	87.62	0.00e+00	1937.00
IUUC-Mpu-066744	Mustela putorius furo	36.36	8.00e-164	570.00
IUUC-Nle-070064	Nomascus leucogenys	36.20	4.00e-164	571.00
IUUC-Ont-072095	Oreochromis niloticus	35.38	4.00e-167	581.00
IUUC-Ola-086640	Oryzias latipes	35.87	3.00e-168	585.00
IUUC-Oga-089059	Otolemur garnettii	34.06	2.00e-140	493.00
IUUC-Pan-091717	Papio anubis	36.20	7.00e-164	570.00
IUUC-Pma-094648	Petromyzon marinus	37.08	4.00e-164	571.00
IUUC-Pfo-096181	Poecilia formosa	35.34	9.00e-167	580.00
IUUC-Pop-100083	Populus trichocarpa	92.91	0.00e+00	2051.00
IUUC-Ppe-101523	Prunus persica	91.95	0.00e+00	2016.00
IUUC-Sha-107439	Sarcophilus harrisii	36.39	1.00e-163	570.00
IUUC-Spo-108019	Schizosaccharomyces pombe	36.64	5.00e-149	521.00
IUUC-Sly-111774	Solanum lycopersicum	85.29	0.00e+00	1923.00
IUUC-Stu-112387	Solanum tuberosum	85.65	0.00e+00	1927.00
IUUC-Sar-113685	Sorex araneus	35.93	1.00e-159	556.00
IUUC-Tgu-116767	Taeniopygia guttata	36.57	3.00e-168	585.00
IUUC-Tru-118208	Takifugu rubripes	36.18	3.00e-165	575.00
IUUC-Tni-119890	Tetraodon nigroviridis	36.27	2.00e-165	575.00
IUUC-Tre-122169	Trichoderma reesei	36.70	1.00e-171	596.00
IUUC-Tme-127045	Tuber melanosporum	38.18	1.00e-173	603.00
IUUC-Uma-129535	Ustilago maydis	39.00	0.00e+00	674.00
IUUC-Vda-129708	Verticillium dahliae	35.45	4.00e-173	601.00
IUUC-Vvi-131308	Vitis vinifera	91.23	0.00e+00	2008.00
IUUC-Xtr-132073	Xenopus tropicalis	35.97	7.00e-165	573.00
IUUC-Xma-133949	Xiphophorus maculatus	35.48	8.00e-166	577.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence