iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oan-073378

Ensembl Protein ID

ENSOANP00000016238.3

UniProt Accession

F7AD40; F7AD40_ORNAN

Protein Name

Presenilin

Gene Name

PSEN2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOANG00000010238.3	ENSOANT00000016241.3	ENSOANP00000016238.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/Alpha-Helix/CUE	4.80e-07	29.9	283	310

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/CUE

   S: 2    letaleqLkeiFPnldysviqvvLeant 29
           +eta+e++++iFP+l+ys+ +v+++ ++
   Q: 283  VETAQERNEPIFPALIYSSAMVWPVGMA 310
           89**********************9887 PP

Organism

Ornithorhynchus anatinus

Functional Description
(View)

Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.

Protein Sequence
(Fasta)

MITFMNSDSE EEVCNERTSL MSAESPTSRS YQDGTAVPEA GEDVAQRKHP ANWDPGTGAV 60
RCAPGSRGAA RSPALENEEE EEEPSLKYGA KHVIMLFVPV TLCMVVVVAT IKSVRFYTEK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGGGGGGCGT GGCCTGGGAA GGGGGCGTGG CCTTGGGGGT CGGGGGGCGG GGCCCGGCTG 60
CGAGCGCAGG GACCGGTGCT GTGATCAACA TCTCCGGGCC GGGCGGGCGG TGGAGGTAGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0333--Golgi apparatus
KW-0378--Hydrolase
KW-0472--Membrane
KW-0914--Notch signaling pathway
KW-0645--Protease
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR001493--Pept_A22A_PS2
IPR001108--Peptidase_A22A
IPR006639--Preselin/SPP

Pfam

PF01080--Presenilin

PRINTS

PR01072--PRESENILIN
PR01074--PRESENILIN2

SMART

SM00730--PSN

Gene Ontology

GO:0005813--C:centrosome
GO:0005789--C:endoplasmic reticulum membrane
GO:0000139--C:Golgi membrane
GO:0005887--C:integral component of plasma membrane
GO:0000776--C:kinetochore
GO:0043025--C:neuronal cell body
GO:0005637--C:nuclear inner membrane
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0030018--C:Z disc
GO:0004190--F:aspartic-type endopeptidase activity
GO:0004175--F:endopeptidase activity
GO:0042987--P:amyloid precursor protein catabolic process
GO:0050435--P:beta-amyloid metabolic process
GO:0006816--P:calcium ion transport
GO:0035556--P:intracellular signal transduction
GO:0006509--P:membrane protein ectodomain proteolysis
GO:0043066--P:negative regulation of apoptotic process
GO:0007220--P:Notch receptor processing
GO:0007219--P:Notch signaling pathway
GO:0043085--P:positive regulation of catalytic activity
GO:0016485--P:protein processing

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002356	Ailuropoda melanoleuca	67.49	3.00e-116	411.00
IUUC-Apl-003959	Anas platyrhynchos	74.39	1.00e-144	505.00
IUUC-Aca-005160	Anolis carolinensis	69.60	1.00e-144	505.00
IUUC-Ame-010686	Astyanax mexicanus	76.74	2.00e-121	427.00
IUUC-Bta-013097	Bos taurus	74.63	9.00e-146	509.00
IUUC-Cel-018553	Caenorhabditis elegans	52.81	1.00e-81	296.00
IUUC-Cja-018824	Callithrix jacchus	72.68	2.00e-142	498.00
IUUC-Cfa-020253	Canis familiaris	74.38	2.00e-144	504.00
IUUC-Cpo-021401	Cavia porcellus	73.66	6.00e-145	506.00
IUUC-Cre-022747	Chlamydomonas reinhardtii	35.48	6.00e-29	121.00
IUUC-Csa-023369	Chlorocebus sabaeus	75.56	6.00e-149	519.00
IUUC-Cin-025780	Ciona intestinalis	59.71	5.00e-99	353.00
IUUC-Dre-028526	Danio rerio	67.82	2.00e-130	458.00
IUUC-Dor-031127	Dipodomys ordii	73.30	6.00e-138	483.00
IUUC-Eca-034387	Equus caballus	74.81	1.00e-142	498.00
IUUC-Eeu-034846	Erinaceus europaeus	66.25	5.00e-110	390.00
IUUC-Fca-035396	Felis catus	73.53	4.00e-148	517.00
IUUC-Fal-037457	Ficedula albicollis	75.12	8.00e-147	512.00
IUUC-Gmo-038550	Gadus morhua	82.08	9.00e-99	352.00
IUUC-Gga-040706	Gallus gallus	74.14	5.00e-144	503.00
IUUC-Gac-042511	Gasterosteus aculeatus	63.86	2.00e-114	405.00
IUUC-Ggo-045338	Gorilla gorilla	75.56	1.00e-148	518.00
IUUC-Hsa-046455	Homo sapiens	75.56	2.00e-148	518.00
IUUC-Itr-048731	Ictidomys tridecemlineatus	74.88	4.00e-148	517.00
IUUC-Lch-049638	Latimeria chalumnae	66.27	1.00e-127	449.00
IUUC-Loc-052427	Lepisosteus oculatus	72.02	3.00e-143	501.00
IUUC-Laf-053758	Loxodonta africana	72.93	1.00e-154	538.00
IUUC-Mcc-054755	Macaca mulatta	75.56	1.00e-148	519.00
IUUC-Mmr-060890	Microcebus murinus	73.66	4.00e-146	510.00
IUUC-Mdo-062197	Monodelphis domestica	78.24	3.00e-164	570.00
IUUC-Mmu-063823	Mus musculus	74.39	1.00e-148	518.00
IUUC-Mpu-066181	Mustela putorius furo	73.17	4.00e-144	503.00
IUUC-Nle-069596	Nomascus leucogenys	75.85	9.00e-151	525.00
IUUC-Opr-070344	Ochotona princeps	75.31	3.00e-151	527.00
IUUC-Ont-071867	Oreochromis niloticus	68.73	6.00e-121	426.00
IUUC-Ocu-074652	Oryctolagus cuniculus	75.31	1.00e-147	515.00
IUUC-Ola-086707	Oryzias latipes	70.26	2.00e-101	361.00
IUUC-Oga-088560	Otolemur garnettii	74.32	2.00e-143	501.00
IUUC-Oar-089200	Ovis aries	74.14	1.00e-143	502.00
IUUC-Ptr-090569	Pan troglodytes	75.31	7.00e-148	516.00
IUUC-Pan-091742	Papio anubis	75.56	4.00e-149	520.00
IUUC-Psi-093297	Pelodiscus sinensis	74.65	8.00e-130	456.00
IUUC-Pma-094612	Petromyzon marinus	73.33	4.00e-110	390.00
IUUC-Ppa-095431	Physcomitrella patens	32.77	3.00e-24	105.00
IUUC-Pab-098531	Pongo abelii	75.56	6.00e-149	519.00
IUUC-Pca-101120	Procavia capensis	72.44	7.00e-139	486.00
IUUC-Pva-102934	Pteropus vampyrus	68.54	1.00e-140	492.00
IUUC-Rno-106052	Rattus norvegicus	74.15	3.00e-152	530.00
IUUC-Sha-106876	Sarcophilus harrisii	77.86	5.00e-158	550.00
IUUC-Ssc-115380	Sus scrofa	74.88	3.00e-148	517.00
IUUC-Tgu-117280	Taeniopygia guttata	75.62	2.00e-149	521.00
IUUC-Tbe-127632	Tupaia belangeri	80.44	5.00e-135	473.00
IUUC-Ttr-129008	Tursiops truncatus	70.98	2.00e-142	498.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence