iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCAFG00000002804.4	ENSCAFT00000044819.2	ENSCAFP00000038300.1
ENSCAFG00000002804.4	ENSCAFT00000004493.3	ENSCAFP00000004153.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	9.90e-35	117.4	179	216
UBD/Beta-Prp	3.40e-52	177.8	278	539

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvll 36
           gH +sv+c+ f  + +++ +GsdD+ +k+W +++g+ll
   Q: 179  GHLSSVYCVTFdRTgRRIFTGSDDCLVKIWATDDGRLL 216
           8**********955599*****************9987 PP

UBD/Beta-Prp

   S: 19   spdksllatgsrdgtikvwdvttgkl.....lrsl.sgheaevtavk..fspdgkilvtgseDrtikvw..dlstgkcvhtlkghedsv 97
           s +k++l ++++dgti  w ++ g+l      +++ +   ++v+ ++  fs  g +l+tgs+D++i+v+     +++ ++ l+ h+d+v
   Q: 278  SGSKRYLSSTGADGTICFWLWDAGTLkinprPAKFtERPRPGVQMICssFSAGGMFLATGSTDHIIRVYffGSGQPEKISELEFHTDKV 366
           67899***********999999999988988555547777888765522777888**************777779999*********** PP
   S: 98   lslsfspsgdklvsGshdrtirvwdletgqclee................tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgk 170
            s++fs +++++vsGs+d t+r+w+ + +++ +                  +++++  v++v+++  +n ++++ ++ t+++W++ tg+
   Q: 367  DSIQFSNTSNRFVSGSRDGTARIWQFKRREWKSIlldmatrpagqnlqgiEDKITKMKVTMVAWDRHDNTVITAVNNMTLKVWNSYTGQ 455
           ********************************99***************888899999******************************* PP
   S: 171  llrtltgghtdsvysls...fdsngkelvsgsldgtvklwdlqtgecvrtlnght.....dnvksvrfspnderlvsgssDgsiriW 249
           l++ l g h+d v  l+   fd+  + l s+++dg v++wdl +g  +r++ +         v + + sp++++++++ s+g + i+
   Q: 456  LIHVLMG-HEDEVFVLEphpFDP--RVLFSAGHDGNVIVWDLARGVKIRSYFNMIegqghGAVFDCKCSPDGQHFACTDSHGHLLIF 539
           ******9.*********999999..89******************999998875544445566667777999999999999988887 PP

Organism

Canis familiaris

Protein Sequence
(Fasta)

MSCERKGLSE LRSELYFLIA RFLEDGPCQQ AAQVICGSMD NGSLLPKKQS WKGPYKYYVN 60
LVKYYRHLAP DHLLQICHRL GPLLEQEIPQ SVPGVQTLLG AGRQSLLRTN KSCKHVVWKG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GACATCTTCT CCGACTGGAA ATAAATAAAT AAATCGCACC TTTGGCCGGG GAGGCGGGGG 60
CAGGGGTCTC GCCGCCCGGG GCGCGGGGGC GCGGGGGCGC GGGGCCCAAG GCACTCCTTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0103--Bromodomain
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR001487--Bromodomain
IPR018359--Bromodomain_CS
IPR028738--PHIP
IPR027295--Quinoprotein_ADH-like_fam
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00633--BROMODOMAIN_1
PS50014--BROMODOMAIN_2
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00439--Bromodomain
PF00400--WD40

PRINTS

PR00503--BROMODOMAIN

SMART

SM00297--BROMO
SM00320--WD40

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0007010--P:cytoskeleton organization
GO:0008286--P:insulin receptor signaling pathway
GO:2001237--P:negative regulation of extrinsic apoptotic signaling pathway
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0008360--P:regulation of cell shape
GO:0006357--P:regulation of transcription from RNA polymerase II promoter

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002299	Ailuropoda melanoleuca	98.14	0.00e+00	3242.00
IUUC-Apl-003700	Anas platyrhynchos	86.54	0.00e+00	2876.00
IUUC-Aca-004474	Anolis carolinensis	81.23	0.00e+00	2786.00
IUUC-Bta-013125	Bos taurus	96.70	0.00e+00	3150.00
IUUC-Bdi-014797	Brachypodium distachyon	30.47	4.00e-60	227.00
IUUC-Cja-018868	Callithrix jacchus	93.25	0.00e+00	3275.00
IUUC-Cpo-022077	Cavia porcellus	90.76	0.00e+00	3062.00
IUUC-Csa-023618	Chlorocebus sabaeus	95.61	0.00e+00	3311.00
IUUC-Cho-024794	Choloepus hoffmanni	90.32	0.00e+00	872.00
IUUC-Dre-028029	Danio rerio	79.01	0.00e+00	1318.00
IUUC-Dno-030048	Dasypus novemcinctus	95.19	0.00e+00	3211.00
IUUC-Dor-030195	Dipodomys ordii	85.08	0.00e+00	1467.00
IUUC-Ete-032748	Echinops telfairi	84.50	0.00e+00	1169.00
IUUC-Eca-034274	Equus caballus	97.95	0.00e+00	3204.00
IUUC-Eeu-034688	Erinaceus europaeus	86.00	0.00e+00	1431.00
IUUC-Fca-035451	Felis catus	97.90	0.00e+00	3120.00
IUUC-Fal-037465	Ficedula albicollis	84.46	0.00e+00	2850.00
IUUC-Gmo-039451	Gadus morhua	68.38	0.00e+00	723.00
IUUC-Gga-040798	Gallus gallus	85.23	0.00e+00	2928.00
IUUC-Hsa-046757	Homo sapiens	95.66	0.00e+00	3284.00
IUUC-Hvu-047706	Hordeum vulgare	31.84	2.00e-37	149.00
IUUC-Itr-048843	Ictidomys tridecemlineatus	93.32	0.00e+00	1178.00
IUUC-Laf-054140	Loxodonta africana	96.42	0.00e+00	3235.00
IUUC-Mcc-055061	Macaca mulatta	95.88	0.00e+00	3315.00
IUUC-Mmr-060837	Microcebus murinus	95.17	0.00e+00	3244.00
IUUC-Mdo-061903	Monodelphis domestica	90.53	0.00e+00	3157.00
IUUC-Mmu-063772	Mus musculus	93.52	0.00e+00	3231.00
IUUC-Mpu-066359	Mustela putorius furo	98.85	0.00e+00	3020.00
IUUC-Mlu-067928	Myotis lucifugus	95.00	0.00e+00	3197.00
IUUC-Nle-070094	Nomascus leucogenys	94.73	0.00e+00	3232.00
IUUC-Opr-070971	Ochotona princeps	74.22	0.00e+00	954.00
IUUC-Ont-072221	Oreochromis niloticus	74.49	0.00e+00	1292.00
IUUC-Oan-073185	Ornithorhynchus anatinus	87.06	0.00e+00	2878.00
IUUC-Ocu-074033	Oryctolagus cuniculus	94.05	0.00e+00	2859.00
IUUC-Ogl-077493	Oryza glaberrima	24.49	5.00e-33	137.00
IUUC-Ogu-078641	Oryza glumaepatula	24.28	1.00e-29	125.00
IUUC-Oin-079669	Oryza indica	31.13	4.00e-52	199.00
IUUC-Olo-080755	Oryza longistaminata	31.65	4.00e-54	207.00
IUUC-Oni-082991	Oryza nivara	27.78	2.00e-39	158.00
IUUC-Oga-088578	Otolemur garnettii	96.13	0.00e+00	3167.00
IUUC-Oar-090247	Ovis aries	96.70	0.00e+00	3143.00
IUUC-Ptr-091266	Pan troglodytes	95.89	0.00e+00	3194.00
IUUC-Pan-092734	Papio anubis	95.83	0.00e+00	3316.00
IUUC-Pab-098402	Pongo abelii	95.72	0.00e+00	3285.00
IUUC-Pop-099185	Populus trichocarpa	35.42	2.00e-70	261.00
IUUC-Pca-101128	Procavia capensis	86.52	0.00e+00	2863.00
IUUC-Pva-103058	Pteropus vampyrus	96.70	0.00e+00	1600.00
IUUC-Rno-106013	Rattus norvegicus	93.41	0.00e+00	3147.00
IUUC-Sha-107496	Sarcophilus harrisii	91.20	0.00e+00	3094.00
IUUC-Sar-113520	Sorex araneus	92.27	0.00e+00	1554.00
IUUC-Ssc-115461	Sus scrofa	92.32	0.00e+00	3132.00
IUUC-Tgu-116821	Taeniopygia guttata	85.03	0.00e+00	2891.00
IUUC-Tsy-119132	Tarsius syrichta	84.64	0.00e+00	2587.00
IUUC-Tbe-127479	Tupaia belangeri	92.02	0.00e+00	1451.00
IUUC-Ttr-128427	Tursiops truncatus	90.78	0.00e+00	3053.00
IUUC-Vpa-130160	Vicugna pacos	93.82	0.00e+00	3062.00
IUUC-Xtr-132717	Xenopus tropicalis	74.15	0.00e+00	2534.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence