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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045686
Ensembl Protein ID ENSP00000355583.3
UniProt Accession Q5TCX8; B2RN34; Q5TCX7; Q5TCX9; Q8WWN1; Q8WWN2; Q96JM1; M3KL4_HUMAN
Genbank Protein ID CAC84639.1; CAC84640.1; BAB47433.1; CAI23045.1; CAI23046.1; CAI23047.1; EAW69988.1; AAI36649.1; AAI36650.1
Protein Name Mitogen-activated protein kinase kinase kinase MLK4; Mixed lineage kinase 4
Genbank Nucleotide ID AJ311797; AJ311798; AB058707; AL133380; AL133380; AL133380; CH471098; BC136648; BC136649
Gene Name RP5-862P8.2; MLK4; KIAA1804
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000143674.10 ENST00000366623.7 ENSP00000355582.3
ENSG00000143674.10 ENST00000366624.7 ENSP00000355583.3
ENSG00000143674.10 ENST00000366622.1 ENSP00000355581.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsiteCircNetmiRTarBase
microRNATRANSFACTargetScanRepTar
SomamiRRAID2
Protein-protein Interaction
IIDMentha
Protein 3D Structure
PDBMMDB
Disease-associated Variation
GWASdbGWAS CentralOMIM
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMHPRD
Phospho.ELMUniProt
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/SH3 1.30e-13 52.3 44 99
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/SH3
   S: 7    qvlydyeaqnddeLtlkkGdvvlvi...ekeeqdegWlkgvkelegkrGlfPenFvek 61
            +lydyea  +deL+l++G  v+v+      + degW+ g  + + + G+fP+n+v+ 
   Q: 44   AALYDYEARGEDELSLRRGQLVEVLsqdAAVSGDEGWWAG--QVQRRLGIFPANYVAP 99
           69***********************54444578*******..7*************86 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Negative regulator of TLR4 signaling. Does not activate JNK1/MAPK8 pathway, p38/MAPK14, nor ERK2/MAPK1 pathways.
 Negative regulator of TLR4 signaling. Does not activate JNK1/MAPK8 pathway, p38/MAPK14, nor ERK2/MAPK1 pathways.
Protein Sequence
(Fasta)
MALRGAAGAT DTPVSSAGGA PGGSASSSST SSGGSASAGA GLWAALYDYE ARGEDELSLR 60
RGQLVEVLSQ DAAVSGDEGW WAGQVQRRLG IFPANYVAPC RPAASPAPPP SRPSSPVHVA 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045686|UBD,SH3|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CAGGGCCTGG GCACGACCAT GGTGGGACGT CGCCCGCGGC TTCGGGGACC GCTGCGGCAG 60
CAGAGGCGGC TGGCCAGGAA CGCGGGCCGA GGCTGGACCC TTTGGGCAGC TAGCCCGTGA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045686|UBD,SH3|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0723--Serine/threonine-protein kinase
KW-0728--SH3 domain
KW-0808--Transferase
Interpro

IPR011009--Kinase-like_dom
IPR016231--MLK1/MLK2/MLK4
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR008271--Ser/Thr_kinase_AS
IPR001452--SH3_domain
PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST
PS50002--SH3
Pfam

PF07714--Pkinase_Tyr
PF14604--SH3_9
PRINTS

PR00452--SH3DOMAIN
PR00109--TYRKINASE
SMART

SM00220--S_TKc
SM00326--SH3
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005524--F:ATP binding
GO:0004706--F:JUN kinase kinase kinase activity
GO:0042803--F:protein homodimerization activity
GO:0007257--P:activation of JUN kinase activity
GO:0046777--P:protein autophosphorylation
GO:0006468--P:protein phosphorylation
KEGG hsa:84451
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aca-005356 Anolis carolinensis 64.52 0.00e+00 1107.00
IUUC-Ame-011769 Astyanax mexicanus 59.23 0.00e+00 929.00
IUUC-Bta-012631 Bos taurus 75.21 0.00e+00 1166.00
IUUC-Cja-019307 Callithrix jacchus 89.58 0.00e+00 1467.00
IUUC-Cfa-020962 Canis familiaris 77.65 0.00e+00 1164.00
IUUC-Cpo-021521 Cavia porcellus 84.36 0.00e+00 919.00
IUUC-Csa-023781 Chlorocebus sabaeus 94.52 0.00e+00 1449.00
IUUC-Dre-027645 Danio rerio 67.68 0.00e+00 877.00
IUUC-Gmo-039264 Gadus morhua 67.28 0.00e+00 851.00
IUUC-Gga-040976 Gallus gallus 69.62 0.00e+00 1184.00
IUUC-Gac-042068 Gasterosteus aculeatus 67.33 0.00e+00 862.00
IUUC-Ggo-044536 Gorilla gorilla 97.58 0.00e+00 1602.00
IUUC-Loc-052411 Lepisosteus oculatus 59.05 0.00e+00 901.00
IUUC-Mcc-055881 Macaca mulatta 95.17 0.00e+00 1444.00
IUUC-Mdo-062770 Monodelphis domestica 83.87 0.00e+00 1108.00
IUUC-Mmu-063237 Mus musculus 68.33 0.00e+00 999.00
IUUC-Ont-071825 Oreochromis niloticus 67.52 0.00e+00 871.00
IUUC-Ocu-074362 Oryctolagus cuniculus 81.09 0.00e+00 1189.00
IUUC-Oga-087967 Otolemur garnettii 83.94 0.00e+00 1288.00
IUUC-Pfo-096763 Poecilia formosa 56.80 0.00e+00 899.00
IUUC-Rno-105010 Rattus norvegicus 68.59 0.00e+00 999.00
IUUC-Ssc-115831 Sus scrofa 77.40 0.00e+00 1159.00
IUUC-Tru-117957 Takifugu rubripes 57.53 0.00e+00 907.00
Created Date 25-Jun-2017

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