iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mdo-061971

Ensembl Protein ID

ENSMODP00000035507.1

UniProt Accession

F7DVK7; F7DVK7_MONDO

Protein Name

E3 ubiquitin-protein ligase

Gene Name

SIAH2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000021275.2	ENSMODT00000027070.2	ENSMODP00000026594.2
ENSMODG00000021275.2	ENSMODT00000037093.1	ENSMODP00000035507.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	98.82	3.00e-152	535.00	IUUC-Hsa-046179
E3 activity/RING/RING	98.82	9.00e-152	533.00	IUUC-Mmu-063206
E3 activity/RING/RING	98.82	7.00e-152	533.00	IUUC-Rno-105477

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Monodelphis domestica

Functional Description
(View)

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

Protein Sequence
(Fasta)

HAPSQAAPPA AATISAAGPG SSAVAAAAAV ISGPGGGGGG GGPVSPQHHE LTSLFECPVC 60
FDYVLPPILQ CQAGHLVCNQ CRQKLSCCPT CRGSLTPSIR NLAMEKVASA VLFPCKYATT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCAGCACAAC AAGCCGGGCT CCTCCTTCCC GGGTCGGGGC GGAGAACGCC TCCCTCGGCC 60
CACGCCCCGC TGCGAAGCCA GGCGGAGTCA AGCTCCGTGG GCAGCCTGCC GCTGCCATTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR018121--7-in-absentia-prot_TRAF-dom
IPR001370--BIR_rpt
IPR004162--SINA-like
IPR008974--TRAF-like
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR013010--Znf_SIAH

PROSITE

PS50089--ZF_RING_2
PS51081--ZF_SIAH

Pfam

PF03145--Sina

Gene Ontology

GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0007275--P:multicellular organism development
GO:0090090--P:negative regulation of canonical Wnt signaling pathway
GO:0043154--P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:2001237--P:negative regulation of extrinsic apoptotic signaling pathway
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000061	Aegilops tauschii	35.46	5.00e-40	157.00
IUUC-Aml-001409	Ailuropoda melanoleuca	98.84	6.00e-155	540.00
IUUC-Atr-002857	Amborella trichopoda	36.76	6.00e-41	160.00
IUUC-Apl-003813	Anas platyrhynchos	84.92	2.00e-130	457.00
IUUC-Aca-005014	Anolis carolinensis	84.92	2.00e-130	458.00
IUUC-Aly-006522	Arabidopsis lyrata	36.55	3.00e-37	149.00
IUUC-Ath-007192	Arabidopsis thaliana	36.14	8.00e-37	147.00
IUUC-Ame-011678	Astyanax mexicanus	92.09	3.00e-141	494.00
IUUC-Bta-012750	Bos taurus	98.43	3.00e-153	534.00
IUUC-Bdi-014200	Brachypodium distachyon	36.90	1.00e-40	160.00
IUUC-Bol-015983	Brassica oleracea	36.14	2.00e-37	149.00
IUUC-Bra-017336	Brassica rapa	35.08	3.00e-38	152.00
IUUC-Cel-018320	Caenorhabditis elegans	69.72	8.00e-109	387.00
IUUC-Cja-019800	Callithrix jacchus	98.82	1.00e-153	535.00
IUUC-Cfa-020505	Canis familiaris	99.22	2.00e-153	534.00
IUUC-Cpo-021394	Cavia porcellus	95.70	8.00e-154	536.00
IUUC-Csa-023374	Chlorocebus sabaeus	98.82	1.00e-153	535.00
IUUC-Cho-024933	Choloepus hoffmanni	98.82	2.00e-153	534.00
IUUC-Cin-025674	Ciona intestinalis	82.40	3.00e-126	444.00
IUUC-Csv-026233	Ciona savignyi	82.00	1.00e-125	441.00
IUUC-Dre-027711	Danio rerio	91.70	5.00e-141	493.00
IUUC-Dno-029260	Dasypus novemcinctus	98.78	1.00e-146	512.00
IUUC-Dor-030489	Dipodomys ordii	97.30	4.00e-108	382.00
IUUC-Dme-031700	Drosophila melanogaster	82.26	3.00e-115	407.00
IUUC-Ete-032946	Echinops telfairi	98.07	2.00e-155	541.00
IUUC-Eca-033546	Equus caballus	98.45	2.00e-154	538.00
IUUC-Eeu-034861	Erinaceus europaeus	94.96	2.00e-147	514.00
IUUC-Fca-035362	Felis catus	84.92	2.00e-130	458.00
IUUC-Fal-037160	Ficedula albicollis	88.05	3.00e-132	464.00
IUUC-Gmo-039091	Gadus morhua	90.51	1.00e-139	489.00
IUUC-Gga-040252	Gallus gallus	97.67	2.00e-151	528.00
IUUC-Gac-041673	Gasterosteus aculeatus	89.72	2.00e-139	488.00
IUUC-Gma-042926	Glycine max	34.52	1.00e-35	143.00
IUUC-Ggo-044618	Gorilla gorilla	98.82	1.00e-153	535.00
IUUC-Hsa-046179	Homo sapiens	98.82	1.00e-153	535.00
IUUC-Hvu-047574	Hordeum vulgare	35.86	2.00e-40	159.00
IUUC-Itr-048976	Ictidomys tridecemlineatus	97.67	2.00e-152	530.00
IUUC-Lch-049496	Latimeria chalumnae	95.33	4.00e-149	520.00
IUUC-Lpe-050879	Leersia perrieri	38.27	5.00e-39	154.00
IUUC-Loc-052107	Lepisosteus oculatus	92.80	2.00e-141	494.00
IUUC-Laf-054257	Loxodonta africana	98.45	2.00e-152	531.00
IUUC-Mcc-055023	Macaca mulatta	98.82	1.00e-153	535.00
IUUC-Meu-055922	Macropus eugenii	97.65	3.00e-149	520.00
IUUC-Mtr-058747	Medicago truncatula	34.52	3.00e-37	149.00
IUUC-Mga-060070	Meleagris gallopavo	96.11	1.00e-147	515.00
IUUC-Mmr-061494	Microcebus murinus	98.82	1.00e-153	535.00
IUUC-Mmu-063206	Mus musculus	98.82	7.00e-153	533.00
IUUC-Mac-065014	Musa acuminata	37.25	2.00e-39	156.00
IUUC-Mpu-066597	Mustela putorius furo	98.82	1.00e-153	535.00
IUUC-Mlu-067199	Myotis lucifugus	98.43	9.00e-153	532.00
IUUC-Nle-069342	Nomascus leucogenys	98.82	1.00e-153	535.00
IUUC-Opr-070341	Ochotona princeps	56.86	6.00e-50	190.00
IUUC-Ont-071906	Oreochromis niloticus	90.12	2.00e-140	491.00
IUUC-Oan-073701	Ornithorhynchus anatinus	53.85	1.00e-49	189.00
IUUC-Ocu-073950	Oryctolagus cuniculus	98.46	3.00e-155	541.00
IUUC-Oba-075454	Oryza barthii	38.27	1.00e-38	153.00
IUUC-Obr-076037	Oryza brachyantha	33.86	2.00e-36	145.00
IUUC-Ogl-077712	Oryza glaberrima	38.27	1.00e-38	153.00
IUUC-Ogu-078910	Oryza glumaepatula	37.19	1.00e-38	153.00
IUUC-Oin-079749	Oryza indica	38.27	1.00e-38	153.00
IUUC-Olo-080244	Oryza longistaminata	34.92	5.00e-36	145.00
IUUC-Ome-081318	Oryza meridionalis	37.19	1.00e-38	153.00
IUUC-Oni-083109	Oryza nivara	38.27	1.00e-38	153.00
IUUC-Opu-084065	Oryza punctata	37.60	6.00e-39	154.00
IUUC-Oru-084785	Oryza rufipogon	38.27	1.00e-38	153.00
IUUC-Osa-085610	Oryza sativa	38.27	1.00e-38	153.00
IUUC-Ola-086814	Oryzias latipes	84.92	5.00e-130	456.00
IUUC-Oga-089154	Otolemur garnettii	98.82	1.00e-153	535.00
IUUC-Oar-089446	Ovis aries	98.44	8.00e-153	532.00
IUUC-Ptr-091088	Pan troglodytes	98.82	1.00e-153	535.00
IUUC-Pan-092012	Papio anubis	84.92	2.00e-130	458.00
IUUC-Psi-093079	Pelodiscus sinensis	99.24	3.00e-159	553.00
IUUC-Pma-094387	Petromyzon marinus	84.58	6.00e-129	453.00
IUUC-Ppa-095212	Physcomitrella patens	35.74	3.00e-37	148.00
IUUC-Pfo-097007	Poecilia formosa	86.17	1.00e-133	469.00
IUUC-Pab-098092	Pongo abelii	98.82	1.00e-153	535.00
IUUC-Pop-099970	Populus trichocarpa	34.13	2.00e-41	162.00
IUUC-Pca-100328	Procavia capensis	95.69	4.00e-147	513.00
IUUC-Ppe-101760	Prunus persica	36.55	4.00e-39	154.00
IUUC-Pva-102368	Pteropus vampyrus	99.11	1.00e-63	236.00
IUUC-Rno-105477	Rattus norvegicus	98.82	7.00e-153	533.00
IUUC-Sha-107630	Sarcophilus harrisii	99.62	2.00e-159	554.00
IUUC-Smo-109412	Selaginella moellendorffii	33.87	2.00e-35	142.00
IUUC-Sit-110595	Setaria italica	35.71	3.00e-38	152.00
IUUC-Sly-111259	Solanum lycopersicum	35.63	1.00e-37	150.00
IUUC-Stu-112571	Solanum tuberosum	36.03	6.00e-38	151.00
IUUC-Sbi-114090	Sorghum bicolor	35.71	9.00e-39	154.00
IUUC-Ssc-116441	Sus scrofa	98.43	3.00e-153	533.00
IUUC-Tgu-116579	Taeniopygia guttata	84.92	2.00e-130	457.00
IUUC-Tru-118004	Takifugu rubripes	87.35	1.00e-134	472.00
IUUC-Tsy-119548	Tarsius syrichta	88.72	5.00e-67	247.00
IUUC-Tni-120846	Tetraodon nigroviridis	88.93	3.00e-137	480.00
IUUC-Tca-121228	Theobroma cacao	34.26	5.00e-37	147.00
IUUC-Tae-123647	Triticum aestivum	35.46	5.00e-40	157.00
IUUC-Tur-126049	Triticum urartu	32.80	3.00e-34	139.00
IUUC-Ttr-129166	Tursiops truncatus	83.90	2.00e-118	419.00
IUUC-Vpa-130799	Vicugna pacos	98.27	7.00e-103	365.00
IUUC-Vvi-131365	Vitis vinifera	37.24	1.00e-37	149.00
IUUC-Xtr-132113	Xenopus tropicalis	94.19	1.00e-147	515.00
IUUC-Xma-133670	Xiphophorus maculatus	84.92	5.00e-130	456.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence