iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

mRNA Expression
GEO	FFGED
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Protein 3D Structure
PDB	MMDB
Post-translational Modifications (PTMs)
CPLM	dbPAF	dbPTM	UniProt
PHOSIDA	BioGRID
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
DUB/ULP	ULP	12654900; 20516210

Classification

Family	E-value	Score	Start	End
DUB/ULP	5.20e-43	145.7	433	589

Active Site

Position(s)	Description	Evidence
514	N/A	{ECO:0000269\|PubMed:10882122}
531		{ECO:0000269\|PubMed:10882122}
580		{ECO:0000269\|PubMed:10882122}

Domain Profile

DUB/ULP

   S: 1    isvtnedlkcLeegeflnDviidfylkylvleklkkekverihifssffykklkqkerrrvktwtr..kvdlfekdlifvpinea.aHWslavvcfkkksil 99
           i++t +d+k+L+++++lnD+ii+f++k ++++++     +++ +f+sffy++l++++++ v++w++  k+++ + d if+pin + +HW+l ++++kkk+i 
   Q: 433  IEITVRDFKTLAPRRWLNDTIIEFFMK-YIEKST-----PNTVAFNSFFYTNLSERGYQGVRRWMKrkKTQIDKLDKIFTPINLNqSHWALGIIDLKKKTIG 528
           579************************.555555.....7899**********************977556666677*******88**************** PP
   S: 100  llDSlr...gasksnvvkklreylevevkkkskrefskeklkgsnpkvpqQkNssDCGvyvlqyve 162
           ++DSl+   +a++ +++++l++y+++e+k++  ++f+  +l+     +pqQ+N++DCG+yv++++ 
   Q: 529  YVDSLSngpNAMSFAILTDLQKYVMEESKHTIGEDFDLIHLD-----CPQQPNGYDCGIYVCMNTL 589
           *****9887889999***********************8877.....****************985 PP

Organism

Saccharomyces cerevisiae

Functional Description
(View)

Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SMT3 to its mature form and deconjugation of SMT3 from targeted proteins. Has an essential role in the G2/M phase of the cell cycle.

Protein Sequence
(Fasta)

MSVEVDKHRN TLQYHKKNPY SPLFSPISTY RCYPRVLNNP SESRRSASFS GIYKKRTNTS 60
RFNYLNDRRV LSMEESMKDG SDRASKAGFI GGIRETLWNS GKYLWHTFVK NEPRNFDGSE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTCAGTTG AAGTAGATAA GCACCGGAAC ACACTACAGT ATCATAAAAA GAACCCTTAC 60
TCCCCTTTAT TCTCCCCAAT TTCTACATAT AGGTGTTATC CTCGGGTATT GAACAATCCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR003653--Peptidase_C48_C

PROSITE

PS50600--ULP_PROTEASE

Pfam

PF02902--Peptidase_C48

Gene Ontology

GO:0005635--C:nuclear envelope
GO:0005730--C:nucleolus
GO:0008234--F:cysteine-type peptidase activity
GO:0004175--F:endopeptidase activity
GO:0016929--F:SUMO-specific protease activity
GO:0000086--P:G2/M transition of mitotic cell cycle
GO:0016926--P:protein desumoylation

KEGG

sce:YPL020C

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001166	Aegilops tauschii	31.25	3.00e-21	93.60
IUUC-Aml-001885	Ailuropoda melanoleuca	31.86	4.00e-27	114.00
IUUC-Atr-003110	Amborella trichopoda	31.03	3.00e-21	94.40
IUUC-Apl-004162	Anas platyrhynchos	37.06	1.00e-27	115.00
IUUC-Aca-005011	Anolis carolinensis	34.51	8.00e-29	119.00
IUUC-Aly-006005	Arabidopsis lyrata	33.17	3.00e-22	97.80
IUUC-Ath-006783	Arabidopsis thaliana	30.74	7.00e-23	99.00
IUUC-Ago-007930	Ashbya gossypii	49.04	3.00e-119	419.00
IUUC-Acl-008277	Aspergillus clavatus	30.10	2.00e-20	92.80
IUUC-Afl-008417	Aspergillus flavus	27.19	9.00e-21	94.00
IUUC-Afu-008940	Aspergillus fumigatus	27.54	2.00e-22	99.40
IUUC-Ani-009245	Aspergillus nidulans	26.98	2.00e-19	89.40
IUUC-Ang-009510	Aspergillus niger	28.64	5.00e-18	85.10
IUUC-Aor-010104	Aspergillus oryzae	28.16	3.00e-20	89.70
IUUC-Ate-010312	Aspergillus terreus	34.53	5.00e-17	81.30
IUUC-Ame-011519	Astyanax mexicanus	29.52	8.00e-21	93.20
IUUC-Bgr-012165	Blumeria graminis	32.03	2.00e-25	108.00
IUUC-Bta-012319	Bos taurus	31.86	4.00e-27	114.00
IUUC-Bci-013594	Botrytis cinerea	29.39	2.00e-22	98.20
IUUC-Bdi-014678	Brachypodium distachyon	32.77	2.00e-23	101.00
IUUC-Bol-015882	Brassica oleracea	35.67	1.00e-21	95.50
IUUC-Bra-017525	Brassica rapa	32.66	1.00e-22	99.00
IUUC-Cel-018426	Caenorhabditis elegans	31.58	2.00e-26	112.00
IUUC-Cja-019463	Callithrix jacchus	32.30	2.00e-27	115.00
IUUC-Cfa-020654	Canis familiaris	31.86	5.00e-27	114.00
IUUC-Cpo-022243	Cavia porcellus	31.86	3.00e-27	114.00
IUUC-Cre-022877	Chlamydomonas reinhardtii	27.33	5.00e-12	61.60
IUUC-Csa-023353	Chlorocebus sabaeus	30.56	3.00e-19	88.20
IUUC-Cho-024917	Choloepus hoffmanni	32.00	9.00e-27	113.00
IUUC-Cin-025277	Ciona intestinalis	33.16	4.00e-24	102.00
IUUC-Csv-026222	Ciona savignyi	33.67	3.00e-24	102.00
IUUC-Cgl-026530	Colletotrichum gloeosporioides	27.91	2.00e-16	79.30
IUUC-Cne-026848	Cryptococcus neoformans	29.44	6.00e-16	75.90
IUUC-Cme-027184	Cyanidioschyzon merolae	28.06	2.00e-19	88.60
IUUC-Dre-028702	Danio rerio	31.82	6.00e-25	107.00
IUUC-Dno-029507	Dasypus novemcinctus	31.86	5.00e-27	114.00
IUUC-Dor-030693	Dipodomys ordii	32.40	2.00e-20	92.00
IUUC-Dse-031224	Dothistroma septosporum	30.59	2.00e-13	67.00
IUUC-Dme-031646	Drosophila melanogaster	32.88	1.00e-27	117.00
IUUC-Ete-033044	Echinops telfairi	30.56	5.00e-19	87.80
IUUC-Eca-033511	Equus caballus	32.30	4.00e-27	114.00
IUUC-Eeu-034586	Erinaceus europaeus	36.04	2.00e-27	115.00
IUUC-Fca-036319	Felis catus	30.13	3.00e-25	108.00
IUUC-Fal-037325	Ficedula albicollis	35.61	1.00e-25	107.00
IUUC-Fox-037968	Fusarium oxysporum	24.88	3.00e-13	68.90
IUUC-Fso-038417	Fusarium solani	24.29	3.00e-13	68.60
IUUC-Gmo-039275	Gadus morhua	31.05	2.00e-22	97.40
IUUC-Ggr-039804	Gaeumannomyces graminis	29.85	3.00e-20	92.00
IUUC-Gga-041045	Gallus gallus	31.28	1.00e-28	119.00
IUUC-Gac-042067	Gasterosteus aculeatus	33.62	3.00e-28	116.00
IUUC-Gma-043405	Glycine max	31.60	9.00e-23	99.40
IUUC-Ggo-044694	Gorilla gorilla	31.14	1.00e-24	105.00
IUUC-Hsa-046229	Homo sapiens	31.86	6.00e-27	114.00
IUUC-Hvu-047684	Hordeum vulgare	31.65	2.00e-22	98.20
IUUC-Itr-048917	Ictidomys tridecemlineatus	31.86	4.00e-27	114.00
IUUC-Kpa-049223	Komagataella pastoris	35.21	3.00e-33	134.00
IUUC-Lch-049483	Latimeria chalumnae	32.30	8.00e-28	116.00
IUUC-Lpe-051248	Leersia perrieri	32.51	4.00e-22	97.10
IUUC-Loc-052844	Lepisosteus oculatus	32.61	1.00e-27	115.00
IUUC-Lma-052978	Leptosphaeria maculans	29.28	1.00e-13	69.30
IUUC-Laf-053658	Loxodonta africana	32.30	6.00e-27	113.00
IUUC-Mcc-055432	Macaca mulatta	32.30	7.00e-28	116.00
IUUC-Meu-056435	Macropus eugenii	32.46	1.00e-26	112.00
IUUC-Mor-056912	Magnaporthe oryzae	28.64	8.00e-17	81.30
IUUC-Mpo-057341	Magnaporthe poae	29.91	1.00e-21	97.10
IUUC-Mtr-058174	Medicago truncatula	32.48	3.00e-22	97.80
IUUC-Mla-058978	Melampsora laricipopulina	35.55	9.00e-27	111.00
IUUC-Mga-059454	Meleagris gallopavo	37.06	2.00e-26	111.00
IUUC-Mvi-060257	Microbotryum violaceum	31.07	2.00e-17	82.40
IUUC-Mmr-061104	Microcebus murinus	31.86	3.00e-27	114.00
IUUC-Mdo-062256	Monodelphis domestica	33.48	2.00e-29	121.00
IUUC-Mmu-063629	Mus musculus	31.42	1.00e-26	112.00
IUUC-Mac-064839	Musa acuminata	30.90	4.00e-22	97.10
IUUC-Mpu-066790	Mustela putorius furo	31.86	4.00e-27	114.00
IUUC-Mlu-067849	Myotis lucifugus	31.86	4.00e-27	114.00
IUUC-Nfi-068579	Neosartorya fischeri	27.54	4.00e-23	102.00
IUUC-Ncr-068706	Neurospora crassa	28.86	1.00e-17	83.60
IUUC-Nle-069931	Nomascus leucogenys	31.86	1.00e-26	113.00
IUUC-Opr-070806	Ochotona princeps	31.34	2.00e-23	102.00
IUUC-Ont-072628	Oreochromis niloticus	34.16	5.00e-26	110.00
IUUC-Oan-073271	Ornithorhynchus anatinus	30.99	2.00e-18	85.90
IUUC-Ocu-074506	Oryctolagus cuniculus	30.77	1.00e-27	115.00
IUUC-Oba-074983	Oryza barthii	31.33	5.00e-22	96.30
IUUC-Obr-076231	Oryza brachyantha	31.33	1.00e-22	98.20
IUUC-Ogl-076987	Oryza glaberrima	29.33	7.00e-21	92.80
IUUC-Ogu-078658	Oryza glumaepatula	29.92	2.00e-19	88.60
IUUC-Oin-079674	Oryza indica	31.33	7.00e-22	96.30
IUUC-Olo-080443	Oryza longistaminata	31.33	6.00e-22	96.70
IUUC-Ome-081681	Oryza meridionalis	31.33	7.00e-22	96.70
IUUC-Oni-082881	Oryza nivara	29.35	1.00e-19	89.00
IUUC-Opu-083766	Oryza punctata	30.04	3.00e-20	90.90
IUUC-Oru-084743	Oryza rufipogon	31.33	6.00e-22	96.70
IUUC-Osa-085764	Oryza sativa	31.33	6.00e-22	96.70
IUUC-Ola-087348	Oryzias latipes	32.74	2.00e-26	110.00
IUUC-Olu-087729	Ostreococcus lucimarinus	32.16	2.00e-19	87.00
IUUC-Oga-089135	Otolemur garnettii	30.57	9.00e-25	106.00
IUUC-Oar-090004	Ovis aries	31.86	8.00e-27	113.00
IUUC-Ptr-091310	Pan troglodytes	32.00	7.00e-27	113.00
IUUC-Pan-092232	Papio anubis	31.86	1.00e-26	113.00
IUUC-Psi-093140	Pelodiscus sinensis	34.20	2.00e-30	125.00
IUUC-Pma-094606	Petromyzon marinus	32.17	2.00e-28	116.00
IUUC-Pno-094805	Phaeosphaeria nodorum	29.63	5.00e-13	67.80
IUUC-Ppa-095997	Physcomitrella patens	35.12	4.00e-25	107.00
IUUC-Pfo-096571	Poecilia formosa	34.16	1.00e-27	115.00
IUUC-Pab-097640	Pongo abelii	31.86	6.00e-27	114.00
IUUC-Pop-098978	Populus trichocarpa	31.34	2.00e-17	82.00
IUUC-Pca-100611	Procavia capensis	32.44	4.00e-27	114.00
IUUC-Ppe-101189	Prunus persica	34.39	2.00e-22	97.80
IUUC-Pva-102437	Pteropus vampyrus	35.71	3.00e-26	111.00
IUUC-Pgr-103502	Puccinia graminis	32.37	5.00e-22	97.10
IUUC-Ptt-103854	Puccinia triticina	26.77	4.00e-07	46.60
IUUC-Pte-104020	Pyrenophora teres	29.10	3.00e-10	58.50
IUUC-Pyt-104575	Pyrenophora triticirepentis	28.34	1.00e-09	56.20
IUUC-Rno-105520	Rattus norvegicus	31.42	5.00e-27	114.00
IUUC-Sha-106929	Sarcophilus harrisii	33.63	2.00e-28	116.00
IUUC-Sja-107906	Schizosaccharomyces japonicus	34.95	3.00e-34	137.00
IUUC-Spo-108221	Schizosaccharomyces pombe	34.35	8.00e-34	136.00
IUUC-Ssl-108445	Sclerotinia sclerotiorum	28.16	6.00e-22	96.70
IUUC-Smo-108869	Selaginella moellendorffii	30.22	3.00e-19	86.30
IUUC-Sit-110193	Setaria italica	32.17	1.00e-23	102.00
IUUC-Sly-111643	Solanum lycopersicum	32.75	1.00e-21	95.50
IUUC-Stu-112651	Solanum tuberosum	33.19	2.00e-21	95.50
IUUC-Sar-113372	Sorex araneus	27.40	3.00e-21	94.70
IUUC-Sbi-114067	Sorghum bicolor	33.19	4.00e-25	107.00
IUUC-Sre-115071	Sporisorium reilianum	30.46	2.00e-19	89.70
IUUC-Ssc-115376	Sus scrofa	31.86	4.00e-27	114.00
IUUC-Tgu-116621	Taeniopygia guttata	33.63	2.00e-28	117.00
IUUC-Tru-118431	Takifugu rubripes	32.30	2.00e-28	118.00
IUUC-Tsy-119028	Tarsius syrichta	33.16	2.00e-23	101.00
IUUC-Tni-120194	Tetraodon nigroviridis	34.25	2.00e-29	121.00
IUUC-Tca-121652	Theobroma cacao	31.47	4.00e-20	90.90
IUUC-Tre-122246	Trichoderma reesei	23.92	1.00e-12	65.90
IUUC-Tvi-122348	Trichoderma virens	25.96	2.00e-11	61.60
IUUC-Tae-125765	Triticum aestivum	31.65	7.00e-23	99.80
IUUC-Tur-126817	Triticum urartu	31.65	8.00e-23	99.40
IUUC-Tme-126945	Tuber melanosporum	29.75	5.00e-24	103.00
IUUC-Tbe-127763	Tupaia belangeri	35.07	6.00e-15	73.90
IUUC-Ttr-128910	Tursiops truncatus	30.13	2.00e-25	108.00
IUUC-Uma-129373	Ustilago maydis	38.84	2.00e-20	92.40
IUUC-Vda-129779	Verticillium dahliae	27.27	4.00e-17	81.30
IUUC-Vpa-130375	Vicugna pacos	32.00	1.00e-26	112.00
IUUC-Vvi-131660	Vitis vinifera	29.74	9.00e-21	92.80
IUUC-Xtr-132587	Xenopus tropicalis	33.91	1.00e-28	119.00
IUUC-Xma-133896	Xiphophorus maculatus	33.91	9.00e-30	122.00
IUUC-Yli-134367	Yarrowia lipolytica	26.73	2.00e-29	121.00
IUUC-Zma-135913	Zea mays	31.90	3.00e-23	100.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence