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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046823
UUCD1 version UUC-HoS-00044
Ensembl Protein ID ENSP00000358283.4
UniProt Accession O94874; A0PJ53; B4DJ57; C0H5X5; Q8N765; Q9NTQ0; UFL1_HUMAN
Genbank Protein ID BAA34496.1; BAG58719.1; CAH73710.1; CAH73710.1; CAI20401.1; CAI20401.1; EAW48507.1; AAH15377.1; AAH28608.1; AAH36379.1
Protein Name E3 UFM1-protein ligase 1; Novel LZAP-binding protein; Regulator of C53/LZAP and DDRGK1
Genbank Nucleotide ID AB018319; AK295934; AL590404; AL132776; AL132776; AL590404; CH471051; BC015377; BC028608; BC036379
Gene Name UFL1; KIAA0776; NLBP; RCAD
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000014123.9 ENST00000369278.4 ENSP00000358283.4
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
THPAHPM
DNA & RNA Element
UTRdbAREsiteCircNetmiRTarBase
microRNATRANSFACTargetScanRepTar
miRNAMapSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtBioGRID
mUbiSiDa
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/Other E3 activity/Other 20018847; 20368332
ULD/UDP/UBQ/UBQ_Other UBQ_Other 20018847
Reviewed
Classification
Family Identity E-value Score Source Orthology
E3 activity/Other 90.55 0.00e+00 1377.00 IUUC-Mmu-064248
Organism Homo sapiens
Functional Description
(View)

Functional Description


     E3 protein ligase that mediates ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to substrate proteins, a post-translational modification on lysine residues of proteins that may play a crucial role in a number of cellular processes. Mediates DDRGK1 ufmylation and may regulate the proteasomal degradation of DDRGK1 and CDK5RAP3 thereby modulating NF-kappa-B signaling (PubMed:20018847, PubMed:20164180, PubMed:20228063, PubMed:25219498). May also through TRIP4 ufmylation play a role in nuclear receptors-mediated transcription (PubMed:25219498). May play a role in the unfolded protein response, mediating the ufmylation of multiple proteins in response to endoplasmic reticulum stress (PubMed:23152784).
 E3 protein ligase that mediates ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to substrate proteins, a post-translational modification on lysine residues of proteins that may play a crucial role in a number of cellular processes. Mediates DDRGK1 ufmylation and may regulate the proteasomal degradation of DDRGK1 and CDK5RAP3 thereby modulating NF-kappa-B signaling (PubMed:20018847, PubMed:20164180, PubMed:20228063, PubMed:25219498). May also through TRIP4 ufmylation play a role in nuclear receptors-mediated transcription (PubMed:25219498). May play a role in the unfolded protein response, mediating the ufmylation of multiple proteins in response to endoplasmic reticulum stress (PubMed:23152784).
Protein Sequence
(Fasta)
MADAWEEIRR LAADFQRAQF AEATQRLSER NCIEIVNKLI AQKQLEVVHT LDGKEYITPA 60
QISKEMRDEL HVRGGRVNIV DLQQVINVDL IHIENRIGDI IKSEKHVQLV LGQLIDENYL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046823|E3,E3 activity/Other;ULD,UBQ_Other|Homo sapiens
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Nucleotide Sequence
(Fasta)
TGAGCCCTGC ATCCTGCCCA CGACCCCCCC AGAAACACCT ACGCACCACT CTCCTAGCCG 60
CCGCAGCCCC GCCAGTCTCG CCGGGAGGAA CCCCCAGCGC CGCGGTACAA CCACGGCACT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046823|E3,E3 activity/Other;ULD,UBQ_Other|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0256--Endoplasmic reticulum
KW-0436--Ligase
KW-0488--Methylation
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0043--Tumor suppressor
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
Interpro

IPR018611--E3_UFM1_ligase_1
Pfam

PF09743--DUF2042
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005783--C:endoplasmic reticulum
GO:0005789--C:endoplasmic reticulum membrane
GO:0016020--C:membrane
GO:0043005--C:neuron projection
GO:0043234--C:protein complex
GO:0016874--F:ligase activity
GO:0071568--F:UFM1 transferase activity
GO:0043066--P:negative regulation of apoptotic process
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0031397--P:negative regulation of protein ubiquitination
GO:0001649--P:osteoblast differentiation
GO:0008284--P:positive regulation of cell proliferation
GO:0060252--P:positive regulation of glial cell proliferation
GO:1990592--P:protein K69-linked ufmylation
GO:0071569--P:protein ufmylation
GO:0033146--P:regulation of intracellular estrogen receptor signaling pathway
GO:0032434--P:regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032880--P:regulation of protein localization
GO:0034976--P:response to endoplasmic reticulum stress
GO:1902065--P:response to L-glutamate
KEGG hsa:23376
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000068 Aegilops tauschii 30.64 3.00e-41 163.00
IUUC-Aml-001894 Ailuropoda melanoleuca 92.95 0.00e+00 1449.00
IUUC-Atr-003137 Amborella trichopoda 32.46 4.00e-54 205.00
IUUC-Apl-003993 Anas platyrhynchos 73.86 0.00e+00 1076.00
IUUC-Aca-004941 Anolis carolinensis 74.92 0.00e+00 850.00
IUUC-Aly-006023 Arabidopsis lyrata 28.08 9.00e-48 185.00
IUUC-Ath-007249 Arabidopsis thaliana 28.35 5.00e-48 186.00
IUUC-Ame-011084 Astyanax mexicanus 71.96 4.00e-136 477.00
IUUC-Bta-012960 Bos taurus 91.81 0.00e+00 1444.00
IUUC-Bdi-014730 Brachypodium distachyon 31.02 4.00e-49 189.00
IUUC-Bol-016306 Brassica oleracea 29.09 6.00e-47 182.00
IUUC-Bra-016735 Brassica rapa 29.36 4.00e-47 183.00
IUUC-Cel-018267 Caenorhabditis elegans 28.13 9.00e-36 145.00
IUUC-Cja-019432 Callithrix jacchus 97.61 0.00e+00 1463.00
IUUC-Cfa-020879 Canis familiaris 91.56 0.00e+00 1390.00
IUUC-Cpo-021915 Cavia porcellus 86.70 0.00e+00 1301.00
IUUC-Cre-022838 Chlamydomonas reinhardtii 44.53 3.00e-24 104.00
IUUC-Csa-023667 Chlorocebus sabaeus 98.36 0.00e+00 1501.00
IUUC-Cin-025254 Ciona intestinalis 42.22 9.00e-180 624.00
IUUC-Csv-026110 Ciona savignyi 41.74 4.00e-174 605.00
IUUC-Cme-027205 Cyanidioschyzon merolae 30.00 1.70e-01 30.80
IUUC-Dre-028832 Danio rerio 63.27 0.00e+00 932.00
IUUC-Dno-029396 Dasypus novemcinctus 87.89 0.00e+00 1288.00
IUUC-Dor-030872 Dipodomys ordii 78.08 3.00e-166 578.00
IUUC-Dme-031860 Drosophila melanogaster 41.08 1.00e-92 334.00
IUUC-Ete-032382 Echinops telfairi 88.66 0.00e+00 1304.00
IUUC-Eca-034175 Equus caballus 88.32 0.00e+00 1380.00
IUUC-Eeu-035073 Erinaceus europaeus 75.46 1.00e-169 589.00
IUUC-Fca-035655 Felis catus 88.79 0.00e+00 1368.00
IUUC-Fal-037594 Ficedula albicollis 72.79 0.00e+00 913.00
IUUC-Fso-038403 Fusarium solani 37.84 2.00e-02 31.20
IUUC-Gmo-038897 Gadus morhua 61.91 0.00e+00 814.00
IUUC-Gga-040147 Gallus gallus 74.59 0.00e+00 1098.00
IUUC-Gac-042365 Gasterosteus aculeatus 60.20 0.00e+00 954.00
IUUC-Gma-044359 Glycine max 32.74 3.00e-42 167.00
IUUC-Ggo-045085 Gorilla gorilla 99.62 0.00e+00 1493.00
IUUC-Hvu-047672 Hordeum vulgare 27.79 3.00e-70 259.00
IUUC-Itr-048558 Ictidomys tridecemlineatus 93.70 0.00e+00 1410.00
IUUC-Lch-050099 Latimeria chalumnae 71.27 0.00e+00 1109.00
IUUC-Lpe-051353 Leersia perrieri 31.18 4.00e-51 196.00
IUUC-Loc-052237 Lepisosteus oculatus 73.04 0.00e+00 634.00
IUUC-Laf-053535 Loxodonta africana 89.32 0.00e+00 1342.00
IUUC-Mcc-054991 Macaca mulatta 98.74 0.00e+00 1507.00
IUUC-Meu-055924 Macropus eugenii 79.93 5.00e-99 355.00
IUUC-Mtr-058527 Medicago truncatula 28.57 2.00e-54 207.00
IUUC-Mga-059514 Meleagris gallopavo 75.00 0.00e+00 1092.00
IUUC-Mmr-061625 Microcebus murinus 94.33 0.00e+00 1446.00
IUUC-Mdo-062551 Monodelphis domestica 84.76 0.00e+00 1272.00
IUUC-Mmu-064248 Mus musculus 90.55 0.00e+00 1362.00
IUUC-Mac-065571 Musa acuminata 33.83 2.00e-57 217.00
IUUC-Mpu-065883 Mustela putorius furo 93.07 0.00e+00 1426.00
IUUC-Mlu-067468 Myotis lucifugus 90.68 0.00e+00 1419.00
IUUC-Nle-069831 Nomascus leucogenys 98.36 0.00e+00 1507.00
IUUC-Opr-071153 Ochotona princeps 70.69 0.00e+00 852.00
IUUC-Ont-072677 Oreochromis niloticus 66.42 0.00e+00 988.00
IUUC-Oan-073682 Ornithorhynchus anatinus 76.56 0.00e+00 1098.00
IUUC-Ocu-074268 Oryctolagus cuniculus 94.21 0.00e+00 1446.00
IUUC-Oba-075467 Oryza barthii 27.50 1.00e-70 261.00
IUUC-Obr-076760 Oryza brachyantha 28.83 7.00e-71 262.00
IUUC-Ogl-077088 Oryza glaberrima 27.72 5.00e-71 262.00
IUUC-Ogu-078509 Oryza glumaepatula 27.74 7.00e-72 265.00
IUUC-Oin-079276 Oryza indica 28.04 4.00e-73 270.00
IUUC-Olo-080814 Oryza longistaminata 27.50 1.00e-70 261.00
IUUC-Ome-081647 Oryza meridionalis 31.30 4.00e-50 193.00
IUUC-Oni-082954 Oryza nivara 27.37 4.00e-70 259.00
IUUC-Opu-083580 Oryza punctata 27.07 1.00e-62 234.00
IUUC-Oru-084627 Oryza rufipogon 28.04 4.00e-73 270.00
IUUC-Osa-086096 Oryza sativa 28.04 4.00e-73 270.00
IUUC-Ola-087322 Oryzias latipes 62.52 0.00e+00 976.00
IUUC-Olu-087693 Ostreococcus lucimarinus 26.74 2.00e-20 94.40
IUUC-Oga-088769 Otolemur garnettii 90.44 0.00e+00 1375.00
IUUC-Oar-090007 Ovis aries 91.32 0.00e+00 1431.00
IUUC-Ptr-090760 Pan troglodytes 99.62 0.00e+00 1491.00
IUUC-Pan-092162 Papio anubis 98.99 0.00e+00 1508.00
IUUC-Psi-093045 Pelodiscus sinensis 77.33 0.00e+00 1115.00
IUUC-Ppa-095424 Physcomitrella patens 34.42 2.00e-58 220.00
IUUC-Pfo-096108 Poecilia formosa 60.10 0.00e+00 959.00
IUUC-Pab-098057 Pongo abelii 96.60 0.00e+00 1457.00
IUUC-Pop-099790 Populus trichocarpa 31.59 3.00e-54 206.00
IUUC-Pca-100307 Procavia capensis 86.52 0.00e+00 1309.00
IUUC-Ppe-102029 Prunus persica 30.17 1.00e-51 198.00
IUUC-Pva-102386 Pteropus vampyrus 88.17 0.00e+00 875.00
IUUC-Ptt-103715 Puccinia triticina 25.48 1.10e-01 32.00
IUUC-Rno-105550 Rattus norvegicus 90.68 0.00e+00 1336.00
IUUC-Sha-107442 Sarcophilus harrisii 85.64 0.00e+00 1278.00
IUUC-Spo-108126 Schizosaccharomyces pombe 29.57 6.40e-02 32.30
IUUC-Smo-109447 Selaginella moellendorffii 32.90 4.00e-55 209.00
IUUC-Sit-110568 Setaria italica 31.02 9.00e-49 188.00
IUUC-Sly-111028 Solanum lycopersicum 30.85 4.00e-49 189.00
IUUC-Stu-112317 Solanum tuberosum 30.33 3.00e-47 183.00
IUUC-Sar-113662 Sorex araneus 84.44 0.00e+00 1284.00
IUUC-Sbi-114636 Sorghum bicolor 31.25 1.00e-49 191.00
IUUC-Ssc-116423 Sus scrofa 91.56 0.00e+00 1431.00
IUUC-Tgu-116977 Taeniopygia guttata 73.30 0.00e+00 1098.00
IUUC-Tru-118314 Takifugu rubripes 68.06 5.00e-173 601.00
IUUC-Tsy-119391 Tarsius syrichta 90.81 0.00e+00 1363.00
IUUC-Tni-120594 Tetraodon nigroviridis 62.71 0.00e+00 917.00
IUUC-Tca-121351 Theobroma cacao 30.23 7.00e-56 212.00
IUUC-Tae-122849 Triticum aestivum 28.63 2.00e-20 95.10
IUUC-Tur-126308 Triticum urartu 28.63 2.00e-20 94.70
IUUC-Tbe-127999 Tupaia belangeri 92.33 0.00e+00 1292.00
IUUC-Ttr-129189 Tursiops truncatus 85.39 0.00e+00 1303.00
IUUC-Vpa-130734 Vicugna pacos 87.28 0.00e+00 1335.00
IUUC-Vvi-131695 Vitis vinifera 27.08 2.00e-11 65.10
IUUC-Xtr-132004 Xenopus tropicalis 65.12 0.00e+00 959.00
IUUC-Xma-134108 Xiphophorus maculatus 61.88 0.00e+00 840.00
IUUC-Zma-135513 Zea mays 31.40 6.00e-49 189.00
Created Date 25-Jun-2017

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