iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Pfo-097396

Ensembl Protein ID

ENSPFOP00000022420.1

UniProt Accession

A0A096LTC9; A0A096LTC9_POEFO

Genbank Protein ID

ENSPFOP00000022420

Protein Name

Presenilin

Genbank Nucleotide ID

AYCK01013016

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPFOG00000023620.1	ENSPFOT00000024332.1	ENSPFOP00000022420.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/Alpha-Helix/CUE	3.10e-08	34.0	278	306

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/CUE

   S: 2    letaleqLkeiFPnldysviqvvLeantg 30
           +eta+e++++iFP+l+ys+++v+L+++++
   Q: 278  VETAQERNEPIFPALIYSSTMVWLVNMAD 306
           89*************************98 PP

Organism

Poecilia formosa

Functional Description
(View)

Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.

Protein Sequence
(Fasta)

MANNAEDVEN NMKDQQQANS SPEAAQQPQE APATRARSRG GSGDEGGGDG SGPEQNGQPP 60
AAHPARVVEN EEEEDEEMTL KYGAKHVIML FVPVTLCMVV VVATIKSVSF YTKNDGQRLI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCGTTTCCGG CTTCCACTGG AGCTGCTTCC GCCTGCCTCC GGAGCTCCGC CACCGCAGCT 60
CGATGAGAGC CGAATCGACT CGAGCAGGAA GCGGACGGAT GTTCTGGGAG GAAGGCAGGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0333--Golgi apparatus
KW-0378--Hydrolase
KW-0472--Membrane
KW-0914--Notch signaling pathway
KW-0645--Protease
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR002031--Pept_A22A_PS1
IPR001108--Peptidase_A22A
IPR006639--Preselin/SPP

Pfam

PF01080--Presenilin

PRINTS

PR01072--PRESENILIN

SMART

SM00730--PSN

Gene Ontology

GO:0005789--C:endoplasmic reticulum membrane
GO:0000139--C:Golgi membrane
GO:0016021--C:integral component of membrane
GO:0004190--F:aspartic-type endopeptidase activity
GO:0035556--P:intracellular signal transduction
GO:0007219--P:Notch signaling pathway
GO:0016485--P:protein processing

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000686	Aegilops tauschii	33.12	1.00e-24	108.00
IUUC-Aml-001648	Ailuropoda melanoleuca	72.19	3.00e-123	434.00
IUUC-Atr-003039	Amborella trichopoda	30.11	2.00e-37	150.00
IUUC-Apl-003727	Anas platyrhynchos	74.88	6.00e-148	517.00
IUUC-Aca-004582	Anolis carolinensis	76.54	2.00e-151	528.00
IUUC-Aly-005455	Arabidopsis lyrata	30.23	5.00e-17	82.40
IUUC-Ath-006730	Arabidopsis thaliana	31.63	6.00e-18	85.50
IUUC-Ame-011500	Astyanax mexicanus	83.06	6.00e-167	580.00
IUUC-Bta-013026	Bos taurus	74.69	9.00e-147	513.00
IUUC-Bdi-014196	Brachypodium distachyon	33.24	2.00e-31	130.00
IUUC-Bol-015841	Brassica oleracea	33.65	1.00e-29	124.00
IUUC-Bra-017580	Brassica rapa	58.62	8.00e-18	84.70
IUUC-Cel-018553	Caenorhabditis elegans	51.98	5.00e-100	358.00
IUUC-Cja-019994	Callithrix jacchus	74.81	5.00e-144	504.00
IUUC-Cfa-020074	Canis familiaris	76.50	4.00e-147	514.00
IUUC-Cpo-022237	Cavia porcellus	75.69	2.00e-144	505.00
IUUC-Cre-022747	Chlamydomonas reinhardtii	33.64	8.00e-29	122.00
IUUC-Csa-023537	Chlorocebus sabaeus	74.81	9.00e-145	506.00
IUUC-Cho-024735	Choloepus hoffmanni	68.08	9.00e-135	473.00
IUUC-Cin-025780	Ciona intestinalis	63.25	4.00e-124	438.00
IUUC-Csv-025967	Ciona savignyi	62.08	3.00e-120	425.00
IUUC-Dre-028689	Danio rerio	82.00	1.00e-157	549.00
IUUC-Dno-029758	Dasypus novemcinctus	76.56	5.00e-147	514.00
IUUC-Dor-031127	Dipodomys ordii	72.40	3.00e-93	335.00
IUUC-Dme-031929	Drosophila melanogaster	54.22	2.00e-109	389.00
IUUC-Ete-033081	Echinops telfairi	52.43	2.00e-56	213.00
IUUC-Eca-034387	Equus caballus	66.17	1.00e-119	423.00
IUUC-Eeu-035134	Erinaceus europaeus	74.19	3.00e-110	391.00
IUUC-Fca-036243	Felis catus	75.00	1.00e-146	513.00
IUUC-Fal-036600	Ficedula albicollis	76.22	5.00e-151	527.00
IUUC-Gmo-039665	Gadus morhua	79.39	7.00e-130	457.00
IUUC-Gga-040993	Gallus gallus	76.22	1.00e-151	529.00
IUUC-Gac-042342	Gasterosteus aculeatus	76.51	7.00e-156	543.00
IUUC-Gma-043822	Glycine max	36.36	5.00e-21	95.50
IUUC-Ggo-045338	Gorilla gorilla	71.54	2.00e-100	359.00
IUUC-Hsa-046822	Homo sapiens	74.81	1.00e-144	506.00
IUUC-Hvu-047141	Hordeum vulgare	31.90	9.00e-27	114.00
IUUC-Itr-048731	Ictidomys tridecemlineatus	71.54	2.00e-100	359.00
IUUC-Lch-049946	Latimeria chalumnae	70.82	1.00e-129	456.00
IUUC-Lpe-051132	Leersia perrieri	51.49	3.00e-15	76.60
IUUC-Loc-052469	Lepisosteus oculatus	67.63	4.00e-143	501.00
IUUC-Laf-053979	Loxodonta africana	73.57	2.00e-133	469.00
IUUC-Mcc-055682	Macaca mulatta	74.81	1.00e-144	506.00
IUUC-Meu-056004	Macropus eugenii	61.40	7.00e-117	414.00
IUUC-Mtr-058392	Medicago truncatula	34.47	1.00e-29	124.00
IUUC-Mga-059466	Meleagris gallopavo	75.76	2.00e-151	529.00
IUUC-Mmr-060890	Microcebus murinus	65.41	2.00e-120	426.00
IUUC-Mdo-062122	Monodelphis domestica	73.66	2.00e-148	518.00
IUUC-Mmu-063176	Mus musculus	75.69	9.00e-139	486.00
IUUC-Mac-064858	Musa acuminata	36.36	4.00e-19	89.00
IUUC-Mpu-065927	Mustela putorius furo	76.94	3.00e-146	511.00
IUUC-Mlu-067079	Myotis lucifugus	76.57	2.00e-153	535.00
IUUC-Nle-070180	Nomascus leucogenys	74.81	1.00e-144	506.00
IUUC-Opr-070847	Ochotona princeps	67.53	2.00e-139	488.00
IUUC-Ont-071846	Oreochromis niloticus	85.13	0.00e+00	667.00
IUUC-Oan-072783	Ornithorhynchus anatinus	73.08	1.00e-113	402.00
IUUC-Ocu-074527	Oryctolagus cuniculus	76.19	2.00e-147	515.00
IUUC-Oba-075256	Oryza barthii	31.72	5.00e-25	108.00
IUUC-Obr-076302	Oryza brachyantha	42.07	2.00e-15	77.40
IUUC-Ogl-077097	Oryza glaberrima	31.23	3.00e-26	112.00
IUUC-Ogu-078570	Oryza glumaepatula	31.23	5.00e-26	112.00
IUUC-Oin-079244	Oryza indica	31.51	2.00e-26	113.00
IUUC-Olo-080484	Oryza longistaminata	59.26	9.00e-16	77.40
IUUC-Ome-081814	Oryza meridionalis	29.73	4.00e-21	96.30
IUUC-Oni-082057	Oryza nivara	31.51	2.00e-26	113.00
IUUC-Opu-084176	Oryza punctata	31.32	2.00e-25	110.00
IUUC-Oru-084618	Oryza rufipogon	31.23	6.00e-26	112.00
IUUC-Osa-085602	Oryza sativa	31.76	4.00e-26	112.00
IUUC-Ola-086707	Oryzias latipes	77.98	7.00e-89	320.00
IUUC-Olu-087811	Ostreococcus lucimarinus	32.58	4.00e-41	162.00
IUUC-Oga-088560	Otolemur garnettii	65.16	3.00e-120	425.00
IUUC-Oar-090348	Ovis aries	75.69	9.00e-148	516.00
IUUC-Ptr-091060	Pan troglodytes	74.81	1.00e-144	506.00
IUUC-Pan-091855	Papio anubis	68.17	1.00e-129	456.00
IUUC-Psi-093505	Pelodiscus sinensis	75.52	8.00e-151	526.00
IUUC-Pma-094612	Petromyzon marinus	69.52	6.00e-121	427.00
IUUC-Ppa-095431	Physcomitrella patens	31.65	2.00e-24	107.00
IUUC-Pab-098591	Pongo abelii	74.81	1.00e-144	506.00
IUUC-Pop-099661	Populus trichocarpa	31.96	7.00e-32	131.00
IUUC-Pca-101029	Procavia capensis	72.47	3.00e-136	478.00
IUUC-Ppe-101495	Prunus persica	29.89	2.00e-34	140.00
IUUC-Pva-102244	Pteropus vampyrus	73.18	3.00e-140	492.00
IUUC-Rno-105861	Rattus norvegicus	74.11	5.00e-141	494.00
IUUC-Sha-107045	Sarcophilus harrisii	74.36	1.00e-149	523.00
IUUC-Smo-109325	Selaginella moellendorffii	35.44	6.00e-35	141.00
IUUC-Sit-110624	Setaria italica	57.14	2.00e-15	77.40
IUUC-Sly-110865	Solanum lycopersicum	56.36	1.00e-06	44.70
IUUC-Stu-112433	Solanum tuberosum	31.58	3.00e-29	122.00
IUUC-Sar-113169	Sorex araneus	70.59	1.00e-110	393.00
IUUC-Sbi-114305	Sorghum bicolor	32.48	1.00e-23	104.00
IUUC-Ssc-115766	Sus scrofa	75.99	4.00e-147	514.00
IUUC-Tgu-117280	Taeniopygia guttata	71.36	1.00e-128	453.00
IUUC-Tru-117732	Takifugu rubripes	84.15	0.00e+00	647.00
IUUC-Tsy-119624	Tarsius syrichta	67.84	2.00e-130	459.00
IUUC-Tni-119852	Tetraodon nigroviridis	80.43	0.00e+00	627.00
IUUC-Tca-121865	Theobroma cacao	31.66	5.00e-35	142.00
IUUC-Tae-123984	Triticum aestivum	34.41	7.00e-26	112.00
IUUC-Tur-126237	Triticum urartu	34.41	3.00e-26	112.00
IUUC-Tbe-128148	Tupaia belangeri	64.50	1.00e-102	366.00
IUUC-Ttr-128793	Tursiops truncatus	75.94	4.00e-142	498.00
IUUC-Vpa-130625	Vicugna pacos	62.47	2.00e-113	402.00
IUUC-Vvi-131312	Vitis vinifera	31.47	5.00e-32	132.00
IUUC-Xtr-131790	Xenopus tropicalis	76.94	3.00e-140	491.00
IUUC-Xma-133377	Xiphophorus maculatus	92.66	0.00e+00	711.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence