iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Fca-036313

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AANG02134635

Gene Name

USP18

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFCAG00000030232.1	ENSFCAT00000025474.1	ENSFCAP00000019001.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	2.50e-59	201.2	56	370

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeq 89
           +Gl+N+g tC +NS++Q L++   +++ l++    ++++   +e+  ++  +l  l+e +++s++kav+p el  +l+k+++    + q
   Q: 56   VGLHNIGQTCCLNSLIQILIMNVGFTRILKR---ITVPRGT-EEQRRSVPFQLLLLLERMQDSRHKAVQPLELAYCLQKYNVP--MFVQ 138
           6******************************...4444432.466789*********************************98..79** PP
   S: 90   qDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpg 178
           +Da  +   + + +++++                          ++    + ++ l+ +++k+++ clec ++ sr++++l+l+lp+ +
   Q: 139  HDAAQLYLTVWNLIKDQI--------------------------TDVDLVERLQALYTIRMKESLACLECTTERSRNSSMLTLPLPLFD 201
           ******************..........................66778899************************************9 PP
   S: 179  keetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlsp.fct 266
            +++ +++l+d+L+ f+++ el g+ +++ce+c kk+  ++ lkl++lP++L++hL Rfs ++  ++ eki  +++fp++Ldls+  ++
   Q: 202  MDSKPLKTLEDALRCFFQPRELSGKSECFCENCGKKTCGKQVLKLTHLPQTLTIHLLRFSIRN--SQTEKICHSLYFPQSLDLSQvLLI 288
           99999******************************************************7655..7899***************74444 PP
   S: 267  speekqke...kkkYeLiavvvHsGslssGHYvayvkn.ekgkWllfdDskVtevkeeevleetg.......staYvlfYkr 337
           +++  ++e    ++YeL+avv H G ++ GHY+ay++n  +gkW++f+Ds+V  v++e+++ + g       +taY+l+Y++
   Q: 289  EEDLCSAEeqlGRQYELFAVVAHVGAADFGHYCAYIQNsVDGKWFCFNDSNVCWVSWEDIQCTYGnhnyrwrETAYLLVYMK 370
           4443333344599*************************45677*******************888***************97 PP

Organism

Felis catus

Protein Sequence
(Fasta)

KGSGVGVPEE ICQCILAESQ HFSAELVEKK EENNMKRKKE ELRERLSALD CPHGPVGLHN 60
IGQTCCLNSL IQILIMNVGF TRILKRITVP RGTEEQRRSV PFQLLLLLER MQDSRHKAVQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTTCACAGAG CTCCCACCAA AGCTGACTCA GAGCTCTTCC TGGAAGTGTG CAGTCCTGAA 60
GACAGGCCAG ACAGCTCATG GCCGGGGAAT TTTGGAGTGA TCAGTAAAGG GTCAGGTGTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0019785--F:ISG15-specific protease activity
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0016579--P:protein deubiquitination
GO:0035634--P:response to stilbenoid
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001615	Ailuropoda melanoleuca	93.56	0.00e+00	671.00
IUUC-Apl-004006	Anas platyrhynchos	56.88	9.00e-107	379.00
IUUC-Aca-005088	Anolis carolinensis	54.35	8.00e-91	327.00
IUUC-Ame-010606	Astyanax mexicanus	32.81	2.00e-40	159.00
IUUC-Bta-013036	Bos taurus	80.00	1.00e-157	548.00
IUUC-Cja-019052	Callithrix jacchus	76.40	1.00e-143	502.00
IUUC-Cfa-020554	Canis familiaris	94.40	0.00e+00	668.00
IUUC-Cpo-022421	Cavia porcellus	71.54	9.00e-155	539.00
IUUC-Csa-023737	Chlorocebus sabaeus	79.21	3.00e-96	343.00
IUUC-Cho-024807	Choloepus hoffmanni	70.56	5.00e-72	264.00
IUUC-Dre-027408	Danio rerio	33.12	1.00e-44	173.00
IUUC-Dno-029813	Dasypus novemcinctus	67.20	3.00e-128	451.00
IUUC-Dor-030532	Dipodomys ordii	73.92	3.00e-162	564.00
IUUC-Ete-032254	Echinops telfairi	69.44	4.00e-151	527.00
IUUC-Eca-033482	Equus caballus	86.56	2.00e-169	587.00
IUUC-Eeu-034451	Erinaceus europaeus	78.30	5.00e-101	359.00
IUUC-Fal-037216	Ficedula albicollis	54.32	5.00e-107	380.00
IUUC-Gmo-038649	Gadus morhua	33.75	2.00e-39	155.00
IUUC-Gga-041082	Gallus gallus	54.91	1.00e-94	339.00
IUUC-Gac-042439	Gasterosteus aculeatus	36.71	4.00e-50	191.00
IUUC-Ggo-044957	Gorilla gorilla	82.72	4.00e-136	477.00
IUUC-Hsa-046381	Homo sapiens	78.49	9.00e-174	602.00
IUUC-Itr-047918	Ictidomys tridecemlineatus	76.96	2.00e-166	577.00
IUUC-Loc-052688	Lepisosteus oculatus	31.55	5.00e-44	171.00
IUUC-Laf-054109	Loxodonta africana	78.28	4.00e-176	610.00
IUUC-Mcc-054814	Macaca mulatta	77.69	4.00e-174	603.00
IUUC-Meu-056253	Macropus eugenii	67.71	4.00e-110	390.00
IUUC-Mmr-061613	Microcebus murinus	79.94	2.00e-162	565.00
IUUC-Mdo-061890	Monodelphis domestica	65.29	3.00e-130	457.00
IUUC-Mmu-064329	Mus musculus	70.43	6.00e-149	520.00
IUUC-Mpu-066342	Mustela putorius furo	92.18	0.00e+00	690.00
IUUC-Mlu-067010	Myotis lucifugus	81.72	0.00e+00	641.00
IUUC-Nle-069148	Nomascus leucogenys	77.38	5.00e-169	587.00
IUUC-Opr-070988	Ochotona princeps	70.06	8.00e-65	240.00
IUUC-Ont-072039	Oreochromis niloticus	33.74	2.00e-47	182.00
IUUC-Oan-073740	Ornithorhynchus anatinus	58.06	2.00e-77	281.00
IUUC-Ocu-074498	Oryctolagus cuniculus	77.36	3.00e-153	534.00
IUUC-Ola-086753	Oryzias latipes	35.67	2.00e-50	192.00
IUUC-Oga-088497	Otolemur garnettii	77.93	2.00e-167	581.00
IUUC-Oar-089505	Ovis aries	80.00	1.00e-157	548.00
IUUC-Ptr-091656	Pan troglodytes	77.96	7.00e-173	599.00
IUUC-Pan-092498	Papio anubis	77.69	4.00e-173	600.00
IUUC-Psi-093409	Pelodiscus sinensis	53.26	2.00e-106	378.00
IUUC-Pfo-096507	Poecilia formosa	36.31	5.00e-49	187.00
IUUC-Pab-097828	Pongo abelii	81.37	4.00e-158	550.00
IUUC-Pca-100299	Procavia capensis	73.14	9.00e-99	353.00
IUUC-Pva-102972	Pteropus vampyrus	80.00	4.00e-171	593.00
IUUC-Rno-105738	Rattus norvegicus	69.09	8.00e-153	533.00
IUUC-Sha-107309	Sarcophilus harrisii	63.98	2.00e-121	428.00
IUUC-Sar-112983	Sorex araneus	68.52	7.00e-132	463.00
IUUC-Ssc-116049	Sus scrofa	82.50	9.00e-165	572.00
IUUC-Tgu-117115	Taeniopygia guttata	56.92	3.00e-103	368.00
IUUC-Tru-118022	Takifugu rubripes	33.02	9.00e-41	160.00
IUUC-Tsy-118986	Tarsius syrichta	61.90	3.00e-62	231.00
IUUC-Tni-120306	Tetraodon nigroviridis	33.12	3.00e-40	158.00
IUUC-Tbe-127768	Tupaia belangeri	68.69	5.00e-113	400.00
IUUC-Ttr-128686	Tursiops truncatus	76.06	7.00e-160	556.00
IUUC-Xtr-132032	Xenopus tropicalis	44.65	4.00e-72	264.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence