iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCJAG00000006106.2	ENSCJAT00000011892.2	ENSCJAP00000011269.2
ENSCJAG00000006106.2	ENSCJAT00000011965.2	ENSCJAP00000011340.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	3.10e-41	142.8	387	695

Active Site

Position(s)	Description	Evidence
665	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 7    krlevefvgEe...gldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlpl 92
           + +ev +v E+   g +++G+++efl+ll+++l+n++  lf  + + +++l+ n+++      +++l++ +G++l+++l++g + + ++
   Q: 387  YAIEVAYVIENdnfGSEQPGSKQEFLSLLMQHLENSS--LF--EGSLSKNLSLNSQAL-----KENLYYEAGKMLAISLVHGGPSPGFF 466
           56788888877777***********************..45..677788888888885.....689*********************** PP
   S: 93   sksfyklllgkklsledleevdpelyks.lkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvvey 180
           sk+++ +l+  +   e+++ + +++ ++ + +i  +   ++ ++ +dl++      ++e++++    g+ +   t ++k++ vk+++ y
   Q: 467  SKTLFDCLVYGP---EHTQPILDDVSDFdVAQIIIRI--NTATTVADLKSV-----INECSNYLEFIGCLRLITTLSDKYMLVKDILVY 545
           ***********8...*************988888774..556666788876.....88999**99************************ PP
   S: 181  rlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevl.eef....sseerkaf 264
           ++ ++++e +++f++G++++  le+++++ e   ++l+++ e+++++ l +   ++ ++ +d +a+  Fw+ + +++    s ++  ++
   Q: 546  HVIQRVQEPFKSFKQGLKTLGVLEKIQAYPEAFYSILCHKPESLSAKILGD--LFTVHTLPDVKAL-GFWNSYlQAVedgkSTTKMEDI 631
           *************************************************99..888899******8.8887664555111144556778 PP
   S: 265  LqFvTgssrlPlgGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           L F+Tg++++P++Gf++ + ++ +++      ++P  n+C n+L +P  +++++++e++ +Ai++t ++e
   Q: 632  LIFATGCNSIPPAGFKPTP-SIECLHM-----DFPVGNKCNNCLAIPITNTYKEFQENMDFAIRNTLRLE 695
           88****************9.9999999.....********************************987665 PP

Organism

Callithrix jacchus

Protein Sequence
(Fasta)

MNENKPGDSQ NLACVFCRKN DDCPNKYGEK KTNEKWNLTV HYYCLLMSSG IWQRGKEEEG 60
VYGFLIEDIR KEVNRASKLK CSICKKNGAS IGCVAPRCKR SYHFPCGLER ECIFQFTGNF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAATTTGAAT CTTGTGGGCC GTTGAGTGTG GCTGCTCGCG GTCGGCGTGC CGCGGCGCCG 60
AGCGGGCAGG GAAAAGTGAC ACTGACGTTG TGGAACTTCT GCTGGGTGCA CGTTGGTGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR034732--EPHD
IPR000569--HECT_dom
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51805--EPHD
PS50237--HECT
PS01359--ZF_PHD_1

Pfam

PF00632--HECT

SMART

SM00119--HECTc
SM00249--PHD

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding

KEGG

cjc:100393333

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001501	Ailuropoda melanoleuca	89.63	0.00e+00	1336.00
IUUC-Apl-003763	Anas platyrhynchos	59.29	0.00e+00	830.00
IUUC-Aca-004328	Anolis carolinensis	60.75	0.00e+00	867.00
IUUC-Ame-011288	Astyanax mexicanus	39.97	4.00e-162	565.00
IUUC-Bta-012496	Bos taurus	85.65	0.00e+00	1280.00
IUUC-Cfa-020806	Canis familiaris	88.49	0.00e+00	1323.00
IUUC-Cpo-022519	Cavia porcellus	85.49	0.00e+00	1250.00
IUUC-Csa-023957	Chlorocebus sabaeus	95.17	0.00e+00	1396.00
IUUC-Cho-024375	Choloepus hoffmanni	82.03	0.00e+00	1162.00
IUUC-Cin-025325	Ciona intestinalis	42.37	8.00e-69	253.00
IUUC-Csv-026262	Ciona savignyi	43.51	5.00e-70	258.00
IUUC-Dre-027829	Danio rerio	40.31	3.00e-153	535.00
IUUC-Dno-029362	Dasypus novemcinctus	87.64	0.00e+00	1287.00
IUUC-Dor-030710	Dipodomys ordii	83.10	0.00e+00	1244.00
IUUC-Dme-031692	Drosophila melanogaster	35.06	2.00e-43	170.00
IUUC-Ete-032282	Echinops telfairi	83.68	0.00e+00	916.00
IUUC-Eca-033963	Equus caballus	88.78	0.00e+00	1331.00
IUUC-Eeu-035029	Erinaceus europaeus	85.09	0.00e+00	1269.00
IUUC-Fca-036229	Felis catus	89.35	0.00e+00	1338.00
IUUC-Fal-037015	Ficedula albicollis	57.07	0.00e+00	854.00
IUUC-Gmo-039715	Gadus morhua	40.32	1.00e-79	289.00
IUUC-Gga-040298	Gallus gallus	57.41	0.00e+00	881.00
IUUC-Gac-041444	Gasterosteus aculeatus	39.29	2.00e-141	496.00
IUUC-Ggo-045456	Gorilla gorilla	94.32	0.00e+00	1383.00
IUUC-Hsa-046297	Homo sapiens	94.74	0.00e+00	1392.00
IUUC-Itr-047897	Ictidomys tridecemlineatus	87.00	0.00e+00	910.00
IUUC-Lch-050287	Latimeria chalumnae	65.75	2.00e-105	376.00
IUUC-Loc-052839	Lepisosteus oculatus	55.96	1.00e-32	130.00
IUUC-Laf-053581	Loxodonta africana	86.85	0.00e+00	1276.00
IUUC-Mcc-055615	Macaca mulatta	95.17	0.00e+00	1396.00
IUUC-Meu-056753	Macropus eugenii	48.88	1.00e-128	453.00
IUUC-Mga-059902	Meleagris gallopavo	57.49	0.00e+00	885.00
IUUC-Mmr-061522	Microcebus murinus	91.76	0.00e+00	1353.00
IUUC-Mdo-063022	Monodelphis domestica	65.57	0.00e+00	895.00
IUUC-Mmu-063609	Mus musculus	75.52	0.00e+00	1152.00
IUUC-Mpu-066656	Mustela putorius furo	88.64	0.00e+00	1328.00
IUUC-Mlu-067011	Myotis lucifugus	87.57	0.00e+00	1285.00
IUUC-Nle-069949	Nomascus leucogenys	94.46	0.00e+00	1386.00
IUUC-Opr-071224	Ochotona princeps	83.27	2.00e-130	459.00
IUUC-Ont-072174	Oreochromis niloticus	37.30	4.00e-135	475.00
IUUC-Oan-072712	Ornithorhynchus anatinus	67.34	0.00e+00	960.00
IUUC-Ocu-073776	Oryctolagus cuniculus	88.64	0.00e+00	1308.00
IUUC-Ola-087247	Oryzias latipes	37.01	2.00e-129	456.00
IUUC-Oga-088094	Otolemur garnettii	86.47	0.00e+00	1206.00
IUUC-Oar-090248	Ovis aries	85.65	0.00e+00	1273.00
IUUC-Ptr-090634	Pan troglodytes	94.60	0.00e+00	1389.00
IUUC-Pan-092876	Papio anubis	95.31	0.00e+00	1398.00
IUUC-Psi-093580	Pelodiscus sinensis	60.40	0.00e+00	866.00
IUUC-Pma-094295	Petromyzon marinus	53.17	6.00e-73	266.00
IUUC-Pfo-096351	Poecilia formosa	36.36	3.00e-140	492.00
IUUC-Pab-097596	Pongo abelii	94.60	0.00e+00	1389.00
IUUC-Pca-100309	Procavia capensis	80.51	0.00e+00	1185.00
IUUC-Pva-102526	Pteropus vampyrus	90.41	0.00e+00	840.00
IUUC-Rno-105432	Rattus norvegicus	81.25	0.00e+00	1216.00
IUUC-Sha-107089	Sarcophilus harrisii	65.23	0.00e+00	1002.00
IUUC-Sar-113667	Sorex araneus	70.83	0.00e+00	763.00
IUUC-Ssc-116200	Sus scrofa	89.47	0.00e+00	1321.00
IUUC-Tgu-116467	Taeniopygia guttata	57.08	0.00e+00	838.00
IUUC-Tru-117690	Takifugu rubripes	37.41	1.00e-149	523.00
IUUC-Tsy-119481	Tarsius syrichta	86.60	0.00e+00	903.00
IUUC-Tni-119669	Tetraodon nigroviridis	36.85	2.00e-133	469.00
IUUC-Tbe-127241	Tupaia belangeri	80.68	0.00e+00	1143.00
IUUC-Ttr-129057	Tursiops truncatus	80.11	0.00e+00	1141.00
IUUC-Vpa-130685	Vicugna pacos	86.49	0.00e+00	1250.00
IUUC-Xtr-132555	Xenopus tropicalis	53.38	0.00e+00	750.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence