iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mlu-067780

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAPE02009698

Gene Name

HECW1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMLUG00000003954.2	ENSMLUT00000003961.2	ENSMLUP00000003607.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.30e-90	303.4	1270	1600

Active Site

Position(s)	Description	Evidence
1568	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlld 89
           + ++++l+v+fvgEegld++G++ref++lls+el+np++glf+ys+nd++t+q++p s +  ++hl+++ +   ll  a ++   l 
   Q: 1270 ELQRNKLYVTFVGEEGLDYSGPSREFFFLLSQELFNPYYGLFEYSANDTYTVQISPMSAFV-ENHLEWWFLRDALLDYAYMHISSLF 1355
           567899****************************************************985.5999999777777777766654433 PP
   S: 90   lplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvkl 176
             +  +f   ll+   ++  l  +  + + +++++k ++   i++    l +  +e+i++ ++e+eLk+gG+n++Vt++Nk+eY+++
   Q: 1356 SLF--PFSPSLLKYAAHIFSLLFLIMTWIYFIEFLKTKVVLRIKK----LIYIFKEKIFPPVTERELKSGGANTQVTEKNKKEYIER 1436
           322..4556777777888888888888888999999775444444....344456999***************************** PP
   S: 177  vveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerka 263
           +v++r+++g+ +q+ea+ +Gf+evi+ +l+s+F+++elel+i G++eid++d++++t+y+ggy++ + +i+wFw ++e f++e+r +
   Q: 1437 MVKWRVERGVVQQTEALVRGFYEVIDSRLVSVFDARELELVIAGTAEIDLNDWRNNTEYRGGYHDGHLVIRWFWAAVEHFNNEQRLR 1523
           *************************************************************************************** PP
   S: 264  fLqFvTgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFels 336
           +LqFvTg+s++P +Gfa+l+     r+f+i+k+++ ++lP+++TCfn+L+LP+Y+s++ l+ekLl+A+eet+ F+l+
   Q: 1524 LLQFVTGTSSVPYEGFAALRgsngLRRFCIEKWGKITSLPRAHTCFNRLDLPPYPSYSMLYEKLLTAVEETSTFGLE 1600
           ************************999***********************************************985 PP

Organism

Myotis lucifugus

Protein Sequence
(Fasta)

LLIVCLSPQN LYQNRFLGLA AMASPSRNNQ NRRRCKEPLR HSYNPSQFHS MAIRTSPHGT 60
VTIPRSTSDT DLVTSDSRST LMVSSSYYSI GHSQDLVIHW DIKEEVDAGD WIGMYLIGNI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTGCTGATTG TCTGCTTATC CCCACAGAAT CTGTACCAGA ACAGGTTTTT AGGCCTGGCC 60
GCCATGGCAT CTCCATCTAG AAACAACCAG AACAGGCGCC GCTGCAAGGA GCCACTTCGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR032348--HECW_N
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF16562--HECW_N
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005829--C:cytosol
GO:0016021--C:integral component of membrane
GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001636	Ailuropoda melanoleuca	81.18	0.00e+00	1983.00
IUUC-Apl-003299	Anas platyrhynchos	73.87	0.00e+00	2216.00
IUUC-Aca-005024	Anolis carolinensis	73.64	0.00e+00	2168.00
IUUC-Bta-012604	Bos taurus	84.38	0.00e+00	2451.00
IUUC-Cja-019880	Callithrix jacchus	77.93	0.00e+00	2011.00
IUUC-Cfa-021216	Canis familiaris	82.92	0.00e+00	1617.00
IUUC-Cpo-021466	Cavia porcellus	87.46	0.00e+00	1529.00
IUUC-Csa-023080	Chlorocebus sabaeus	83.65	0.00e+00	2420.00
IUUC-Cho-024740	Choloepus hoffmanni	74.97	0.00e+00	1058.00
IUUC-Dre-028750	Danio rerio	66.98	0.00e+00	1385.00
IUUC-Dno-030019	Dasypus novemcinctus	82.80	0.00e+00	2427.00
IUUC-Dor-031030	Dipodomys ordii	65.06	0.00e+00	979.00
IUUC-Ete-032352	Echinops telfairi	84.48	0.00e+00	1106.00
IUUC-Eca-033948	Equus caballus	82.60	0.00e+00	2342.00
IUUC-Eeu-034474	Erinaceus europaeus	73.32	0.00e+00	753.00
IUUC-Fca-036148	Felis catus	85.28	0.00e+00	2433.00
IUUC-Fal-036957	Ficedula albicollis	75.37	0.00e+00	2200.00
IUUC-Gga-041194	Gallus gallus	75.34	0.00e+00	2201.00
IUUC-Gac-041366	Gasterosteus aculeatus	71.81	0.00e+00	1246.00
IUUC-Ggo-045442	Gorilla gorilla	68.48	0.00e+00	1772.00
IUUC-Hsa-045730	Homo sapiens	83.42	0.00e+00	2414.00
IUUC-Itr-048439	Ictidomys tridecemlineatus	83.33	0.00e+00	2429.00
IUUC-Lch-050185	Latimeria chalumnae	70.53	0.00e+00	1337.00
IUUC-Loc-052744	Lepisosteus oculatus	69.27	0.00e+00	2011.00
IUUC-Laf-054368	Loxodonta africana	89.29	0.00e+00	1343.00
IUUC-Mcc-055487	Macaca mulatta	83.29	0.00e+00	2424.00
IUUC-Mga-059545	Meleagris gallopavo	75.37	0.00e+00	2195.00
IUUC-Mmr-061078	Microcebus murinus	82.03	0.00e+00	2276.00
IUUC-Mdo-062176	Monodelphis domestica	77.43	0.00e+00	1514.00
IUUC-Mmu-063513	Mus musculus	80.24	0.00e+00	2297.00
IUUC-Mpu-065786	Mustela putorius furo	84.48	0.00e+00	2435.00
IUUC-Nle-069213	Nomascus leucogenys	82.24	0.00e+00	2367.00
IUUC-Opr-070208	Ochotona princeps	87.84	0.00e+00	1335.00
IUUC-Ont-072132	Oreochromis niloticus	73.40	0.00e+00	1226.00
IUUC-Oan-072807	Ornithorhynchus anatinus	78.00	0.00e+00	1605.00
IUUC-Ocu-074745	Oryctolagus cuniculus	79.06	0.00e+00	2316.00
IUUC-Ola-086981	Oryzias latipes	67.31	0.00e+00	1334.00
IUUC-Oga-087965	Otolemur garnettii	82.57	0.00e+00	2301.00
IUUC-Oar-089749	Ovis aries	84.00	0.00e+00	2371.00
IUUC-Ptr-091243	Pan troglodytes	83.23	0.00e+00	2409.00
IUUC-Pan-092201	Papio anubis	83.57	0.00e+00	2442.00
IUUC-Psi-093511	Pelodiscus sinensis	72.72	0.00e+00	2140.00
IUUC-Pfo-097001	Poecilia formosa	60.87	0.00e+00	1420.00
IUUC-Pab-098728	Pongo abelii	80.61	0.00e+00	2295.00
IUUC-Pca-100129	Procavia capensis	73.81	0.00e+00	1104.00
IUUC-Pva-102250	Pteropus vampyrus	74.66	0.00e+00	1978.00
IUUC-Rno-105031	Rattus norvegicus	79.68	0.00e+00	2317.00
IUUC-Tgu-117515	Taeniopygia guttata	74.04	0.00e+00	2198.00
IUUC-Tru-117914	Takifugu rubripes	69.90	0.00e+00	1236.00
IUUC-Tsy-119379	Tarsius syrichta	84.06	0.00e+00	718.00
IUUC-Tni-120178	Tetraodon nigroviridis	70.44	0.00e+00	1258.00
IUUC-Tbe-127762	Tupaia belangeri	76.04	0.00e+00	1754.00
IUUC-Ttr-128806	Tursiops truncatus	84.69	0.00e+00	1570.00
IUUC-Vpa-130812	Vicugna pacos	87.17	0.00e+00	647.00
IUUC-Xtr-132903	Xenopus tropicalis	67.74	0.00e+00	1694.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence