iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Laf-053909

UUCD1 version

UUC-LoA-01114

Ensembl Protein ID

ENSLAFP00000025828.1

UniProt Accession

G3UDC0; G3UDC0_LOXAF

Protein Name

Ubiquitinyl hydrolase 1

Gene Name

USP13

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000015504.3	ENSLAFT00000030717.1	ENSLAFP00000025828.1
ENSLAFG00000015504.3	ENSLAFT00000015506.3	ENSLAFP00000012992.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.00e-55	189.6	339	862
UBD/Alpha-Helix/UBA	2.90e-18	65.7	733	770

Active Site

Position(s)	Description	Evidence
348	Nucleophile	{ECO:0000256\|PIRSR:PIRSR016308-1}
826	Proton acceptor	{ECO:0000256\|PIRSR:PIRSR016308-1}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeel......................wkskkka 67
           tGlkNlgN+CY+ Sv+Q++++ipe+++++  + ++ ++ + p +p++++ ++++kl + l                       k +++ 
   Q: 339  TGLKNLGNSCYLSSVMQAIFSIPEFQRAYVGNLPRIFDYS-PLDPTQDFNTQMTKLGHGLlsgqyskppvkselieqvikedHKPQQNG 426
           7******************************788777765.79*****************8888888888888777765544488888* PP
   S: 68   vsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikc 156
           +spr++++ +++ ++efs+++qqDaqEf+ +l++ +e++                               +++  sd+F++ ++++i+c
   Q: 427  ISPRMFKAFVSNSHPEFSSNRQQDAQEFFLHLVNLVERHR-----------------------------IGSENPSDVFRFLVEERIQC 486
           ************************************9988.............................788899************** PP
   S: 157  lecdnvssreepfldlslpvpgkeetkke...........................slqdcLesftkeeelegenkyycekckkkqeae 218
            + ++v  +e   + ++lpv ++  t+k                             ++ cL++++++e++++   ++++  ++k+  +
   Q: 487  CQTRKVRYTERVDYLMQLPVAMEAATNKDeliayeltrreaetnrrplpelvrakiPFSACLQAYSEPENVDD---FWSSALQAKSAGV 572
           ******9999999999999999998887799****************************************97...************* PP
   S: 219  kklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts........................................ 267
           k+ ++ ++Pe+L++++k+f+f  + ++++k++ ++++p+ Ld+++  ++                                        
   Q: 573  KTSRFASFPEYLVVQIKKFTFGLD-WVPKKFDVSIDMPDLLDINHLRARglqpgeeelpdisppivipddskdrlmnqlidpsdidess 660
           *********************997.*******************998888999999999999999998888888888888888887777 PP
   S: 268  ......................................................................................... 267
                                                                                                    
   Q: 661  vmqlaemgfpleacrkavyftgnmgaevafnwiiihmeepdfaepltipgyggaasagasafgatgldnkppeeivaiitsmgfqrnqa 749
           77777777777777777777777777777777777777777777777777777777777777766666666666666666666665555 PP
   S: 268  ......peekqke................................................kkkYeLiavvvHsG.slssGHYvayvkn 301
                 +     +                                                + +YeL+a ++H+G s+ sGHYv+++k+
   Q: 750  vqalraT-----NhnleraldwifghpefeedsdfvigmennananiiseakpegprvkdgSGTYELFAFISHMGtSTMSGHYVCHIKK 833
           5555550.....0555555555555555555566666666666667777788888888888**************************** PP
   S: 302  ekgkWllfdDskVtevkeeevleetgstaYvlfYk 336
            +g+W+ ++D+kV ++  e+  +   + +Y++fY 
   Q: 834  -EGRWVIYNDHKVCAS--ERPPK---DLGYLYFYC 862
           .9***********999..67888...89*****96 PP

UBD/Alpha-Helix/UBA

   S: 4    edkleqlveMGFdreealqaLraannnleaAveyLldg 41
           e++++ +++MGF r++a+qaLra+n nle+A+++++ +
   Q: 733  EEIVAIITSMGFQRNQAVQALRATNHNLERALDWIFGH 770
           899********************************976 PP

Organism

Loxodonta africana

Protein Sequence
(Fasta)

MQRRGALFSV PGGRGSRKMA AGDIGELLVP HMPTIRVPRS GDRVYKNECA FSYDSPNSEG 60
GLYVCMNTFL AFGREHVERH FRKTGQSVYM HLKRHVREKV RGASGGALPK RRNSKIFLDL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCAGCGCC GGGGCGCCCT TTTCAGCGTG CCGGGCGGCA GAGGCAGCAG GAAGATGGCT 60
GCAGGAGACA TCGGCGAGCT GCTGGTGCCC CACATGCCCA CGATCCGAGT GCCCAGGTCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR016652--Ubiquitinyl_hydrolase
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS50030--UBA
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00627--UBA
PF00443--UCH
PF02148--zf-UBP

SMART

SM00165--UBA
SM00290--ZnF_UBP

Gene Ontology

GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:1904454--F:ubiquitin-specific protease activity involved in positive regulation of ERAD pathway
GO:0008270--F:zinc ion binding
GO:0008283--P:cell proliferation
GO:1904378--P:maintenance of unfolded protein involved in ERAD pathway
GO:0035523--P:protein K29-linked deubiquitination
GO:0044313--P:protein K6-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0050821--P:protein stabilization
GO:0010506--P:regulation of autophagy
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

lav:100670440

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001356	Ailuropoda melanoleuca	96.06	0.00e+00	1579.00
IUUC-Apl-003712	Anas platyrhynchos	81.82	0.00e+00	1328.00
IUUC-Aca-004634	Anolis carolinensis	81.99	0.00e+00	1372.00
IUUC-Ame-011470	Astyanax mexicanus	73.11	0.00e+00	1259.00
IUUC-Bta-013349	Bos taurus	95.61	0.00e+00	1617.00
IUUC-Cja-019021	Callithrix jacchus	94.80	0.00e+00	1568.00
IUUC-Cfa-020614	Canis familiaris	96.07	0.00e+00	1588.00
IUUC-Cpo-022484	Cavia porcellus	96.21	0.00e+00	1486.00
IUUC-Csa-024078	Chlorocebus sabaeus	96.54	0.00e+00	1597.00
IUUC-Cho-024522	Choloepus hoffmanni	79.88	0.00e+00	1148.00
IUUC-Cme-027335	Cyanidioschyzon merolae	25.52	2.00e-52	200.00
IUUC-Dre-027651	Danio rerio	73.14	0.00e+00	1320.00
IUUC-Dno-028975	Dasypus novemcinctus	95.85	0.00e+00	1585.00
IUUC-Dor-030130	Dipodomys ordii	71.67	0.00e+00	1040.00
IUUC-Ete-032251	Echinops telfairi	81.36	0.00e+00	1263.00
IUUC-Eca-033568	Equus caballus	96.30	0.00e+00	1480.00
IUUC-Eeu-034612	Erinaceus europaeus	78.15	0.00e+00	1126.00
IUUC-Fca-036280	Felis catus	96.42	0.00e+00	1479.00
IUUC-Fal-036610	Ficedula albicollis	82.84	0.00e+00	1303.00
IUUC-Gmo-038906	Gadus morhua	71.96	0.00e+00	1232.00
IUUC-Gga-041215	Gallus gallus	81.57	0.00e+00	1404.00
IUUC-Gac-042441	Gasterosteus aculeatus	70.19	0.00e+00	1247.00
IUUC-Ggo-044446	Gorilla gorilla	96.30	0.00e+00	1597.00
IUUC-Hsa-046546	Homo sapiens	96.42	0.00e+00	1594.00
IUUC-Itr-048147	Ictidomys tridecemlineatus	88.30	0.00e+00	1409.00
IUUC-Lch-050425	Latimeria chalumnae	76.61	0.00e+00	1326.00
IUUC-Loc-052072	Lepisosteus oculatus	76.25	0.00e+00	1282.00
IUUC-Mcc-054686	Macaca mulatta	96.54	0.00e+00	1596.00
IUUC-Meu-056361	Macropus eugenii	78.87	0.00e+00	1278.00
IUUC-Mga-059972	Meleagris gallopavo	77.51	0.00e+00	1272.00
IUUC-Mmr-060916	Microcebus murinus	94.69	0.00e+00	1585.00
IUUC-Mdo-062302	Monodelphis domestica	87.91	0.00e+00	1475.00
IUUC-Mmu-063639	Mus musculus	94.23	0.00e+00	1578.00
IUUC-Mpu-066533	Mustela putorius furo	96.42	0.00e+00	1591.00
IUUC-Mlu-067786	Myotis lucifugus	89.47	0.00e+00	1438.00
IUUC-Nle-069997	Nomascus leucogenys	96.50	0.00e+00	1471.00
IUUC-Ont-071859	Oreochromis niloticus	71.10	0.00e+00	1248.00
IUUC-Oan-072959	Ornithorhynchus anatinus	85.95	1.00e-124	438.00
IUUC-Ocu-074265	Oryctolagus cuniculus	95.94	0.00e+00	1567.00
IUUC-Ola-087344	Oryzias latipes	70.30	0.00e+00	1248.00
IUUC-Oga-088734	Otolemur garnettii	96.29	0.00e+00	1531.00
IUUC-Oar-089636	Ovis aries	95.68	0.00e+00	1541.00
IUUC-Ptr-090982	Pan troglodytes	96.42	0.00e+00	1596.00
IUUC-Pan-091991	Papio anubis	96.65	0.00e+00	1598.00
IUUC-Psi-093509	Pelodiscus sinensis	84.78	0.00e+00	1425.00
IUUC-Pfo-096029	Poecilia formosa	72.95	0.00e+00	1290.00
IUUC-Pab-098672	Pongo abelii	92.15	0.00e+00	1494.00
IUUC-Pca-100860	Procavia capensis	73.36	0.00e+00	1021.00
IUUC-Pva-102545	Pteropus vampyrus	88.34	0.00e+00	1445.00
IUUC-Rno-105210	Rattus norvegicus	94.11	0.00e+00	1569.00
IUUC-Sar-113733	Sorex araneus	94.10	0.00e+00	758.00
IUUC-Tgu-116591	Taeniopygia guttata	83.04	0.00e+00	1403.00
IUUC-Tru-118627	Takifugu rubripes	70.15	0.00e+00	1255.00
IUUC-Tsy-119278	Tarsius syrichta	87.28	0.00e+00	1319.00
IUUC-Tni-120804	Tetraodon nigroviridis	72.80	0.00e+00	1283.00
IUUC-Tbe-127699	Tupaia belangeri	78.13	0.00e+00	856.00
IUUC-Ttr-128295	Tursiops truncatus	86.85	0.00e+00	1435.00
IUUC-Vpa-130170	Vicugna pacos	85.06	0.00e+00	1304.00
IUUC-Xtr-132809	Xenopus tropicalis	72.83	0.00e+00	1241.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence