iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mlu-067888

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAPE02039489

Gene Name

TRAF6

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMLUG00000003605.2	ENSMLUT00000003606.2	ENSMLUP00000003284.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/U-box	2.20e-07	30.9	66	127

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 4    eeflCpIslelMrdPvvlpsGitydrssIekwlasggktcPvtrqplteedlvPnltlrrli 65
           + + CpI l   r+ v +p+G+ + +++I k +++ g++cP++++ l e++l P ++ +r i
   Q: 66   SKYECPICLMALREAVQTPCGHRFCKACITKSIRDAGHKCPIDNEILLETQLFPDNFAKREI 127
           5689*****************************999999*****************999977 PP

Organism

Myotis lucifugus

Protein Sequence
(Fasta)

MSLLNCEISC ASSQSESDCC AAMASSCSAA AKDDSVGATA STGNLSSSFM EEIQGYDVEF 60
DPPLESKYEC PICLMALREA VQTPCGHRFC KACITKSIRD AGHKCPIDNE ILLETQLFPD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAGTCTGC TAAACTGTGA AATCAGCTGT GCCTCCAGCC AGTCTGAGAG CGACTGCTGC 60
GCGGCCATGG CCAGCTCCTG TAGTGCTGCA GCAAAAGACG ACAGCGTGGG CGCCACTGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR002083--MATH/TRAF_dom
IPR012227--TNF_rcpt--assoc_TRAF
IPR008974--TRAF-like
IPR027139--TRAF6
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
IPR001293--Znf_TRAF

PROSITE

PS50144--MATH
PS00518--ZF_RING_1
PS50089--ZF_RING_2
PS50145--ZF_TRAF

Pfam

PF02176--zf-TRAF

SMART

SM00061--MATH
SM00184--RING

Gene Ontology

GO:0035631--C:CD40 receptor complex
GO:0009898--C:cytoplasmic side of plasma membrane
GO:0005829--C:cytosol
GO:0005811--C:lipid particle
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0043234--C:protein complex
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0007250--P:activation of NF-kappaB-inducing kinase activity
GO:0019886--P:antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0045453--P:bone resorption
GO:0048468--P:cell development
GO:0071222--P:cellular response to lipopolysaccharide
GO:0007249--P:I-kappaB kinase/NF-kappaB signaling
GO:0070498--P:interleukin-1-mediated signaling pathway
GO:0043011--P:myeloid dendritic cell differentiation
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0001843--P:neural tube closure
GO:0042475--P:odontogenesis of dentin-containing tooth
GO:0001503--P:ossification
GO:0030316--P:osteoclast differentiation
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045084--P:positive regulation of interleukin-12 biosynthetic process
GO:0032743--P:positive regulation of interleukin-2 production
GO:0045410--P:positive regulation of interleukin-6 biosynthetic process
GO:0043507--P:positive regulation of JUN kinase activity
GO:0031666--P:positive regulation of lipopolysaccharide-mediated signaling pathway
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0045672--P:positive regulation of osteoclast differentiation
GO:0002726--P:positive regulation of T cell cytokine production
GO:0042102--P:positive regulation of T cell proliferation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:2000679--P:positive regulation of transcription regulatory region DNA binding
GO:0051865--P:protein autoubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0042981--P:regulation of apoptotic process
GO:0051023--P:regulation of immunoglobulin secretion
GO:0050852--P:T cell receptor signaling pathway
GO:0042088--P:T-helper 1 type immune response

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001262	Ailuropoda melanoleuca	91.11	0.00e+00	957.00
IUUC-Apl-004062	Anas platyrhynchos	72.36	0.00e+00	805.00
IUUC-Aca-004636	Anolis carolinensis	70.80	0.00e+00	765.00
IUUC-Ame-011682	Astyanax mexicanus	54.93	8.00e-162	563.00
IUUC-Bta-012692	Bos taurus	87.82	0.00e+00	963.00
IUUC-Bci-013998	Botrytis cinerea	24.07	1.00e-12	68.20
IUUC-Cja-019426	Callithrix jacchus	88.27	0.00e+00	950.00
IUUC-Cfa-020948	Canis familiaris	89.16	0.00e+00	842.00
IUUC-Cpo-021378	Cavia porcellus	88.40	0.00e+00	958.00
IUUC-Csa-024045	Chlorocebus sabaeus	88.29	0.00e+00	957.00
IUUC-Cho-024973	Choloepus hoffmanni	69.44	4.00e-93	335.00
IUUC-Csv-026300	Ciona savignyi	41.15	5.00e-46	177.00
IUUC-Dre-027557	Danio rerio	58.42	1.00e-174	606.00
IUUC-Dno-030032	Dasypus novemcinctus	84.36	5.00e-142	496.00
IUUC-Dor-030790	Dipodomys ordii	87.71	0.00e+00	941.00
IUUC-Dse-031478	Dothistroma septosporum	25.00	2.00e-11	64.30
IUUC-Dme-031921	Drosophila melanogaster	27.86	1.00e-41	164.00
IUUC-Ete-032952	Echinops telfairi	83.83	6.00e-166	577.00
IUUC-Eca-033924	Equus caballus	86.00	0.00e+00	869.00
IUUC-Eeu-034734	Erinaceus europaeus	81.97	0.00e+00	852.00
IUUC-Fca-036222	Felis catus	82.54	0.00e+00	840.00
IUUC-Fal-036834	Ficedula albicollis	73.89	0.00e+00	734.00
IUUC-Fox-037935	Fusarium oxysporum	31.16	2.00e-21	97.10
IUUC-Gmo-039061	Gadus morhua	59.68	1.00e-85	310.00
IUUC-Ggr-040084	Gaeumannomyces graminis	27.03	8.00e-13	68.60
IUUC-Gga-040599	Gallus gallus	73.35	0.00e+00	815.00
IUUC-Gac-041977	Gasterosteus aculeatus	56.45	5.00e-169	587.00
IUUC-Ggo-044508	Gorilla gorilla	83.15	0.00e+00	878.00
IUUC-Hsa-046349	Homo sapiens	88.66	0.00e+00	965.00
IUUC-Itr-047966	Ictidomys tridecemlineatus	88.64	0.00e+00	947.00
IUUC-Lch-049821	Latimeria chalumnae	66.55	0.00e+00	739.00
IUUC-Lpe-051025	Leersia perrieri	25.54	7.00e-07	48.10
IUUC-Loc-051995	Lepisosteus oculatus	60.99	0.00e+00	641.00
IUUC-Laf-054115	Loxodonta africana	84.47	0.00e+00	932.00
IUUC-Mcc-055298	Macaca mulatta	87.92	0.00e+00	952.00
IUUC-Mor-057263	Magnaporthe oryzae	30.52	1.00e-17	84.30
IUUC-Mpo-057517	Magnaporthe poae	29.68	3.00e-16	80.10
IUUC-Mga-059340	Meleagris gallopavo	73.35	0.00e+00	813.00
IUUC-Mvi-060553	Microbotryum violaceum	28.12	1.00e-15	77.40
IUUC-Mmr-061063	Microcebus murinus	90.13	0.00e+00	960.00
IUUC-Mdo-062075	Monodelphis domestica	79.37	0.00e+00	875.00
IUUC-Mmu-063780	Mus musculus	86.03	0.00e+00	897.00
IUUC-Mpu-065748	Mustela putorius furo	89.46	0.00e+00	953.00
IUUC-Ncr-068632	Neurospora crassa	28.78	4.00e-17	82.80
IUUC-Nle-069234	Nomascus leucogenys	88.85	0.00e+00	964.00
IUUC-Opr-070393	Ochotona princeps	97.18	2.00e-124	439.00
IUUC-Ont-072459	Oreochromis niloticus	57.31	2.00e-173	602.00
IUUC-Oan-073578	Ornithorhynchus anatinus	81.62	0.00e+00	901.00
IUUC-Ocu-074201	Oryctolagus cuniculus	90.02	0.00e+00	964.00
IUUC-Ola-087319	Oryzias latipes	62.34	9.00e-88	317.00
IUUC-Olu-087748	Ostreococcus lucimarinus	22.63	7.00e-10	58.20
IUUC-Oga-087936	Otolemur garnettii	87.80	0.00e+00	945.00
IUUC-Oar-089379	Ovis aries	87.45	0.00e+00	964.00
IUUC-Ptr-090758	Pan troglodytes	89.03	0.00e+00	959.00
IUUC-Pan-092590	Papio anubis	88.10	0.00e+00	952.00
IUUC-Psi-093948	Pelodiscus sinensis	71.48	0.00e+00	803.00
IUUC-Pma-094434	Petromyzon marinus	45.89	2.00e-126	446.00
IUUC-Pfo-096912	Poecilia formosa	55.75	5.00e-168	584.00
IUUC-Pab-097651	Pongo abelii	89.03	0.00e+00	963.00
IUUC-Pca-100958	Procavia capensis	83.76	0.00e+00	688.00
IUUC-Pva-103247	Pteropus vampyrus	89.68	1.00e-125	443.00
IUUC-Pte-104279	Pyrenophora teres	27.85	2.00e-14	74.70
IUUC-Rno-104994	Rattus norvegicus	84.54	0.00e+00	905.00
IUUC-Sha-106494	Sarcophilus harrisii	80.82	0.00e+00	894.00
IUUC-Sar-113375	Sorex araneus	84.94	0.00e+00	912.00
IUUC-Sre-115218	Sporisorium reilianum	28.26	2.00e-17	84.00
IUUC-Ssc-115417	Sus scrofa	88.54	0.00e+00	967.00
IUUC-Tgu-117232	Taeniopygia guttata	75.35	0.00e+00	791.00
IUUC-Tru-118321	Takifugu rubripes	56.05	6.00e-167	580.00
IUUC-Tni-120475	Tetraodon nigroviridis	56.77	1.00e-164	572.00
IUUC-Tbe-127719	Tupaia belangeri	76.99	0.00e+00	796.00
IUUC-Ttr-129264	Tursiops truncatus	84.98	2.00e-118	419.00
IUUC-Uma-129620	Ustilago maydis	28.79	2.00e-19	91.30
IUUC-Vpa-130244	Vicugna pacos	85.38	1.00e-121	429.00
IUUC-Xtr-131948	Xenopus tropicalis	64.87	0.00e+00	730.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence