iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000101079.1	ENSDART00000160682.1	ENSDARP00000136785.1
ENSDARG00000101079.1	ENSDART00000168532.1	ENSDARP00000138470.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.60e-75	254.8	4050	4410

Active Site

Position(s)	Description	Evidence
4384	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglf.......lysendketlqpnpdsglknpehlklFeflGrllgkalq 83
           d ++ ++++f+gEe+++++G++r+fl++++kelq++ l+l+        + +++k+ l+p p ++     +++l +f+G+llg+a++
   Q: 4050 DPTYAFNIRFTGEEVHGTSGSFRHFLWQVCKELQSSALSLLlpcpsaaANRNKGKYILTPCPITY----AEEQLLNFFGQLLGIAIR 4132
           5667788**********************************888887666677999999999999....689*************** PP
   S: 84   dgrlldlplsksfyklllgkklsl.edleevdpelykslkeikena.esdieelgldltfs.vseei.................lge 150
            + +l+l+l  sf+k l+g+ l+   dl e d  +y ++k+ +++  e+++e+l+++++++ +   +                   +
   Q: 4133 ADVPLPLDLLGSFWKGLVGEALDPeADLREADLLTYSYIKKFESLCdEAELEALCAEVSSQsP---LgespdspsrpcctftyiTMT 4216
           ************************99************8888877524566666555555531...244567888999999966556 PP
   S: 151  tkeeeLkpgGenipVtneNkeeYvklvveyrlke.gikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkyk 236
            +e+eL++gG++i V +eNk+ Yv++v e+rl+e +  e++ a+r+G+ ++ipl+ll+l+++ e+el +cG ++i++e lk++t+y+
   Q: 4217 GEEVELCQGGRDIAVSWENKDVYVRAVRELRLRElQNVECMSAVRAGLGSIIPLQLLTLLSPAEVELRTCGLPDINLEFLKAHTMYQ 4303
           66777*****************************9**************************************************** PP
   S: 237  ggytedspaiqwFwevleefsseerkafLqFvTgssrlPl......gGfaelk....prlfvirk...dasddrlPssnTCfnyLkL 310
            g++e++++i++Fw +le+f++ee ++f++F+++++r+P+      gG ++ +    p+++  ++    + d+r+++++TC+++ kL
   Q: 4304 VGLMETDQHIEFFWAALEMFTQEELSKFIKFACNQERIPFtcpckdGGPDTAHvppyPMKIAPPDgtvGSPDQRYIRVETCMFMVKL 4390
           **********************************************99999999988888888889966667*************** PP
   S: 311  PeYsskeilkekLlyAieet 330
           P+Yss +++ ekL+yAi+++
   Q: 4391 PQYSSLDVMLEKLRYAIHYR 4410
           *****************986 PP

Organism

Danio rerio

Protein Sequence
(Fasta)

SGAVDSSQWL SVKEETIFLH DGLIRVTDLA ELPSEIGVSE QAESEQEILT FETKNPVELA 60
ERLRAVCGNQ SNAYARLLEY RLNALRGLWG AQRQLALEEQ QDHDGVVSAS GGGSDEETLA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGGCGCCTGA CTGACAGCTG GAGCAGCTTT ATAGACTGAA TAAATCGCTC GATAAATCCC 60
TCGCAGTCAG CGCGATCGCG AATTAGTCAC ACGCGAATAT CAATTCAAGA CCTGCGCAAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom

PROSITE

PS50237--HECT

Pfam

PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002256	Ailuropoda melanoleuca	79.37	0.00e+00	4412.00
IUUC-Apl-004161	Anas platyrhynchos	82.35	0.00e+00	2972.00
IUUC-Aca-005341	Anolis carolinensis	75.39	0.00e+00	4354.00
IUUC-Ame-011574	Astyanax mexicanus	86.67	0.00e+00	5350.00
IUUC-Bta-012514	Bos taurus	73.69	0.00e+00	1485.00
IUUC-Cja-019148	Callithrix jacchus	79.72	0.00e+00	3026.00
IUUC-Cfa-020499	Canis familiaris	80.48	0.00e+00	4830.00
IUUC-Cpo-021894	Cavia porcellus	83.53	0.00e+00	2376.00
IUUC-Csa-023079	Chlorocebus sabaeus	77.94	0.00e+00	6390.00
IUUC-Cho-024415	Choloepus hoffmanni	76.10	0.00e+00	4157.00
IUUC-Dno-029595	Dasypus novemcinctus	78.85	0.00e+00	5040.00
IUUC-Dor-030849	Dipodomys ordii	82.61	0.00e+00	1527.00
IUUC-Ete-032563	Echinops telfairi	70.10	0.00e+00	872.00
IUUC-Eca-034202	Equus caballus	79.55	0.00e+00	4409.00
IUUC-Eeu-035175	Erinaceus europaeus	83.03	0.00e+00	931.00
IUUC-Fca-036295	Felis catus	81.78	0.00e+00	4356.00
IUUC-Fal-037003	Ficedula albicollis	77.54	0.00e+00	5578.00
IUUC-Gmo-038579	Gadus morhua	87.76	0.00e+00	2937.00
IUUC-Gga-040961	Gallus gallus	80.42	0.00e+00	5069.00
IUUC-Gac-041899	Gasterosteus aculeatus	88.70	0.00e+00	3008.00
IUUC-Ggo-045099	Gorilla gorilla	79.27	0.00e+00	5220.00
IUUC-Hsa-046331	Homo sapiens	77.87	0.00e+00	6274.00
IUUC-Itr-048190	Ictidomys tridecemlineatus	75.18	0.00e+00	1491.00
IUUC-Lch-049923	Latimeria chalumnae	73.65	0.00e+00	2328.00
IUUC-Loc-052630	Lepisosteus oculatus	82.93	0.00e+00	3946.00
IUUC-Laf-053394	Loxodonta africana	80.55	0.00e+00	4667.00
IUUC-Mcc-055763	Macaca mulatta	77.53	0.00e+00	6409.00
IUUC-Meu-056039	Macropus eugenii	82.49	0.00e+00	2399.00
IUUC-Mga-059500	Meleagris gallopavo	79.32	0.00e+00	4443.00
IUUC-Mmr-060868	Microcebus murinus	74.96	0.00e+00	4863.00
IUUC-Mdo-062772	Monodelphis domestica	77.44	0.00e+00	6453.00
IUUC-Mmu-063606	Mus musculus	79.82	0.00e+00	5026.00
IUUC-Mpu-065860	Mustela putorius furo	77.35	0.00e+00	4291.00
IUUC-Mlu-067376	Myotis lucifugus	79.21	0.00e+00	4391.00
IUUC-Nle-069693	Nomascus leucogenys	75.93	0.00e+00	6069.00
IUUC-Opr-071065	Ochotona princeps	78.08	0.00e+00	970.00
IUUC-Ont-072470	Oreochromis niloticus	85.48	0.00e+00	4754.00
IUUC-Oan-073693	Ornithorhynchus anatinus	82.05	0.00e+00	2960.00
IUUC-Ocu-074032	Oryctolagus cuniculus	76.92	0.00e+00	6407.00
IUUC-Ola-087433	Oryzias latipes	86.65	0.00e+00	1654.00
IUUC-Oga-088546	Otolemur garnettii	81.53	0.00e+00	4216.00
IUUC-Oar-089643	Ovis aries	79.36	0.00e+00	667.00
IUUC-Ptr-090504	Pan troglodytes	77.35	0.00e+00	5876.00
IUUC-Pan-092543	Papio anubis	77.88	0.00e+00	6382.00
IUUC-Psi-093952	Pelodiscus sinensis	75.26	0.00e+00	5761.00
IUUC-Pfo-096356	Poecilia formosa	83.90	0.00e+00	6933.00
IUUC-Pab-098240	Pongo abelii	77.88	0.00e+00	6442.00
IUUC-Pca-100994	Procavia capensis	81.62	0.00e+00	2501.00
IUUC-Pva-102263	Pteropus vampyrus	78.41	0.00e+00	4339.00
IUUC-Rno-104888	Rattus norvegicus	80.25	0.00e+00	4646.00
IUUC-Sha-106944	Sarcophilus harrisii	76.33	0.00e+00	5892.00
IUUC-Sar-113556	Sorex araneus	77.80	0.00e+00	870.00
IUUC-Ssc-116187	Sus scrofa	83.84	0.00e+00	2836.00
IUUC-Tgu-116655	Taeniopygia guttata	82.65	0.00e+00	2974.00
IUUC-Tru-118093	Takifugu rubripes	87.77	0.00e+00	3089.00
IUUC-Tni-119739	Tetraodon nigroviridis	87.04	0.00e+00	1660.00
IUUC-Tbe-127962	Tupaia belangeri	75.68	2.00e-179	624.00
IUUC-Ttr-128819	Tursiops truncatus	82.43	0.00e+00	2102.00
IUUC-Vpa-130482	Vicugna pacos	78.24	0.00e+00	3701.00
IUUC-Xtr-132222	Xenopus tropicalis	75.93	0.00e+00	5794.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence