iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Ath-007531

Ensembl Protein ID

AT3G12760.1

UniProt Accession

Q9LTV9; Q9LTV9_ARATH

Genbank Protein ID

AAN12949.1; AEE75243.1; BAB02420.1

Protein Name

Defective in cullin neddylation protein

Genbank Nucleotide ID

AY150404; CP002686; AB024033

Gene Name

At3g12760

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
AT3G12760	AT3G12760.1	AT3G12760.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/DCUN1	DCUN1	24711811

Classification

Family	E-value	Score	Start	End
E3 activity/DCUN1	3.50e-90	302.0	56	242
UBD/Alpha-Helix/UBA	6.70e-07	30.1	8	46

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/DCUN1

   S: 2    skkkleelferYkdpqedligieglekfcedlgvdpediavLvlawkleaatlcefsreefldgltalgcdsieklqeklktleselkdeqkfkdiYr 99
           ++++leel++rYkdp++d+i++eg++ +c+dl+v+p+di++Lvl+w+++aat+cefsr+ef++gl+alg+dsi klqekl++++selkdeqkf++iY+
   Q: 56   EVRRLEELYNRYKDPYSDMILAEGISVLCNDLEVEPQDIVTLVLSWHMNAATACEFSRQEFISGLQALGVDSIGKLQEKLPFMRSELKDEQKFHEIYN 153
           689*********************************************************************************************** PP
   S: 100  fafnfakdkgqksldldtaialwkLllaerefklldawlkfLeeekkksiskDtWnllLefskviakdlsnYdeegaWPvliDefveyl 188
           faf +ak+kgqksl+ldtai +w+Ll+aere++l+++w++fL+++++k+iskDtW++lLefs++++++lsnYd+egaWP+liDefveyl
   Q: 154  FAFGWAKEKGQKSLALDTAIGMWQLLFAEREWPLVTHWCDFLQDRHNKAISKDTWAQLLEFSRMVDPVLSNYDAEGAWPYLIDEFVEYL 242
           ***************************************************************************************97 PP

UBD/Alpha-Helix/UBA

   S: 3    dedkleqlve.MGFdreealqaLraannnleaAveyLld 40
           + dkl+q+v+ +G +++ alqaL a++++leaA + +++
   Q: 8    NRDKLQQFVAiTGASEKNALQALKASDWHLEAAFDVFYS 46
           569******************************999886 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.

Protein Sequence
(Fasta)

MHKLSRSNRD KLQQFVAITG ASEKNALQAL KASDWHLEAA FDVFYSQPQP RSNAAEVRRL 60
EELYNRYKDP YSDMILAEGI SVLCNDLEVE PQDIVTLVLS WHMNAATACE FSRQEFISGL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGAAATGAAA AAAACATTTT GCATAGAAGA GAGAGAGGCG GAGAGAGAGG AAAGTGAAGA 60
AGCAATCGTG AGAGACTCTC TCGAGTCTTC CCTGAGTCAC TCCTCTCCTC TCACACCTTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR014764--DCN-prot
IPR005176--PONY_dom
IPR009060--UBA-like

PROSITE

PS51229--DCUN1

Pfam

PF03556--Cullin_binding

Gene Ontology

GO:0000151--C:ubiquitin ligase complex
GO:0097602--F:cullin family protein binding
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0032182--F:ubiquitin-like protein binding
GO:0051443--P:positive regulation of ubiquitin-protein transferase activity
GO:0045116--P:protein neddylation

KEGG

ath:AT3G12760

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000561	Aegilops tauschii	70.80	5.00e-107	379.00
IUUC-Aml-001879	Ailuropoda melanoleuca	43.90	4.00e-58	217.00
IUUC-Atr-002697	Amborella trichopoda	81.82	3.00e-52	196.00
IUUC-Apl-003933	Anas platyrhynchos	44.31	4.00e-59	220.00
IUUC-Aca-005269	Anolis carolinensis	44.94	6.00e-58	216.00
IUUC-Aly-006285	Arabidopsis lyrata	84.80	2.00e-121	427.00
IUUC-Ago-007806	Ashbya gossypii	26.29	9.00e-18	83.20
IUUC-Acl-008172	Aspergillus clavatus	25.47	1.00e-22	99.80
IUUC-Afl-008569	Aspergillus flavus	28.68	3.00e-29	121.00
IUUC-Afu-009005	Aspergillus fumigatus	26.01	7.00e-17	79.30
IUUC-Ani-009241	Aspergillus nidulans	24.41	1.00e-21	95.90
IUUC-Ang-009664	Aspergillus niger	27.89	5.00e-24	103.00
IUUC-Aor-009902	Aspergillus oryzae	29.36	1.00e-10	58.20
IUUC-Ate-010414	Aspergillus terreus	26.92	2.00e-27	115.00
IUUC-Ame-011763	Astyanax mexicanus	45.93	8.00e-61	226.00
IUUC-Bgr-011991	Blumeria graminis	32.37	7.00e-20	90.10
IUUC-Bta-013561	Bos taurus	43.10	6.00e-53	199.00
IUUC-Bci-013824	Botrytis cinerea	31.58	6.00e-29	120.00
IUUC-Bdi-014138	Brachypodium distachyon	70.00	6.00e-106	375.00
IUUC-Bol-015564	Brassica oleracea	92.80	2.00e-138	483.00
IUUC-Bra-017111	Brassica rapa	92.00	8.00e-137	478.00
IUUC-Cel-018441	Caenorhabditis elegans	35.77	6.00e-42	163.00
IUUC-Cja-018854	Callithrix jacchus	44.31	7.00e-59	219.00
IUUC-Cfa-020523	Canis familiaris	43.53	1.00e-53	201.00
IUUC-Cpo-022196	Cavia porcellus	43.90	4.00e-58	217.00
IUUC-Cre-022620	Chlamydomonas reinhardtii	44.53	6.00e-60	223.00
IUUC-Csa-023551	Chlorocebus sabaeus	44.13	9.00e-59	219.00
IUUC-Cho-024373	Choloepus hoffmanni	43.50	3.00e-54	204.00
IUUC-Cin-025269	Ciona intestinalis	43.72	4.00e-61	226.00
IUUC-Csv-025976	Ciona savignyi	41.28	1.00e-34	139.00
IUUC-Cgl-026386	Colletotrichum gloeosporioides	27.78	6.00e-17	79.70
IUUC-Cne-026950	Cryptococcus neoformans	36.47	2.00e-39	155.00
IUUC-Cme-027199	Cyanidioschyzon merolae	28.00	2.00e-06	45.80
IUUC-Dre-028247	Danio rerio	45.93	2.00e-60	225.00
IUUC-Dno-028974	Dasypus novemcinctus	44.13	9.00e-59	219.00
IUUC-Dor-030143	Dipodomys ordii	43.50	2.00e-58	218.00
IUUC-Dse-031365	Dothistroma septosporum	28.99	2.00e-24	105.00
IUUC-Dme-032197	Drosophila melanogaster	40.76	2.00e-56	212.00
IUUC-Ete-032371	Echinops telfairi	43.90	3.00e-58	217.00
IUUC-Eca-033242	Equus caballus	43.90	4.00e-58	217.00
IUUC-Eeu-035317	Erinaceus europaeus	44.31	2.00e-58	218.00
IUUC-Fca-036061	Felis catus	43.72	3.00e-58	217.00
IUUC-Fal-036715	Ficedula albicollis	44.31	4.00e-59	220.00
IUUC-Fox-037884	Fusarium oxysporum	28.67	4.00e-13	67.00
IUUC-Fso-038150	Fusarium solani	23.84	3.00e-17	81.60
IUUC-Gmo-038885	Gadus morhua	45.93	6.00e-59	219.00
IUUC-Ggr-039959	Gaeumannomyces graminis	28.17	1.00e-15	77.40
IUUC-Gga-040935	Gallus gallus	43.72	3.00e-58	217.00
IUUC-Gac-041937	Gasterosteus aculeatus	45.12	2.00e-59	221.00
IUUC-Gma-043516	Glycine max	75.10	2.00e-114	404.00
IUUC-Ggo-044972	Gorilla gorilla	44.53	1.00e-59	221.00
IUUC-Hsa-046994	Homo sapiens	44.53	7.00e-60	223.00
IUUC-Hvu-047636	Hordeum vulgare	39.81	1.00e-20	91.70
IUUC-Itr-047902	Ictidomys tridecemlineatus	43.90	6.00e-58	216.00
IUUC-Kpa-049127	Komagataella pastoris	30.98	9.00e-29	119.00
IUUC-Lch-049751	Latimeria chalumnae	45.34	1.00e-60	225.00
IUUC-Lpe-051540	Leersia perrieri	70.97	3.00e-107	380.00
IUUC-Loc-052509	Lepisosteus oculatus	45.34	1.00e-59	222.00
IUUC-Lma-053103	Leptosphaeria maculans	29.41	2.00e-27	115.00
IUUC-Laf-053972	Loxodonta africana	44.72	9.00e-60	222.00
IUUC-Mcc-054700	Macaca mulatta	44.13	3.00e-59	221.00
IUUC-Meu-056791	Macropus eugenii	39.18	7.00e-45	173.00
IUUC-Mor-056909	Magnaporthe oryzae	26.64	1.00e-21	95.90
IUUC-Mpo-057299	Magnaporthe poae	26.47	9.00e-21	93.20
IUUC-Mtr-057964	Medicago truncatula	74.49	5.00e-112	396.00
IUUC-Mla-058990	Melampsora laricipopulina	27.24	8.00e-16	77.40
IUUC-Mga-060072	Meleagris gallopavo	44.72	2.00e-59	221.00
IUUC-Mvi-060312	Microbotryum violaceum	33.85	5.00e-37	147.00
IUUC-Mmr-060851	Microcebus murinus	43.90	5.00e-58	216.00
IUUC-Mdo-063074	Monodelphis domestica	43.90	3.00e-57	216.00
IUUC-Mmu-063816	Mus musculus	43.32	2.00e-58	218.00
IUUC-Mac-065016	Musa acuminata	77.35	1.00e-84	304.00
IUUC-Mpu-066870	Mustela putorius furo	43.53	1.00e-53	201.00
IUUC-Mlu-067701	Myotis lucifugus	43.50	5.00e-57	213.00
IUUC-Nfi-068610	Neosartorya fischeri	26.01	1.00e-16	79.00
IUUC-Ncr-068780	Neurospora crassa	24.34	8.00e-18	83.60
IUUC-Nle-069475	Nomascus leucogenys	44.53	2.00e-59	221.00
IUUC-Opr-070682	Ochotona princeps	43.15	2.00e-44	171.00
IUUC-Ont-071408	Oreochromis niloticus	44.90	4.00e-59	220.00
IUUC-Oan-073031	Ornithorhynchus anatinus	44.31	3.00e-58	217.00
IUUC-Ocu-074648	Oryctolagus cuniculus	43.90	4.00e-58	217.00
IUUC-Oba-074993	Oryza barthii	71.49	2.00e-108	384.00
IUUC-Obr-076341	Oryza brachyantha	71.08	8.00e-109	385.00
IUUC-Ogl-077099	Oryza glaberrima	71.49	2.00e-108	384.00
IUUC-Ogu-078285	Oryza glumaepatula	71.49	2.00e-108	384.00
IUUC-Oin-079441	Oryza indica	71.89	7.00e-109	385.00
IUUC-Olo-081037	Oryza longistaminata	71.89	7.00e-109	385.00
IUUC-Ome-081357	Oryza meridionalis	71.89	7.00e-109	385.00
IUUC-Oni-082632	Oryza nivara	71.89	1.00e-108	385.00
IUUC-Opu-083351	Oryza punctata	71.79	9.00e-102	362.00
IUUC-Oru-084306	Oryza rufipogon	71.89	7.00e-109	385.00
IUUC-Osa-085307	Oryza sativa	71.89	7.00e-109	385.00
IUUC-Ola-086868	Oryzias latipes	44.72	7.00e-60	223.00
IUUC-Olu-087646	Ostreococcus lucimarinus	41.87	4.00e-53	200.00
IUUC-Oga-088621	Otolemur garnettii	43.50	4.00e-58	217.00
IUUC-Oar-090405	Ovis aries	43.50	2.00e-57	214.00
IUUC-Ptr-091595	Pan troglodytes	44.31	1.00e-58	218.00
IUUC-Pan-092825	Papio anubis	44.13	2.00e-59	221.00
IUUC-Psi-093029	Pelodiscus sinensis	43.53	6.00e-53	199.00
IUUC-Pma-094196	Petromyzon marinus	39.57	5.00e-41	160.00
IUUC-Pno-095145	Phaeosphaeria nodorum	30.30	6.00e-21	93.60
IUUC-Ppa-095306	Physcomitrella patens	70.56	4.00e-105	373.00
IUUC-Pfo-096774	Poecilia formosa	45.31	5.00e-60	223.00
IUUC-Pab-098197	Pongo abelii	43.53	1.00e-53	201.00
IUUC-Pop-098821	Populus trichocarpa	82.30	6.00e-55	204.00
IUUC-Pca-100218	Procavia capensis	43.09	3.00e-57	214.00
IUUC-Ppe-102032	Prunus persica	77.20	5.00e-118	416.00
IUUC-Pva-102691	Pteropus vampyrus	44.94	2.00e-60	224.00
IUUC-Pgr-103633	Puccinia graminis	28.42	9.00e-22	96.70
IUUC-Ptt-103979	Puccinia triticina	35.82	5.00e-03	34.70
IUUC-Pyt-104428	Pyrenophora triticirepentis	27.49	4.00e-22	97.40
IUUC-Rno-105016	Rattus norvegicus	43.72	1.00e-58	218.00
IUUC-Sce-106358	Saccharomyces cerevisiae	26.64	2.00e-20	92.40
IUUC-Sha-106542	Sarcophilus harrisii	43.72	2.00e-58	218.00
IUUC-Sja-107938	Schizosaccharomyces japonicus	29.10	3.00e-21	94.70
IUUC-Spo-108207	Schizosaccharomyces pombe	33.18	6.00e-23	100.00
IUUC-Ssl-108410	Sclerotinia sclerotiorum	32.03	2.00e-29	122.00
IUUC-Smo-108750	Selaginella moellendorffii	63.93	1.00e-89	321.00
IUUC-Sit-110052	Setaria italica	73.90	6.00e-112	395.00
IUUC-Sly-111489	Solanum lycopersicum	77.82	5.00e-117	412.00
IUUC-Stu-112517	Solanum tuberosum	59.60	1.00e-91	328.00
IUUC-Sar-113509	Sorex araneus	43.02	4.00e-38	150.00
IUUC-Sbi-114113	Sorghum bicolor	73.90	2.00e-111	394.00
IUUC-Sre-115221	Sporisorium reilianum	27.68	3.00e-24	105.00
IUUC-Ssc-115547	Sus scrofa	44.13	9.00e-59	219.00
IUUC-Tgu-117196	Taeniopygia guttata	44.72	3.00e-59	221.00
IUUC-Tru-117740	Takifugu rubripes	46.94	2.00e-61	228.00
IUUC-Tsy-119599	Tarsius syrichta	43.90	3.00e-58	217.00
IUUC-Tni-120315	Tetraodon nigroviridis	43.09	8.00e-57	213.00
IUUC-Tca-121033	Theobroma cacao	77.11	5.00e-118	416.00
IUUC-Tre-121986	Trichoderma reesei	25.00	6.00e-20	90.90
IUUC-Tvi-122607	Trichoderma virens	31.50	8.00e-26	109.00
IUUC-Tae-125740	Triticum aestivum	60.82	3.00e-101	360.00
IUUC-Tur-126375	Triticum urartu	55.00	2.00e-96	345.00
IUUC-Tme-126878	Tuber melanosporum	32.27	3.00e-34	138.00
IUUC-Tbe-127429	Tupaia belangeri	43.15	4.00e-44	171.00
IUUC-Ttr-129086	Tursiops truncatus	40.24	5.00e-50	190.00
IUUC-Uma-129364	Ustilago maydis	29.19	2.00e-30	125.00
IUUC-Vda-129929	Verticillium dahliae	27.23	3.00e-17	82.00
IUUC-Vpa-130048	Vicugna pacos	37.40	1.00e-43	169.00
IUUC-Vvi-130834	Vitis vinifera	77.60	6.00e-118	416.00
IUUC-Xtr-131888	Xenopus tropicalis	43.90	1.00e-58	218.00
IUUC-Xma-134122	Xiphophorus maculatus	44.31	3.00e-61	227.00
IUUC-Yli-134595	Yarrowia lipolytica	30.51	2.00e-30	125.00
IUUC-Zma-135864	Zea mays	74.90	2.00e-112	397.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence