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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-064212
Ensembl Protein ID ENSMUSP00000110795.2
UniProt Accession Q8BN78; Q8C226; Q9WTZ7; KAISO_MOUSE
Genbank Protein ID AAD20989.1; BAC39866.1; BAC40875.1
Protein Name Transcriptional regulator Kaiso; Zinc finger and BTB domain-containing protein 33
Genbank Nucleotide ID AF097416; AK087417; AK089423
Gene Name Zbtb33; Kaiso
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000048047.3 ENSMUST00000115142.2 ENSMUSP00000110795.2
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarRAID2
Protein-protein Interaction
IIDHINTMentha
Post-translational Modifications (PTMs)
dbPAFPhosphositePlus
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB 7.70e-11 43.3 32 90
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/BCR/BTB_Other: BTB
   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgkl 65
           +Dv+++v++++f+ah+ +L+asS +F+ lf+        +  ve++ + +e f ++l+++Y++k+
   Q: 32   CDVTVIVEDRKFRAHRNILSASSTYFHQLFSV------AGQVVELSFIRAEIFAEILNYIYSSKV 90
           8*****************************44......478999999***************987 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Transcriptional regulator with bimodal DNA-binding specificity. Binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' and also binds to the non-methylated consensus sequence 5'-CTGCNA-3' also known as the consensus kaiso binding site (KBS). May recruit the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. Contributes to the repression of target genes of the Wnt signaling pathway. May also activate transcription of a subset of target genes by the recruitment of CTNND2. Represses expression of MMP7 in conjunction with transcriptional corepressors CBFA2T3, CBFA2T2 and RUNX1T1 (By similarity).
 Transcriptional regulator with bimodal DNA-binding specificity. Binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' and also binds to the non-methylated consensus sequence 5'-CTGCNA-3' also known as the consensus kaiso binding site (KBS). May recruit the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. Contributes to the repression of target genes of the Wnt signaling pathway. May also activate transcription of a subset of target genes by the recruitment of CTNND2. Represses expression of MMP7 in conjunction with transcriptional corepressors CBFA2T3, CBFA2T2 and RUNX1T1 (By similarity).
Protein Sequence
(Fasta)
MESRKLISAT DIQYSASLLN SLNEQRGHGL FCDVTVIVED RKFRAHRNIL SASSTYFHQL 60
FSVAGQVVEL SFIRAEIFAE ILNYIYSSKV VRVRADLLDE LIKSGQLLGV KFIAELGVPL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-064212|E3,BTB_Other|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGAAACTGGA GCGACATTTA AAGCGGCAGC AGCGGCGCTG CGGAGTCCGG CTGCTTGGGG 60
TAGGACTCTG ACCCTGCCTC GGCCCCGAGG AGGAGAAAGC GGCCGCCGCG GAGCAGGTGA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-064212|E3,BTB_Other|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0010--Activator
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0879--Wnt signaling pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR000210--BTB/POZ_dom
IPR011333--SKP1/BTB/POZ
IPR013087--Znf_C2H2_type
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50097--BTB
PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2
Pfam

PF00651--BTB
SMART

SM00225--BTB
SM00355--ZnF_C2H2
Gene Ontology

GO:0005829--C:cytosol
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0046872--F:metal ion binding
GO:0008327--F:methyl-CpG binding
GO:0043565--F:sequence-specific DNA binding
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
GO:0016055--P:Wnt signaling pathway
KEGG mmu:56805
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001231 Ailuropoda melanoleuca 87.98 0.00e+00 1126.00
IUUC-Apl-004182 Anas platyrhynchos 64.62 0.00e+00 806.00
IUUC-Aca-005098 Anolis carolinensis 65.70 1.00e-120 426.00
IUUC-Ame-011249 Astyanax mexicanus 43.77 6.00e-83 301.00
IUUC-Bta-013501 Bos taurus 86.80 0.00e+00 1125.00
IUUC-Cja-019946 Callithrix jacchus 86.35 0.00e+00 1149.00
IUUC-Cfa-020364 Canis familiaris 88.43 0.00e+00 1132.00
IUUC-Cpo-021927 Cavia porcellus 85.78 0.00e+00 1140.00
IUUC-Csa-023859 Chlorocebus sabaeus 87.69 0.00e+00 1146.00
IUUC-Cho-024727 Choloepus hoffmanni 79.86 4.00e-109 389.00
IUUC-Dre-028165 Danio rerio 50.35 2.00e-77 283.00
IUUC-Dno-029909 Dasypus novemcinctus 88.43 0.00e+00 1150.00
IUUC-Ete-032594 Echinops telfairi 81.54 0.00e+00 1073.00
IUUC-Eca-034341 Equus caballus 88.28 0.00e+00 1151.00
IUUC-Eeu-034685 Erinaceus europaeus 85.31 0.00e+00 1108.00
IUUC-Fca-036226 Felis catus 87.01 0.00e+00 1033.00
IUUC-Fal-037578 Ficedula albicollis 59.68 0.00e+00 742.00
IUUC-Gmo-038965 Gadus morhua 52.99 5.00e-78 285.00
IUUC-Gga-040745 Gallus gallus 63.07 0.00e+00 744.00
IUUC-Gac-041793 Gasterosteus aculeatus 50.87 2.00e-83 303.00
IUUC-Ggo-044435 Gorilla gorilla 88.13 0.00e+00 1153.00
IUUC-Hsa-045883 Homo sapiens 87.98 0.00e+00 1151.00
IUUC-Itr-048497 Ictidomys tridecemlineatus 87.70 0.00e+00 1168.00
IUUC-Lch-050532 Latimeria chalumnae 55.56 0.00e+00 680.00
IUUC-Loc-052122 Lepisosteus oculatus 53.52 8.00e-96 344.00
IUUC-Laf-054186 Loxodonta africana 85.79 0.00e+00 840.00
IUUC-Mcc-054996 Macaca mulatta 87.98 0.00e+00 1149.00
IUUC-Mga-059557 Meleagris gallopavo 60.41 0.00e+00 732.00
IUUC-Mmr-060657 Microcebus murinus 88.59 0.00e+00 1121.00
IUUC-Mdo-062476 Monodelphis domestica 72.89 0.00e+00 913.00
IUUC-Mpu-066496 Mustela putorius furo 87.69 0.00e+00 1122.00
IUUC-Mlu-067539 Myotis lucifugus 87.24 0.00e+00 1119.00
IUUC-Nle-069615 Nomascus leucogenys 88.28 0.00e+00 1156.00
IUUC-Ont-072534 Oreochromis niloticus 52.65 1.00e-80 294.00
IUUC-Oan-073502 Ornithorhynchus anatinus 64.55 1.00e-92 332.00
IUUC-Ocu-074395 Oryctolagus cuniculus 84.12 0.00e+00 1101.00
IUUC-Ola-087440 Oryzias latipes 69.66 2.00e-54 206.00
IUUC-Oga-088841 Otolemur garnettii 85.91 0.00e+00 1122.00
IUUC-Oar-089694 Ovis aries 86.94 0.00e+00 1125.00
IUUC-Ptr-091355 Pan troglodytes 88.13 0.00e+00 1153.00
IUUC-Pan-091850 Papio anubis 86.94 0.00e+00 1150.00
IUUC-Psi-094073 Pelodiscus sinensis 64.53 0.00e+00 815.00
IUUC-Pfo-097523 Poecilia formosa 45.21 2.00e-70 260.00
IUUC-Pab-097644 Pongo abelii 86.20 0.00e+00 1150.00
IUUC-Pca-100162 Procavia capensis 83.31 0.00e+00 1096.00
IUUC-Pva-103193 Pteropus vampyrus 86.35 0.00e+00 1146.00
IUUC-Rno-104989 Rattus norvegicus 96.13 0.00e+00 1261.00
IUUC-Sha-107147 Sarcophilus harrisii 72.78 0.00e+00 896.00
IUUC-Sja-107901 Schizosaccharomyces japonicus 27.78 6.20e-01 28.10
IUUC-Sar-113674 Sorex araneus 80.39 0.00e+00 971.00
IUUC-Ssc-116157 Sus scrofa 87.83 0.00e+00 1104.00
IUUC-Tgu-117210 Taeniopygia guttata 60.41 0.00e+00 740.00
IUUC-Tru-117894 Takifugu rubripes 50.36 5.00e-78 285.00
IUUC-Tni-120188 Tetraodon nigroviridis 50.54 4.00e-76 278.00
IUUC-Tbe-127795 Tupaia belangeri 80.92 0.00e+00 1057.00
IUUC-Ttr-128538 Tursiops truncatus 88.72 0.00e+00 1144.00
IUUC-Vpa-130051 Vicugna pacos 86.91 0.00e+00 736.00
IUUC-Xtr-132437 Xenopus tropicalis 50.47 3.00e-179 621.00
IUUC-Xma-133444 Xiphophorus maculatus 44.28 9.00e-73 267.00
Created Date 25-Jun-2017

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