iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Fal-037468

Ensembl Protein ID

ENSFALP00000006091.1

UniProt Accession

U3JTI7; U3JTI7_FICAL

Genbank Protein ID

ENSFALP00000006091

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AGTO01000322

Gene Name

HECTD1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFALG00000005851.1	ENSFALT00000006118.1	ENSFALP00000006091.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.40e-123	412.2	2127	2585

Active Site

Position(s)	Description	Evidence
2554	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysen..dketlqpnpdsglknp..................... 65
           ++d+k++levef+gEeg++l G+t+ef+al+++e+q++dlg++l++++  d+e++q++   glk+p                     
   Q: 2127 HADRKSVLEVEFLGEEGTGL-GPTLEFYALVAAEFQRTDLGAWLCDDDfpDDESRQVDIGGGLKPPgyyvqrscglftapfpqdsde 2212
           6899****************.******************************************988********************* PP
   S: 66   ..ehlklFeflGrllgkalqdgrlldlplsksfykll.................................................. 100
             + +klF+flG++l+k++qd+rl+dlp+sk+f+kl+                                                  
   Q: 2213 leRITKLFHFLGIFLAKCIQDNRLVDLPISKPFFKLMcmgdiksnmskliyesrgdrdlhctesqseasteeghdslsvgsleedsk 2299
           *************************************99999999999999999999999999999999999999988888887777 PP
   S: 101  ...............lgkklsledleevdpelykslkeikenaes..................................dieelgld 138
                          ++  l++ed+e v+p+++++lkeik++a +                                  +ie+lgl+
   Q: 2300 sefildppkpkppawFNGILTWEDFELVNPHRARFLKEIKDLAIKrrqilsnknlsedekntklqelmlknpsgsgpplSIEDLGLN 2386
           7777777666666666668***********************933444555566777778889999999999*************** PP
   S: 139  ltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeid 225
           ++f++s++++g t+++ LkpgGe++ Vt++N+eeYv+l++++++++gi++q+eafr+Gfn+v+p+e+ls+F++ee+++++cG+   +
   Q: 2387 FQFCPSSKVYGFTAVD-LKPGGEDETVTMDNAEEYVDLMFDFCMHTGIQKQMEAFRDGFNRVFPMEKLSSFSHEEVQMILCGN---Q 2469
           *************999.******************************************************************...6 PP
   S: 226  vedlkket..ky...kggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnTCfn 306
           ++++++e+  +y   k gyt+dsp++ +F++vl+++ss+erkafLqF+Tg+s+lP+gG+a+l+prl+++rk da+d+++Ps+nTC++
   Q: 2470 SPSWAAEDiiNYtepKLGYTRDSPGFLRFVRVLCGMSSDERKAFLQFTTGCSTLPPGGLANLHPRLTIVRKvDATDASYPSVNTCVH 2556
           666666665555555************************************************************************ PP
   S: 307  yLkLPeYsskeilkekLlyAieetkgFels 336
           yLkLPeYss+ei++e+Ll+A++e kgF+l+
   Q: 2557 YLKLPEYSSEEIMRERLLAATME-KGFHLN 2585
           ***********************.****86 PP

Organism

Ficedula albicollis

Protein Sequence
(Fasta)

MADVDPDTLL EWLQMGQGDE RDMQLIALEQ LCMLLLMSDN VDRCFETCPP RTFLPALCKI 60
FLDESAPDNV LEVTARAITY YLDVSAECTR RIVGVDGAIK ALCNRLVVVE LNNRTSRDLA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGGGGGGGG GGGGGGGGGG GGGGGGGGGG GGGGGGGGGG GGGGGGGGGG GGGGGGCTTT 60
TTTTTTTTTT ATAAATAACC ATGGCAGATG TGGATCCAGA CACATTGCTG GAATGGCTGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0040--ANK repeat
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR008979--Galactose-bd-like
IPR000569--HECT_dom
IPR010606--Mib_Herc2
IPR012919--SUN_dom

PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50237--HECT
PS51416--MIB_HERC2

Pfam

PF12796--Ank_2
PF00632--HECT
PF06701--MIB_HERC2
PF07738--Sad1_UNC

SMART

SM00248--ANK
SM00119--HECTc

Gene Ontology

GO:0046872--F:metal ion binding
GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001987	Ailuropoda melanoleuca	95.56	0.00e+00	2837.00
IUUC-Apl-003493	Anas platyrhynchos	97.34	0.00e+00	2892.00
IUUC-Aca-004521	Anolis carolinensis	96.63	0.00e+00	4509.00
IUUC-Ame-011258	Astyanax mexicanus	90.04	0.00e+00	2385.00
IUUC-Bta-012835	Bos taurus	95.44	0.00e+00	2841.00
IUUC-Cel-018153	Caenorhabditis elegans	52.70	1.00e-173	604.00
IUUC-Cja-019174	Callithrix jacchus	93.92	0.00e+00	2758.00
IUUC-Cfa-021115	Canis familiaris	95.20	0.00e+00	2786.00
IUUC-Cpo-022382	Cavia porcellus	89.57	0.00e+00	2597.00
IUUC-Csa-023230	Chlorocebus sabaeus	95.56	0.00e+00	2837.00
IUUC-Cho-024711	Choloepus hoffmanni	93.71	0.00e+00	1614.00
IUUC-Cin-025342	Ciona intestinalis	52.38	0.00e+00	1372.00
IUUC-Csv-026031	Ciona savignyi	51.77	0.00e+00	1409.00
IUUC-Dre-027435	Danio rerio	89.67	0.00e+00	2630.00
IUUC-Dno-029954	Dasypus novemcinctus	95.73	0.00e+00	2814.00
IUUC-Dor-030734	Dipodomys ordii	90.34	0.00e+00	1409.00
IUUC-Dme-031739	Drosophila melanogaster	59.39	0.00e+00	1625.00
IUUC-Ete-033192	Echinops telfairi	87.02	0.00e+00	1166.00
IUUC-Eca-033434	Equus caballus	94.45	0.00e+00	2797.00
IUUC-Eeu-035031	Erinaceus europaeus	79.18	0.00e+00	1056.00
IUUC-Fca-035998	Felis catus	93.07	0.00e+00	2723.00
IUUC-Gmo-038495	Gadus morhua	88.56	0.00e+00	1363.00
IUUC-Gga-040736	Gallus gallus	98.30	0.00e+00	4538.00
IUUC-Gac-041777	Gasterosteus aculeatus	90.01	0.00e+00	2394.00
IUUC-Ggo-044677	Gorilla gorilla	91.30	0.00e+00	2657.00
IUUC-Hsa-045879	Homo sapiens	95.56	0.00e+00	2837.00
IUUC-Itr-048664	Ictidomys tridecemlineatus	95.73	0.00e+00	2840.00
IUUC-Lch-050444	Latimeria chalumnae	93.47	0.00e+00	2691.00
IUUC-Loc-051986	Lepisosteus oculatus	89.05	0.00e+00	2616.00
IUUC-Laf-054230	Loxodonta africana	95.21	0.00e+00	2772.00
IUUC-Mcc-054787	Macaca mulatta	95.56	0.00e+00	2837.00
IUUC-Meu-056502	Macropus eugenii	87.97	0.00e+00	1302.00
IUUC-Mga-059409	Meleagris gallopavo	96.82	0.00e+00	1937.00
IUUC-Mmr-061667	Microcebus murinus	94.58	0.00e+00	2800.00
IUUC-Mdo-061960	Monodelphis domestica	95.98	0.00e+00	2836.00
IUUC-Mmu-063941	Mus musculus	94.39	0.00e+00	2779.00
IUUC-Mpu-065939	Mustela putorius furo	95.56	0.00e+00	2837.00
IUUC-Mlu-068112	Myotis lucifugus	95.50	0.00e+00	2839.00
IUUC-Nle-069001	Nomascus leucogenys	95.56	0.00e+00	2838.00
IUUC-Opr-071222	Ochotona princeps	90.98	0.00e+00	2070.00
IUUC-Ont-072101	Oreochromis niloticus	85.45	0.00e+00	2617.00
IUUC-Oan-072814	Ornithorhynchus anatinus	96.21	0.00e+00	2836.00
IUUC-Ocu-074011	Oryctolagus cuniculus	95.62	0.00e+00	2839.00
IUUC-Ola-086412	Oryzias latipes	90.02	0.00e+00	2405.00
IUUC-Oar-089668	Ovis aries	95.44	0.00e+00	2834.00
IUUC-Ptr-090517	Pan troglodytes	94.79	0.00e+00	2792.00
IUUC-Pan-091849	Papio anubis	92.30	0.00e+00	2701.00
IUUC-Psi-093390	Pelodiscus sinensis	95.32	0.00e+00	4404.00
IUUC-Pma-094628	Petromyzon marinus	82.32	0.00e+00	1585.00
IUUC-Pfo-097075	Poecilia formosa	83.95	0.00e+00	2871.00
IUUC-Pab-098176	Pongo abelii	95.56	0.00e+00	2837.00
IUUC-Pca-101123	Procavia capensis	90.47	0.00e+00	1550.00
IUUC-Pva-103008	Pteropus vampyrus	95.74	0.00e+00	1572.00
IUUC-Rno-105885	Rattus norvegicus	94.96	0.00e+00	2822.00
IUUC-Sha-107048	Sarcophilus harrisii	95.40	0.00e+00	2820.00
IUUC-Sar-113071	Sorex araneus	90.10	0.00e+00	1260.00
IUUC-Ssc-115963	Sus scrofa	94.96	0.00e+00	2816.00
IUUC-Tgu-117167	Taeniopygia guttata	99.65	0.00e+00	1717.00
IUUC-Tru-118626	Takifugu rubripes	85.54	0.00e+00	2628.00
IUUC-Tsy-119504	Tarsius syrichta	92.01	0.00e+00	2244.00
IUUC-Tni-119877	Tetraodon nigroviridis	90.47	0.00e+00	2410.00
IUUC-Tbe-127602	Tupaia belangeri	89.03	0.00e+00	1027.00
IUUC-Ttr-128394	Tursiops truncatus	96.39	0.00e+00	1673.00
IUUC-Vpa-130280	Vicugna pacos	94.96	0.00e+00	2811.00
IUUC-Xtr-131787	Xenopus tropicalis	83.12	0.00e+00	3955.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence